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Cardiac pacing

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https://www.readbyqxmd.com/read/28814710/left-univentricular-pacing-by-rate-adaptive-atrioventricular-delay-in-treatment-of-chronic-heart-failure
#1
Lulu Zhao, Ling Zhao, Lijin Pu, Baotong Hua, Yu Wang, Shumin Li, Qing Li, Tao Guo
BACKGROUND Cardiac resynchronization therapy (CRT) is efficacious in the treatment of chronic heart failure (CHF); however, because it is non-physiological, some patients are unresponsive. The present study used rate-adaptive atrioventricular delay (RAAVD) to track the physiological atrioventricular delay and investigated the effects of left univentricular pacing on CRT. MATERIAL AND METHODS Patients with CHF fulfilling the indication of CRT Class I were categorized into a left univentricular pacing by RAAVD group and a standard biventricular pacing group...
August 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28811555/identification-of-novel-micrornas-in-the-sheep-heart-and-their-regulation-in-heart-failure
#2
Lee Lee Wong, Miriam T Rademaker, Eng Leng Saw, Kar Sheng Lew, Leigh J Ellmers, Christopher J Charles, Arthur Mark Richards, Peipei Wang
Study of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811391/cardiac-implantable-electronic-device-lead-extraction-using-the-lead-locking-device-system-keeping-it-simple-safe-and-inexpensive-with-mechanical-tools-and-local-anesthesia
#3
Antonis S Manolis, Georgios Georgiopoulos, Sofia Metaxa, Spyridon Koulouris, Dimitris Tsiachris
OBJECTIVE: We have previously reported our successful approach for percutaneous cardiac implantable electronic device (CIED) lead extraction using inexpensive tools, which we have continued over the years. Herein we report the results of the systematic use of a unique stylet, the lead-locking device (LLD), which securely locks the entire lead lumen, aided with non-powered telescoping sheaths in 54 patients to extract 98 CIED leads. METHODS: This prospective observational clinical study included 38 men and 16 women aged 68...
August 11, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28807986/a-turbine-driven-ventilator-improves-adherence-to-advanced-cardiac-life-support-guidelines-during-a-cardiopulmonary-resuscitation-simulation
#4
Scott G Allen, Lara Brewer, Erik S Gillis, Nathan L Pace, Derek J Sakata, Joseph A Orr
BACKGROUND: Research has shown that increased breathing frequency during cardiopulmonary resuscitation is inversely correlated with systolic blood pressure. Rescuers often hyperventilate during cardiopulmonary resuscitation (CPR). Current American Heart Association advanced cardiac life support recommends a ventilation rate of 8 -10 breaths/min. We hypothesized that a small, turbine-driven ventilator would allow rescuers to adhere more closely to advanced cardiac life support (ACLS) guidelines...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28807663/incidence-and-predictors-of-late-atrioventricular-conduction-recovery-among-patients-requiring-permanent-pacemaker-for-complete-heart-block-after-cardiac-surgery
#5
Erich L Kiehl, Tarek Makki, Ralph M Matar, Douglas R Johnston, John W Rickard, Khaldoun G Tarakji, Mohamed Kanj, Oussama M Wazni, Walid I Saliba, Niraj Varma, Bruce L Wilkoff, Daniel J Cantillon
BACKGROUND: New-onset complete heart block (CHB) commonly complicates cardiac surgery, for which some patients require a permanent pacemaker (PPM). Little is known regarding late atrioventricular (AV) conduction recovery. OBJECTIVE: To characterize the incidence and predictors of late AV conduction recovery among patients requiring PPM after cardiac surgery. METHODS: Consecutive patients receiving PPM for CHB following cardiac surgery at a high-volume US center from 2000-2014 were evaluated...
