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Hormesis

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https://www.readbyqxmd.com/read/29133226/the-effect-of-dietary-neonicotinoid-pesticides-on-non-flight-thermogenesis-in-worker-bumble-bees-bombus-terrestris
#1
Robert Potts, Rebecca M Clarke, Sophie E Oldfield, Lisa K Wood, Natalie Hempel de Ibarra, James E Cresswell
For bumble bees (genus Bombus), the capacity for non-flight thermogenesis is essential for two fundamental processes undertaken by adult workers, namely recovery from torpor after chilling and brood incubation. Farmland bees can be widely exposed to dietary residues of neurotoxic neonicotinoid insecticides that appear in the nectar and pollen of treated bee-attractive crops, which may harm them. An earlier study shows that dietary neonicotinoids cause complex alterations to thermoregulation in honey bees, but their effects on the thermogenic capabilities of individual bumble bees has been untested previously...
November 10, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29126094/evolutionarily-adapted-hormesis-inducing-stressors-can-be-a-practical-solution-to-mitigate-harmful-effects-of-chronic-exposure-to-low-dose-chemical-mixtures
#2
REVIEW
Se-A Kim, Yu-Mi Lee, Je-Yong Choi, David R Jacobs, Duk-Hee Lee
Although the toxicity of synthetic chemicals at high doses is well known, chronic exposure to low-dose chemical mixtures has only recently been linked to many age-related diseases. However, it is nearly impossible to avoid the exposure to these low-dose chemical mixtures as humans are exposed to a myriad of synthetic chemicals as a part of their daily lives. Therefore, coping with possible harms due to low dose chemical mixtures is challenging. Interestingly, within the range of environmental exposure, disease risk does not increase linearly with increasing dose of chemicals, but often tends to plateau or even decrease with increasing dose...
November 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29115439/low-dose-irradiation-inhibits-proliferation-of-the-p53null-type-human-prostate-cancer-cells-through-the-atm-p21-pathway
#3
Si-Jie Li, Xin-Yue Liang, Hai-Jun Li, Guo-Zi Yang, Wei Li, Zhuo Li, Lei Zhou, Xue Wen, De-Hai Yu, Jiu-Wei Cui
Low-dose ionizing radiation (LDIR) induces hormesis, exerts an adoptive effect on normal mammalian cells and stimulates cell proliferation; however, this effect is absent in cancer cells. Little is known on the molecular mechanisms underlying this differential response between normal and cancer cells. In the present study, it was demonstrated that the human prostate cancer cell line PC-3 and the normal prostate cell line RWPE-1 exhibited differential biological responses to LDIR. Through cell cycle analyses, it was demonstrated that LDIR inhibited cell growth and arrested the cell cycle at the S and G2/M phases in PC-3 cells, but not in RWPE-1 cells...
November 7, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29105050/knowledge-and-awareness-of-radiation-hazards-among-palestinian-radio-technologists
#4
Ahmed Hamarsheh, Ahmad Amro
This study investigated 94.4% of Palestinian radio technologists and the mean percentage of correct answers for knowledge and awareness questions was 26.4%. The percentage of correct answers for questions testing knowledge of the ALARA (As Low As Reasonably Achievable) principle and hormesis hypothesis was 66.5% and 17.2%, respectively. Radio technologists with education level higher than bachelor degree and < 5 years' work experience showed a significantly higher level of knowledge. The most radiosensitive organs were correctly identified as the lungs and stomach by 6...
October 30, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29091795/toxic-responses-of-microorganisms-to-nickel-exposure-in-farmland-soil-in-the-presence-of-earthworm-eisenia-fetida
#5
Xiaoqian Xia, Siyuan Lin, Jun Zhao, Wei Zhang, Kuangfei Lin, Qiang Lu, Bingsheng Zhou
Nickel (Ni)-contamination impairs soil ecosystem, threatening human health. A laboratory simulation of Ni-polluted farmland soil study, in the presence or absence of earthworm, was carried out to investigate the toxic responses of soil microorganisms, including microbial biomass C (MBC), soil basal respiration (SBR), metabolic quotient (qCO2), urease (UA) and dehydrogenase activities (DHA). Additionally, the variations of Ni bioavailability were also explored. Results manifested that MBC and SBR were stimulated at 50 and 100 mg·kg(-1) of Ni but inhibited by further increasing Ni level, showing a Hormesis effect...
