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JOURNAL ARTICLE
J Guillermo Sanchez, Scott Rankin, Emily Paul, Heather A McCauley, Daniel O Kechele, Jacob R Enriquez, Nana-Hawa Jones, Siri A W Greeley, Lisa Letourneau-Friedberg, Aaron M Zorn, Mansa Krishnamurthy, James M Wells
The gastrointestinal tract is complex and consists of multiple organs with unique functions. Rare gene mutations can cause congenital malformations of the human GI tract, although the molecular basis of these has been poorly studied. We identified a patient with compound-heterozygous mutations in RFX6 presenting with duodenal mal-rotation and atresia, implicating RFX6 in development of the proximal intestine. To identify how mutations in RFX6 impact intestinal patterning and function, we derived iPSCs from this patient to generate human intestinal organoids (HIOs)...
April 8, 2024: Development
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JOURNAL ARTICLE
Qian Chen, Nan Xu, Chen Zhao, Yulin He, Sandy Hio Tong Kam, Xue Wu, Pan Huang, Min Yang, Clarence Tsun Ting Wong, Gandhi Radis-Baptista, Benqin Tang, Guangyi Fan, Guiyi Gong, Simon Ming-Yuen Lee
Our recent multi-omics studies have revealed rich sources of novel bioactive proteins and polypeptides from marine organisms including cnidarians. In the present study, we initially conducted a transcriptomic analysis to review the composition profile of polypeptides from Zoanthus sociatus. Then, a newly discovered NPY-like polypeptide-ZoaNPY was selected for further in silico structural, binding and virtually pharmacological studies. To evaluate the pro-angiogenic effects of ZoaNPY, we employed an in vitro HUVECs model and an in vivo zebrafish model...
April 3, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
#3
JOURNAL ARTICLE
Suhao Wang, Wenjin Zhu, Ian E Jacobs, William A Wood, Zichen Wang, Suraj Manikandan, Jens Wenzel Andreasen, Hio-Ieng Un, Sarah Ursel, Sébastien Peralta, Shaoliang Guan, Jean-Claude Grivel, Stéphane Longuemart, Henning Sirringhaus
Doping is a crucial strategy to enhance the performance of various organic electronic devices. However, in many cases, the random distribution of dopants in conjugated polymers leads to the disruption of the polymer microstructure, severely constraining the achievable performance of electronic devices. Here, it is shown that by ion-exchange doping polythiophene-based P[(3HT)1-x -stat-(T)x ] (x = 0 (P1), 0.12 (P2), 0.24 (P3), and 0.36 (P4)), remarkably high electrical conductivity of >400 S cm-1 and power factor of >16 µW m-1 K-2 are achieved for the random copolymer P3, ranking it among highest ever reported for unaligned P3HT-based films, significantly higher than that of P1 (<40 S cm-1 , <4 µW m-1 K-2 )...
April 1, 2024: Advanced Materials
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JOURNAL ARTICLE
Janny Pineiro-Llanes, Lais da Silva, John Huang, Rodrigo Cristofoletti
Extracellular matrix (ECM) plays a critical role in cell behavior and development. Organoids generated from human induced pluripotent stem cells (hiPSCs) are in the spotlight of many research areas. However, the lack of physiological cues in classical cell culture materials hinders efficient iPSC differentiation. Incorporating commercially available ECM into stem cell culture provides physical and chemical cues beneficial for cell maintenance. Animal-derived commercially available basement membrane products are composed of ECM proteins and growth factors that support cell maintenance...
March 15, 2024: Journal of Visualized Experiments: JoVE
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JOURNAL ARTICLE
Dooseon Hwang, Tae-Won Goo, Seung Hun Lee, Eun-Young Yun
As the aging population increases, so has interest among emerging seniors in anti-aging ingredients that enhance functionality by incorporating fermentation with natural materials. In this study, fermentation conditions for enhancing the functionality of Hermetia illucens larvae oil (HIO) were established, and its anti-aging potential was evaluated. First, the lipase activity and amount of lipid degradation products of the fermentation strains were measured in order to select Lactobacillus gasseri and Lactiplantibacillus plantarum as the strains with high fermentation ability...
