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https://www.readbyqxmd.com/read/28340517/piecemeal-mechanism-combining-sprouting-and-intussusceptive-angiogenesis-in-intravenous-papillary-formation-induced-by-pge2-and-glycerol
#1
Lucio Díaz-Flores, Ricardo Gutiérrez, M Del Pino García, Francisco J Sáez, Lucio Díaz-Flores, Juan F Madrid
Recently, we demonstrated that in human intravascular papillary endothelial hyperplasia (IPEH), vein wall vascularization occurs in association with myriad papillae, a large part of which formed in the vascularized vein wall. Previously, using an animal model, we observed that PGE2 and glycerol administration around the femoral vein originates intense vascularization of the vein wall from its intimal endothelial cells (ECs). This vascularization is similar to that in IPEH. The aim of this study is to assess the mechanism of papillary formation, using this model after demonstrating papillary development in neo-vascularized femoral vein walls...
March 24, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28340463/hypoxia-and-hydrogen-sulfide-differentially-affect-normal-and-tumor-derived-vascular-endothelium
#2
Serena Bianco, Daniele Mancardi, Annalisa Merlino, Benedetta Bussolati, Luca Munaron
BACKGROUND: endothelial cells play a key role in vessels formation both under physiological and pathological conditions. Their behavior is influenced by blood components including gasotransmitters (H2S, NO and CO). Tumor cells are subjected to a cyclic shift between pro-oxidative and hypoxic state and, in this scenario, H2S can be both cytoprotective and detrimental depending on its concentration. H2S effects on tumors onset and development is scarcely studied, particularly concerning tumor angiogenesis...
March 18, 2017: Redox Biology
https://www.readbyqxmd.com/read/28340392/-237-np-analytical-method-using-239-np-tracers-and-application-to-a-contaminated-nuclear-disposal-facility
#3
Mathew S Snow, Samuel S Morrison, Sue B Clark, John E Olson, Matthew G Watrous
Environmental (237)Np analyses are challenged by low (237)Np concentrations and lack of an available yield tracer; we report a rapid, inexpensive (237)Np analytical approach employing the short lived (239)Np (t1/2 = 2.3 days) as a chemical yield tracer followed by (237)Np quantification using inductively coupled plasma-mass spectrometry. (239)Np tracer is obtained via separation from a (243)Am stock solution and standardized using gamma spectrometry immediately prior to sample processing. Rapid digestions using a commercial, 900 W "Walmart" microwave and Parr microwave vessels result in 99...
March 21, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28340234/detection-of-severe-digital-vasculopathy-in-systemic-sclerosis-by-colour-doppler-sonography-is-associated-with-digital-ulcers
#4
Susanne Lüders, Stefanie Friedrich, Sarah Ohrndorf, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus
Objective.: Colour Doppler ultrasonography (CDUS) is very important in general vascular diagnostic procedures. Its role in determining the extent of vasculopathy in Systemic Sclerosis (SSc) needs further investigation. The aim of this study was to compare the presence of altered arteries with nailfold capillaroscopy and clinical signs of ischaemia, that is, digital ulcers or pitting scars (DU/PS). A feasible CDUS protocol is provided. Methods.: Two thousand five hundred and twenty-eight arteries of the fingers, palms and wrists from 79 SSc patients (32 arteries per patient) were examined using CDUS...
March 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/28340100/glioblastoma-stem-cell-differentiation-into-endothelial-cells-evidenced-through-live-cell-imaging
#5
Xin Mei, Yin-Sheng Chen, Fu-Rong Chen, Shao-Yan Xi, Zhong-Ping Chen
Background.: Glioblastoma cell-initiated vascularization is an alternative angiogenesis called vasculogenic mimicry. However, current knowledge on the mechanism of de novo vessel formation from glioblastoma stem cells (GSCs) is limited. Methods.: Sixty-four glioblastoma samples from patients and 10 fluorescent glioma xenograft samples were examined by immunofluorescence staining for endothelial marker (CD34 and CD31) and glial cell marker (glial fibrillary acidic protein [GFAP]) expression...
