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https://www.readbyqxmd.com/read/29251178/putamen-volume-differences-among-older-adults-depression-status-melancholia-and-age
#1
Natalie J Sachs-Ericsson, Greg Hajcak, Julia L Sheffler, Ian H Stanley, Edward A Selby, Guy G Potter, David C Steffens
BACKGROUND: Individuals with major depressive disorder (MDD) may exhibit smaller striatal volumes reflecting deficits in the reward circuit. Deficits may change with age and be more pronounced among the melancholic subtype. Limited research has investigated striatal volume differences in older adults and by depression subtypes. METHOD: We used baseline data from the Neurocognitive Outcomes of Depression in the Elderly study. We examined volumetric differences in the putamen and caudate nucleus among older adults (60 years and older), comparing healthy control participants (n = 134) to depressed participants (n = 226), and comparing nonmelancholic depressed participants (n = 93) to melancholic depressed participants (n = 133)...
January 2018: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/29247900/risk-factors-for-recurrence-in-depression-in-the-lundby-population-1947-1997
#2
Linnéa Nöbbelin, Mats Bogren, Cecilia Mattisson, Louise Brådvik
BACKGROUND: Depression is a common disorder in both men and women, and the recurrence rate is high. The aim of this study was to identify risk factors for recurrence in depression in the Lundby Study. METHODS: The Lundby Study is a community-based longitudinal study with focus on mental health. The study started in 1947 and three follow-ups have been carried out since, the last one in 1997. The population consists of 3563 subjects. Data from 508 subjects afflicted by depression was gathered...
November 24, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29197929/transdiagnostic-symptom-clusters-and-associations-with-brain-behavior-and-daily-function-in-mood-anxiety-and-trauma-disorders
#3
Katherine A Grisanzio, Andrea N Goldstein-Piekarski, Michelle Yuyun Wang, Abdullah P Rashed Ahmed, Zoe Samara, Leanne M Williams
Importance: The symptoms that define mood, anxiety, and trauma disorders are highly overlapping across disorders and heterogeneous within disorders. It is unknown whether coherent subtypes exist that span multiple diagnoses and are expressed functionally (in underlying cognition and brain function) and clinically (in daily function). The identification of cohesive subtypes would help disentangle the symptom overlap in our current diagnoses and serve as a tool for tailoring treatment choices...
February 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29150144/atypical-depression-and-non-atypical-depression-is-hpa-axis-function-a-biomarker-a-systematic-review
#4
REVIEW
Mario F Juruena, Mariia Bocharova, Bruno Agustini, Allan H Young
BACKGROUND: The link between the abnormalities of the Hypothalamic-pituitary-adrenal (HPA) axis and depression has been one of the most consistently reported findings in psychiatry. At the same time, multiple studies have demonstrated a stronger association between the increased activation of HPA-axis and melancholic, or endogenous depression subtype. This association has not been confirmed for the atypical subtype, and some researchers have suggested that as an antinomic depressive subtype, it may be associated with the opposite type, i...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29103192/lipid-peroxidation-and-immune-biomarkers-are-associated-with-major-depression-and-its-phenotypes-including-treatment-resistant-depression-and-melancholia
#5
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
To examine immune-inflammatory and oxidative (I&O) biomarkers in major depression (MDD) and its related phenotypes, we recruited 114 well-phenotyped depressed patients and 50 healthy controls and measured serum levels of interleukin (IL)-1α, soluble IL-1 receptor antagonist (sIL-1RA), soluble IL-2 receptor (sIL-2R), soluble IL-6 receptor (sIL-6R), soluble tumor necrosis factor receptor 60 and 80 kDa (sTNF-R1/R2), and thiobarbituric acid reactive substances (TBARS). Obtained results indicate that MDD is characterized by increased sIL-1RA, sTNF-R1, and TBARS concentrations...
November 4, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/29042881/clinical-validation-of-the-psychotic-depression-assessment-scale-hamilton-depression-rating-scale-6-and-brief-psychiatric-rating-scale-5-results-from-the-clinical-research-center-for-depression-study
#6
Seon-Cheol Park, Eun Young Jang, Jae-Min Kim, Tae-Youn Jun, Min-Soo Lee, Jung-Bum Kim, Hyeon-Woo Yim, Yong Chon Park
OBJECTIVE: The aim of this study was to validate the psychotic depression assessment scale (PDAS), which includes the six-item melancholia subscale from the Hamilton depression rating scale (HAMD-6) and the five-item psychosis subscale from the brief psychiatric rating scale (BPRS-5). Data from the Clinical Research Center for Depression (CRESCEND) study, which is a 52-week naturalistic trial, were analyzed. METHODS: Fifty-two patients with psychotic depression from the CRESCEND study met our inclusion criteria...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29022850/the-devolution-of-melancholia-into-psychosis-the-case-of-a-child-whose-mother-was-unable-to-grieve
#7
Yaakov Roitman
The author explores the intersubjective aspect of the devolution of melancholia into psychosis, particularly as it involves the unconscious intersubjective role of the mother. The author considers the possibility that maternal inability to mourn contributes significantly to the foreclosure of the child's "tertiary processes" (the processes involved in the child's development of a differentiated autonomous self and symbolization). In the clinical case presented in detail in this paper, the child's undifferentiated experience with his mother (who was unable to grieve) left no room for the father as the necessary third element in the child's maturational processes...
