keyword
https://read.qxmd.com/read/38505726/diseases-categorized-as-autoinflammatory-keratinization-diseases-aikds-and-their-pathologies-and-treatments
#1
REVIEW
Masashi Akiyama
Whole-exome and whole-genome sequencing have become widespread in approximately the last 15 years, and the predisposing factors and pathomechanisms of inflammatory keratinization diseases, which have been unknown for a long time, have gradually been revealed. Hence, various inflammatory keratinization diseases are recognized to cause innate immunity hyperactivation. Therefore, we have been advocating for the clinical entity, "autoinflammatory keratinization diseases (AiKDs)" since 2017. AiKDs are inflammatory keratinization diseases caused by autoinflammatory-related pathomechanisms in the skin...
February 2024: Nagoya Journal of Medical Science
https://read.qxmd.com/read/38423685/hidradenitis-suppurativa-related-autoinflammatory-syndromes-an-updated-review-on-the-clinics-genetics-and-treatment-of-pyoderma-gangrenosum-acne-and-suppurative-hidradenitis-pash-pyogenic-arthritis-pyoderma-gangrenosum-acne-and-suppurative-hidradenitis-papash
#2
REVIEW
Carlo Alberto Maronese, Chiara Moltrasio, Angelo Valerio Marzano
Hidradenitis suppurativa (HS) is an autoinflammatory skin disorder of the terminal hair follicle, which can present in sporadic, familial, or syndromic form. A classification has been proposed for the latter, distinguishing cases associated with a known genetic condition, with follicular keratinization disorders or with autoinflammatory diseases. This review focuses on the clinical and genetic features of those entities (ie, pyoderma gangrenosum [PG], acne and HS; PG, acne, pyogenic arthritis and HS; psoriatic arthritis, PG, acne and HS; synovitis, acne, pustulosis, hyperostosis, osteitis; and so forth) for which the collective term HS-related autoinflammatory syndromes is proposed...
April 2024: Dermatologic Clinics
https://read.qxmd.com/read/38031879/genetic-mutations-in-pyoderma-gangrenosum-hidradenitis-suppurativa-and-associated-autoinflammatory-syndromes-insights-into-pathogenic-mechanisms-and-shared-pathways
#3
REVIEW
Takashi K Satoh
Pyoderma gangrenosum (PG), hidradenitis suppurativa (HS), and the associated autoinflammatory syndromes, including pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome, PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PASH) syndrome, and pyogenic arthritis, pyoderma gangrenosum, acne, and suppurative hidradenitis (PAPASH) syndrome are dermatological conditions characterized by chronic inflammation and tissue damage...
November 30, 2023: Journal of Dermatology
https://read.qxmd.com/read/37986703/advances-in-surgical-treatment-of-hidradenitis-suppurative
#4
JOURNAL ARTICLE
Yiran Wang, Chunmao Han, Xingang Wang
Hidradenitis suppurative is a chronic, refractory and recurrent dermatological disease. The disease should be managed by targeted surgical intervention on the basis of medical treatment. Currently, the surgical treatment methods include incision and drainage, unroofing, laser therapy, intense pulsed light therapy, photodynamic therapy, and other local treatments, as well as complete lesion resection such as skin-tissue-saving excision with electrosurgical peeling and extended excision. The clearance range, therapeutic effect, postoperative complications, and recurrence risk are different among the different treatment methods...
November 2, 2023: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/37898343/expanding-the-therapeutic-versatility-of-clacosterone
#5
EDITORIAL
Warren R Heymann
No abstract text is available yet for this article.
January 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/37722942/what-should-a-surgeon-know-about-hidradenitis-suppurativa
#6
REVIEW
Anne Cecile Ezanno, Philippe Guillem, Cécile Gorin, Germaine Gabison, Brice Malgras, Anne-Claire Fougerousse
Otherwise known as Verneuil's disease, hidradenitis suppurative (HS) is a severe dermatosis of heterogeneous appearance affecting 1% of the population. Its pathophysiology is multifactorial, involving genetic predisposition, inflammatory disorder and environmental elements. Its diagnosis is based on the association of three clinical characteristics: characteristic lesions, typical localizations, and the chronic and recurrent nature of the lesions. Given its diversified aspects, diagnosis can be difficult to achieve...
September 16, 2023: Journal of Visceral Surgery
https://read.qxmd.com/read/37662678/retracted-a-novel-ncstn-mutation-in-a-three-generation-chinese-family-with-hidradenitis-suppurative
#7
Journal Of Healthcare Engineering
[This retracts the article DOI: 10.1155/2022/1540774.].