October 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29081787/plant-hormesis-management-with-biostimulants-of-biotic-origin-in-agriculture
#6
REVIEW
Marcela Vargas-Hernandez, Israel Macias-Bobadilla, Ramon G Guevara-Gonzalez, Sergio de J Romero-Gomez, Enrique Rico-Garcia, Rosalia V Ocampo-Velazquez, Luz de L Alvarez-Arquieta, Irineo Torres-Pacheco
Over time plants developed complex mechanisms in order to adapt themselves to the environment. Plant innate immunity is one of the most important mechanisms for the environmental adaptation. A myriad of secondary metabolites with nutraceutical features are produced by the plant immune system in order to get adaptation to new environments that provoke stress (stressors). Hormesis is a phenomenon by which a stressor (i.e., toxins, herbicides, etc.) stimulates the cellular stress response, including secondary metabolites production, in order to help organisms to establish adaptive responses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29080703/hormesis-as-a-mechanistic-approach-to-understanding-herbal-treatments-in-traditional-chinese-medicine
#7
REVIEW
Dali Wang, Edward J Calabrese, Baoling Lian, Zhifen Lin, Vittorio Calabrese
Traditional Chinese medicine (TCM) has been long practiced and is becoming ever more widely recognized as providing curative and/or healing treatments for a number of diseases and physiological conditions. This paper posits that herbal medicines used in TCM treatments may act through hormetic dose-response mechanisms. It is proposed that the stimulatory (i.e., low dose) and inhibitory (i.e., high dose) components of the hormetic dose response correspond to respective "regulating" and "curing" aspects of TCM herbal treatments...
October 25, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28983749/first-study-of-hormesis-effect-on-mushroom-cultivation
#8
Diego Cunha Zied, Fernanda Aparecida Dourado, Eustáquio Souza Dias, Arturo Pardo-Giménez
The use of fungicides is common in mushroom cultivation, but no study was carried out applying reduced doses of fungicides in order to increase yield, taking account the hormesis effect. The aim of this manuscript was to verify the effects of different concentrations of fungicides to stimulate the productivity of different strains of Agaricus bisporus. Two stages were developed, an in vitro study to define the best concentration to be applied in the second experiment an agronomic study, which consisted of the application of the selected fungicides, in their respective concentrations, in an experiment carried out in the mushroom chamber...
October 5, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28975358/nicosulfuron-plus-atrazine-herbicides-and-trichogrammatidae-hymenoptera-in-no-choice-test-selectivity-and-hormesis
#9
Germano L D Leite, Paula D de Paulo, José C Zanuncio, Wagner de S Tavares, Anarelly C Alvarenga, Luan R Dourado, Edilson P R Bispo, Marcus A Soares
The aim of this study was to evaluate the effect of the herbicide mixture nicosulfuron + atrazine on 10 trichogrammatid species. A female of each trichogrammatid was placed in a test tube (no-choice) with a card with 45 Anagasta kuehniella eggs. Parasitism was allowed over a 48 h period, then the cards were sprayed with a solution containing nicosulfuron (30 g ha(-1)) + atrazine (1500 g ha(-1)), besides the control (distilled water). The nicosulfuron + atrazine mixture increased the Trichogramma atopovirilia and T...