February 27, 2024: International Journal of Molecular Sciences
#6
REVIEW
Tsuyoshi Hayashi, Sakura Kobayashi, Junki Hirano, Kosuke Murakami
Human norovirus (HuNoV) is a major cause of acute gastroenteritis and foodborne diseases, affecting all age groups. Despite its clinical needs, no approved antiviral therapies are available. Since the discovery of HuNoV in 1972, studies on anti-norovirals, mechanism of HuNoV infection, viral inactivation, etc., have been hampered by the lack of a robust laboratory-based cultivation system for HuNoV. A recent breakthrough in the development of HuNoV cultivation systems has opened opportunities for researchers to investigate HuNoV biology in the context of de novo HuNoV infections...
March 12, 2024: Journal of Virology
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JOURNAL ARTICLE
Elana Curtis, Rebekah Jaung, Sarah-Jane Paine, Melissa McLeod, Jade Tamatea, June Atkinson, Yannan Jiang, Bridget Robson, Papaarangi Reid, Ricci B Harris
INTRODUCTION: The COVID-19 pandemic has had both direct and indirect impacts on the health of populations worldwide. While racial/ethnic health inequities in COVID-19 infection are now well known (and ongoing), knowledge about the impact of COVID-19 pandemic management on non-COVID-19-related outcomes for Indigenous peoples is less well understood. This article presents the study protocol for the Health Research Council of New Zealand funded project 'Mā te Mōhio ka Mārama: Impact of COVID-19 on Māori:non-Māori inequities'...
March 8, 2024: BMJ Open
#8
JOURNAL ARTICLE
Mahmood Yousefi, Satar Rezaei, Sakineh Hajebrahimi, Niloofar Falsafi, Fatemeh Keshvari-Shad
BACKGROUND: There is little economic evidence on different modalities among patients with end-stage renal disease (ESRD) in Iran. This study aimed to assess the cost-utility of peritoneal dialysis (PD) and hemodialysis (HD) among ESRD patients in Iran. METHODS: From the health system perspective and with a 10-year time horizon, we conducted a cost-utility analysis based on a Markov model to compare three strategies of PD and HD [the second scenario (30% PD, 70% HD), the third scenario (50% PD, 50% HD) and the fourth scenario (70% PD, 30% HD)] among ESRD patients with the current situation (PD, 3% vs...
March 6, 2024: BMC Nephrology
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JOURNAL ARTICLE
Yadi Liu, Zhongyan Sun, Ruixue Dong, Peiyu Liu, Xi Zhang, Yiran Li, Xiaoshan Lai, Hio-Fai Cheong, Yuwei Wu, Yilin Wang, Hua Zhou, Dingkun Gui, Youhua Xu
BACKGROUND: In diabetic liver injury, nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. Rutin is a bioflavonoid produced by the hydrolysis of glucosidases to quercetin. Its biological activities include lowering blood glucose, regulating insulin secretion, regulating dyslipidemia, and exerting anti-inflammatory effects have been demonstrated. However, its effect on diabetic NAFLD is rarely reported. PURPOSE: Our study aimed to investigate the protective effects of Rutin on diabetic NAFLD and potential pharmacological mechanism...
February 9, 2024: Phytomedicine
#10
JOURNAL ARTICLE
Huamin Wang, James Zuiani, P Toby Coates Ao, Yun Xia
No abstract text is available yet for this article.
March 2024: Kidney International
#11
JOURNAL ARTICLE
Dynamic characteristics of parent-adolescent closeness: Predicting adolescent emotion dysregulation.
Shou-Chun Chiang, Sunhye Bai, Hio Wa Mak, Gregory M Fosco
Emotion dysregulation is linked to adolescent psychological problems. However, little is known about how lability in daily closeness of parent-adolescent dyads affects the development of emotion dysregulation. This study examined how closeness lability with parents was associated with emotion dysregulation 12 months later. The sample included 144 adolescents (M = 14.62, SD = 0.83) who participated in a baseline assessment, 21-day daily diaries, and a 12-month follow-up assessment...
February 21, 2024: Family Process
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Ingrid Jurickova, Benjamin W Dreskin, Elizabeth Angerman, Erin Bonkowski, Kentaro Tominaga, Kentaro Iwasawa, Tzipi Braun, Takanori Takebe, Michael A Helmrath, Yael Haberman, James M Wells, Lee A Denson
BACKGROUND AND AIMS: We previously identified small molecules predicted to reverse an ileal gene signature for future Crohn's Disease (CD) strictures. Here we used a new human intestinal organoid (HIO) model system containing macrophages to test a lead candidate, eicosatetraynoic acid (ETYA). METHODS: Induced pluripotent stem cell lines (iPSC) were derived from CD patients and differentiated into macrophages and HIOs. Macrophages and macrophage:HIO co-cultures were exposed to lipopolysaccharide (LPS) with and without ETYA pre-treatment...