March 8, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28340078/image-integration-into-3-dimensional-electro-anatomical-mapping-system-facilitates-safe-ablation-of-ventricular-arrhythmias-originating-from-the-aortic-root-and-its-vicinity
#6
Mario Jularic, Ruken Özge Akbulak, Benjamin Schäffer, Julia Moser, Jana Nuehrich, Christian Meyer, Christian Eickholt, Stephan Willems, Boris A Hoffmann
Aims: During ablation in the vicinity of the coronary arteries establishing a safe distance from the catheter tip to the relevant vessels is mandatory and usually assessed by fluoroscopy alone. The aim of the study was to investigate the feasibility of an image integration module (IIM) for continuous monitoring of the distance of the ablation catheter tip to the main coronary arteries during ablation of ventricular arrhythmias (VA) originating in the sinus of valsalva (SOV) and the left ventricular summit part of which can be reached via the great cardiac vein (GCV)...
March 7, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28339957/effects-of-caponization-and-age-on-the-histology-lipid-localization-and-fiber-diameter-in-muscles-from-greenleg-partridge-cockerels
#7
M Gesek, M Zawacka, D Murawska
The preference of modern consumers for high-quality meat has forced breeders to use native breeds to produce capons. Caponization, both chemical and surgical, leads to androgen deficiency and changes in lipid metabolism and results in the accumulation of abdominal, subcutaneous, and intramuscular lipids, which change the sensory values of the meat. The aim of this study was to histologically evaluate selected skeletal muscles from Greenleg Partridge capons and cockerels. We examined lipid localization in the muscular tissue and also assessed both fiber type and fiber diameter in the pectoral muscles...
March 3, 2017: Poultry Science
https://www.readbyqxmd.com/read/28339741/shear-stress-regulated-mir-27b-controls-pericyte-recruitment-by-repressing-sema6a-and-sema6d
#8
Shemsi Demolli, Anuradha Doddaballapur, Kavi Devraj, Konstantin Stark, Yosif Manavski, Annekathrin Eckart, Christoph Zehendner, Tina Lucas, Thomas Korff, Markus Hecker, Steffen Massberg, Stefan Liebner, David Kaluza, Reinier A Boon, Stefanie Dimmeler
Aims: Vessel maturation involves the recruitment of mural cells such as pericytes and smooth muscle cells. Laminar shear stress is a major trigger for vessel maturation, but the molecular mechanisms by which shear stress affects recruitment of pericytes are unclear. MicroRNAs (miRs) are small non-coding RNAs, which post-transcriptionally control gene expression. The aim of the present study was to unveil the mechanism by which shear stress-regulated microRNAs contribute to vessel maturation...
February 23, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28339733/a-two-phase-mixture-model-of-platelet-aggregation
#9
Jian Du, Aaron L Fogelson
We present a two-phase model of platelet aggregation in coronary-artery-sized blood vessels. The model tracks the number densities of three platelet populations as well as the concentration of a platelet activating chemical. Through the formation of elastic bonds, activated platelets can cohere with one another to form a platelet thrombus. Bound platelets in a thrombus move in a velocity field different from that of the bulk fluid. Stresses produced by the elastic bonds act on the bound platelet material. Movement of the bound platelet material and that of the background fluid are coupled through an interphase drag and an incompressibility constraint...
February 20, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28339713/evaluation-of-the-effectiveness-of-intermittent-mechanical-pressure-with-short-loading-duration-new-type-of-intermittent-force-for-orthodontic-treatment
#10
Kento Shoman, Yoshiaki Sato, Eisuke Nishikawa, Yuusuke Kudo, Takaaki Yamamoto, Junichiro Iida
Background: Since it is difficult to precisely control the magnitude of force in orthodontic practice, controlling the duration of force is expected to prevent tissue damage. The use of an actuator as an appliance for intermittent force application is a possible solution for controlling the duration. However, effectiveness of an actuator for controlling the duration is still not clear. Aim: To determine whether a short loading duration of intermittent force has the potential to maintain a sound condition of the capillaries and induce dilation of capillaries, which is a requisite phenomenon for orthodontic tooth movement...
