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https://www.readbyqxmd.com/read/29471490/pharmacologic-assessment-of-bovine-ruminal-and-mesenteric-vascular-serotonin-receptor-populations
#1
M A Snider, D L Harmon, J L Klotz
Prior work using a contractility bioassay determined that the serotonin (5-HT) receptor subtype 5-HT2A is present in bovine lateral saphenous veins and plays a role in ergot alkaloid-induced vascular contraction in steers grazing endophyte-infected (Epichloë coenophiala) tall fescue (Lolium arundinaceum). Ergot alkaloids have also been shown to be vasoactive in bovine gut vasculature. To determine what 5-HT receptors are involved in vasoconstriction of gut vasculature, contractility of ruminal and mesenteric arteries and veins collected from cattle were evaluated in the presence of agonists selective for 5-HT1B (CP 93129) 5-HT1D (L-694, 247), 5-HT2A (TCB-2), 5-HT2B (BW 723C86), 5-HT4 (BIMU-8) and 5-HT7 (LP 44) receptors...
February 17, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29471140/activation-of-endothelial-trkb-receptors-induces-relaxation-of-resistance-arteries
#2
P Totoson, M Pedard, C Marie, C Demougeot
While brain-derived neurotrophic factor (BDNF) was previously reported to induce relaxation of conduit artery, whether the BDNF/TrkB (tropomyosin-related kinase) pathway is involved in the tone control of resistance arteries is not known. This study investigated TrkB receptors levels/localization and the vasomotor effect of the TrkB receptor agonist LM22A-4 in isolated third-order mesenteric arteries from rats. Immunostaining revealed the presence of both full-length and truncated TrkB receptors, especially at the endothelial level...
February 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29471134/citrobacter-freundii-impairs-the-phosphoryl-transfer-network-in-the-gills-of-rhamdia-quelen-impairment-of-bioenergetics-homeostasis
#3
Matheus D Baldissera, Carine F Souza, Guerino B Junior, Karen Luise S Moreira, Marcelo L da Veiga, Maria Izabel U M da Rocha, Bernardo Baldisserotto
The precise coupling of spatially separated intracellular adenosine triphosphate (ATP)-producing and ATP-consuming, catalyzed by creatine kinase (CK), adenylate kinase (AK), and pyruvate kinase (PK), is a critical process in the bioenergetics of tissues with high energy demand, such as the branchial tissue. The effects of Citrobacter freundii infection on gills remain poorly understood, limited only to histopathological studies. Thus, the aim of this study was to evaluate whether experimental infection by C...
February 19, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29471105/icariin-doped-bioactive-glasses-seeded-with-rat-adipose-derived-stem-cells-to-promote-bone-repair-via-enhanced-osteogenic-and-angiogenic-activities
#4
Xingzhi Jing, Weifeng Yin, Hongtao Tian, Mengcun Chen, Xudong Yao, Wentao Zhu, Fengjing Guo, Yaping Ye
AIMS: Cell communication between mesenchymal stem cells and blood vessel cells are crucial for bone repair. We have previously shown that the phyto-molecule icariin significantly promoted osteogenic differentiation of rat adipose-derived stem cells (ASCs). In the present study, we aimed to investigate the relationship between icariin induced osteogenic differentiation of ASCs and angiogenesis of rat endothelial progenitor cells (EPCs). Besides, we used icariin doped 45S5 Bioglass seeded with ASCs to promote bone healing in rat calvarial bone defect models...
February 19, 2018: Life Sciences
https://www.readbyqxmd.com/read/29470997/predictors-of-favorable-outcome-after-mechanical-thrombectomy-for-anterior-circulation-acute-ischemic-stroke-in-octogenarians
#5
Matthias Barral, Louis Lassalle, Cyril Dargazanli, Mikael Mazighi, Hocine Redjem, Raphael Blanc, Georges Rodesch, Bertrand Lapergue, Michel Piotin
INTRODUCTION: Mechanical thrombectomy for anterior circulation large vessel occlusion (LVO) improves functional outcome at three months. This therapeutic approach is the new gold standard, with a benefit being also observed in elderly patients. However, data are limited in this heterogeneous and fragile population. The objectives of this study were, first, to describe outcome after mechanical thrombectomy in a representative group of patients over 80. Second, to evaluate factors associated with a favorable functional outcome after thrombectomy for anterior circulation LVO in elderly patients (aged≥ 80 years)...
