keyword
MENU ▼
Read by QxMD icon Read
search

HIV associated nephropathy

keyword
https://www.readbyqxmd.com/read/27811066/transmembrane-tnf-%C3%AE-facilitates-hiv-1-infection-of-podocytes-cultured-from-children-with-hiv-associated-nephropathy
#1
Jinliang Li, Jharna R Das, Pingtao Tang, Zhe Han, Jyoti K Jaiswal, Patricio E Ray
Studies have shown that podocytes and renal tubular epithelial cells from patients with HIV-associated nephropathy (HIVAN) express HIV-1 transcripts, suggesting that productive infection of renal epithelial cells precipitates development of HIVAN. However, podocytes and renal tubular epithelial cells do not express CD4 receptors, and it is unclear how these cells become productively infected in vivo We investigated the mechanisms underlying the infection by HIV-1 of podocytes cultured from the urine of children with HIVAN...
November 3, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27736906/refinement-of-the-hivan1-susceptibility-locus-on-chr-3a1-a3-via-generation-of-sub-congenic-strains
#2
Natalia Papeta, Ami Patel, Vivette D D'Agati, Ali G Gharavi
HIV-1 transgenic mice on the FVB/NJ background (TgFVB) represent a validated model of HIV-associated nephropathy (HIVAN). A major susceptibility locus, HIVAN1, was previously mapped to chromosome 3A1-A3 in a cross between TgFVB and CAST/EiJ (CAST) strains, and introgression of a 51.9 Mb segment encompassing HIVAN1 from CAST into TgFVB resulted in accelerated development of nephropathy. We generated three sub-congenic strains carrying CAST alleles in the proximal or distal regions of the HIVAN1 locus (Sub-II, 3...
2016: PloS One
https://www.readbyqxmd.com/read/27695357/update-on-current-management-of-chronic-kidney-disease-in-patients-with-hiv-infection
#3
REVIEW
Nina E Diana, Saraladevi Naicker
The prevalence of HIV-associated chronic kidney disease (CKD) varies geographically and depends on the definition of CKD used, ranging from 4.7% to 38% globally. The incidence, however, has decreased with the use of effective combined antiretroviral therapy (cART). A wide variety of histological patterns are seen in HIV-associated kidney diseases that include glomerular and tubulointerstitial pathology. In resource-rich settings, there has been a plateau in the incidence of end-stage renal disease secondary to HIV-associated nephropathy (HIVAN)...
2016: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/27621665/interstitial-nephritis-caused-by-hiv-infection-by-itself-a-case-report
#4
Asako Doi, Kentaro Iwata, Shigeo Hara, Yukihiro Imai, Toshikazu Hasuike, Hiroaki Nishioka
Interstitial nephritis is a common cause of renal dysfunction. It is primarily caused by drugs, infections, or autoimmune disorders. Patients with human immunodeficiency virus (HIV) infection can develop interstitial nephritis, although it typically occurs because of the aforementioned etiologies and not as a direct consequence of HIV infection. Interstitial lesions may occur in patients with HIV-associated nephropathy (HIVAN). However, interstitial nephritis without the glomerular injuries characteristic of HIVAN, and without the risk factors described earlier, is very rare...
2016: International Journal of General Medicine
https://www.readbyqxmd.com/read/27599995/impact-of-apol1-polymorphism-and-il-1%C3%AE-priming-in-the-entry-and-persistence-of-hiv-1-in-human-podocytes
#5
Joanna Mikulak, Ferdinando Oriolo, Federica Portale, Paolo Tentorio, Xiqian Lan, Moin A Saleem, Karl Skorecki, Pravin C Singhal, Domenico Mavilio
BACKGROUND: Patients of African ancestry with untreated HIV-1 infection and carrying the G1 or G2 kidney disease risk variants (Vs) at the APOL1 gene have a tenfold higher risk of developing HIV-associated nephropathy (HIVAN) compared to those with the non-risk wild type (WT) G0 variant. However, the mechanistic contribution of the APOL1 allelic state to kidney injury in HIV-1 infection remains to be elucidated. RESULTS: Non-risk WT APOL1 is associated with lower intracellular levels of HIV-1 in conditionally immortalized human podocytes, while the over expression of G1 or G2 risk Vs significantly increases viral accumulation...