November 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28955983/on-mechanism-of-antioxidant-effect-of-fullerenols
#10
A S Sachkova, E S Kovel, G N Churilov, O A Guseynov, A A Bondar, I A Dubinina, N S Kudryasheva
Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, specific allotropic form of carbon, bioactive compounds and perspective pharmaceutical agents. Antioxidant activity of fullerenols was studied in model solutions of organic and inorganic toxicants of oxidative type - 1,4-benzoquinone and potassium ferricyanide. Two fullerenol preparations were tested: С60О2-4(ОН)20-24 and mixture of two types of fullerenols С60О2-4(ОН)20-24+С70О2-4(ОН)20-24. Bacteria-based and enzyme-based bioluminescent assays were used to evaluate a decrease in cellular and biochemical toxicities, respectively...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28947171/a-preliminary-attempt-to-establish-multiple-stress-response-profiles-of-human-skin-fibroblasts-exposed-to-mild-or-severe-stress-during-ageing-in-vitro
#11
Suresh I S Rattan, Dino Demirovic, Carine Nizard
Optimal stress response (SR) is an essential aspect of the property of dynamic homeostasis of all biological systems, including cells in culture. Whereas severe stress can induce the so-called stress-induced premature senescence (SIPS), a model developed by Olivier Toussaint, mild stress can strengthen homeodynamics and can postpone senescence through the phenomenon of hormesis. We have attempted to establish multiple stress response profiles (SRP) of early passage young and late passage senescent human facial skin fibroblasts, FSF-1, exposed to either mild (41°C) and severe (43°C) heat shock for 1h, or to mild (2%) and severe (0%) serum deprivation for up to 48h...
September 22, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28944077/how-does-hormesis-impact-biology-toxicology-and-medicine
#12
REVIEW
Edward J Calabrese, Mark P Mattson
Hormesis refers to adaptive responses of biological systems to moderate environmental or self-imposed challenges through which the system improves its functionality and/or tolerance to more severe challenges. The past two decades have witnessed an expanding recognition of the concept of hormesis, elucidation of its evolutionary foundations, and underlying cellular and molecular mechanisms, and practical applications to improve quality of life. To better inform future basic and applied research, we organized and re-evaluated recent hormesis-related findings with the intent of incorporating new knowledge of biological mechanisms, and providing fundamental insights into the biological, biomedical and risk assessment implications of hormesis...
2017: NPJ Aging and Mechanisms of Disease
https://www.readbyqxmd.com/read/28923722/high-doses-of-ethylenediurea-edu-as-soil-drenches-did-not-increase-leaf-n-content-or-cause-phytotoxicity-in-willow-grown-in-fertile-soil
#13
Evgenios Agathokleous, Elena Paoletti, William J Manning, Mitsutoshi Kitao, Costas J Saitanis, Takayoshi Koike
Ground-level ozone (O3) levels are nowadays elevated in wide regions of the Earth, causing significant effects on plants that finally lead to suppressed productivity and yield losses. Ethylenediurea (EDU) is a chemical compound which is widely used in research projects as phytoprotectant against O3 injury. The EDU mode of action remains still unclear, while there are indications that EDU may contribute to plants with nitrogen (N) when the soil is poor in N and the plants have relatively small leaf area. To reveal whether the N content of EDU acts as a fertilizer to plants when the soil is not poor in N and the plants have relatively large total plant leaf area, willow plants (Salix sachalinensis Fr...
January 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28884409/chronic-exposure-to-rapamycin-and-episodic-serum-starvation-modulate-ageing-of-human-fibroblasts-in-vitro
#14
Lakshman Sodagam, Anna Lewinska, Maciej Wnuk, Suresh I S Rattan
Mild stress-induced activation of stress response (SR) pathways, such as autophagy, heat shock response, oxidative SR, DNA damage response, and inflammatory response, can be potentially health beneficial. Using the model system of cellular ageing and replicative senescence in vitro, we have studied the ageing modulatory effects of the two conditions, rapamycin and serum starvation. Chronic exposure to 0.1, 1 and 10 nM rapamycin positively modulated the survival, growth, morphology, telomere length, DNA methylation levels, 8-oxo-dG level in DNA, N(6)-methyl-adenosine level in RNA, and ethanol stress tolerance of serially passaged normal human skin fibroblasts...
