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Hepatitic B

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https://www.readbyqxmd.com/read/29133292/intracellular-hepatitis-b-virus-increases-hepatic-cholesterol-deposition-in-alcoholic-fatty-liver-via-hepatitis-b-core-protein
#1
Ya-Qi Wang, Ting Wu, Dan-Qing Hu, Xin-Xin Weng, Xiao-Jing Wang, Pei-Jer Chen, Xiao-Ping Luo, Hong-Wu Wang, Qin Ning
Hepatits B virus (HBV) infection is a prevalent infectious disease with serious outcomes like chronic and acute hepatitis, cirrhosis and hepatocellular carcinoma. However, the metabolic alteration by HBV is rarely taken into concerns. With the high prevalence of alcohol consumption and chronic HBV infection, their overlap is assumed as an increasing latent hazard although without exact calculation, moreover, the impact of chronic alcoholic consumption combined with HBV on cholesterol metabolism is unknown. Six-week-old male FVB/Ncrl mice were hydrodynamically injected with a pGEM-4Z-1...
November 13, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28977233/chronic-hepatitis-b-and-d-prognosis-according-to-child-pugh-score
#2
Marcelo Siqueira de Oliveira, Romeu Paulo Martins Silva, Suiane da Costa Negreiros do Valle, Elisabeth Níglio de Figueiredo, Dayana Fram
Objective: compare chronic hepatitis B patients to those superinfected with hepatitis D virus, according to Child-Pugh score regarding disease severity. Method: retrospective descriptive study, performed with 59 patients followed in the ambulatory, of which 22 (37.3%) were chronically infected with hepatitis B virus (Group HBV) and 37 (62.7%) superinfected with Delta virus (Group HBV+HDV); variables of sex, age and items of Child-Pugh score were collected by consulting medical records...
September 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28967199/levels-and-determinants-of-breast-and-cervical-cancer-screening-uptake-in-hiv-infected-women-compared-with-the-general-population-in-france
#3
L Tron, F Lert, B Spire, R Dray-Spira
OBJECTIVES: Cancer is a growing concern for HIV-infected people, and screening plays a major role in alleviating the burden it causes. We sought to investigate the levels and determinants of breast cancer screening (BCS) and cervical cancer screening (CCS) in HIV-infected women as compared with the general population. METHODS: The Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study was conducted in 2011 in a national representative sample of 3022 HIV-infected hospital out-patients in France...
March 2017: HIV Medicine
https://www.readbyqxmd.com/read/28902234/monitoring-of-post-vaccination-anti-hbs-titles-vaccine-in-children-and-adolescents-in-the-pre-dialysis-of-chronic-kidney-disease
#4
Nathália Cristina Pereira da Costa, Mônica Ribeiro Canhestro, Cristina Maria Bouissou Morais Soares, Juliana Scudilio Rodrigues
INTRODUCTION: Bacterial or viral diseases are one of the major causes of death in patients with chronic kidney disease (CKD). These patients show a quantitative reduction of levels of antibodies over time. Among the infectious diseases that affect CKD patients, stands out hepatitis B (HB). Immunization and control of antibodies levels against the hepatitis B surface antigen (anti-HBs) are ways to prevent the HB infection in this population. Patients with anti-HBs levels ≥10 IU/ml are considered adequate responders, whereas those with anti-HBs levels ≥ 100 IU/ml are considered excellent responders...
July 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28562795/low-completion-rate-of-hepatitis-b-vaccination-in-female-sex-workers
#5
Rosilane de Lima Brito Magalhães, Sheila Araújo Teles, Renata Karina Reis, Marli Teresinha Gimeniz Galvão, Elucir Gir
Objective: to assess predictive factors for noncompletion of the hepatitis B vaccination schedule in female sex workers in the city of Teresina, Northeastern Brazil. Method: 402 women were interviewed and, for those who did not wish to visit specialized sites, or did not know their hepatitis B vaccination status, the vaccine was offered at their workplaces. Bi- and multivariate analyses were performed to identify potential predictors for noncompletion of the vaccination schedule...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28489180/does-infection-by-the-hepatitis-c-virus-decrease-the-response-of-immunization-against-the-hepatitis-b-virus-in-individuals-undergoing-dialysis
#6
Tarcila Maria Bonfim Ferreira, Tácio Giordano Santana Guimarães, Andrea Martins Melo Fontenele, Natalino Salgado, Adalgisa de Souza Paiva Ferreira, Alessandra Porto de Macedo Costa
INTRODUCTION: Vaccination is the most effective tool in preventing transmission of Hepatitis B Virus (HBV). The patient with chronic kidney disease (CKD) on dialysis appear to be at greater risk of becoming infected with this virus and does not show the same vaccine response when compared to patients without uremia. OBJECTIVES: To evaluate the results related to the HBV vaccine and identify factors associated with the response in patients with CKD on hemodialysis...