February 19, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29470857/numerical-study-on-the-hemodynamics-of-patient-specific-carotid-bifurcation-using-a-new-mesh-approach
#6
S I S Pinto, J B L M Campos, E Azevedo, C F Castro, L C Sousa
The definition of a suitable mesh to simulate blood flow in the human carotid bifurcation has been investigated. In this research, a novel mesh generation method is proposed: hexahedral cells at the centre of the vessel and a fine grid of tetrahedral cells near the artery wall, in order to correctly simulate the large blood velocity gradients associated with specific locations. The selected numerical examples to show the pertinence of the novel generation method are supported by carotid ultrasound (US) image data of a patient-specific case...
February 22, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29470729/retromesenteric-course-of-the-middle-colic-artery-challenges-and-pitfalls-in-d3-right-colectomy-for-cancer
#7
Bojan V Stimec, Bjarte T Andersen, Stefan R Benz, Jean H D Fasel, Knut M Augestad, Dejan Ignjatovic
BACKGROUND: The middle colic artery (MCA) is of crucial importance in abdominal surgery, for laparoscopic or open right and transverse colectomies. Against this background, a high number of reports concerning anatomical variations of the MCA have been published intended to contribute to the improvement of operative techniques for the treatment of colon cancer. Despite this extensive literature, briefly reviewed in the present paper, a course of the MCA posterior to the superior mesenteric vein, called a retromesenteric trajectory, has been related to only once, to the best of our knowledge...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470606/anatomical-and-histological-evaluation-of-the-retroauricular-fascia-flap-for-staged-auricular-reconstruction
#8
Yiyuan Li, Chunxiao Cui, Ruhong Zhang, Qun Zhang, Zhicheng Xu, Feng Xu, Datao Li
OBJECTIVES: The retroauricular fascia flap (RFF) is one of the most commonly used vascularized linings for auriculocephalic sulcus reconstruction in staged total auricular reconstruction. This study aims to investigate the histomorphometric features regarding the retroauricular fascia. METHODS: Histological evaluation included qualitative observation and quantitative analysis of sections of RFF stained with hematoxylin and eosin, Masson's trichrome, Elastica van Gieson, CD31, and Lyve-1...
February 22, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29470522/quantification-of-edematous-changes-by-diffusion-magnetic-resonance-imaging-in-gastrocnemius-muscles-after-spinal-nerve-ligation
#9
Koji Abe, Toshiyasu Nakamura, Eiko Yamabe, Koichi Oshio, Takeshi Miyamoto, Masaya Nakamura, Morio Matsumoto, Kazuki Sato
Patients with complex regional pain syndrome (CRPS) exhibit diverse symptoms, such as neuropathic pain, allodynia, local edema and skin color changes in the affected lesion. Although nerve injury may cause CRPS, pathophysiological mechanisms underlying the syndrome are unclear, and local edema, a characteristic of CRPS, has not been evaluated quantitatively for technical reasons. Here, using a rat spinal nerve ligation-induced CRPS model, we show that edematous changes in gastrocnemius muscle can be detected quantitatively by diffusion magnetic resonance imaging (MRI)...
2018: PloS One
https://www.readbyqxmd.com/read/29470359/cd44-deficiency-in-mice-protects-the-heart-against-angiotensin-ii-induced-cardiac-fibrosis
#10
Li-Wang Yang, Dong-Ze Qin, Erskine James, Robert J McKallip, Ning-Ping Wang, Wei-Wei Zhang, Rong-Hua Zheng, Qing-Hua Han, Zhi-Qing Zhao
This study tested the hypothesis that CD44 is involved in development of cardiac fibrosis via angiotensin II (Ang II) AT1 receptor stimulated TNFα/NFκB/IκB signaling pathways. Study was conducted in C57BL/6 wild type and CD44 knockout mice subjected to Ang II infusion (1000 ng/kg/min) using osmotic minipumps up to 4 weeks or with gastric gavage administration of the AT1 receptor blocker, telmisartan at a dose of 10 mg/kg/day. Results indicated that Ang II enhances expression of the AT1 receptor, TNFα, NFκB and CD44 as well as downregulates IκB...
