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https://www.readbyqxmd.com/read/29162067/necrotizing-fasciitis-after-high-dose-rate-brachytherapy-and-external-beam-radiation-for-prostate-cancer-a-case-report
#1
Shimpei Yamashita, Yasuo Kohjimoto, Akinori Iba, Kazuro Kikkawa, Isao Hara
BACKGROUND: In recent years, the delayed side effects associated with radiotherapy for prostate cancer have drawn the interest of urologists. Although urosymphyseal fistula is one of these delayed side effects, this serious complication is rarely described in literature and is poorly recognized. CASE PRESENTATION: We report our experience in treating a 77-year-old male patient with necrotizing fasciitis after high-dose rate brachytherapy plus external beam radiation for prostate cancer...
November 21, 2017: BMC Urology
https://www.readbyqxmd.com/read/29159764/establishing-iaea-trs-457-diagnostic-x-ray-beam-qualities-at-the-australian-primary-standard-dosimetry-laboratory
#2
Kam L Lee, Duncan Butler, Tracy Bailey
This paper reports the process and findings in establishing the diagnostic beam qualities for the calibration of diagnostic dose meters in the Australian primary standard dosimetry laboratory at the Australian Radiation Protection and Nuclear Safety Agency, ARPANSA. A novel iterative method to achieve the RQR beam quality requirements described by IEC 61267 is presented. The correction factors for the primary standard free-air chamber and their uncertainties are reported. The calibration procedure with detailed uncertainty budget of a typical diagnostic ionisation chamber (model PTW 34060) is reported...
November 20, 2017: Australasian Physical & Engineering Sciences in Medicine
https://www.readbyqxmd.com/read/29158124/improved-survival-with-increased-time-to-radiation-and-sequential-chemotherapy-after-surgery-for-pn2-non-small-cell-lung-cancer
#3
Karna Sura, Inga S Grills, Charles C Vu, Craig W Stevens, Hong Ye, Thomas M Guerrero
BACKGROUND: Currently, the ideal timing for postoperative radiotherapy (PORT) and chemotherapy is unknown. The present study evaluated their relative timing on overall survival (OS) using the National Cancer Database (NCDB). MATERIALS AND METHODS: The NCDB was queried for patients from 2004 to 2012 with resected non-small-cell lung cancer (NSCLC), pathologically involved N2 (pN2) nodes, and negative margins. All patients underwent adjuvant chemotherapy and external beam radiotherapy...
November 17, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29158037/quantitative-imaging-dosimetry-and-metrology-where-do-national-metrology-institutes-fit-in
#4
A J Fenwick, J L Wevrett, K M Ferreira, A M Denis-Bacelar, A P Robinson
In External Beam Radiotherapy, National Metrology Institutes (NMIs) play a critical role in the delivery of accurate absorbed doses to patients undergoing treatment. In contrast for nuclear medicine the role of the NMI is less clear and although significant work has been done in order to establish links for activity measurement, the calculation of administered absorbed doses is not traceable in the same manner as EBRT. Over recent decades the use of novel radiolabelled pharmaceuticals has increased dramatically...
November 11, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29156902/symptomatic-palliation-with-radiotherapy-in-extensive-heterotopic-ossifications
#5
Mary Jiayi Tao, Linda Probyn, Michael Poon, Hans Kreder, Bo Angela Wan, Patrick Diaz, Edward Chow
Heterotopic ossification (HTO) is the dystrophic formation of mature lamellar bone outside the confines of normal osseous tissues. It is frequently a complication which occurs following traumatic insult, both iatrogenic and non-iatrogenic, and neurological compromise. While mild degree of disease is often asymptomatic, significant pain and mobility limitations may result in reduced quality of life in advanced cases. Currently, the commonly accepted management for patients experiencing significant symptomatic HTOs is a combination therapy of surgical excision with prophylactic radiotherapy in the immediate perioperative period...