2023: Journal of Healthcare Engineering
https://read.qxmd.com/read/37652190/assessment-tools-and-phenotype-classification-for-hidradenitis-suppurativa
#8
JOURNAL ARTICLE
Nicole D K Koerts, Klasiena Bouwman, Lisette M Prens, Barbara Horváth
Hidradenitis suppurativa (HS) is a heterogeneous chronic relapsing skin disease. Several assessment tools are used to assess disease severity and to classify disease phenotype; however, no consensus currently exists. This review evaluates the various assessment tools and phenotypes, assessing their validity and reliability. Numerous assessment tools and phenotype classifications have been proposed for identifying various subtypes within the HS disease spectrum. Each has a with different purpose, such as use in daily practice or in clinical trial settings...
August 29, 2023: Clinics in Dermatology
https://read.qxmd.com/read/37473764/-abdominoplasties-and-suppurative-hydradenitis-acne-inversa-in-patients-after-massive-weight-loss
#9
JOURNAL ARTICLE
Ulrich Eugen Ziegler, Petronela Sakova, Hans Bernd Reith
Post-bariatric surgical procedures in patients after massive weight loss (MWL) are often associated with elevated minor and major complications (17-55%). If there is additionally a long history of hydradenitis suppurativa (HS) in the lower abdomen and groin area, complications of infection can appear in all patients. Differentiated pre-, peri- and postoperative therapy regime is then indicated.From 2010 to 2021, a total of 12 (66.6% women, 33.3% men) consecutive patients underwent conventional (Pittsburg rating scale [PRS]: Grade 2) or fleur-de-lis abdominoplasty (PRS: Grade 3) after massive weight loss...
July 20, 2023: Zentralblatt Für Chirurgie
https://read.qxmd.com/read/37325045/hidradenitis-suppurativa-in-patients-with-and-without-erythrasma
#10
JOURNAL ARTICLE
Mariela Del Ángel Hernández, Carlos Daniel Sánchez Cárdenas, Juan Carlos López Mena Gómez, Diana Carolina Vega Sánchez, Tania Mendoza Ibarra, Sarahí Hernández García, Nancy Pulido Díaz, Roberto Arenas
No abstract text is available yet for this article.
September 2023: JAAD international
https://read.qxmd.com/read/37171791/obesity-and-hidradenitis-suppurativa-targeting-meta-inflammation-for-therapeutic-gain
#11
JOURNAL ARTICLE
Dillon Mintoff, Rachel Agius, Farida Benhadou, Anupam Das, John W Frew, Nikolai P Pace
Hidradenitis Suppurativa (HS) is a chronic, suppurative condition of the pilosebaceous unit. The typical HS patient is characterized as obese, smoker, manifesting nodules, abscesses and/or draining tunnels predominantly distributed in intertriginous skin. It is established that lifestyle and genetic factors are the main pathophysiological drivers of HS. In this critical review, we explore the interrelatedness of the meta-inflammation, obesity and HS and discuss if and how this relationship may be manipulated for a therapeutic end...
May 12, 2023: Clinical and Experimental Dermatology
https://read.qxmd.com/read/37147873/hidradenitis-suppurativa-and-social-disadvantage-a-nationwide-administrative-data-study-of-the-french-hospitalized-population
#12
JOURNAL ARTICLE
Julie Bulsei, Eric Fontas, Thierry Passeron
BACKGROUND: A lower socioeconomical status (SES) has been reported in patients suffering from hidradenitis suppurative (HS). However, limitations in the available studies prevent drawing definitive conclusions. OBJECTIVES: The objective of this study was to assess the SES of HS patients using a specific SES indicator, the French DEPrivation index (FDep), specifically designed and validated for the French population. METHODS: This cross-sectional cohort study compared the HS hospitalized population with the general hospitalized population without HS...
May 5, 2023: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/37065337/langerhans-cell-histiocytosis-presenting-with-clinical-features-of-hidradenitis-suppurativa
#13
Miranda L Yousif, Claire S Faulkner, Lise Harper, Lindsay Ackerman
Langerhans cell histiocytosis (LCH) is a rare neoplastic disease of myeloid dendritic cells with a widely variable presentation of organ system involvement and severity. In this case report, we share the details of a rare case of cutaneous LCH resembling hidradenitis suppurativa (HS).
March 2023: Curēus
https://read.qxmd.com/read/36943386/irisin-a-novel-metabolic-biomarker-in-hidradenitis-suppurativa-correlation-with-clinical-responsivity-to-anti-tnf-%C3%AE-therapy
#14
JOURNAL ARTICLE
Sara Cacciapuoti, Emanuele Scala, Maria A Luciano, Claudio Marasca, Matteo Megna, Giuseppina Caiazzo, Melania Parisi, Maria Quaranta, Gabriella Fabbrocini
BACKGROUND: Suppurative hidradenitis (HS) is a chronic, inflammatory skin disease of the hair follicle unit. Adalimumab (ADA), an anti-tumor necrosis factor (TNF) alpha, is the only FDA-approved biologic available for the management of HS. TNF-α can also affect glucose and lipid metabolism, promoting insulin resistance and obesity by negatively regulating irisin, a new adipomyokine. METHODS: A total of 17 HS patients were enrolled in the study. Blood samples were collected from all patients at baseline and week-16...