February 21, 2018: Shock
https://www.readbyqxmd.com/read/29470262/serum-s100-proteins-as-a-marker-of-disease-activity-in-large-vessel-vasculitis
#11
Jason Michael Springer, Paul Monach, David Cuthbertson, Simon Carette, Nader A Khalidi, Carol A McAlear, Christian Pagnoux, Philip Seo, Kenneth J Warrington, Steven R Ytterberg, Gary Hoffman, Carol Langford, Thomas Hamilton, Dirk Foell, Thomas Vogl, Dirk Holzinger, Peter A Merkel, Johannes Roth, Rula A Hajj-Ali
No abstract text is available yet for this article.
February 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29470246/design-and-evaluation-of-a-structural-reinforced-small-intestinal-submucosa-vascular-graft-for-hemodialysis-access-in-a-porcine-model
#12
Juliana Jaramillo, Karen T Valencia-Rivero, Francisco J Cedano-Serrano, Rocío López, Néstor Sandoval, Juan C Briceño
Synthetic vascular access for hemodialysis exhibits biological and mechanical material properties mismatch with the native vessels. These limitations prevent infiltration of endothelial cells and decrease grafts long-term patency, particularly in small diameter vessels. We aimed to design a curved structural reinforced small intestinal submucosa (SIS) vascular graft for hemodialysis access and to evaluate in a porcine animal model graft patency by Doppler ultrasonography, tissue remodeling by histology, and vascular wall Young's modulus after implantation by biaxial tensile test...
March 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29470163/abdominal-exploration-in-neonates-using-transumbilical-exposure-compared-with-transverse-laparotomies
#13
Hanna Alemayehu, Richard Sola, Nhatrang H Le, David Juang, Pablo Aguayo, Jason D Fraser, Shawn D St Peter
INTRODUCTION: The vertical transumbilical incision (TU) technique during neonatal abdominal exploration involves dissection and ligation of umbilical vessels, which allow access to all quadrants of the abdomen and complete bowel evisceration with minimal violation to the anterior abdominal wall. We compared patient characteristics and outcomes for neonates undergoing TU with standard transverse exploration. MATERIALS AND METHODS: A single-center retrospective review of neonates who underwent abdominal exploration between January 2010 and September 2015 was conducted after obtaining Institutional Review Board approval...
February 22, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29470154/unipedal-diagnostic-lymphangiography-followed-by-sequential-ct-examinations-in-patients-with-idiopathic-chyluria-a-retrospective-study
#14
Jian Dong, Jianfeng Xin, Wenbin Shen, Xiaobai Chen, Tingguo Wen, Chunyan Zhang, Rengui Wang
OBJECTIVE: The objective of our study was to investigate the clinical value of diagnostic lymphangiography followed by sequential CT examinations in patients with idiopathic chyluria. MATERIALS AND METHODS: Thirty-six patients with idiopathic chyluria underwent unipedal diagnostic lymphangiography and then underwent sequential CT examinations. The examinations were reviewed separately by two radiologists. Abnormal distribution of contrast medium, lymphourinary leakages, and retrograde flow were noted, and the range and distribution of lymphatic vessel lesions were recorded...
February 22, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29470108/application-of-80-kvp-scan-and-raw-data-based-iterative-reconstruction-for-reduced-iodine-load-abdominal-pelvic-ct-in-patients-at-risk-of-contrast-induced-nephropathy-referred-for-oncological-assessment-effects-on-radiation-dose-image-quality-and-renal-function
#15
Yasunori Nagayama, Shota Tanoue, Akinori Tsuji, Joji Urata, Mitsuhiro Furusawa, Seitaro Oda, Takeshi Nakaura, Daisuke Utsunomiya, Eri Yoshida, Morikatsu Yoshida, Masafumi Kidoh, Machiko Tateishi, Yasuyuki Yamashita
OBJECTIVE: To evaluate the image quality, radiation dose, and renal safety of contrast medium (CM)-reduced abdominal-pelvic CT combining 80-kVp and sinogram-affirmed iterative reconstruction (SAFIRE) in patients with renal dysfunction for oncological assessment. METHODS: We included 45 patients with renal dysfunction (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73m2) who underwent reduced-CM abdominal-pelvic CT (360 mgI/kg, 80-kVp, SAFIRE) for oncological assessment...
