Vanessa-Fernanda da Silva, Vitor Gayger-Dias, Rafaela Sampaio da Silva, Thomas Michel Sobottka, Anderson Cigerce, Lílian Juliana Lissner, Krista Minéia Wartchow, Letícia Rodrigues, Caroline Zanotto, Fernanda Carolina Telles da Silva Fróes, Marina Seady, André Quincozes-Santos, Carlos-Alberto Gonçalves
Caloric restriction (CR) has been proposed as a nutritional strategy to combat chronic diseases, including neurodegenerative diseases, as well as to delay aging. However, despite the benefits of CR, questions remain about its underlying mechanisms and cellular and molecular targets. Objective: As inflammatory processes are the basis or accompany chronic diseases and aging, we investigated the protective role of CR in the event of an acute inflammatory stimulus. Methods: Peripheral inflammatory and metabolic parameters were evaluated in Wistar rats following CR and/or acute lipopolysaccharide (LPS) administration, as well as glial changes (microglia and astrocytes), in two regions of the brain (hippocampus and hypothalamus) involved in the inflammatory response...
February 22, 2024: Nutritional Neuroscience