Mackenzie Thornton, Nicole Sommer, Mercedes McGonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Praveen V Chakravarthi, Sumedha Gunewardena, Jaya Talreja, Pravin Singhal, Timothy A Fields, Patricio E Ray, Navneet K Dhillon, Madhulika Sharma
UNLABELLED: Antiretroviral therapy (ART) has profoundly decreased HIV-1 associated morbidity. However, despite ART, immune cells remain latently infected and slowly release viral proteins, leading to chronic inflammation and HIV associated comorbidities. Thus, new strategies are needed to reduce the inflammatory effects of HIV-1. In previous studies we found that gamma secretase inhibitor (GSIXX) ameliorated renal lesions of HIV-Tg26 mice carrying replication defective HIV-1 PNL4-3 by inhibiting Notch activation...
September 13, 2023: bioRxiv