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https://www.readbyqxmd.com/read/29221343/adult-onset-langerhans-cell-histiocytosis-of-the-sternum
#1
Yi-Jhih Huang, Kuan-Hsun Lin, Tai-Kuang Chao, Tsai-Wang Huang, Hsu-Kai Huang
Langerhans cell histiocytosis (LCH) is a rare disease with uncertain etiology that is more prevalent in children. LCH typically invades skeletal systems, but in rare cases, it has been reported in the ribs or sternum. Optimal treatment choices for single-site, skeletal LCH are still undefined. We report a case of adult-onset LCH of the sternum. The range of surrounding soft tissue invasion was confirmed by three-dimensional fusion and reconstruction of chest computed tomography and magnetic resonance images...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29214010/giant-cell-tumour-of-the-distal-radius-ulna-response-to-pre-operative-treatment-with-short-term-denosumab
#2
Catherine L McCarthy, Christopher L M H Gibbons, Kevin M Bradley, A Bass Hassan, Henk Giele, Nicholas A Athanasou
Background: Treatment of giant cell tumour of bone (GCTB) of the distal radius/ulna poses a surgical challenge, as complex reconstructive surgery may be required. This study evaluates the clinical, radiological and pathological findings in five cases of GCTB of the distal forearm where a 3 month course of denosumab was given prior to surgery. Methods: Patients with biopsy proven distal forearm GCTB, treated for 3 months with denosumab, followed by salvage surgery (curettage and cementation) were included...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/29209799/-chondroblastoma
#3
REVIEW
G Jundt, D Baumhoer
Chondroblastomas are very rare benign primary bone tumors occurring preferentially in the epiphyses or apophyses of long bones in children and adolescents. In most cases the typical histological and imaging findings lead to a correct diagnosis that may be substantiated by demonstrating the highly specific point mutation in the H3F3B gene (p.K36M), either by sequencing or immunohistochemistry. Recurrences occur in 5-15% of cases, postsurgical metastatic deposits to the lungs are very rare (<1%). Histologically "malignant" chondroblastomas have been reported as single case reports...
December 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29207391/tooth-extraction-locally-stimulates-proliferation-of-multiple-myeloma-in-a-patient-with-mandibular-localizations
#4
Jean-Daniel Kün-Darbois, Léonie Quenel, Smaïl Badja, Daniel Chappard
OBJECTIVES: Multiple myeloma (MM) is characterized by the occurrence of osteolytic lesions. MM treatment usually involves antiresorptive drugs (mainly bisphosphonates). CASE REPORT: A patient with an MM presented osteolytic lesions of the mandible. Extraction of teeth 45 and 46 was performed 5 years after the diagnosis of periodontitis. Four months later, osteonecrosis of the jaw (ONJ) was diagnosed at the extraction site. X-ray showed an extension of osteolytic lesions on the right side, close to the extraction site, without modification of the lesions on the left side...
December 6, 2017: Acta Haematologica
https://www.readbyqxmd.com/read/29206281/giant-cell-tumours-of-bone-treated-with-denosumab-histologic-immunohistochemical-and-h3f3a-mutation-analyses
#5
Ikuma Kato, Mitsuko Furuya, Kosuke Matsuo, Yusuke Kawabata, Reiko Tanaka, Kenichi Ohashi
AIMS: Denosumab, a human monoclonal antibody directed against the receptor activator of nuclear factor-kappa B ligand (RANKL), is a therapeutic agent for giant cell tumour of bone (GCTB). Although some studies reported that denosumab shrinks tumours and induces bone formation, the actual effects of RANKL suppression on GCTB remain unclear. A mutation in the H3 histone family member 3A gene (H3F3A) was recently identified as a genetic signature for GCTB. The aim of this study was to investigate the histopathological features and H3F3A mutation status of GCTBs treated with denosumab...
December 5, 2017: Histopathology
https://www.readbyqxmd.com/read/29200828/fentanyl-induced-respiratory-depression-is-attenuated-in-pregnant-patients
#6
Xiaofei Cao, Shijiang Liu, Jie Sun, Min Yu, Yin Fang, Zhengnian Ding
Background: Respiratory depression is a complication of intravenous fentanyl administration. The effect of pregnancy on respiratory depression following opioid administration is unclear. This study investigated the effect of pregnancy on fentanyl-induced respiratory depression. Patients and methods: Female patients were divided into three groups (n=20 per group): control group (non-pregnant and scheduled for laparoscopic surgery), early pregnancy group (pregnant for 45-60 days and scheduled for abortion), and postpartum group (5-7 days postpartum scheduled for complete curettage of uterine cavity)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29187414/postpartum-management-of-hypertensive-disorders-of-pregnancy-a-systematic-review
#7
Alexandra E Cairns, Louise Pealing, James M N Duffy, Nia Roberts, Katherine L Tucker, Paul Leeson, Lucy H MacKillop, Richard J McManus
OBJECTIVES: Hypertensive disorders of pregnancy (HDP) affect one in ten pregnancies and often persist postpartum when complications can occur. We aimed to determine the effectiveness and safety of pharmacological interventions, other interventions and different care models for postpartum hypertension management. DESIGN: A systematic review was undertaken. Nine electronic databases, including Medline, were searched from inception to 16 March 2017. After duplicate removal, 4561 records were screened...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29187182/sacroiliac-joint-tuberculosis-surgical-management-by-posterior-open-window-focal-debridement-and-joint-fusion
#8
Guo Zhu, Li-Yuan Jiang, Zhang Yi, Li Ping, Chun-Yue Duan, Cao Yong, Jin-Yang Liu, Jian-Zhong Hu
BACKGROUND: Sacroiliac joint tuberculosis(SJT) is relatively uncommon, but it may cause severe sacroiliac joint destruction and functional disorder. Few studies in the literature have been presented on SJT, reports of surgical treatment for SJT are even fewer. In this study, we retrospectively reviewed surgical management of patients with severe SJT of 3 different types and proposed to reveal the clinical manifestations and features and aim to determine the efficiency and security of such surgical treatment...