April 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28404133/effect-on-hbs-antigen-clearance-of-addition-of-pegylated-interferon-alfa-2a-to-nucleos-t-ide-analogue-therapy-versus-nucleos-t-ide-analogue-therapy-alone-in-patients-with-hbe-antigen-negative-chronic-hepatitis-b-and-sustained-undetectable-plasma-hepatitis-b
#7
Marc Bourlière, Pascaline Rabiega, Nathalie Ganne-Carrie, Lawrence Serfaty, Patrick Marcellin, Yoann Barthe, Dominique Thabut, Dominique Guyader, Christophe Hezode, Magali Picon, Xavier Causse, Vincent Leroy, Jean Pierre Bronowicki, Patrizia Carrieri, Ghassan Riachi, Isabelle Rosa, Pierre Attali, Jean Michel Molina, Yannick Bacq, Albert Tran, Jean Didier Grangé, Fabien Zoulim, Hélène Fontaine, Laurent Alric, Inga Bertucci, Magali Bouvier-Alias, Fabrice Carrat
BACKGROUND: Findings from uncontrolled studies suggest that addition of pegylated interferon in patients with HBe antigen (HBeAg)-negative chronic hepatitis B receiving nucleos(t)ide analogues with undetectable plasma hepatitis B virus (HBV) DNA might increase HBs antigen (HBsAg) clearance. We aimed to assess this strategy. METHODS: In this randomised, controlled, open-label trial, we enrolled patients aged 18-75 years with HBeAg-negative chronic hepatitis B and documented negative HBV DNA while on stable nucleos(t)ide analogue regimens for at least 1 year from 30 hepatology tertiary care wards in France...
March 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28299974/causes-of-peripheral-cytopenia-in-hepatitic-cirrhosis-and-portal-hypertensive-splenomegaly
#8
Yunfu Lv, Wan Yee Lau, Hongfei Wu, XiaoYu Han, Xiaoguang Gong, Ning Liu, Jie Yue, Qingqing Li, YeJuan Li, Jie Deng
The clinical data of 183 patients with hepatitic cirrhosis and portal hypertensive splenomegaly complicated by peripheral cytopenia were retrospectively analyzed to investigate the causes of peripheral cytopenia, as well as the proportion of the causes in these patients. All patients underwent splenectomy. Before operation, these patients had one or more types of peripheral cytopenia (cumulative cytopenia: 390 patient-times). After splenectomy, blood counts in 79.2% (309/390) returned to normal, while in 15...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27625202/prevalence-of-and-factors-associated-with-depression-among-people-living-with-hiv-in-france
#9
P Feuillet, F Lert, L Tron, C Aubriere, B Spire, R Dray-Spira
OBJECTIVES: Depression is common among people living with HIV (PLWHIV) and is associated with poorer therapeutic outcomes and risky behaviours. We sought to estimate the prevalence of major depressive episode (MDE) across PLWHIV groups, to compare this with its prevalence in the general population and to assess factors associated with it. METHODS: We used data from the Agence Nationale de Recherche sur le Sida et les Hépatites Virales (ANRS)-Vespa2 study, a national study on a representative sample of PLWHIV conducted in France in 2011...
July 2017: HIV Medicine
https://www.readbyqxmd.com/read/27453412/the-correlation-analysis-of-primary-liver-cancer-with-type-2-diabetes
#10
Q Su, F Sun, J Li, H Zhang, M Wang, H Zhou, L Qiao
OBJECTIVE: To explore the relationship between Type 2 diabetes and primary liver cancer. MATERIALS AND METHODS: In the period from December 2008 to December 2014, all blood sugar data of patients in our hospital was collected, and the total number is 18213. Except for repeatedly hospitalized diabetic person, newborn stress status, or venous transfusion blood glucose, gestational diabetes, etc., By retrieving the medical record information of patients in the hospital, and using telephone or letter follow-up the patients, we collected 127 people with type 1 diabetes and found no liver cancer patients; Type 2 diabetes, 10,794 cases of patient information, 59 with primary liver cancer...