2016: Retrovirology
https://www.readbyqxmd.com/read/27576285/-henoch-sch%C3%A3-nlein-purpura-in-a-cocaine-consumer-man-with-hiv-infection-and-anca-p-positivity
#6
María C De Paoli, Dino Moretti, Carlos M Scolari Pasinato, Martín G Buncuga
The Henoch-Schönlein purpura (HSP) is a small vessel vasculitis with IgA immune complex deposition. The presentation in adults is rare and severe. Reported cases of HSP in patients infected with HIV are scarce. Neutrophil cytoplasmic antibodies (ANCA) are commonly found in other systemic vasculitis, but rarely in HSP and even more unusual the perinuclear pattern. Beside small vessel vasculitis, positivity of ANCA can be detected in a number of different pathological conditions in association with infectious processes, including HIV, or cocaine use, and especially the pattern of ANCA-p, associated with drugs, inflammatory bowel or autoimmune diseases...
2016: Medicina
https://www.readbyqxmd.com/read/27557072/-patient-from-gambia-with-sonographic-white-kidneys
#7
Eva Aebert, Maike Büttner-Herold, Frederick Pfister, Thomas Mühlbacher, Christoph Berg, Martin Müller, Michael Haap, Ferruh Artunc
HISTORY AND ADMISSION FINDINGS: A 39-year-old male refugee from Gambia is admitted to the emergency room with fever, body aches and productive cough. INVESTIGATIONS: Laboratory, ultrasound and CT investigations show a sepsis due to Staphylcoccus aureus, a renal failure with the appearance of "snow-white" kidneys on ultrasound and a previously unknown acute HIV-infection. DIAGNOSIS, TREATMENT AND COURSE: Broad antibiotic treatment and an antiretroviral therapy (adapted to the impaired renal function) as well as hemodialysis are commenced...
August 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27477363/ajkd-atlas-of-renal-pathology-hiv-associated-nephropathy%C3%A2-hivan
#8
Agnes B Fogo, Mark A Lusco, Behzad Najafian, Charles E Alpers
No abstract text is available yet for this article.
August 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27469157/hiv-associated-renal-disease-an-overview
#9
Nicola Wearne, Ikechi G Okpechi
The cause of the human immunodeficiency virus (HIV) epidemic in South Africa (SA) was worsened by the denial by key political players that HIV causes acquired immunodeficiency syndrome (AIDS). South Africa continues to have the highest rate of HIV world-wide, which has had a huge impact on the development of both chronic kidney disease and acute kidney injury. Fortunately, there is now an effective antiretroviral therapy (ART) roll-out program. SA is also dealing with a collision of epidemics of HIV, tuberculosis, and non-communicable disease, particularly hypertension and diabetes...
2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27335373/podocyte-injury-the-role-of-proteinuria-urinary-plasminogen-and-oxidative-stress
#10
Leopoldo Raij, Runxia Tian, Jenny S Wong, John C He, Kirk N Campbell
Podocytes are the key target for injury in proteinuric glomerular diseases that result in podocyte loss, progressive focal segmental glomerular sclerosis (FSGS), and renal failure. Current evidence suggests that the initiation of podocyte injury and associated proteinuria can be separated from factors that drive and maintain these pathogenic processes leading to FSGS. In nephrotic urine aberrant glomerular filtration of plasminogen (Plg) is activated to the biologically active serine protease plasmin by urokinase-type plasminogen activator (uPA)...
