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exercise after myocardial infarction

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https://www.readbyqxmd.com/read/29695718/exercise-induces-new-cardiomyocyte-generation-in-the-adult-mammalian-heart
#1
Ana Vujic, Carolin Lerchenmüller, Ting-Di Wu, Christelle Guillermier, Charles P Rabolli, Emilia Gonzalez, Samuel E Senyo, Xiaojun Liu, Jean-Luc Guerquin-Kern, Matthew L Steinhauser, Richard T Lee, Anthony Rosenzweig
Loss of cardiomyocytes is a major cause of heart failure, and while the adult heart has a limited capacity for cardiomyogenesis, little is known about what regulates this ability or whether it can be effectively harnessed. Here we show that 8 weeks of running exercise increase birth of new cardiomyocytes in adult mice (~4.6-fold). New cardiomyocytes are identified based on incorporation of 15 N-thymidine by multi-isotope imaging mass spectrometry (MIMS) and on being mononucleate/diploid. Furthermore, we demonstrate that exercise after myocardial infarction induces a robust cardiomyogenic response in an extended border zone of the infarcted area...
April 25, 2018: Nature Communications
https://www.readbyqxmd.com/read/29628970/acute-kidney-injury-in-pediatric-patients-with-rhabdomyolysis
#2
Young Shin Lim, Heeyeon Cho, Sang Taek Lee, Yeonhee Lee
Purpose: This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children. Methods: Medical records of 39 Korean children, who were newly diagnosed with rhabdomyolysis from January 2008 to December 2015, were retrospectively analyzed. The diagnosis was made from the medical history, elevated serum creatinine kinase level >1,000 IU/L, and plasma myoglobin level >150 ng/mL...
March 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29609582/ex-met-study-exercise-in-prevention-on-of-metabolic-syndrome-a-randomized-multicenter-trial-rational-and-design
#3
Arnt Erik Tjønna, Joyce S Ramos, Axel Pressler, Martin Halle, Klaus Jungbluth, Erika Ermacora, Øyvind Salvesen, Jhennyfer Rodrigues, Carlos Roberto Bueno, Peter Scott Munk, Jeff Coombes, Ulrik Wisløff
BACKGROUND: Metabolic syndrome substantially increases risk of cardiovascular events. It is therefore imperative to develop or optimize ways to prevent or attenuate this condition. Exercise training has been long recognized as a corner-stone therapy for reducing individual cardiovascular risk factors constituting the metabolic syndrome. However, the optimal exercise dose and its feasibility in a real world setting has yet to be established. The primary objective of this randomized trial is to investigate the effects of different volumes of aerobic interval training (AIT) compared to the current exercise guideline of moderate-intensity continuous training (MICT) on the composite number of cardiovascular disease risk factors constituting the metabolic syndrome after a 16 week, 1-year, and 3-year follow-up...
April 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29609265/-relationships-between-percentage-of-skeletal-muscle-mass-and-cardiorespiratory-fitness-in-elderly-patients-with-coronary-heart-disease
#4
Y P Wang, S H Yao, D Liu, T Shen, W Zhao, W Gao, S L Xu
Objective: To determine the relative percentage of skeletal muscle mass (SMM) in elderly patients with coronary heart disease, analyse the relationship between percentage of SMM and cardiorespiratory fitness (CRF), predict exercise capacity and cardiac reserve. Methods: Patients aged 65 years and over after PCI, receiving cardiopulmonary exercise testing (CPET) during February 2014 to December 2016 in Department of Cardiology at Peking University Third Hospital were enrolled.All patients' basic data, percentage of SMM and CPET related parameters, including peak oxygen uptake (VO(2)peak), oxygen pulse (VO(2)/HR), oxygen uptake efficiency slope (OUES) and other cardiorespiratory endurance indicators were collected, to do correlation analysis...
March 20, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29589673/cardiac-rehabilitation-after-stemi
#5
Stefano Urbinati, Elisabetta Tonet
Cardiac rehabilitation is the most important evidence-based intervention for secondary prevention after STEMI, nevertheless, only a minority of patients may access to a cardiac rehabilitation programme. In this review the priority criteria for admission to cardiac rehabilitation and the main barriers that limit a larger involvement of the patients are discussed. Among the components of cardiac rehabilitation exercise is crucial and a tailored exercise training program and a tight monitoring of adherence to lifestyle recommendations are mandatory...
March 28, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29584915/interleukin-1-blockade-in-cardiovascular-diseases-a-clinical-update
#6
Leo F Buckley, Antonio Abbate
Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical research has defined important roles for IL-1 in atherosclerosis, acute myocardial infarction (AMI), and heart failure (HF). IL-1 promotes the formation of the atherosclerotic plaque and facilitates its progression and complication. In a large phase III clinical trial of stable patients with prior AMI, blocking IL-1 activity using a monoclonal antibody prevented recurrent atherothrombotic cardiovascular events...
