Sheng Wang, Yan Xie, Yan-Wu Huo, Yan Li, Peter W Abel, Haihong Jiang, Xiaohan Zou, Hai-Zhan Jiao, Xiaolin Kuang, Dennis W Wolff, You-Guo Huang, Thomas B Casale, Reynold A Panettieri, Taotao Wei, Zhengyu Cao, Yaping Tu
Overuse of β2-adrenoceptor agonist bronchodilators evokes receptor desensitization, decreased efficacy, and an increased risk of death in asthma patients. Bronchodilators that do not target β2-adrenoceptors represent a critical unmet need for asthma management. Here, we characterize the utility of osthole, a coumarin derived from a traditional Chinese medicine, in preclinical models of asthma. In mouse precision-cut lung slices, osthole relaxed preconstricted airways, irrespective of β2-adrenoceptor desensitization...
November 24, 2020: Science Signaling