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https://www.readbyqxmd.com/read/28737967/integral-membrane-proteins-bottom-up-top-down-and-structural-proteomics
#1
Upendra Karr, Margaret Simonian, Julian P Whitelegge
Integral membrane proteins and lipids constitute the bilayer membranes that surround cells and sub-cellular compartments, and modulate movements of molecules and information between them. Since membrane protein drug targets represent a disproportionately large segment of the proteome, technical developments need timely review. Areas covered and literature search strategy: Publically available resources such as Pubmed were surveyed. Bottom-up proteomics analyses now allow efficient extraction and digestion such that membrane protein coverage is essentially complete, making up around one third of the proteome...
July 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28737221/development-of-paradoxical-inflammatory-disorders-during-treatment-of-psoriasis-with-tnf-inhibitors-a-review-of-published-cases
#2
REVIEW
Martin Havmose, Simon Francis Thomsen
BACKGROUND: TNF inhibitors have proven to be effective and relatively safe in the management of psoriasis. While infections and certain malignancies are established as acknowledged side effects, paradoxical inflammatory, non-neoplastic, noninfectious adverse events are being recognized less frequently. We aimed to identify published, peer-reviewed cases of paradoxical inflammatory, non-neoplastic, noninfectious adverse events in psoriasis patients during TNF inhibitor therapy. METHODS: A literature search in MEDLINE was performed for articles published from inception through the 8th of June 2016 that reported suspected incidents fulfilling a predefined search strategy...
July 24, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28736853/tai-chi-for-risk-of-falls-a-meta-analysis
#3
Rafael Lomas-Vega, Esteban Obrero-Gaitán, Francisco J Molina-Ortega, Rafael Del-Pino-Casado
OBJECTIVES: To analyze the effectiveness of tai chi for falls prevention. DESIGN: Systematic review and meta-analysis. SETTING: Pubmed, Scopus, CINHAL, and Physiotherapy Evidence Database (PEDro) were searched to May 26, 2016. PARTICIPANTS: Older adult population and at-risk adults. INTERVENTION: Randomized controlled trials analyzing the effect of tai chi versus other treatments on risk of falls...
July 24, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28736836/identification-of-adults-with-congenital-heart-disease-of-moderate-or-great-complexity-from-administrative-data
#4
Jill M Steiner, James N Kirkpatrick, Susan R Heckbert, Asma Habib, James Sibley, William Lober, J Randall Curtis
INTRODUCTION: There is relatively sparse literature on the use of administrative datasets for research in patients with adult congenital heart disease (ACHD). The goal of this analysis is to examine the accuracy of administrative data for identifying patients with ACHD who died. METHODS: A list of the International Classification of Diseases codes representing ACHD of moderate- or great-complexity was created. A search for these codes in the electronic health record of adults who received care in 2010-2016 was performed, and used state death records to identify patients who died during this period...
July 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28736580/supportive-and-non-supportive-interactions-in-families-with-a-type-2-diabetes-patient-an-integrative-review
#5
REVIEW
Birgitte B Bennich, Michael E Røder, Dorthe Overgaard, Ingrid Egerod, Lene Munch, Filip K Knop, Tina Vilsbøll, Hanne Konradsen
BACKGROUND: Type 2 diabetes and its management affect the patient and the close family potentially causing either psychological distress or increased sense of responsibility and collaboration in these families. Interactions between patient and family play an important role in maintaining lifestyle changes and diabetes self-management. The purpose of this integrative review was to summarise and assess published studies on the intra-family perspective of supportive and non-supportive interactions in families with a type 2 diabetes patient...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28733911/effects-of-cognitive-behavioural-therapy-for-depression-in-heart-failure-patients-a-systematic-review-and-meta-analysis
#6
REVIEW
Kishaan Jeyanantham, Dipak Kotecha, Devsaagar Thanki, Rebecca Dekker, Deirdre A Lane
This systematic review and meta-analysis aimed to evaluate the effects of cognitive behavioural therapy (CBT) on depression, quality of life, hospitalisations and mortality in heart failure patients. The search strategy was developed for Ovid MEDLINE and modified accordingly to search the following bibliographic databases: PubMed, EMBASE, PsycINFO, CENTRAL and CINAHL. Databases were searched from inception to 6 March 2016 for randomised controlled trials (RCTs) or observational studies that used CBT in heart failure patients with depression or depressive symptoms...
July 22, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28733189/systematic-review-of-serum-steroid-reference-intervals-developed-using-mass-spectrometry
#7
REVIEW
Nevada Tavita, Ronda F Greaves
The aim of this study was to perform a systematic review of the published literature to determine the available serum/plasma steroid reference intervals generated by mass spectrometry (MS) methods across all age groups in healthy subjects and to suggest recommendations to achieve common MS based reference intervals for serum steroids. MEDLINE, EMBASE and PubMed databases were used to conduct a comprehensive search for English language, MS-based reference interval studies for serum/plasma steroids. Selection of steroids to include was based on those listed in the Royal College of Pathologists of Australasia Quality Assurance Programs, Chemical Pathology, Endocrine Program...