December 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27169551/clinical-scenarios-in-chronic-kidney-disease-parenchymal-chronic-renal-diseases-part-2
#11
Ilaria Petrucci, Sara Samoni, Mario Meola
Secondary nephropathies can be associated with disreactive immunological disorders or with a non-inflammatory glomerular damage. In systemic lupus erythematosus (SLE), scleroderma and rheumatoid arthritis as in other connective tissue diseases, kidney volume and cortex echogenicity are the parameters that best correlate with clinical severity of the disease, even if the morphological aspect is generally non-specific. Doppler studies in SLE document the correlation between resistance indexes (RIs) values and renal function...
2016: Contributions to Nephrology
https://www.readbyqxmd.com/read/27163710/hiv-infection-induced-transcriptional-program-in-renal-tubular-epithelial-cells-activates-a-cxcr2-driven-cd4-t-cell-chemotactic-response
#12
Ping Chen, Zhengzi Yi, Weijia Zhang, Mary E Klotman, Benjamin K Chen
OBJECTIVE: Viral replication and interstitial inflammation play important roles in the pathogenesis of HIV-associated nephropathy. Cell-cell interactions between renal tubule epithelial cells (RTECs) and HIV-infected T cells can trigger efficient virus internalization and viral gene expression by RTEC. To understand how HIV replication initiates HIV-associated nephropathy, we studied the cellular response of RTECs to HIV, examining the transcriptional profiles of primary RTECs exposed to cell-free HIV or HIV-infected T cells...
July 31, 2016: AIDS
https://www.readbyqxmd.com/read/27159517/pathology-image-of-the-month-cough-and-shortness-of-breath-in-a-noncompliant-patient-with-hiv-aids
#13
Reggie Thomasson, Tracy Dewenter, Robin R McGoey
A 37- year-old man with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) was admitted to the intensive care unit following a four month history of progressive shortness of breath, productive cough, and flu-like symptoms. His HIV/AIDS was diagnosed at the age of 19 (CD4 count =15; viral load = 294,436 copies/ mL) and was complicated by hemodialysis-dependent, HIV-associated nephropathy, prior Pneumocystis pneumonia and known noncompliance with prescribed antiretroviral therapy. Chest film at admission was interpreted as diffuse bilateral interstitial and airspace opacities with a right sided layering density representative of laminar pleural effusion...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27138544/pathology-image-of-the-month-cough-and-shortness-of-breath-in-a-noncompliant-patient-with-hiv-aids
#14
Reggie Thomasson Md, Tracy Dewenter Md, Robin R McGoey Md
A 37- year-old man with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) was admitted to the intensive care unit following a four month history of progressive shortness of breath, productive cough, and flu-like symptoms. His HIV/AIDS was diagnosed at the age of 19 (CD4 count =15; viral load = 294,436 copies/ mL) and was complicated by hemodialysis-dependent, HIV-associated nephropathy, prior Pneumocystis pneumonia and known noncompliance with prescribed antiretroviral therapy. Chest film at admission was interpreted as diffuse bilateral interstitial and airspace opacities with a right sided layering density representative of laminar pleural effusion...
July 2015: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/27097894/the-podocyte-as-a-direct-target-for-treatment-of-glomerular-disease
#15
Sandeep K Mallipattu, John C He
The Centers for Disease Control and Prevention estimates more than 10% of adults in the United States, over 20 million Americans, have chronic kidney disease (CKD). A failure to maintain the glomerular filtration barrier directly contributes to the onset of CKD. The visceral epithelial cells, podocytes, are integral to the maintenance of this renal filtration barrier. Direct podocyte injury contributes to the onset and progression of glomerular diseases such as minimal change disease (MCD), focal segmental glomerular sclerosis (FSGS), diabetic nephropathy, and HIV-associated nephropathy (HIVAN)...
July 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27092563/care-of-patients-with-hiv-infection-medical-complications-and-comorbidities
#16
REVIEW
Philip Bolduc, Navid Roder, Emily Colgate, Sarah H Cheeseman
Care of patients with HIV infection starts with diagnosis as soon as possible, preferably at or near the time of acute infection. Opportunistic infections, malignancies, and other conditions develop progressively over time, particularly in untreated patients. The AIDS-defining opportunistic infections most common in the United States include Pneumocystis jirovecii pneumonia, Candida esophagitis, toxoplasmic encephalitis, tuberculosis, disseminated Mycobacterium avium complex, cryptococcal meningitis, and cytomegalovirus retinitis...
