Alex Cleber Improta-Caria, Luis Felipe Rodrigues, Victor Hugo Antonio Joaquim, Ricardo Augusto Leoni De Sousa, Tiago Fernandes, Edilamar Menezes Oliveira
Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity develop long-term fibrotic processes in the heart, promoting pathological cardiac remodeling, including after myocardial infarction, reparative fibrotic processes also occur. These processes are regulated by many intracellular signaling pathways that have not yet been completely elucidated, including those associated with microRNA (miRNA) expression. miRNAs are small RNA transcripts (18-25 nucleotides in length) that act as post-transcriptionally regulators of gene expression, inhibiting or degrading one or more target messenger RNAs (mRNAs), and proven to be involved in many biological processes such as cell cycle, differentiation, proliferation, migration, and apoptosis, directly affecting the pathophysiology of several diseases, including cardiac fibrosis...
December 8, 2023: American Journal of Physiology. Heart and Circulatory Physiology