Xiao Gao, Yuru Tang, Lingli Kong, Yong Fan, Chunxia Wang, Rui Wang
Depression is a highly prevalent disorder of the central nervous system. The neuropsychiatric symptoms of clinical depression are persistent and include fatigue, anorexia, weight loss, altered sleep patterns, hyperalgesia, melancholia, anxiety, and impaired social behaviours. Mounting evidences suggest that neuroinflammation triggers dysregulated cellular immunity and increases susceptibility to psychiatric diseases. Neuroimmune responses have transformed the clinical approach to depression because of their roles in its pathophysiology and their therapeutic potential...
August 21, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society