January 30, 2024: bioRxiv
#13
JOURNAL ARTICLE
J Thomas Gebert, Francesca J Scribano, Kristen A Engevik, Joseph M Hyser
Calcium signaling is an integral regulator of nearly every tissue. Within the intestinal epithelium, calcium is involved in the regulation of secretory activity, actin dynamics, inflammatory responses, stem cell proliferation, and many other uncharacterized cellular functions. As such, mapping calcium signaling dynamics within the intestinal epithelium can provide insight into homeostatic cellular processes and unveil unique responses to various stimuli. Human intestinal organoids (HIOs) are a high-throughput, human-derived model to study the intestinal epithelium and thus represent a useful system to investigate calcium dynamics...
January 19, 2024: Journal of Visualized Experiments: JoVE
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JOURNAL ARTICLE
Ohman Kwon, Hana Lee, Jaeeun Jung, Ye Seul Son, Sojeong Jeon, Won Dong Yoo, Naeun Son, Kwang Bo Jung, Eunho Choi, In-Chul Lee, Hyung-Jun Kwon, Chuna Kim, Mi-Ok Lee, Hyun-Soo Cho, Dae Soo Kim, Mi-Young Son
Three-dimensional human intestinal organoids (hIO) are widely used as a platform for biological and biomedical research. However, reproducibility and challenges for large-scale expansion limit their applicability. Here, we establish a human intestinal stem cell (ISC) culture method expanded under feeder-free and fully defined conditions through selective enrichment of ISC populations (ISC3D-hIO ) within hIO derived from human pluripotent stem cells. The intrinsic self-organisation property of ISC3D-hIO , combined with air-liquid interface culture in a minimally defined medium, forces ISC3D-hIO to differentiate into the intestinal epithelium with cellular diversity, villus-like structure, and barrier integrity...
January 27, 2024: Nature Communications
#15
JOURNAL ARTICLE
Hio Tong Ngan, Philippe Sautet
Selective hydrogenation of α,β-unsaturated aldehydes to produce unsaturated alcohols remains a challenge in catalysis. Here, we explore, on the basis of first-principles simulations, single-atom alloy (SAA) catalysts on copper as a class of catalytic materials to enhance the selectivity for C═O bond hydrogenation in unsaturated aldehydes by controlling the binding strength of the C═C and C═O bonds. We show that on SAA of early transition metals such as Ti, Zr, and Hf, the C═O binding mode of acrolein is favored but the strong binding renders subsequent hydrogenation and desorption impossible...
January 22, 2024: Journal of the American Chemical Society
#16
JOURNAL ARTICLE
Hio-Ieng Un, Yang Lu, Jiaxuan Li, Renhao Dong, Xinliang Feng, Henning Sirringhaus
2D conjugated coordination polymers (cCPs) based on square-planar transition metal-complexes (such as MO4 , M(NH)4 , and MS4 , M = metal) are an emerging class of (semi)conducting materials that are of great interest for applications in supercapacitors, catalysis, and thermoelectrics. Finding synthetic approaches to high-performance nickel-nitrogen (Ni-N) based cCP films is a long-standing challenge. Here, a general, dynamically controlled on-surface synthesis that produces highly conductive Ni-N-based cCP films is developed and the thermoelectric properties as a function of the molecular structure and their dependence on interactions with ambient atmosphere are studied...
January 16, 2024: Advanced Materials
#17
JOURNAL ARTICLE
Soraia Pinto, Mahya Hosseini, Stephen Buckley, Wen Yin, Javad Garousi, Torbjörn Gräslund, Sven van Ijzendoorn, Hélder A Santos, Bruno Sarmento
Semaglutide is the first oral glucagon-like peptide-1 (GLP-1) analog commercially available for the treatment of type 2 diabetes. In this work, semaglutide was incorporated into poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles (NPs) to improve its delivery across the intestinal barrier. The nanocarriers were surface-decorated with either a peptide or an affibody that target the human neonatal Fc receptor (hFcRn), located on the luminal cell surface of the enterocytes. Both ligands were successfully conjugated with the PLGA-PEG via maleimide-thiol chemistry and thereafter, the functionalized polymers were used to produce semaglutide-loaded NPs...