April 2023: Italian journal of dermatology and venereology
https://read.qxmd.com/read/36923186/revision-of-the-failed-cleft-lift-for-pilonidal-disease
#15
JOURNAL ARTICLE
Steven C Immerman
The cleft lift has been demonstrated to be one of the most successful operations for the treatment of pilonidal disease, however, there are times this procedure fails and further surgery is necessary. This article describes a reproducible and successful technique for the revision of a failed cleft lift. This procedure was performed on 76 consecutive patients who had previous cleft lift procedures. Failures were manifested by either a wound, sinus, abscess, dehiscence or fragile scar. The revision flattened the lower gluteal cleft with a rotation and advancement flap that placed the skin incision off-midline...
February 2023: Curēus
https://read.qxmd.com/read/36766606/the-development-of-systemic-inflammatory-diseases-in-hidradenitis-suppurativa
#16
REVIEW
Natsuko Saito-Sasaki, Yu Sawada
It is understood that the skin is a peripheral lymphoid tissue that defends against external environmental stimuli. Continuous activation from these factors, on the other hand, promotes persistent inflammation at the local location and, occasionally, tissue damage. Hidradenitis suppurativa (HS) is a typical inflammatory skin disease and becomes a source of numerous inflammatory cytokines due to the chronic intractable repeated inflamed tissues. Because inflammatory cells and cytokines circulate throughout the body from the inflamed organ, it has been hypothesized that HS-mediated skin inflammation impacts the systemic functioning of numerous organs...
January 30, 2023: Diagnostics
https://read.qxmd.com/read/36738185/-guidelines-for-the-management-of-patients-with-hidradenitis-suppurativa
#17
JOURNAL ARTICLE
Joana Cabete, Inês Aparício Martins
Hidradenitis suppurativa is a chronic and recurrent inflammatory dermatosis characterized by the presence of inflammatory nodules and abscesses in the apocrine gland-rich areas that may progress to suppurative fistulas and scars. Despite being considered one of the dermatological conditions with the greatest impact on patient quality of life, it is often underdiagnosed. Hidradenitis suppurativa, especially in its severe forms, is associated with numerous comorbidities, so a holistic and multidisciplinary perspective is crucial for the management of these patients...
February 1, 2023: Acta Médica Portuguesa
https://read.qxmd.com/read/36695130/a-bibliometric-analysis-of-hidradenitis-suppurativa-literature-over-the-past-50%C3%A2-years
#18
JOURNAL ARTICLE
Galia Peles, Amir Horev
BACKGROUND: We aimed to describe the existing literature on hidradenitis suppurative (HS) in the last 50 years and the key processes made over time. METHODS: On July 27, 2022, we searched for HS studies published in the last 50 years (from 1972 to 2022) using Web of Science. The search was made using the keywords "Hidradenitis Suppurativa" and "Acne Inversa." The data are subdivided according to publications and citations rate, country, publication year, journal and impact factor, keywords analysis of top 100 cited papers study design, and pediatric versus adults...
January 25, 2023: International Journal of Dermatology
https://read.qxmd.com/read/36691658/the-psychosocial-burden-of-hidradenitis-suppurativa-in-singapore
#19
JOURNAL ARTICLE
Xue Ting Ooi, Ellie Choi, Huirong Han, Hafizah Ahmad, Kalyani Rajesh Patwardhan, Nisha Suyien Chandran
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic debilitating inflammatory skin disorder known to result in significant psychological symptoms and impaired quality of life. However, most of these studies are limited to western countries, with limited data from other sociocultural regions. OBJECTIVE: To understand the psychosocial burden of HS in the Asian context, by exploring the correlation between objective disease measures with psychosocial health and work productivity...
March 2023: JAAD international
https://read.qxmd.com/read/36654647/-the-terror-of-death-began-to-stalk-him-the-mysterious-fistula-of-charles-the-wise
#20
REVIEW
Matthew D Turner
For 23 years, Charles V "The Wise" of France suffered from a mysterious fistula on his left arm that continuously drained pus. For all this time, he believed that as soon as the fistula ceased to weep, he would have a mere 15 days before death followed. His death in 1380, at the young age of 42, seemingly proved this assumption correct. This paper explores the possible explanations from arsenic poisoning at the hands of his longtime nemesis Charles II, as many of his contemporaries believed, to an undiagnosed case of hidradenitis suppurativa, to an underlying tuberculosis infection, to the possibility that his condition was entirely self-inflicted...
December 2022: Curēus
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