October 2017: Psychoanalytic Review
https://www.readbyqxmd.com/read/28987022/debate-on-defining-melancholia-a-core-mood-disorder
#8
Lucas Primo de Carvalho Alves, Neusa Sica da Rocha
OBJECTIVES: Recently, a debate article by Parker et al. was published regarding the biological type of depression, melancholia, in which they discussed its clinical presentation, particularly that involving psychomotor disturbances. However, there is one feature of melancholia that is frequently forgotten, to which this article aims to devote special attention: ruminative thoughts of guilt. METHODS: A critical review of the literature. RESULTS: The symptom of ruminative thoughts of guilt has been described historically in melancholia, and some recent data, such as neurobiological abnormalities and poor prognosis, support it as an important feature of depression...
October 7, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28971468/post-operative-delirium-in-elderly-people-diagnostic-and-management-issues-of-post-operative-delirium-in-elderly-people
#9
Christina Florou, Dimitrios Theofilopoulos, Styliani Tziaferi, Maria Chania
Hippocrates a Greek physician commonly known as the Father of Medicine was the first to describe delirium, 'phrenitis', differencing it from other disorders such as melancholia and mania. Since then, it still remains a clinical problem which is not yet resolved.Postoperative delirium is a common medical problem that occurs preferentially in surgical patients aged 65 years and older. It is a true medical emergency that requires immediate professional attention and treatment. Faced by health professionals and especially nurses it is often undetected, misdiagnosed, and under-treated as a complication by them during clinical care...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28941779/historical-and-conceptual-aspects-of-motor-disorders-in-the-psychoses
#10
German E Berrios, Ivana S Marková
Historical epistemology is a useful method to understand the longitudinal construction of the movement disorders in psychiatry. Four periods can be identified in such a process. The first, extending from Classical times to the work of Griesinger, included disorders such as catalepsy, crocidism, epilepsy and paralysis. The second period, stretching from Griesinger to Kahlbaum, concentrated on the study of melancholia attonita, stupor and catatonia. The third period, covering the time from Kahlbaum to WWI, witnessed important conceptual shifts such as: the transformation of madness into psychoses; the redefinition of movement and motility in psychiatry; the appearance of self-contained syndromes as dyskinesias, tics, akathisia, complex disorders like the cases of encephalitis lethargica, etc...
September 20, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28931368/depression-differed-by-midnight-cortisol-secretion-alexithymia-and-anxiety-between-diabetes-types-a-cross-sectional-comparison
#11
Eva O Melin, Maria Thunander, Mona Landin-Olsson, Magnus Hillman, Hans O Thulesius
BACKGROUND: Increased prevalence of depression is found in both type 2 diabetes (T2D) and type 1 diabetes (T1D). Melancholia and atypical depression differ by cortisol secretion and clinical features. The aim was to compare the clinical presentation of T1D and T2D patients in relation to self-reported depression, self-reported anxiety, alexithymia, obesity, and midnight salivary cortisol (MSC). METHODS: Comparative cross-sectional design. The participants were consecutively recruited from one hospital diabetes outpatient clinic: 24 T2D patients (31-59 years) and 148 T1D patients (32-59 years)...
September 20, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28867391/are-there-differences-in-lipid-peroxidation-and-immune-biomarkers-between-major-depression-and-bipolar-disorder-effects-of-melancholia-atypical-depression-severity-of-illness-episode-number-suicidal-ideation-and-prior-suicide-attempts
#12
Magdalena Sowa-Kućma, Krzysztof Styczeń, Marcin Siwek, Paulina Misztak, Rafał J Nowak, Dominika Dudek, Janusz K Rybakowski, Gabriel Nowak, Michael Maes
BACKGROUND: There is evidence that major depression (MDD) and bipolar disorder (BD) are accompanied by activated immune & oxidative (I&O) pathways. METHODS: To compare I&O biomarkers between MDD and BD we assessed serum levels of thiobarbituric acid reactive substances (TBARS; a lipid peroxidation marker), soluble interleukin-2 receptor (sIL-2R), sIL-6R, IL-α, sIL-1R antagonist (sIL-1RA), tumor necrosis factor receptor 60kDa/80kDa (sTNFR60/R80) in 114 MDD and 133 BD patients, and 50 healthy controls...