February 22, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28339582/hypoxia-in-the-glioblastoma-microenvironment-shaping-the-phenotype-of-cancer-stem-like-cells
#11
Nicole Colwell, Mioara Larion, Amber J Giles, Ashlee N Seldomridge, Saman Sizdahkhani, Mark R Gilbert, Deric M Park
Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to maintenance of the GSCs by supporting the critical stem cell traits of multipotency, self-renewal, and tumorigenicity...
January 19, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28339503/rat-retinal-vasomotion-assessed-by-laser-speckle-imaging
#12
Anastasiia Y Neganova, Dmitry D Postnov, Olga Sosnovtseva, Jens Christian B Jacobsen
Vasomotion is spontaneous or induced rhythmic changes in vascular tone or vessel diameter that lead to rhythmic changes in flow. While the vascular research community debates the physiological and pathophysiological consequence of vasomotion, there is a great need for experimental techniques that can address the role and dynamical properties of vasomotion in vivo. We apply laser speckle imaging to study spontaneous and drug induced vasomotion in retinal network of anesthetized rats. The results reveal a wide variety of dynamical patterns...
2017: PloS One
https://www.readbyqxmd.com/read/28339485/chronic-parp-1-inhibition-reduces-carotid-vessel-remodeling-and-oxidative-damage-of-the-dorsal-hippocampus-in-spontaneously-hypertensive-rats
#13
Krisztian Eros, Klara Magyar, Laszlo Deres, Arpad Skazel, Adam Riba, Zoltan Vamos, Tamas Kalai, Ferenc Gallyas, Balazs Sumegi, Kalman Toth, Robert Halmosi
Vascular remodeling during chronic hypertension may impair the supply of tissues with oxygen, glucose and other compounds, potentially unleashing deleterious effects. In this study, we used Spontaneously Hypertensive Rats and normotensive Wistar-Kyoto rats with or without pharmacological inhibition of poly(ADP-ribose)polymerase-1 by an experimental compound L-2286, to evaluate carotid artery remodeling and consequent damage of neuronal tissue during hypertension. We observed elevated oxidative stress and profound thickening of the vascular wall with fibrotic tissue accumulation induced by elevated blood pressure...
2017: PloS One
https://www.readbyqxmd.com/read/28339483/temporal-evolution-of-vasospasm-and-clinical-outcome-after-intra-arterial-vasodilator-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#14
Laleh Daftari Besheli, Can Ozan Tan, Donnie L Bell, Joshua A Hirsch, Rajiv Gupta
Intra-arterial (IA) vasodilator therapy is one of the recommended treatments to minimize the impact of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm refractory to standard management. However, its usefulness and efficacy is not well established. We evaluated the effect IA vasodilator therapy on middle cerebral artery blood flow and on discharge outcome. We reviewed records for 115 adults admitted to Neurointensive Care Unit to test whether there was a difference in clinical outcome (discharge mRS) in those who received IA infusions...
2017: PloS One
https://www.readbyqxmd.com/read/28339395/effect-of-ovariectomy-and-sideritis-euboea-extract-administration-on-large-artery-mechanics-morphology-and-structure-in-middle-aged-rats
#15
Dimitrios P Sokolis, Constantinos A Dimitriou, Pavlos Lelovas, Nikolaos G Kostomitsopoulos, Ismene A Dontas
BACKGROUND: Arterial function is regulated by estrogen, but no consistent pattern of arterial mechanical remodeling in response to depleted estrogen levels is available. OBJECTIVE: To examine long-term effects of ovariectomy (OVX) on the mechanical properties, morphology, and histological structure of carotid artery in middle-aged rats and a potentially protective effect of Sideritis euboea extract (SID), commonly consumed as "mountain tea". METHODS: 10-month-old female Wistar rats were allocated into control (sham-operated), OVX, OVX+SID, and OVX+MALT (maltodextrin; excipient used for dilution of SID) groups...
