Sandra Romero-Córdoba, Mayel Chirinos, Nancy Noyola-Martínez, Nayeli Torres-Ramirez, Mitzi García-Olivares, Juan Pablo Aragón-Hernández, Jazmín Ixchel Ramírez-Camacho, Rosa Zúñiga, Fernando Larrea, Ali Halhali, David Barrera
Calcitriol and transforming growth factor beta 1 (TGF-β1) are unrelated molecules that regulate biological processes according to the genetic target, cell type, and context. Several studies have shown independent effects of calcitriol and TGF-βs on the placenta, but there is no information regarding the impact of their combination on these cells. Therefore, this study analyzed the effects of calcitriol, TGF-β1, and their combination in primary cultures of human trophoblast cells using a whole genome expression microarray...
October 11, 2023: Molecular and Cellular Endocrinology