January 10, 2024: Journal of Controlled Release
#18
JOURNAL ARTICLE
Ruihong Chen, Hang Hong Lo, Chenxu Yang, Betty Yuen Kwan Law, Xi Chen, Calista Chi In Lam, Charles Ho, Hio Lam Cheong, Qianzi Li, Chenyu Zhong, Jerome Pak Lam Ng, Cheung Kam Fai Peter, Vincent Kam Wai Wong
BACKGROUND: Renal cancer is insensitive to radiotherapy or most chemotherapies. While the loss of the XPC gene was correlated with drug resistance in colon cancer, the expression of XPC and its role in the drug resistance of renal cancer have not yet been elucidated. With the fact that natural small-molecules have been adopted in combinational therapy with classical chemotherapeutic agents to increase the drug sensitivity and reduce adverse effects, the use of herbal compounds to tackle drug-resistance in renal cancer is advocated...
December 20, 2023: Phytomedicine
#19
JOURNAL ARTICLE
Rongjie Zhang, Fangfang Ma, Yangjie Zhang, Jingwen Chen, Jonas Elm, Xu-Cheng He, Hong-Bin Xie
Iodine oxoacids (HIO3 and HIO2 )-driven nucleation has been suggested to efficiently contribute to new particle formation (NPF) in marine atmospheres. Abundant atmospheric nucleation precursors may further enhance HIO3 -HIO2 -driven nucleation through various multicomponent nucleation mechanisms. However, the specific enhancing potential (EP) of different precursors remains largely unknown. Herein, the EP-based screening model of precursors and enhancing mechanism of the precursor with the highest EP on HIO3 -HIO2 nucleation were investigated...
December 22, 2023: Environmental Science & Technology
#20
JOURNAL ARTICLE
Xu-Cheng He, Mario Simon, Siddharth Iyer, Hong-Bin Xie, Birte Rörup, Jiali Shen, Henning Finkenzeller, Dominik Stolzenburg, Rongjie Zhang, Andrea Baccarini, Yee Jun Tham, Mingyi Wang, Stavros Amanatidis, Ana A Piedehierro, Antonio Amorim, Rima Baalbaki, Zoé Brasseur, Lucía Caudillo, Biwu Chu, Lubna Dada, Jonathan Duplissy, Imad El Haddad, Richard C Flagan, Manuel Granzin, Armin Hansel, Martin Heinritzi, Victoria Hofbauer, Tuija Jokinen, Deniz Kemppainen, Weimeng Kong, Jordan Krechmer, Andreas Kürten, Houssni Lamkaddam, Brandon Lopez, Fangfang Ma, Naser G A Mahfouz, Vladimir Makhmutov, Hanna E Manninen, Guillaume Marie, Ruby Marten, Dario Massabò, Roy L Mauldin, Bernhard Mentler, Antti Onnela, Tuukka Petäjä, Joschka Pfeifer, Maxim Philippov, Ananth Ranjithkumar, Matti P Rissanen, Siegfried Schobesberger, Wiebke Scholz, Benjamin Schulze, Mihnea Surdu, Roseline C Thakur, António Tomé, Andrea C Wagner, Dongyu Wang, Yonghong Wang, Stefan K Weber, André Welti, Paul M Winkler, Marcel Zauner-Wieczorek, Urs Baltensperger, Joachim Curtius, Theo Kurtén, Douglas R Worsnop, Rainer Volkamer, Katrianne Lehtipalo, Jasper Kirkby, Neil M Donahue, Mikko Sipilä, Markku Kulmala
The main nucleating vapor in the atmosphere is thought to be sulfuric acid (H2 SO4 ), stabilized by ammonia (NH3 ). However, in marine and polar regions, NH3 is generally low, and H2 SO4 is frequently found together with iodine oxoacids [HIO x , i.e., iodic acid (HIO3 ) and iodous acid (HIO2 )]. In experiments performed with the CERN CLOUD (Cosmics Leaving OUtdoor Droplets) chamber, we investigated the interplay of H2 SO4 and HIO x during atmospheric particle nucleation. We found that HIO x greatly enhances H2 SO4 (-NH3 ) nucleation through two different interactions...
December 15, 2023: Science
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