Matteo Calligaris, Donatella P Spanò, Simone Bonelli, Stephan A Müller, Claudia Carcione, Danilo D'apolito, Giandomenico Amico, Monica Miele, Mariangela Di Bella, Giovanni Zito, Elisa Nuti, Armando Rossello, Carl P Blobel, Stefan F Lichtenthaler, Simone D Scilabra
Proteolytic release of transmembrane proteins from the cell surface, the so called ectodomain shedding, is a key process in inflammation. Inactive rhomboid 2 (iRhom2) plays a crucial role in this context, in that it guides maturation and function of the sheddase ADAM17 (a disintegrin and metalloproteinase 17) in immune cells, and, ultimately, its ability to release inflammatory mediators such as tumor necrosis factor α (TNFα). Yet, the macrophage sheddome of iRhom2/ADAM17, which is the collection of substrates that are released by the proteolytic complex, is only partly known...
April 4, 2024: Cellular and Molecular Life Sciences: CMLS