December 2015: Indian Journal of Cancer
https://www.readbyqxmd.com/read/27384205/hepatitis-b-vaccination-coverage-in-patients-with-diabetes-mellitus
#11
Clarissa Cordeiro Alves Arrelias, Fernando Bellissimo-Rodrigues, Letícia Cristina Lourenço de Lima, Anderson Soares da Silva, Nereida Kilza da Costa Lima, Maria Lucia Zanetti
OBJECTIVE: Analyze the factors associated with full hepatitis B vaccination (three doses) in patients with diabetes mellitus. METHOD: Cross-sectional study, conducted in a health unit in a city in the state of São Paulo, with 255 patients on outpatient follow-up, in 2014. Data were obtained from the computerized system of the Municipal Health Department and via a structured questionnaire. A logistic regression model was used for analysis. RESULTS: Full hepatitis B vaccination was noted in 13...
April 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27187027/psychiatric-and-substance-use-disorders-in-hiv-hepatitis-c-virus-hcv-coinfected-patients-does-hcv-clearance-matter-agence-nationale-de-recherche-sur-le-sida-et-les-h%C3%A3-patites-virales-anrs-hepavih-co13-cohort
#12
L Michel, C Lions, M Winnock, J-P Lang, M-A Loko, E Rosenthal, B Marchou, M-A Valantin, P Morlat, P Roux, P Sogni, B Spire, I Poizot-Martin, K Lacombe, C Lascoux-Combe, C Duvivier, D Neau, F Dabis, D Salmon-Ceron, M P Carrieri
OBJECTIVES: The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. METHODS: The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5...
November 2016: HIV Medicine
https://www.readbyqxmd.com/read/27055505/-effect-of-cik-on-long-term-survival-in-the-treatment-of-hcc-after-rfa-combined-tace
#13
G Z Pan, J B Xu, L Hao, J Zhang, S L Li, Q Z Yuan
OBJECTIVE: To evaluate the clinical effects of autologous cytokine-induced killer cell(CIK) on the cumulative survival and reactivation rate of hepatitics B virus(HBV) after radiofrequency ablation(RFA) combined with transcatheter arterial chemoembolization(TACE). METHODS: A total of 156 patients with hepatocellular carcinoma treated from June 2006 to September 2012 in Shengli Oilfield Central Hosptial were divided into control group(RFA, TACE) and research group(RFA, TACE, CIK)...
March 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26968010/comparison-of-therapeutic-response-and-clinical-outcome-between-hcv-patients-with-normal-and-abnormal-alanine-transaminase-levels
#14
COMPARATIVE STUDY
Cheng-Kung Wu, Kuo-Chin Chang, Po-Lin Tseng, Sheng-Nan Lu, Chien-Hung Chen, Jing-Houng Wang, Chuan-Mo Lee, Ming-Tsung Lin, Yi-Hao Yen, Chao-Hung Hung, Tsung-Hui Hu
BACKGROUND AND AIMS: Patients with chronic hepatitic C (HCV) infection and normal serum alanine transaminase (ALT) levels were considered to have mild disease. In Taiwan, these patients were not suggested for interferon (IFN) based therapies. The aim of study is to compare therapeutic outcomes between HCV patients with normal and elevated ALT levels. METHODS: We conducted a retrospective study on 3241 HCV patients treated by IFN based therapies. Patients with normal ALT levels were classified as group A (n = 186) while those with elevated ALT levels were group B (n = 3055)...
2016: PloS One
https://www.readbyqxmd.com/read/26762993/hiv-1-virological-remission-lasting-more-than-12-years-after-interruption-of-early-antiretroviral-therapy-in-a-perinatally-infected-teenager-enrolled-in-the-french-anrs-epf-co10-paediatric-cohort-a-case-report
#15
Pierre Frange, Albert Faye, Véronique Avettand-Fenoël, Erianna Bellaton, Diane Descamps, Mathieu Angin, Annie David, Sophie Caillat-Zucman, Gilles Peytavin, Catherine Dollfus, Jerome Le Chenadec, Josiane Warszawski, Christine Rouzioux, Asier Sáez-Cirión
BACKGROUND: Durable HIV-1 remission after interruption of combined antiretroviral therapy (ART) has been reported in some adults who started treatment during primary infection; however, whether long-term remission in vertically infected children is possible was unknown. We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption. METHODS: The patient was identified in the ANRS EPF-CO10 paediatric cohort among 100 children infected with HIV perinatally who started ART before 6 months of age...