February 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29469798/complete-resolution-of-erythema-elevatum-diutinum-using-oral-sulfasalazine
#16
Michael L Chen, Agata Chlopik, Maija P Hoang, Gideon P Smith
Erythema elevatum diutinum (EED) is a rare, chronic small-vessel vasculitis that presents as firm, red, violaceous, or brown papules and nodules on the extensor surfaces of the limbs. Oral dapsone is considered first-line therapy for EED; in the current case report, a patient presenting with EED began dapsone treatment and symptoms subsided within two weeks. Seven months later, the patient became pregnant and stopped dapsone owing to her concerns with dapsone use during pregnancy, resulting in recurrence of EED symptoms...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469788/erythematous-asymptomatic-nodule-on-the-sole
#17
Cristina Paret-Sanz, Elena Del Alcázar-Viladomiu, Noelia Pérez-Muñoz, Ana Iglesias-Plaza, Montserrat Salleras-Redonnet
A 75-year-old man presented to the dermatology clinic with an asymptomatic lesion on his right plantar surface. The lesion had progressively grown for two months. Physical examination revealed an erythematous and slightly scaly nodule measuring 10x10 mm. Dermoscopy examination showed central diffuse erythema with small red globules. A punch-biopsy revealed a proliferation of irregularly branched small vessels with collapsed lumen, extending in an infiltrative pattern in the superficial and deep dermis. Although this is a rare location, a diagnosis of microvenular hemangioma was made...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469750/a-case-of-probable-trimethoprim-sulfamethoxazole-induced-circulating-antineutrophil-cytoplasmic-antibody-positive-small-vessel-vasculitis
#18
Therese Woodring, Ronnie Abraham, Stephanie Frisch
Cutaneous leukocytoclastic vasculitis (LCV) can occur as skin-limited disease or as part a systemic vasculitis. Appropriate workup includes the evaluation of antineutrophil cytoplasmic antibodies (ANCAs), with a positive titer raising concern for the associated primary vasculitides including microscopic polyangiitis (MPA), granulomatosis with polyangiitis (GPA), or eosinophilic granulomatosis with polyangiitis (EGPA). In the absence of systemic findings, however, a drug etiology must also be considered. Tumor necrosis factor (TNF) inhibitors, propylthiouracil, levamisole-adulterated cocaine, hydralazine, and minocycline have been previously documented to induce ANCA-positive vasculitis (APV), which may present with conspicuously high ANCA titers...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469634/placenta-structural-changes-in-heavy-smoking-mothers-a-stereological-aspect
#19
Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Nadia Sheibak
OBJECTIVE: Smoking during pregnancy is able to alter structure and function of the placenta. In the present study, quantitative changes of the placenta in smoking mothers were investigated compared to healthy controls by Cavalieri's point counting method. METHODS: Twenty placentas from heavy smoking mothers and non-smoker controls (n = 10 in each group) were selected. Systematic uniform random sampling (SURS) was used for sample selection and tissue sectioning...
February 22, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29469613/aging-and-anatomical-variations-in-lung-tissue-stiffness
#20
Delphine Sicard, Andrew J Haak, Kyoung Moo Choi, Alexandria R Craig, Laura E Fredenburgh, Daniel J Tschumperlin
Lung function is inherently mechanical in nature, and depends on the capacity to conduct air and blood to and from the gas exchange regions. Variations in the elastic properties of the human lung across anatomical compartments and with aging are likely important determinants of lung function, but remain relatively poorly characterized. Here we applied atomic force microscopy to characterize human lung tissue from subjects ranging in age from 11 to 60 years old. We observed striking anatomical variations in elastic modulus, with the airways (200-350 µm diameter) the stiffest and the parenchymal regions the most compliant...
February 22, 2018: American Journal of Physiology. Lung Cellular and Molecular Physiology
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