October 2017: Biogerontology
https://www.readbyqxmd.com/read/28844286/metal-nanoparticle-induced-hormetic-activation-a-novel-mechanism-of-homeopathic-medicines
#15
Prashant S Chikramane, Akkihebbal K Suresh, Shantaram G Kane, Jayesh R Bellare
BACKGROUND: High-potency homeopathic remedies, 30c and 200c have enormous dilution factors of 10(60) and 10(400) respectively. Therefore, the presence of physical entities in them is inconceivable. As a result, their efficacy is highly debated and often dismissed as a placebo. Despite several hypotheses postulated to explain the claimed homeopathic efficacy, none have satisfactorily answered the qualms of the sceptics. Against all beliefs and principles of conventional dilution, we have shown that nanoparticles (NPs) of the starting metals are unequivocally found in the 30c and 200c remedies at concentrations of a few pg/ml...
August 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28844284/hormesis-and-homeopathy-a-step-forward
#16
EDITORIAL
Edward J Calabrese
No abstract text is available yet for this article.
August 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28837107/the-influence-of-lead-on-generation-of-signalling-molecules-and-accumulation-of-flavonoids-in-pea-seedlings-in-response-to-pea-aphid-infestation
#17
Agnieszka Woźniak, Kinga Drzewiecka, Jacek Kęsy, Łukasz Marczak, Dorota Narożna, Marcin Grobela, Rafał Motała, Jan Bocianowski, Iwona Morkunas
The aim of this study was to investigate the effect of an abiotic factor, i.e., lead at various concentrations (low causing a hormesis effect and causing high toxicity effects), on the generation of signalling molecules in pea (Pisum sativum L. cv. Cysterski) seedlings and then during infestation by the pea aphid (Acyrthosiphon pisum Harris). The second objective was to verify whether the presence of lead in pea seedling organs and induction of signalling pathways dependent on the concentration of this metal trigger defense responses to A...
August 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28830010/contradictory-effects-of-silver-nanoparticles-on-activated-sludge-wastewater-treatment
#18
Zhiya Sheng, Joy D Van Nostrand, Jizhong Zhou, Yang Liu
Increased amount of nano-silver will be released into domestic and industrial waste streams due to its extensive application. However, great controversy still exists on the effects of silver nanoparticle (Ag-NP) on biological wastewater treatment processes and a toxicology model has not been built yet. Four sequencing batch reactors with activated sludge has been run for over three months with different silver species at a concentration of 1mg Ag/L in influent. Both freshly prepared Ag-NPs and aged Ag-NPs were tested with released silver ion as control...
August 2, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28818514/effects-of-low-dose-irradiation-on-mice-with-escherichia-coli-induced-sepsis
#19
Kyung-Hee Song, Seung-Youn Jung, Seong-Ho Kho, Sang-Gu Hwang, Hunjoo Ha, Seon Young Nam, Jie-Young Song
Although favorable immune responses to low-dose irradiation (LDI) have been observed in normal mice, i.e., a hormesis effect, little is known about the effects of LDI in infectious diseases. In this study, we examined the effects of LDI on mice with sepsis, a severe and often lethal hyperinflammatory response to bacteria. Female C57BL/6 mice were whole-body irradiated with 10cGy 48h before Escherichia coli infection, and survival, bacterial clearance, cytokines, and antioxidants were quantified. LDI pretreatment significantly increased survival from 46...
October 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28804462/heat-acclimation-mediated-cross-tolerance-origins-in-within-life-epigenetics
#20
REVIEW
Michal Horowitz
The primary outcome of heat acclimation is increased thermotolerance, which stems from enhancement of innate cytoprotective pathways. These pathways produce "ON CALL" molecules that can combat stressors to which the body has never been exposed, via cross-tolerance mechanisms (heat acclimation-mediated cross-tolerance-HACT). The foundation of HACT lies in the sharing of generic stress signaling, combined with tissue/organ- specific protective responses. HACT becomes apparent when acclimatory homeostasis is achieved, lasts for several weeks, and has a memory...
2017: Frontiers in Physiology
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