August 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28804896/load-dependence-of-myocardial-deformation-variables-a-clinical-strain-echocardiographic-study
#6
M Fredholm, K Jörgensen, E Houltz, S-E Ricksten
BACKGROUND: The effects of left ventricular (LV) loading on myocardial deformation variables are not well-studied in the clinical setting. In the present study, we evaluated the effects of isolated changes in preload, afterload and heart rate on LV longitudinal strain, systolic (SR-S) and early diastolic strain rate (SR-E) in post-cardiac surgery patients. METHODS: Twenty-one patients were studied early after cardiac surgery. Longitudinal myocardial strain and SR were analysed off-line using 2-D speckle echocardiography...
August 13, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28804678/capacitively-coupled-arrays-of-multiplexed-flexible-silicon-transistors-for-long-term-cardiac-electrophysiology
#7
Hui Fang, Ki Jun Yu, Christopher Gloschat, Zijian Yang, Chia-Han Chiang, Jianing Zhao, Sang Min Won, Siyi Xu, Michael Trumpis, Yiding Zhong, Enming Song, Seung Won Han, Yeguang Xue, Dong Xu, Gert Cauwenberghs, Matthew Kay, Yonggang Huang, Jonathan Viventi, Igor R Efimov, John A Rogers
Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying layer of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, and thus without the need for direct metal contact...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/28800733/integrative-and-quantitive-evaluation-of-the-efficacy-of-his-bundle-related-pacing-in-comparison-with-conventional-right-ventricular-pacing-a-meta-analysis
#8
Ziqing Yu, Ruizhen Chen, Yangang Su, Xueying Chen, Shengmei Qin, Minghui Li, Fei Han, Junbo Ge
BACKGROUND: Long-term RVP could bring adverse problems to cardiac electro-mechanics and result in inter- and intra-ventricular asynchrony, impaired labor force, and aggravation of cardiac function. HBRP including direct His bundle pacing and para-His bundle pacing was regarded as a novel physiological pacing pattern to avoid devastating cardiac function. This synthetic study was conducted to integratively and quantitatively evaluate the efficacy of His bundle related pacing (HBRP) in comparison with conventional right ventricular pacing (RVP)...
August 11, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28798987/maximization-of-interventricular-conduction-time-by-means-of-quadripolar-leads-for-cardiac-resynchronization-therapy
#9
Giuseppe Stabile, Valter Bianchi, Francesco Solimene, Assunta Iuliano, Quintino Parisi, Patrizia Pepi, Mario Bocchiardo, Francesco Urraro, Antonio De Simone, Roberto Ospizio, Antonio D'Onofrio
PURPOSE: Identifying the left ventricular (LV) site associated with the maximum spontaneous interventricular conduction time (right ventricle (RV)-to-LV interval) has proved to be an effective strategy for optimal LV pacing site selection in cardiac resynchronization therapy (CRT). The aim of our study was to determine whether quadripolar LV lead technology allows RV-to-LV interval maximization. METHODS: We enrolled 108 patients undergoing implantation of a CRT system using an LV quadripolar lead and 114 patients who received a bipolar lead...
August 10, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28797476/temperature-effects-on-aerobic-scope-and-cardiac-performance-of-european-perch-perca-fluviatilis
#10
Denise Lyager Jensen, Johannes Overgaard, Tobias Wang, Hans Gesser, Hans Malte
Several recent studies have highlighted how impaired cardiac performance at high temperatures and in hypoxia may compromise the capacity for oxygen transport. Thus, at high temperatures impaired cardiac capacity is proposed to reduce oxygen transport to a degree that lowers aerobic scope and compromises thermal tolerance (the oxygen- and capacity-limited thermal tolerance (OCLTT) hypothesis). To investigate this hypothesis, we measured aerobic and cardiac performance of a eurythermal freshwater teleost, the European perch (Perca fluviatilis)...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28795253/autonomic-responses-to-head-up-tilt-test-in-children-with-autism-spectrum-disorders
#11
Véronique-Aurélie Bricout, Marion Pace, Léa Dumortier, Anne Favre-Juvin, Michel Guinot
Autism Spectrum Disorders (ASD) is a group of neurodevelopmental disorders often manifested by social and behavioral deficiencies. Autonomic dysfunction is frequently reported in the autistic population but the mechanisms remain largely unknown. We aimed to characterize the cardiac autonomic profile of children with autism during a head-up tilt test. Thirty-nine male children were recruited: 19 controls (9.9 ± 1.6 years) and 20 children with ASD without intellectual disability (10.7 ± 1.2 years). Each child underwent a head-up tilt test on a motorized tilt table...
