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Yongchul Cho, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Seung Ryu, Jinwoong Lee, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn
AIM: The present study aimed to compare the ventricular enhancement time between humeral intraosseous access (HIO) and brachial intravenous access (BIV) during cardiopulmonary resuscitation (CPR) in adult humans. To our knowledge, this is the first such study during CPR in adult humans. METHODS: This prospective single-centre observational cohort study assessed the medical records of patients who underwent CPR between January 2018 and March 2018. The primary endpoints were the left and right ventricular enhancement (LVE and RVE, respectively) times after administration of a microbubble contrast agent via HIO or BIV...
June 18, 2018: Resuscitation
Mari Wataya-Kaneda, Yuuki Ohno, Yasuyuki Fujita, Hiroo Yokozeki, Hironori Niizeki, Masaaki Ogai, Kazuyoshi Fukai, Hiroshi Nagai, Yuichi Yoshida, Izumi Hamada, Taihei Hio, Kenji Shimizu, Hiroyuki Murota
Importance: Most patients with tuberous sclerosis complex (TSC), an autosomal-dominant disorder that is caused by the constitutive activation of mammalian target of rapamycin, experience disfigurement caused by skin lesions involving facial angiofibromas. Many have been left untreated because of a lack of therapeutic options that are less invasive than surgery or laser treatment. Objective: To confirm the efficacy and safety of sirolimus gel, 0.2%, for treatment of patients with angiofibromas and/or skin lesions...
May 19, 2018: JAMA Dermatology
Sunny C Lin, Julia Adler-Milstein
BACKGROUND: Health Information Organizations (HIOs) are third party organizations that facilitate electronic health information exchange (HIE) between providers in a geographic area. Despite benefits from HIE, HIOs have struggled to form and subsequently gain broad provider participation. We sought to assess whether market-level hospital and EHR vendor dynamics are associated with presence and level of hospital participation in HIOs. METHODS: 2014 data on 4523 hospitals and their EHR vendors were aggregated to the market level...
May 8, 2018: BMC Medical Informatics and Decision Making
Chenchen Li, Hio-Ieng Un, Jiawei Peng, Mian Cai, Xiao Wang, Jieyu Wang, Zhenggang Lan, Jian Pei, Xiaobo Wan
Thiazoloisoindigo, a novel structural variation of isoindigo, is for the first time utilized to synthesize conjugated polymers. The polymer based on thiazoloisoindigo merges the advantages of the one based on thienoisoindigo and diazaisoindigo; it not only exhibits a greatly redshifted UV/Vis absorption to the near-infrared region owing to its strong tendency to form quinoidal structures, similar to that based on thienoisoindigo, but also shows excellent ambipolar mobility (hole: 3.93, electron: 1.07 cm2  V-1  s-1 ) in organic field-effect transistors (OFETs), superior to that based on diazaisoindigo, showing the strong electron-withdrawing capability of thiazoloisoindigo...
April 24, 2018: Chemistry: a European Journal
Reiko Nihei, Mizuki Usami, Taro Taguchi, Seigo Amachi
Previously, we hypothesized that microbial laccase oxidizes iodide (I- ) in soils to molecular iodine (I2 ) or hypoiodous acid (HIO), both of which are easily incorporated into natural soil organic matter, and thus plays a role in iodine sorption on soils. In this study, soil iodide oxidase activity was determined by a colorimetric assay to evaluate if laccase is responsible for iodide oxidation in soils. Three types of Japanese soil showed significant iodide oxidase activities (0.751-2.87 mU g soil-1 ) at pH 4...
September 2018: Journal of Environmental Radioactivity
Hio-Ieng Un, Peng Cheng, Ting Lei, Chi-Yuan Yang, Jie-Yu Wang, Jian Pei
Organic field-effect transistors (OFETs) with impressively high hole mobilities over 10 cm2 V-1 s-1 and electron mobilities over 1 cm2 V-1 s-1 have been reported in the past few years. However, significant non-ideal electrical characteristics, e.g., voltage-dependent mobilities, have been widely observed in both small-molecule and polymer systems. This issue makes the accurate evaluation of the electrical performance impossible and also limits the practical applications of OFETs. Here, a semiconductor-unrelated, charge-trapping-induced non-ideality in OFETs is reported, and a revised model for the non-ideal transfer characteristics is provided...
May 2018: Advanced Materials
Hio Teng Leong, Siu Ngor Fu
CONTEXT: Reduction of the subacromial space (SAS) during arm elevation may contribute to rotator cuff tendinopathy. The effects of scapular taping on the SAS in athletes with and without RC tendinopathy is unknown. OBJECTIVES: To investigate the immediate effects of scapular taping on the SAS in athletes with and without RC tendinopathy. DESIGN: Randomized-controlled with repeated measures. SETTING: University laboratory...