April 2016: FP Essentials
https://www.readbyqxmd.com/read/27035887/brief-report-apol1-renal-risk-variants-are-associated-with-chronic-kidney-disease-in-children-and-youth-with-perinatal-hiv-infection
#17
Murli U Purswani, Kunjal Patel, Cheryl A Winkler, Stephen A Spector, Rohan Hazra, George R Seage, Lynne Mofenson, Brad Karalius, Gwendolyn B Scott, Russell B Van Dyke, Jeffrey B Kopp
APOL1 renal risk alleles are associated with chronic kidney disease (CKD) in adults, with the strongest effect being for HIV-associated nephropathy. Their role in youth with perinatal HIV-1 infection (PHIV) has not been studied. In a nested case-control study of 451 PHIV participants in the Pediatric HIV/AIDS Cohort Study, we found a 3.5-fold increased odds of CKD in those carrying high-risk APOL1 genotypes using a recessive model [95% confidence interval (CI): 1.2 to 10.0]. We report an unadjusted incidence of 1...
September 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/26800970/iga-nephropathy-and-infections
#18
REVIEW
Cristiana Rollino, Gisella Vischini, Rosanna Coppo
In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal handling of commensal microbes (gut microbiota). We also focus on particular infections reported in association with classic IgA nephropathy (HIV, malaria, Chlamydia, Lyme disease), as well as on IgA dominant-infection-associated glomerulonephritis...
August 2016: Journal of Nephrology
https://www.readbyqxmd.com/read/26786550/clinical-characteristics-and-outcomes-of-hiv-associated-immune-complex-kidney-disease
#19
John W Booth, Lisa Hamzah, Sophie Jose, Catherine Horsfield, Patrick O'Donnell, Stephen McAdoo, Emil A Kumar, Tabitha Turner-Stokes, Nadia Khatib, Partha Das, Claire Naftalin, Nicola Mackie, Ed Kingdon, Debbie Williams, Bruce M Hendry, Caroline Sabin, Rachael Jones, Jeremy Levy, Rachel Hilton, John Connolly, Frank A Post
BACKGROUND: The pathogenesis and natural history of HIV-associated immune complex kidney disease (HIVICK) is not well understood. Key questions remain unanswered, including the role of HIV infection and replication in disease development and the efficacy of antiretroviral therapy (ART) in the prevention and treatment of disease. METHODS: In this multicentre study, we describe the renal pathology of HIVICK and compare the clinical characteristics of patients with HIVICK with those with IgA nephropathy and HIV-associated nephropathy (HIVAN)...
January 18, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26683666/hiv-promotes-nlrp3-inflammasome-complex-activation-in-murine-hiv-associated-nephropathy
#20
Shabirul Haque, Xiqian Lan, Hongxiu Wen, Rivka Lederman, Amrita Chawla, Mohamed Attia, Ramchandra P Bongu, Mohammad Husain, Joanna Mikulak, Moin A Saleem, Waldemar Popik, Ashwani Malhotra, Praveen N Chander, Pravin C Singhal
Dysregulated growth and loss of podocytes are important features of HIV-associated nephropathy. Recently, HIV was reported to induce a new type of programed cell death, pyroptosis, in T lymphocytes through induction of Nod-like receptor protein 3 (NLRP3) inflammasome complexes. We evaluated the role of HIV in podocyte NLRP3 inflammasome formation both in vivo and in vitro. Renal cortical sections of HIV-transgenic mice (Tg26) displayed increased expression of NLRP3, ASC (a CARD protein), caspase-1, and IL-1β proteins, confirming NLRP3 inflammasome complex formation in podocytes of Tg26 mice...
February 2016: American Journal of Pathology
keyword
keyword
96665
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"