September 12, 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/29156168/new-fixation-methods-for-the-treatment-of-the-diabetic-foot-beaming-external-fixation-and-beyond
#6
REVIEW
Roberto A Brandão, Jeffrey S Weber, David Larson, Mark A Prissel, Patrick E Bull, Gregory C Berlet, Christopher F Hyer
Surgical correction of complex foot and ankle deformities secondary to Charcot neuroarthropathy remains a significant surgical challenge. New technological advancements in hardware have allowed for the use of augmented fixation techniques in midfoot deformity correction, including the use of indication-specific locking plates and beaming techniques that offer enhanced stability. Severe hindfoot deformity management can employ the use of internal fixation, including intramedullary hindfoot nails and circular external fixation frames for limb salvage...
January 2018: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/29155538/aetiological-histopathological-clinical-diagnostic-and-therapeutical-features-of-idiopathic-cervical-resorption
#7
Virginia Robles Gijón, Cristina Lucena Martín, Rosa Mª Pulgar Encinas, José Manuel Navajas
Root resorption is the loss of hard dental tissue as a result of odontoclastic action involving vital and pulpless teeth. Cervical root resorption (CRR) is a type of external resorption which usually occurs immediately below the epithelial attachment of the tooth in the cervical region. The idiopathic cervical resorption (ICR) refers to a clinical situation in which all other causes, whether local or systemic, have been ruled out as the origin of the disease. The early stage is asymptomatic and might be diagnosed by a routine radiograph or a clinical examination...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29153466/focal-boost-to-residual-gross-tumor-volume-in-brachytherapy-for-cervical-cancer-a-feasibility-study
#8
Niluja Thiruthaneeswaran, Nicki Groom, Gerry Lowe, Linda Bryant, Peter J Hoskin
PURPOSE: Image-guided plan optimization with MRI and CT for interstitial and intracavitary brachytherapy is an established technique in treating cervical cancer. The purpose of this study was to assess the feasibility of boosting the dose to the residual gross tumor volume (GTV-Tres) to 140% of the high-risk clinical target volume (HR-CTV) prescription. METHODS AND MATERIALS: Brachytherapy plans from 50 consecutive patients were analyzed in this study. All received external beam radiotherapy followed by brachytherapy (6 Gy × 4 fraction or 7 Gy × 4 fraction to HR-CTV)...
November 15, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29151818/lifetime-cost-effectiveness-analysis-of-intraoperative-radiation-therapy-versus-external-beam-radiation-therapy-for-early-stage-breast-cancer
#9
Rakesh Patel, Olga Ivanov, Jeff Voigt
Background: To date no one has examined the quality of life and direct costs of care in treating early stage breast cancer with adjunct intraoperative radiation therapy (IORT) versus external beam radiation therapy (EBRT) over the life of the patient. As well no one has examined the effects of radiation exposure with both therapies on the longer term sequelae. The purpose of this analysis was to examine the cost-effectiveness of IORT vs. EBRT over the life of the patient. Methods: A Markov decision-analytic model evaluated these treatment strategies in terms of the direct costs in treating patients over their lifetime (including the downstream costs associated with radiation exposure) and the resultant quality of life of these patients...
2017: Cost Effectiveness and Resource Allocation: C/E
https://www.readbyqxmd.com/read/29151782/salvage-low-dose-rate-brachytherapy-for-recurrent-prostate-cancer-after-external-beam-radiotherapy-results-from-a-single-institution-with-focus-on-toxicity-and-functional-outcomes
#10
F Barbera, L Triggiani, M Buglione, P Ghirardelli, P Vitali, B Caraffini, P Borghetti, D Greco, L Bardoscia, N Pasinetti, L Costa, M Maddalo, B Ghedi, B La Face, S M Magrini
Background/aim: Low dose rate brachytherapy has been used as salvage therapy for locally recurrent prostate cancer (PC) after primary external beam radiation therapy (EBRT), along with surgery and cryotherapy. All these techniques, in particular, when applied to the whole gland, involve a relatively high risk of toxicity and may worsen the patient's quality of life. Our aim is to evaluate the results of whole-gland salvage brachytherapy (SBT) after primary EBRT in terms of toxicity, functional outcomes, and efficacy...