February 21, 2018: Journal of Sport Rehabilitation
Hio Teng Cheong, Fei Xu, Chi Tung Choy, Connie Wun Chun Hui, Tony Shu Kam Mok, Chi Hang Wong
Lung cancer has the highest incidence and mortality rate worldwide among all malignancy-associated mortalities, of which non-small cell lung cancer accounts for 80% of all cases. Resistance against epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) develops following 8-12 months of disease progression, and is a critical issue. HCC827 cell lines with resistance to EGFR-TKIs were successfully screened. The half maximal inhibitory concentration values were 1,000-fold higher than the values for the parental HCC827 cell line, thereby demonstrating cross-resistance against the same family of TKIs...
January 2018: Oncology Letters
Tao Huang, Hailing Tan, Fangju Lu, Gong Chen, Zhenqiang Wu
BACKGROUND: Monascus pigments are widely used in the food and pharmaceutical industries due to their safety to human health. Our previous study found that glucose concentration induced extracellular oxidoreduction potential (ORP) changes could influence extracellular water-soluble yellow pigment production by Monascus ruber CGMCC 10910 in submerged fermentation. In this study, H2 O2 and dithiothreitol (DTT) were used to change the oxidoreduction potential for investigating the effects of oxidative or reductive substances on Monascus yellow pigment production by Monascus ruber CGMCC 10910...
November 21, 2017: Microbial Cell Factories
David R Hill, Sha Huang, Melinda S Nagy, Veda K Yadagiri, Courtney Fields, Dishari Mukherjee, Brooke Bons, Priya H Dedhia, Alana M Chin, Yu-Hwai Tsai, Shrikar Thodla, Thomas M Schmidt, Seth Walk, Vincent B Young, Jason R Spence
The human gastrointestinal tract is immature at birth, yet must adapt to dramatic changes such as oral nutrition and microbial colonization. The confluence of these factors can lead to severe inflammatory disease in premature infants; however, investigating complex environment-host interactions is difficult due to limited access to immature human tissue. Here, we demonstrate that the epithelium of human pluripotent stem-cell-derived human intestinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investigate complex host-microbe interactions in this naive epithelium...
November 7, 2017: ELife
Joshua R Vest, Nir Menachemi
BACKGROUND: Increasingly, health care providers need to exchange information to meet policy expectations and business needs. A variety of health information organizations (HIOs) provide services to facilitate health information exchange (HIE). However, the future of these organizations is unclear. PURPOSE: The aim of this study was to explore the environmental context, potential futures, and survivability of community HIOs, enterprise HIEs, and electronic health record vendor-mediated exchange using the population ecology theory...
November 1, 2017: Health Care Management Review
Ricardo Cruz-Acuña, Miguel Quirós, Attila E Farkas, Priya H Dedhia, Sha Huang, Dorothée Siuda, Vicky García-Hernández, Alyssa J Miller, Jason R Spence, Asma Nusrat, Andrés J García
In vitro differentiation of human intestinal organoids (HIOs) from pluripotent stem cells is an unparalleled system for creating complex, multicellular three-dimensional structures capable of giving rise to tissue analogous to native human tissue. Current methods for generating HIOs rely on growth in an undefined tumour-derived extracellular matrix (ECM), which severely limits the use of organoid technologies for regenerative and translational medicine. Here, we developed a fully defined, synthetic hydrogel based on a four-armed, maleimide-terminated poly(ethylene glycol) macromer that supports robust and highly reproducible in vitro growth and expansion of HIOs, such that three-dimensional structures are never embedded in tumour-derived ECM...
November 2017: Nature Cell Biology
Dongsheng Zhang, Ming Tan, Weiming Zhong, Ming Xia, Pengwei Huang, Xi Jiang
Through pluripotent stem cell (PSC) technology, human intestinal organoids (HIOs) with remarkably similarity to the fetal intestine in cellular composition, architecture, and absorptive/secretory functions have been successfully developed, providing a useful in vitro model system to study the structure and function of human congenital gut and intestinally related diseases. We report here the usefulness of HIOs as a model system to study intestinal carbohydrate expression, virus-host interaction, and replication of human noroviruses (huNoVs)...