November 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29184874/persistent-low-level-elevation-of-serum-human-chorionic-gonadotropin-after-termination-of-pregnancy-a-rare-case-of-peritoneal-trophoblastic-implant
#9
Hye Won Seo, Min Jin Jeong, Jung Namkung, Chan Joo Kim, Ji Young Kwon
Peritoneal trophoblastic implant can occur after treatment of ectopic pregnancy. Similarly, after termination of intrauterine pregnancy, trophoblastic implants are rare but can be a complication of perforation during dilatation and curettage. We report an extremely rare case of trophoblastic implant on the myometrium, ovarian surface, and peritoneal wall 4 months after uncomplicated dilatation and curettage. To the best of our knowledge, this is the first case of peritoneal trophoblastic implant following dilatation and curettage without uterine perforation...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29184859/risk-factors-for-massive-postpartum-bleeding-in-pregnancies-in-which-incomplete-placenta-previa-are-located-on-the-posterior-uterine-wall
#10
Hyun Jung Lee, Young Jai Lee, Eun Hee Ahn, Hyeon Chul Kim, Sang Hee Jung, Sung Woon Chang, Ji Yeon Lee
Objective: To identify factors associated with massive postpartum bleeding in pregnancies complicated by incomplete placenta previa located on the posterior uterine wall. Methods: A retrospective case-control study was performed. We identified 210 healthy singleton pregnancies with incomplete placenta previa located on the posterior uterine wall, who underwent elective or emergency cesarean section after 24 weeks of gestation between January 2006 and April 2016...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29182139/a-rare-case-of-aneurymal-bone-cyst-of-cuboid-bone-in-a-10-year-old-girl
#11
N Bojovic, M Raicevic, D Zivanovic, S Ducic
Aneurysmal bone cysts (ABC) are rare and they represent 1- 1.4 % of all primary bone tumors. ABC of cuboid bone are extremely rare, especially in children. Very few cases have been reported in the literature since 1967. We present a case of pathological fracture of cuboid bone due to an aneurysmal cyst in a 10-year-old girl. Surgery was performed, which included open biopsy with aspiration and intralesional curettage . Bone defect was then filled in by fully synthetic cancellous bone graft substitute consisting of pure β-tricalcium phosphate...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29182121/primary-epiphyseal-and-metaepiphyseal-tubercular-osteomyelitis-in-children-a-series-of-8-case
#12
A Agarwal, N Gupta, M Mishra, N Agrawal, D Kumar
Clinical series of primary epiphyseal and metaepiphyseal tubercular osteomyelitis are few. The purpose of our study was to retrospectively review the presentation, healing response and functional results of 8 such cases in children. MATERIAL AND METHODS: The patients were evaluated for pain, deformity, range of motion, limb length discrepancy (if any) and recurrence. Serial radiographs of the region were studied to see remineralization, obliteration of radiological lesions, status of physis and remodeling of the growth plate...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29182118/aneurysmal-bone-cystic-lesions-value-of-genomic-studies
#13
C Galant, P-L Docquier, G Ameye, Y Guiot, J Malghem, H A Poirel
Aneurysmal bone cystic (ABC) lesions can be primary or secondary (to a trauma or a pre-existing benign or malignant tumour). Specific translocations of the USP6 gene are reported in about 70% of primary but never in secondary ABC lesions. We report two cases of ABC lesions in which imbalanced genomic aberrations were detected at initial presentation and showed complex clonal evolution. These demonstrative observations strengthen the guidelines regarding the diagnostic approach when an ABC is suggested by imaging...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29182112/treatment-outcome-in-60-children-with-pathological-fractures-of-the-humerus-caused-by-juvenile-or-aneurysmal-bone-cysts
#14
M Rapp, F Grauel, L M Wessel, P Illing, M M Kaiser
The treatment of pathological fractures of the humerus caused by juvenile or aneurysmal bone cysts (JBC/ABC) should be a single approach with a high success rate and low complication rate. This study evaluates how day by day treatment concepts fulfil these aims. Children below 15 years of age with a pathological fracture of the humerus caused by a JBC or ABC between 01.01.2001 and 31.12.2010, were investigated by chart review in four major paediatric trauma centres. Age, gender, fracture localisation, X-ray findings, treatment and outcome - assessed by the Capanna classification (I to IV), were analysed...