2017: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/29150143/life-after-endometrial-cancer-a-systematic-review-of-patient-reported-outcomes
#11
Robert Shisler, Jennifer A Sinnott, Vivian Wang, Courtney Hebert, Ritu Salani, Ashley S Felix
BACKGROUND: Women with endometrial cancer (EC) are the second largest population of female cancer survivors in the United States. However, the outcomes of EC survivors, from the patient perspective, are not well-understood. Therefore, we conducted a systematic review of patient-reported outcomes (PROs) following an EC diagnosis. METHODS: We searched MEDLINE, EMBASE, Scopus, CINAHL, and reference lists to identify published observational studies that examined PROs among women with EC...
November 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29145247/comparison-of-chemoradiotherapy-with-and-without-brachytherapy-as-adjuvant-therapy-after-radical-surgery-in-early-stage-cervical-cancer-with-poor-prognostic-factors-an-observational-study
#12
Mei-Ling Lan, Xian Yu, He Xiao, Peng Zhou, Nan Hu, Yun Liu, Ge Wang
This study aimed to determine whether the addition of intracavitary brachytherapy (ICBT) to chemoradiotherapy (CRT) improves outcome in patients with cervical cancer and poor prognostic factors. Patients with stage IB to IIA cervical cancer who had undergone radical hysterectomy and pelvic lymphadenectomy between August 2008 and December 2014 were retrospectively registered in this study. All patients received external beam radiation therapy (EBRT) + chemotherapy, and some patients additionally received ICBT...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142872/isolated-tympanic-plate-fracture-detected-by-cone-beam-computed-tomography-report-of-four-cases-with-review-of-literature
#13
Ashita Ritesh Kalaskar, Ritesh Kalaskar
The tympanic plate is a small part of the temporal bone that separates the mandibular condyle from the external auditory canal. Fracture of this small plate is rare and usually associated with other bony fractures, mainly temporal and mandibular bone. There is a limited amount of literature on this subject, which increases the chance of cases being overlooked by physicians and radiologists. This is further supported by purely isolated cases of tympanic plate fracture without evidence of other bony fractures...
October 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29141779/five-field-imrt-class-solutions-and-dosimetric-planning-guidelines-for-implementing-accelerated-partial-breast-irradiation
#14
Sarah Quirk, Petra Grendarova, Michael Roumeliotis
PURPOSE: A comprehensive set of planning guidelines was developed to aid in achieving reproducible dosimetric results for external beam accelerated partial breast irradiation (APBI). The methodology for the development of class solutions for dosimetric planning of the APBI technique, including dose constraint recommendations, is presented for target coverage and conformity as well as normal tissues. METHODS AND MATERIALS: A conservative patient setup was simulated on a linear accelerator, and a comprehensive arrangement of gantry and couch angles was measured for clearance...
September 28, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29140337/direct-imaging-of-tunable-photonic-nanojets-from-a-self-assembled-liquid-crystal-microdroplet
#15
Tatsunosuke Matsui, Kazuya Tsukuda
We report the direct experimental observation of electrically tunable photonic nanojets (PNJs) generated from self-assembled liquid crystal (LC) microdroplets formed by dispersing nematic LCs in polymer matrix. Optical measurements were performed with a home-built laser-scanning confocal microscope system. PNJs with subwavelength beam waists were successfully obtained from LC microdroplets of 5 μm diameter, similar to those from SiO2 microspheres of the same size. By applying external voltage of a few volts, some of major properties of PNJs, such as beam length and brightness, are tuned...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29131499/self-organization-of-amorphous-carbon-nanocapsules-into-diamond-nanocrystals-driven-by-self-nanoscopic-excessive-pressure-under-moderate-electron-irradiation-without-external-heating
#16
Chengbing Wang, San Ling, Jin Yang, Dewei Rao, Zhiguang Guo
Phase transformation between carbon allotropes usually requires high pressures and high temperatures. Thus, the development of low-temperature phase transition approaches between carbon allotropes is highly desired. Herein, novel amorphous carbon nanocapsules are successfully synthesized by pulsed plasma glow discharge. These nanocapsules are comprised of highly strained carbon clusters encapsulated in a fullerene-like carbon matrix, with the formers serving as nucleation sites. These nucleation sites favored the formation of a diamond unit cell driven by the self-nanoscopic local excessive pressure, thereby significantly decreasing the temperature required for its transformation into a diamond nanocrystal...