January 2016: Lancet HIV
https://www.readbyqxmd.com/read/26572068/a-96-week-randomized-trial-of-switching-to-entecavir-in-patients-who-achieved-virological-suppression-on-lamivudine-therapy
#16
MULTICENTER STUDY
Sang Hoon Ahn, Jeong Heo, Jun Yong Park, Hyun Young Woo, Heon Ju Lee, Won Young Tak, Soon Ho Um, Ki Tae Yoon, Soo Young Park, Chang Wook Kim, Hyung Hoi Kim, Kwang-Hyub Han, Mong Cho
BACKGROUND AND AIM: There are limited data assessing whether patients who achieved virological suppression on lamivudine but remain hepatitis B "e" antigen-positive should be switched to a more potent antiviral with a high genetic barrier to resistance or continue with lamivudine. We compared the safety and efficacy of switching with entecavir versus continuing lamivudine. METHODS: This was a Phase IV, randomized, open-label, prospective study in a tertiary care setting...
April 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/26534639/custo-efetividade-do-tenofovir-para-o-tratamento-da-hepatite-b-cr%C3%A3-nica-uma-revis%C3%A3-o-sistem%C3%A3-tica
#17
J C Balbinot, A Wiens, R Pontarolo, A C Sanches
No abstract text is available yet for this article.
November 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/26281177/-immunogenetics-and-progression-of-chronic-viral-hepatites
#18
E V Beloborodova, I A Goncharova, E I Beloborodova, I L Purlik, T P Kalacheva, O E Akbasheva, M I Rachkovskiy, V A Burkovskaya
AIM OF INVESTIGATION: To estimate the role of polymorphic variants of genes IL4 (C-590T), IL4RA (I50V), TNF (G-308A) and SLC1IAI (D543N) in chronic viral hepatitis progression. MATERIAL AND METHODS: Overall 121 patients with chronic viral hepatitis C and B. RESULTS: Study results have demonstrated, that of all investigated polymorphic variants of genes IL4 (C-590T), IL4RA (150V), TNF (G-308A) and SLC11A1 (D543N) in patients with chronic liver diseases of various etiology the <Val/Val> IL4RA gene variant (II50Val) is associated with HBV-infection chronization...
2015: Experimental & Clinical Gastroenterology
https://www.readbyqxmd.com/read/26270682/access-to-costly-new-hepatitis-c-drugs-medicine-money-and-advocacy
#19
REVIEW
Stacey B Trooskin, Helen Reynolds, Jay R Kostman
Hepatitis C affects >3 million people in the United States, and often leads to end-stage liver disease or death. In 2014, several new drugs to treat hepatitic C virus received US Food and Drug Administration approval, with remarkable cure rates exceeding 90%. Medicaid, however, is rationing these drugs, and other insurers have restricted coverage due to their exorbitant costs and the large size of the population in need. These access barriers and disparities have resulted in national patient advocacy mobilization, US congressional inquiry, and legal challenges...
December 15, 2015: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/26219420/activation-induced-cytidine-deaminase-in-b-cells-of-hepatits-c-virus-related-cryoglobulinaemic-vasculitis
#20
S Russi, F Dammacco, S Sansonno, F Pavone, D Sansonno
Immunoglobulin variable region heavy chain (IgVH ) somatic gene diversification is instrumental in the transformation process that characterizes hepatitis C virus (HCV)-related B cell lymphoproliferative disorders. However, the extent to which activation-induced cytidine deaminase (AID), an enzyme essential for IgV gene somatic hypermutation (SHM), is active in cryoglobulinaemic vasculitis (CV) remains unclear. AID mRNA expression in the peripheral blood of 102 chronically hepatitis C virus (HCV)-infected patients (58 with and 44 without CV) and 26 healthy subjects was investigated using real-time reverse transcription-polymerase chain reaction (RT-PCR)...
December 2015: Clinical and Experimental Immunology
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