August 9, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28794367/earlier-right-ventricular-pacing-in-cardiac-resynchronization-therapy-for-a-patient-with-right-axis-deviation
#12
Yusuke Hattori, Kohei Ishibashi, Takashi Noda, Hideo Okamura, Hideaki Kanzaki, Toshihisa Anzai, Satoshi Yasuda, Kengo Kusano
We describe the case of a 37-year-old woman who presented with complete right bundle branch block and right axis deviation. She was admitted to our hospital due to severe heart failure and was dependent on inotropic agents. Cardiac resynchronization therapy was initiated but did not improve her condition. After the optimization of the pacing timing, we performed earlier right ventricular pacing, which led to an improvement of her heart failure. Earlier right ventricular pacing should be considered in patients with complete right bundle branch block and right axis deviation when cardiac resynchronization therapy is not effective...
August 10, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28792844/trpa1-ion-channel-stimulation-enhances-cardiomyocyte-contractile-function-via-a-camkii-dependent-pathway
#13
Spencer R Andrei, Monica Ghosh, Pritam Sinharoy, Souvik Dey, Ian N Bratz, Derek S Damron
RATIONALE: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from our laboratory have demonstrated that TRPA1 ion channels are expressed in adult mouse ventricular cardiomyocytes (CMs) and are localized at the z-disc, costamere and intercalated disc. The functional significance of TRPA1 ion channels in the modulation of CM contractile function have not been explored. OBJECTIVE: To identify the extent to which TRPA1 ion channels are involved in modulating CM contractile function and elucidate the cellular mechanism of action...
August 9, 2017: Channels
https://www.readbyqxmd.com/read/28780600/the-anti-influenza-drug-oseltamivir-reduces-atrial-fibrillation-in-an-experimental-whole-heart-model
#14
Gerrit Frommeyer, André Mittelstedt, Julian Wolfes, Christian Ellermann, Simon Kochhäuser, Patrick Leitz, Dirk G Dechering, Lars Eckardt
Recent experimental studies suggested direct effects of the anti-influenza drug oseltamivir on cardiac electrophysiology. We therefore aimed at analyzing potential antiarrhythmic effects of oseltamivir on atrial fibrillation (AF) in an experimental whole-heart model. Twelve rabbit hearts were isolated and Langendorff perfused. Thereafter, hearts were paced at cycle lengths of 350, 250, and 200 ms in the atrium. A standardized protocol employing atrial burst pacing induced AF in 4 of 12 hearts under baseline conditions (33%, 11 episodes)...
August 6, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28765767/simple-and-effective-solution-for-diaphragm-pacing-by-that-uses-the-transvenous-femoral-approach-in-a-patient-treated-with-cardiac-resynchronization-defibrillator-therapy-the-wrapping-method
#15
Ahmet Taha Alper, Mert İlker Hayıroğlu, Ahmet İlker Tekkeşin, Ceyhan Türkkan
The use of cardiac resynchronization therapy (CRT) has become widespread in patients with heart failure who meet the criteria for implantation. Coronary sinus lead positioning is important to provide the intended biventricular stimulation. Diaphragm pacing is a lead-related complication which occurs secondary to phrenic nerve stimulation. We present the case of a 58-year-old male patient who had diaphragm pacing after CRT with defibrillator implantation. The complication was resolved by using the transvenous femoral approach with the wrapping method...