July 18, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28731650/efficacy-and-safety-of-caspofungin-in-children-systematic-review-and-meta-analysis
#8
María T Rosanova, David Bes, Pedro Serrano Aguilar, Leticia Cuellar Pompa, Norma Sberna, Roberto Lede
INTRODUCTION: Invasive fungal infections are a significant cause of morbidity and mortality in children. Caspofungin is an echinocandin used as an alternative treatment in the prevention and/or treatment of certain invasive fungal infections in children, although compared to the standard treatment there is little evidence on its efficacy and safety. OBJETIVES: To evaluate the efficacy and safety of caspofungin compared with other antifungal drugs for the prevention and/or treatment of invasive fungal infections in children...
August 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28730648/calcineurin-inhibitor-withdrawal-or-tapering-for-kidney-transplant-recipients
#9
REVIEW
Krishna M Karpe, Girish S Talaulikar, Giles D Walters
BACKGROUND: Calcineurin inhibitors (CNI) can reduce acute transplant rejection and immediate graft loss but are associated with significant adverse effects such as hypertension and nephrotoxicity which may contribute to chronic rejection. CNI toxicity has led to numerous studies investigating CNI withdrawal and tapering strategies. Despite this, uncertainty remains about minimisation or withdrawal of CNI. OBJECTIVES: This review aimed to look at the benefits and harms of CNI tapering or withdrawal in terms of graft function and loss, incidence of acute rejection episodes, treatment-related side effects (hypertension, hyperlipidaemia) and death...
July 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28727909/positive-allergen-reaction-in-allergic-and-nonallergic-rhinitis-a-systematic-review
#10
Aneeza W Hamizan, Janet Rimmer, Raquel Alvarado, William A Sewell, Larry Kalish, Raymond Sacks, Richard J Harvey
BACKGROUND: The diagnosis of allergic rhinitis (AR) is based on cutaneous and serological assessment to determine immunoglobulin E (IgE)-mediated disease. However, discrepancies between these tests and nasal provocation exist. Patients diagnosed as non-allergic rhinitis (NAR) but with positive nasal allergen provocation test (NAPT) may represent a local allergic condition or entopy, still suitable to allergy interventions. The objective of this study was to determine the frequency of nasal reactivity toward allergens among AR and NAR patients, and to describe the diagnostic characteristics of NAPT methodologies...
July 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28727900/head-midline-position-for-preventing-the-occurrence-or-extension-of-germinal-matrix-intraventricular-hemorrhage-in-preterm-infants
#11
REVIEW
Olga Romantsik, Maria Grazia Calevo, Matteo Bruschettini
BACKGROUND: Preterm birth is known to constitute the major risk factor for development of germinal matrix-intraventricular hemorrhage (GM-IVH). Head position may affect cerebral hemodynamics and thus may be involved indirectly in development of GM-IVH. Turning the head toward one side may functionally occlude jugular venous drainage on the ipsilateral side while increasing intracranial pressure and cerebral blood volume. Thus, it has been suggested that cerebral venous pressure is reduced and hydrostatic brain drainage improved if the patient is in supine midline position with the bed tilted 30°...
July 20, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28727706/opioids-for-ocular-pain-a-narrative-review
#12
Vinicius Bp Pereira, Renato Garcia, Andre Am Torricelli, Samir J Bechara
BACKGROUND: Refractive surgery is a common procedure, but may be associated with severe post-operative pain. OBJECTIVES: To describe studies addressing the use of opioids for control of pain after ocular surgery, with an emphasis on refractive surgery. STUDY DESIGN: This is a narrative review of relevant articles on the physiology of corneal pain and the use of opioids for its treatment after surgery. SETTING: Single tertiary center...