November 13, 2017: Small
https://www.readbyqxmd.com/read/29129780/prior-radiation-therapy-decreases-time-to-idiopathic-erosion-of-artificial-urinary-sphincter-a-multi-institutional-analysis
#17
Melissa R Kaufman, Douglas F Milam, Niels V Johnsen, Mario A Cleves, Joshua A Broghammer, William O Brant, LeRoy A Jones, Jeffrey D Brady, Martin S Gross, Gerard D Henry
PURPOSE: Substantial controversy and conflicting data exist regarding device survival of the artificial urinary sphincter (AUS) in patients with prior radiation therapy. Herein we present data from a multi-institutional analysis examining the effect of prior radiation for prostate cancer on device survival. MATERIALS AND METHODS: A database was compiled of AUS cuff erosion patients including demographic and comorbid patient characteristics, functional analyses, and interventions...
November 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29129389/adjuvant-therapy-in-patients-with-clear-cell-endometrial-carcinoma-an-analysis-of-the-national-cancer-database
#18
Karina Nieto, William Adams, Nghia Pham, Alec M Block, Surbhi Grover, William Small, Matthew M Harkenrider
OBJECTIVE: To assess the impact of adjuvant treatment, sociodemographic and tumor factors on the survival of patients with non-metastatic clear cell endometrial carcinoma (CCC). METHODS: 4298 patients treated from 1998 to 2011 with Stage I-IVA CCC were identified within the National Cancer Database. FIGO 2009 staging system was used. Adjuvant groups included: hysterectomy (HYS); HYS+vaginal brachytherapy (VBT); HYS+chemotherapy (CT); HYS+external beam radiation therapy (EBRT); HYS+CT+EBRT; and HYS+CT+VBT...
November 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128230/clinical-outcomes-using-image-guided-interstitial-brachytherapy-for-definitive-cervical-cancer-patients-with-high-risk-clinical-target-volumes-greater-than-30%C3%A2-cc
#19
Chenyang Wang, Jagdeep Raince, Uma Swamy, Sang-June Park, Lalaine Zaide, Shane Mesko, D Jeffrey Demanes, Mitchell Kamrava
PURPOSE: Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and toxicity outcomes are acceptable. METHODS: A retrospective review of 37 cervical cancer patients with high-risk clinical target volumes (HR-CTVs) ≥30 cc treated with interstitial image-guided brachytherapy (IS IGBT) was performed...
November 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/29122360/association-between-treatment-planning-and-delivery-factors-and-disease-progression-in-prostate-cancer-radiotherapy-results-from-the-trog-03-04-radar-trial
#20
Marco Marcello, Martin Ebert, Annette Haworth, Allison Steigler, Angel Kennedy, David Joseph, James Denham
BACKGROUND AND PURPOSE: To evaluate the impact of treatment planning and delivery factors on treatment outcome as measured by post-treatment disease progression. MATERIALS AND METHODS: Accruing 813 external beam radiotherapy participants during 2003-2007, the RADAR trial collected a comprehensive range of clinical treatment factor data for each participant. Both the Fine and Gray competing risks modelling and the Kaplan-Meier (KM) analysis were undertaken to determine the impact of these factors on local-composite progression (LCP), with 709 participants available for analysis...
November 6, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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