March 20, 2017: Biorheology
https://www.readbyqxmd.com/read/28339362/diagnostic-performance-of-color-duplex-ultrasonography-along-with-temporal-artery-biopsy-in-suspicion-of-giant-cell-arteritis
#16
Christophe Roncato, Caroline Allix-Béguec, Elisabeth Brottier-Mancini, Bruno Gombert, Guillaume Denis
OBJECTIVES: Giant cell arteritis (GCA) is a vasculitis that occurs in older adults, affecting vessels of medium and large caliber. GCA diagnosis is a challenge for general practitioners and specialists. The aim of this study was to retrospectively analyse performances of temporal artery biopsy (TAB) and color duplex ultrasonography (CDU) for GCA diagnosis. METHODS: All patients with suspicion of GCA and who underwent both TAB and CDU between April 2009 and March 2014 were included in the study...
March 20, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28339357/development-of-a-score-for-assessment-of-radiologic-damage-in-large-vessel-vasculitis-combined-arteritis-damage-score-cards
#17
Daiki Nakagomi, Claire Cousins, Jan Sznajd, Shunsuke Furuta, Aladdin J Mohammad, Raashid Luqmani, David Jayne
OBJECTIVES: Outcome assessment in large-vessel vasculitis (LVV) remains challenging and this impairs patient management and the conduct of clinical studies. Previous proposals for outcome tools have not included imaging. This study aimed to develop an imaging score to quantify damage in LVV and to assess the difference between Takayasu (TAK) and giant cell arteritis (GCA). METHODS: Ninety-six patients (41 TAK, 55 GCA) were identified from local registries at two University Hospitals in the UK...
March 13, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28335059/retrospective-evaluation-of-percutaneous-access-for-tevar-and-evar-time-to-make-it-the-standard-approach
#18
Rohit Philip Thomas, Tobias Kowald, Bernhard Schmuck, Osama Eldergash, Andreas Klausen, Valentin Dikov, Jerry Easo, Ajay Chavan
Introduction To evaluate the safety of percutaneous endovascular aortic repair and the relationship of access site characteristics to complications Materials and Methods All patients undergoing percutaneous TEVAR, EVAR and FEVAR procedures from January 2010 to May 2016 were retrospectively analysed for incidence of complications and their relationship to various access site characteristics like access artery size, degree of vessel calcification, skin to artery distance and sheath to artery ratio. Hemostasis occurring within 15 min after suture closure with or without manual compression was defined as primary hemostasis...
April 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28335021/mri-visible-perivascular-space-location-is-associated-with-alzheimer-s-disease-independently-of-amyloid-burden
#19
Gargi Banerjee, Hee Jin Kim, Zoe Fox, H Rolf Jäger, Duncan Wilson, Andreas Charidimou, Han Kyu Na, Duk L Na, Sang Won Seo, David J Werring
Perivascular spaces that are visible on magnetic resonance imaging (MRI) are a neuroimaging marker of cerebral small vessel disease. Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, while those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis. As cerebral amyloid angiopathy is an almost invariable pathological finding in Alzheimer's disease, we hypothesized that MRI-visible perivascular spaces in the centrum semi-ovale would be associated with a clinical diagnosis of Alzheimer's disease, whereas those in the basal ganglia would be associated with subcortical vascular cognitive impairment...
February 17, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334869/emerging-concepts-in-sporadic-cerebral-amyloid-angiopathy
#20
Andreas Charidimou, Gregoire Boulouis, M Edip Gurol, Cenk Ayata, Brian J Bacskai, Matthew P Frosch, Anand Viswanathan, Steven M Greenberg
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related cognitive decline. The term 'cerebral amyloid angiopathy' now encompasses not only a specific cerebrovascular pathological finding, but also different clinical syndromes (both acute and progressive), brain parenchymal lesions seen on neuroimaging and a set of diagnostic criteria-the Boston criteria, which have resulted in increasingly detected disease during life...
March 13, 2017: Brain: a Journal of Neurology
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