July 2017: Pain Physician
https://www.readbyqxmd.com/read/28725669/data-concerning-the-impact-of-mental-fatigue-on-vigor-as-measured-with-the-brunel-mood-scale-brums-in-both-physically-active-and-trained-subjects-a-mini-meta-analysis
#13
Maamer Slimani, Nicola Luigi Bragazzi
The aim of the present mini meta-analysis was to compute the overall effect of mental fatigue induced by two cognitive tasks (namely, AX-continuous performance test or AX-CPT and incongruent Stroop test) on mood state, particularly on vigor, assessed using the Brunel Mood Scale (BRUMS), in both physically active and trained subjects. Search strategy was taken from a systematic review recently carried out by Van Cutsem and collaborators [1], as well as the quality assessment of the included studies. Mental fatigue was not found to impact on vigor score (n=62, effect size=0...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28724714/sedentary-time-in-older-adults-a-critical-review-of-measurement-associations-with-health-and-interventions
#14
REVIEW
Jennifer L Copeland, Maureen C Ashe, Stuart Jh Biddle, Wendy J Brown, Matthew P Buman, Sebastien Chastin, Paul A Gardiner, Shigeru Inoue, Barbara J Jefferis, Koichiro Oka, Neville Owen, Luís B Sardinha, Dawn A Skelton, Takemi Sugiyama, Shilpa Dogra
Sedentary time (ST) is an important risk factor for a variety of health outcomes in older adults. Consensus is needed on future research directions so that collaborative and timely efforts can be made globally to address this modifiable risk factor. In this review, we examined current literature to identify gaps and inform future research priorities on ST and healthy ageing. We reviewed three primary topics:(1) the validity/reliability of self-report measurement tools, (2) the consequences of prolonged ST on geriatric-relevant health outcomes (physical function, cognitive function, mental health, incontinence and quality of life) and(3) the effectiveness of interventions to reduce ST in older adults...
July 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28724568/bet-2-poor-evidence-on-whether-teaching-cognitive-debiasing-or-cognitive-forcing-strategies-lead-to-a-reduction-in-errors-attributable-to-cognition-in-emergency-medicine-students-or-doctors
#15
Govind Oliver, Gopal Oliver, Rick Body
A short review was carried out to see if teaching cognitive forcing strategies reduces cognitive error in the practice of emergency medicine. Two relevant papers were found using the described search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. There is currently little evidence that teaching cognitive forcing strategies reduces cognitive error in the practice of emergency medicine.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28724566/bet-1-lidocaine-with-propofol-to-reduce-pain-on-injection
#16
Janos P Baombe, Laura Howard
A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site. Four relevant papers were found using the described search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. Although a promising idea, a paucity of good quality evidence suggests further needed research.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28724193/saline-irrigation-for-the-management-of-skin-extravasation-injury-in-neonates
#17
REVIEW
P N Gopalakrishnan, Nitin Goel, Sujoy Banerjee
BACKGROUND: Extravasation injury, a complication commonly seen in the neonatal intensive care unit, can result in scarring with cosmetic and functional sequelae. A wide variety of treatments are available, including subcutaneous irrigation with saline (with or without hyaluronidase), liposuction, use of specific antidotes, topical applications, and normal wound care with dry or wet dressings. All such treatments aim to prevent or reduce the severity of complications. OBJECTIVES: Primary objective To compare the efficacy and safety of saline irrigation or saline irrigation with prior hyaluronidase infiltration versus no intervention or normal wound care for tissue healing in neonates with extravasation injury...
July 19, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28719239/explaining-consumer-safe-food-handling-through-behavior-change-theories-a-systematic-review
#18
Ian Young, Danielle Reimer, Judy Greig, Richard Meldrum, Patricia Turgeon, Lisa Waddell
Consumers often engage in unsafe food handling behaviors at home. Previous studies have investigated the ability of behavior-change theories to explain and predict these behaviors. The purpose of this review was to determine which theories are most consistently associated with consumers' safe food handling behaviors across the published literature. A standardized systematic review methodology was used, consisting of the following steps: comprehensive search strategy; relevance screening of identified references; confirmation of relevance and characterization of relevant articles; risk-of-bias assessment; data extraction; and descriptive analysis of study results...
July 18, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28718176/encouraging-top-down-attention-in-visual-search-a-developmental-perspective
#19
Regan Lookadoo, Yingying Yang, Edward C Merrill
Four experiments are reported in which 60 younger children (7-8 years old), 60 older children (10-11 years old), and 60 young adults (18-25 years old) performed a conjunctive visual search task (15 per group in each experiment). The number of distractors of each feature type was unbalanced across displays to evaluate participants' ability to restrict search to the smaller subset of features. The use of top-down attention processes to restrict search was encouraged by providing external aids for identifying and maintaining attention on the smaller set...
July 17, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28717914/association-of-elevated-pre-operative-hemoglobin-a1c-and-post-operative-complications-in-non-diabetic-patients-a-systematic-review
#20
REVIEW
Negar Karimian, Petru Niculiseanu, Alexandre Amar-Zifkin, Francesco Carli, Liane S Feldman
IMPORTANCE: Pre-operative hyperglycemia is associated with post-operative adverse outcomes in diabetic and non-diabetic patients. Current pre-operative screening includes random plasma glucose, yet plasma glycated hemoglobin (HbA1c) is a better measure of long-term glycemic control. It is not clear whether pre-operative HbA1c can identify non-diabetic patients at risk of post-operative complications. OBJECTIVE: The systematic review summarizes the evidence pertaining to the association of suboptimal pre-operative HbA1c on post-operative outcomes in adult surgical patients with no history of diabetes mellitus...
July 17, 2017: World Journal of Surgery
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