March 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29583083/postmenopausal-osteoporosis-a-clinical-review
#7
Nelson B Watts
In postmenopausal women, osteoporotic fractures are more common than stroke, myocardial infarction, and breast cancer combined, and fractures can be costly and result in disability or death. Because there are no signs or symptoms of osteoporosis other than fracture, risk assessment is necessary to identify those at higher risk for clinical events. For women, a clinical fracture risk assessment (FRAX) is appropriate at menopause. Bone mineral density (BMD) measurement is recommended for women at age 65, and earlier for those who have risk factors...
March 27, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29560335/superior-effects-of-high-intensity-interval-training-compared-to-conventional-therapy-on-cardiovascular-and-psychological-aspects-in-myocardial-infarction
#8
Ha-Yoon Choi, Hee-Jun Han, Ji-Won Choi, Han-Young Jung, Kyung-Lim Joa
Objective: To evaluate the effect of high-intensity interval training (HIIT) on psychological symptoms, activity states, and cardiovascular functions in patients with myocardial infarction (MI) of low and moderate risk stratification. Methods: This prospective study randomly allocated 44 patients with MI to 18 sessions of HIIT or conventional moderate-intensity continuous training (MICT). Outcome measures were assessed at baseline and after 18 sessions. Results: Post-exercise cardiovascular and functional states, maximal oxygen uptake (VO2max ), metabolic equivalents (METs), 6-Minute Walking Test (6MWT), and Korean Activity Scale/Index (KASI) scores were significantly improved in the HIIT group compared to those in the MICT group after 18 exercise sessions...
February 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29538503/impact-of-a-high-intensity-training-on-ventricular-function-in-rats-after-acute-myocardial-infarction
#9
Simone de Campos Neitzke Winter, Rafael Michel de Macedo, Júlio Cesar Francisco, Paula Costa Santos, Ana Paula Sarraff Lopes, Leanderson Franco de Meira, Katherine A Teixeira de Carvalho, José Rocha Faria Neto, Ana Carolina Brandt de Macedo, Luiz César Guarita-Souza
BACKGROUND: Physical exercise should be part of the treatment of post-acute myocardial infarction (AMI) patients. OBJECTIVE: To evaluate the effects of two training prescription models (continuous x interval) and its impact on ventricular function in rats after AMI with normal ventricular function. METHODS: Forty Wistar rats were evaluated by echocardiography 21 days after the AMI. Those with LVEF = 50% (n = 29) were included in the study and randomized to control group (CG n = 10), continuous training group (CTG n = 9) or interval training group (ITG, n = 10)...
March 12, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29534920/cardiorespiratory-responses-nitric-oxide-production-and-inflammatory-factors-in-patients-with-myocardial-infarction-after-rehabilitation
#10
José V Subiela, Sonia H Torres, Juan B De Sanctis, Noelina Hernández
There is evidence that myocardial infarction (MI) patients have an inflammatory process that includes skeletal muscles, and exercise has been reported to reduce some inflammatory markers. The aim of this work was to study NO and some inflammatory markers in quadriceps muscle of MI patients before and after cardiac rehabilitation. Muscle biopsy was obtained in 17 MI patients before and after CR and only once in 11 healthy subjects. Several cardiorespiratory and metabolic parameters were evaluated and skeletal muscle levels of nitric oxide synthases, nitrate, nitrite, nitrotyrosine, tumor necrosis factor alpha (TNF-α), transforming growth factor beta (TGF-β), interleukin- 6 (IL-6) and CD154...
June 1, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29503239/exercise-training-potentiates-the-cardioprotective-effects-of-stem-cells-post-infarction
#11
Stella de Souza Vieira, Ednei Luiz Antonio, Brunno Lemes de Melo, Leslie Andrews Portes, Jairo Montemor, Helenita Antônia Oliveira, Flavia Leticia Martins, Camila Zogbi, Adriana Costa Girardi, José Antônio Silva, Paulo de Tarso Camillo de Carvalho, Paulo José Ferreira Tucci, Andrey Jorge Serra
BACKGROUND: Preconditioning of cell recipients may exert a significant role in attenuating the hostility of the infarction milieu, thereby enhancing the efficacy of cell therapy. This study was conducted to examine whether exercise training potentiates the cardioprotective effects of adipose-derived stem cell (ADSC) transplantation following myocardial infarction (MI) in rats. METHODS: Four groups of female Fisher-344 rats were studied: Sham; non-trained rats with MI (sMI); non-trained rats with MI submitted to ADSCs transplantation (sADSC); trained rats with MI submitted to ADSCs (tADSC)...