August 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28765745/rapid-and-potent-antiarrhythmic-effect-of-cardiac-resynchronization-therapy-in-a-patient-with-advanced-dilated-cardiomyopathy-and-a-large-ventricular-arrhythmia-burden
#16
Dong Sub Jeon, Jong Sung Park
We report a case demonstrating a rapid and potent antiarrhythmic effect of biventricular pacing. A 67-year-old male patient with dilated cardiomyopathy was admitted for heart failure. The initial surface electrocardiogram revealed a left bundle branch block with a QRS complex duration of 200 ms. Echocardiographic examination revealed a left ventricular ejection fraction of 16%, a left ventricular end-diastolic dimension of 91 mm, and marked interventricular dyssynchrony. Continuous rhythm monitoring revealed frequently-recurring non-sustained monomorphic ventricular tachycardia (VT)...
July 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28762918/-noninvasive-electrophysiological-mapping-in-patients-with-complete-left-bundle-branch-block-and-different-modes-of-biventricular-pacing
#17
S V Zubarev, M P Chmelevsky, M A Budanova, M A Trukshina, T A Lyubimtseva, V K Lebedeva, D S Lebedev
OBJECTIVE: to investigate possibilities of noninvasive electrophysiological mapping (NEM) during biventricular (BiV) pacing and to compare the results with data of 12 lead ECG and tissue Doppler echocardiography (TDI). MATERIAL AND METHODS: The study included 25 patients with complete left bundle branch block (LBBB) and implanted cardiac resynchronization therapy (CRT) system. Twenty-two patients were CRT responders, three other patients did not demonstrate a clear effect...
May 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761607/-severe-ventricular-arrhythmias-in-a-patient-with-dilated-cardiomyopathy-and-automated-implantable-defibrillator-aid
#18
Stéphane Méo Ikama, Jospin Makani, Bertrand Ellenga-Mbolla, Louis Igor Ondze-Kafata, Thierry Raoul Gombet, Gisèle Kimbally-Kaky
Severe ventricular arrhythmias are frequent during heart failure; they are a life-threatening condition due to the increased risk of sudden death. Efficient management remains limited in sub-Saharan Africa because of the limited or unavailable medical resources as automated implantable defibrillator (AID). We report the case of a 56-year old patient with non ischemic dilated cardiomyopathy with very low left ventricular ejection fraction (LVEF)who underwent AID implantation for primary prevention of sudden cardiac death due to ventricular arrhythmias in 2012...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28752324/effect-of-glucose-on-3d-cardiac-microtissues-derived-from%C3%A2-human-induced-pluripotent-stem-cells
#19
Michael Balistreri, Justin A Davis, Katherine F Campbell, André Monteiro Da Rocha, Marjorie C Treadwell, Todd J Herron
Maternal hyperglycemia is a risk factor for fetal cardiac anomalies. This study aimed to assess the effect of high glucose on human induced pluripotent stem cell-derived cardiomyocyte self-assembly into 3D microtissues and their calcium handling. Stem cells were differentiated to beating cardiomyocytes using established protocols. On the final day of the differentiation process, cells were treated with control media, 12 mM glucose, or 12 mM mannitol (an osmolality control). Once beating, the cardiac cells were dissociated with trypsin, collected, mixed with collagen, and plated into custom-made silicone micro molds in order to generate 3D cardiac microtissues...
July 27, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28749900/increase-of-autonomic-nerve-factors-in-epicardial-ganglionated-plexi-during-rapid-atrial-pacing-induced-acute-atrial-fibrillation
#20
Yang Li, Yan-Mei Lu, Xian-Hui Zhou, Ling Zhang, Yao-Dong Li, Jiang-Hua Zhang, Qiang Xing, Bao-Peng Tang
BACKGROUND The cardiac autonomic nervous system plays an essential role in epicardial ganglionated plexi (GP) regulation of atrial fibrillation onset and progression. To date, the activity of GP and the function of the cardiac autonomic nervous system are not well understood. The aim of this study was to determine alterations in epicardial GP cholinergic nerve, adrenergic nerve, and nerve growth factor expression using rapid atrial pacing to induce atrial fibrillation in canines. MATERIAL AND METHODS Nine healthy adult beagles were divided into two groups: the pacing experimental group (n=6) and the sham-operation control group (n=3)...
July 27, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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