October 3, 2017: Scientific Reports
Phillips Y Huang, Eve Kandyba, Arnaud Jabouille, Jonas Sjolund, Atul Kumar, Kyle Halliwill, Melissa McCreery, Reyno DelRosario, Hio Chung Kang, Christine E Wong, Jost Seibler, Vincent Beuger, Maurizio Pellegrino, Adam Sciambi, Dennis J Eastburn, Allan Balmain
The G-protein-coupled receptors LGR4, LGR5 and LGR6 are Wnt signaling mediators, but their functions in squamous cell carcinoma (SCC) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2/Rosa26-Tomato and Lgr6-EGFP-CreERT2/Rosa26-Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cell marker in SCCs in vivo. We identify, by single-molecule in situ hybridization and cell sorting, rare cells positive for Lgr6 expression in immortalized keratinocytes and show that their frequency increases in advanced SCCs...
November 2017: Nature Genetics
K B Uldahl, S T Walk, S C Olshefsky, M J Young, X Peng
AIMS: Analysis of the stability and safety of Sulfolobus monocaudavirus 1 (SMV1) during passage through the mammalian GI tract. METHODS AND RESULTS: A major challenge of using nano-vectors to target gut microbiome is their survival during passage through the extremely acidic and proteolytic environment of the mammalian GI tract. Here, we investigated the thermo-acidophilic archaeal virus SMV1 as a candidate therapeutic nano-vector for the distal mammalian GI tract microbiome...
November 2017: Journal of Applied Microbiology
Fu-Peng Wu, Hio-Ieng Un, Yongxi Li, Hailiang Hu, Yi Yuan, Bin Yang, Kai Xiao, Wei Chen, Jie-Yu Wang, Zuo-Quan Jiang, Jian Pei, Liang-Sheng Liao
A new electron-deficient unit with a fused 5-membered heterocyclic ring was developed by replacing a cyclopenta-1,3-diene from electron-rich donor indacenodithiophene (IDT) with a cyclohepta-4,6-diene-1,3-diimde unit. The imide bridge endows dithienylbenzenebisimide (BBI) with a fixed planar configuration and low energy levels for both the highest occupied molecular orbital (HOMO; -6.24 eV) and the lowest unoccupied molecular orbit (LUMO; -2.57 eV). Organic field-effect transistors (OFETs) based on BBI polymers exhibit electron mobility up to 0...
October 20, 2017: Chemistry: a European Journal
Hio Wa Mak, Gregory M Fosco, Mark E Feinberg
The quality of family relationships and youth friendships are intricately linked. Previous studies have examined different mechanisms of family-peer linkage, but few have examined social anxiety. The present study examined whether parental rejection and family climate predicted changes in youth social anxiety, which in turn predicted changes in friendship quality and loneliness. Possible bidirectional associations also were examined. Data for mothers, fathers, and youth (M age at Time 1 = 11.27; 52.3% were female) from 687 two-parent households over three time points are presented...
February 2018: Journal of Youth and Adolescence
Han Cao, Marcus C K Ng, Siti Azma Jusoh, Hio Kuan Tai, Shirley W I Siu
[Formula: see text]-Helical transmembrane proteins are the most important drug targets in rational drug development. However, solving the experimental structures of these proteins remains difficult, therefore computational methods to accurately and efficiently predict the structures are in great demand. We present an improved structure prediction method TMDIM based on Park et al. (Proteins 57:577-585, 2004) for predicting bitopic transmembrane protein dimers. Three major algorithmic improvements are introduction of the packing type classification, the multiple-condition decoy filtering, and the cluster-based candidate selection...
September 2017: Journal of Computer-aided Molecular Design
Kwang Bo Jung, Hana Lee, Ye Seul Son, Ji Hye Lee, Hyun-Soo Cho, Mi-Ok Lee, Jung-Hwa Oh, Jaemin Lee, Seokho Kim, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Human intestinal organoids (hIOs) derived from human pluripotent stem cells (hPSCs) have immense potential as a source of intestines. Therefore, an efficient system is needed for visualizing the stage of intestinal differentiation and further identifying hIOs derived from hPSCs. Here, 2 fluorescent biosensors were developed based on human induced pluripotent stem cell (hiPSC) lines that stably expressed fluorescent reporters driven by intestine-specific gene promoters Krüppel-like factor 5 monomeric Cherry (KLF5mCherry ) and intestine-specific homeobox enhanced green fluorescence protein (ISXeGFP )...
January 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Lei Zhang, Amalia Capilla, Weiye Song, Gustavo Mostoslavsky, Ji Yi
Multi-modal three dimensional (3D) optical imaging combining both structural sensitivity and molecular specificity is highly desirable in biomedical research. In this paper, we present a method termed oblique scanning laser microscopy (OSLM) to combine optical coherence tomography (OCT), for simultaneously volumetric structural and molecular imaging with cellular resolution in all three dimensions. Conventional 3D laser scanning fluorescence microscopy requires repeated optical sectioning to create z-stacks in depth...
August 17, 2017: Scientific Reports
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