September 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28691306/to-define-melancholia-follow-the-path-of-catatonia
#13
Max Fink
No abstract text is available yet for this article.
August 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28671276/love-and-melancholia-in-the-analysis-of-women-by-women
#14
Rosine Jozef Perelberg
This paper suggests that in the analysis of women by women a melancholic core may be encountered at the centre of the transference/countertransference situation that is an expression of the loss of the primary maternal object that has never been mourned. The attachment to the primary, lost object may be preserved in a melancholic, invisible way, and the longing that it is connected to might only reach representation in the après coup of the analytic process. The links between this primary love, melancholia and the unrepresentable in the analysis of women will be explored...
July 3, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28638134/melancholia-narcissism-and-depression
#15
Teresa Pinheiro, Julio Verztman, Diane Viana
This paper discusses ideas about depression as a paradigmatic symptom of contemporaneous psychological suffering and makes a comparison between depression and melancholia. The ideas we describe were stimulated by two comparative studies that were conducted based on an analysis of how depressed subjects relate to the concept of desire, their feelings of shame and their self-image in today's age.
September 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28622810/exploratory-examination-of-the-utility-of-demoralization-as-a-diagnostic-specifier-for-adjustment-disorder-and-major-depression
#16
D W Kissane, I Bobevski, P Gaitanis, J Brooker, N Michael, C Lethborg, G Richardson, P Webster, C Hempton
OBJECTIVE: Demoralization, a state of lowered morale and poor coping, has a prevalence of 13-18% among patients with advanced cancer. We surveyed clinicians' perspectives of the utility of "with demoralization" as a diagnostic specifier for adjustment and depressive disorders. METHOD: Using comparative clinical vignettes in a field survey, clinicians from a range of disciplines were asked their perception of the utility of diagnosis and treatment options. Response frequencies were compared using Cochran's Q and McNemar's tests, with sensitivity and specificity rated against expert rankings of diagnosis...
May 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/28599349/defining-melancholia-a-core-mood-disorder
#17
Gordon Parker, Darryl Bassett, Tim Outhred, Grace Morris, Amber Hamilton, Pritha Das, Bernhard T Baune, Michael Berk, Philip Boyce, Bill Lyndon, Roger Mulder, Ajeet B Singh, Gin S Malhi
No abstract text is available yet for this article.
May 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28585368/psychometric-evaluation-of-a-6-item-chinese-version-of-the-hamilton-depression-rating-scale-mokken-scaling-and-item-analysis
#18
Chin-Pang Lee, Chia-Yih Liu, Ching-I Hung
BACKGROUND: It is unclear whether the 6-item Melancholia subscale of the Hamilton Depression Rating Scale (HAM-D6 ) has better psychometric properties than the parental 17-item version (HAM-D17 ) in the Chinese populations. METHODS: The study was to check the Chinese HAM-D17 and HAM-D6 for reliability and validity with Mokken scale analysis and item analysis. We reanalyzed a clinical sample of adult psychiatric outpatients (N = 214; age, mean (SD) = 38.3 (10...
June 6, 2017: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/28466472/blind-cave-of-eternal-night-the-work-of-mourning-in-tagore-s-play-of-four
#19
Kamalika Mitra
This paper correlates Sigmund Freud and Rabindranath Tagore's writings on mourning through two specific texts. Despite being contemporaries and profoundly influential, Tagore and Freud's spheres of influence have tended to be separate, so that there have been but few attempts at connecting their philosophies. This essay examines the second chapter of Tagore's novella Play of Four (Chaturanga, 1916) in the light of Freud's essay 'Mourning and melancholia' (1917). It explores how mourning may at once demand confirmation and denial; how it affects love and desire...
May 3, 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/28385173/novel-augmentation-strategies-in-major-depression
#20
REVIEW
Klaus Martiny
Hypothesis The hypotheses of all the four included studies share the common idea that it is possible to augment the effect of antidepressant drug treatment by applying different interventions and with each intervention attain a clinically meaningful better effect compared to a control condition, and with minor side effects, thus improving the short- and medium-term outcome in major depression. Procedures Study design The basic study design has been the double blind randomised controlled trial (RCT). In the light therapy study, all patients were treated with sertraline for the whole of the study duration...
April 2017: Danish Medical Journal
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