December 2016: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29181359/articular-reconstruction-using-subchondral-cementation-and-threaded-kirschner-wires-in-giant-cell-tumor-a-novel-technique
#15
Padmanabh H Vora, Rameez Musa, Neel M Bhavsar, Darshan Shah
Introduction: Giant Cell Tumor(GCT) is one of an infrequently encountered tumor by orthopaedic surgeons in clinical practice. It is described as 'locally malignant' tumor found in epimetaphyseal region of long bones, peculiarly around knee. We present a case of a solitary, benign Campanacci Grade 2 GCT in right lateral femoral condyle in 38 year old female and our treatment. Case Report: A 38 year old female presented to our outpatient department with chief complaint of constant, moderate pain in right knee increasing in duration since 3 months...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29181213/therapeutic-management-of-a-substantial-pelvic-aneurysmatic-bone-cyst-including-the-off-label-use-of-denosumab-in-a-35-year-old-female-patient
#16
D Ntalos, M Priemel, C Schlickewei, D M Thiesen, J M Rueger, A S Spiro
Aneurysmal bone cysts (ABC) are benign bone tumors, which are highly vascularized. The main course of treatment is curettage followed by bone grafting or cement insertion. Still recurrence remains a main problem for patients. Denosumab is a monoclonal antibody, which acts as an inhibitor of the RANK/RANKL pathway, diminishing bone turnover. Recent case reports have shown that Denosumab can be a promising therapeutic agent for people suffering from therapy-resistant ABC. We report the case of a 35-year-old female patient presenting with a pronounced ABC of the pelvis...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29181211/placenta-percreta-in-first-trimester-after-multiple-rounds-of-failed-medical-management-for-a-missed-abortion
#17
Jaimin Shah, Eduardo Matta, Fernando Acosta, Natalia Golardi, Cristina Wallace-Huff
Background: The detection of a morbidly adherent placenta (MAP) in the first trimester is rare. Risk factors such as multiparity, advanced maternal age, prior cesarean delivery, prior myomectomy, placenta previa, or previous uterine evacuation place patients at a higher risk for having abnormal placental implantation. If these patients have a first trimester missed abortion and fail medical management, it is important that providers have a heightened suspicion for a MAP. Case: A 24-year-old G4P3003 with 3 prior cesarean deliveries underwent multiple rounds of failed medical management for a missed abortion...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29181183/internal-fixation-combined-with-bone-grafting-for-large-intraosseous-calcaneal-lipoma-a-case-report
#18
Yongxing Cao
Intraosseous lipoma is a rare benign bone tumor that has been reported to occur in the calcaneus and long bones. The etiology of intraosseous lipoma is unknown, although several theories have been proposed. The majority of the cases of intraosseous calcaneal lipoma reported in the literature were localized in the anterior portion of the calcaneus and were treated by curettage and bone grafting. However, for larger lipomas, no specific treatment protocol has been developed to date. We herein present a rare case involving a large intraosseous lipoma of the calcaneus in a 36-year-old man following hindfoot trauma...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29179270/-clinical-outcome-and-high-risk-factor-for-residual-lesion-analysis-of-hsil-half-a-year-after-loop-electrosurgical-excision-procedure-a-clinical-study-of-1-502-cases
#19
L Liu, L M Chen, X Tao, F Dai, L P Guo, H W Zhang, X R Zhou, L Sui
Objective: To analyze clinical outcome of high-grade squamous intraepithelial lesion (HSIL) half a year after loop electrosurgical excision procedure (LEEP) and explore the high risk factor of residual cervical HSIL. Methods: The retrospective study was carried out on 1 502 patients who underwent LEEP, with HSIL in the LEEP histopathology from January 2011 to December 2013 at Obstetrics and Gynecology Hospital of Fudan University to confer the difference between residual group and non-residual group after 6 months of the leep conization...
November 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29172708/a-comparative-study-on-the-role-of-xpert-mtb-rif-in-testing-different-types-of-spinal-tuberculosis-tissue-specimens
#20
Liang Tang, Shiqing Feng, Ruixiao Gao, Chenfu Han, Xiaochen Sun, Yucheng Bao, Wenlong Zhang
AIMS: The aim of the present study was to compare the role of the commercial Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) test in testing different types of spinal tuberculosis (TB) tissue specimens. METHODS: Pus, granulation tissue, and caseous necrotic tissue specimens from 223 patients who were diagnosed with spinal TB and who underwent curettage were collected for bacterial culture and the Xpert MTB/RIF assay to calculate the positive rate. Bacterial culture and phenotypic drug sensitivity testing (pDST) were adopted as the gold standards to calculate the sensitivity and specificity of the Xpert bacterial detection and drug resistance (DR) test...
November 27, 2017: Genetic Testing and Molecular Biomarkers
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