November 22, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29499766/effects-of-combined-high-intensity-aerobic-interval-training-program-and-mediterranean-diet-recommendations-after-myocardial-infarction-interfarct-project-study-protocol-for-a-randomized-controlled-trial
#12
Sara Maldonado-Martín, Jon Ander Jayo-Montoya, Tatiana Matajira-Chia, Beatriz Villar-Zabala, Juan José Goiriena, G Rodrigo Aispuru
BACKGROUND: Exercise therapy has long been used for rehabilitation purposes after myocardial infarction (MI) and the benefit of regular physical exercise is also well-established. High-intensity interval training (HIIT) has been proposed to be more effective than continuous exercise for improving exercise capacity and health-related adaptations to low-volume (LV) and HIIT are also known. Furthermore, the Mediterranean diet (Mediet) has been widely reported to be a model of healthy eating for its contribution to a favorable health status and a better quality of life, reducing overall mortality...
March 2, 2018: Trials
https://www.readbyqxmd.com/read/29483876/pyridostigmine-improves-the-effects-of-resistance-exercise-training-after-myocardial-infarction-in-rats
#13
Daniele J Feriani, Hélio J Coelho-Júnior, Juliana C M F de Oliveira, Maria A Delbin, Cristiano T Mostarda, Paulo M M Dourado, Érico C Caperuto, Maria C C Irigoyen, Bruno Rodrigues
Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Exercise training and pharmacological treatments are important strategies to minimize the deleterious effects of MI. However, little is known about the effects of resistance training combined with pyridostigmine bromide (PYR) treatment on cardiac and autonomic function, as well as on the inflammatory profile after MI. Thus, in the present study, male Wistar rats were randomly assigned into: control (Cont); sedentary infarcted (Inf); PYR - treated sedentary infarcted rats (Inf+P); infarcted rats undergoing resistance exercise training (Inf+RT); and infarcted rats undergoing PYR treatment plus resistance training (Inf+RT+P)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29465559/cardiac-rehabilitation-in-acute-myocardial-infarction-patients-after-percutaneous-coronary-intervention-a-community-based-study
#14
Yong Zhang, HongXia Cao, Pin Jiang, HaiQin Tang
BACKGROUND: Acute myocardial infarction (AMI) is one of the leading causes of death and physical disability worldwide. However, the development of community- based cardiac rehabilitation (CR) in AMI patients is hysteretic. Here, we aimed to evaluate the safety and efficacy of CR applied in the community in AMI patients who underwent percutaneous coronary intervention (PCI). METHODS: A total of 130 ST-segment elevated myocardial infarction (STEMI) patients after PCI were randomly divided into 2 groups in the community, rehabilitation group (n = 65) and control group (n = 65)...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29460403/effects-of-ivabradine-on-endothelial-function-aortic-properties-and-ventricular-arterial-coupling-in-chronic-systolic-heart-failure-patients
#15
Ivano Bonadei, Edoardo Sciatti, Enrico Vizzardi, Davide Fabbricatore, Mattia Pagnoni, Laura Rossi, Valentina Carubelli, Carlo M Lombardi, Marco Metra
AIM: Heart rate (HR) is an important prognostic factor in patients affected by chronic heart failure (CHF); ivabradine has been demonstrated to significantly reduce nonfatal myocardial infarction and hospitalization rate for acute heart failure and to improve left ventricular (LV) reverse remodeling, quality of life, exercise capacity, and arterial elastance (Ea) in these patients. We aimed at evaluating the short-term effects of ivabradine on ventricular-arterial coupling (VAC), aortic stiffness, and endothelial function in stable patients with CHF...
February 20, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29459465/mental-stress-induced-myocardial-ischemia-in-young-patients-with-recent-myocardial-infarction-sex-differences-and-mechanisms
#16
Viola Vaccarino, Samaah Sullivan, Muhammad Hammadah, Kobina Wilmot, Ibhar Al Mheid, Ronnie Ramadan, Lisa Elon, Pratik M Pimple, Ernest V Garcia, Jonathon Nye, Amit J Shah, Ayman Alkhoder, Oleksiy Levantsevych, Hawkins Gay, Malik Obideen, Minxuan Huang, Tené T Lewis, J Douglas Bremner, Arshed A Quyyumi, Paolo Raggi
BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is frequent in patients with coronary artery disease and is associated with worse prognosis. Young women with a previous myocardial infarction (MI), a group with unexplained higher mortality than men of comparable age, have shown elevated rates of MSIMI, but the mechanisms are unknown. METHODS: We studied 306 patients (150 women and 156 men) ≤61 years of age who were hospitalized for MI in the previous 8 months and 112 community controls (58 women and 54 men) frequency matched for sex and age to the patients with MI...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29453669/physical-training-and-cardiac-rehabilitation-in-heart-failure-patients
#17
Cesare de Gregorio
Regardless of advances in medical and interventional treatment of cardiovascular disease (CVD), a limited number of patients attend a cardiac rehabilitation (CR) programme on a regular basis. Due to modern therapies more individuals will be surviving an acute cardiovascular event, but the expected burden of chronic heart failure will be increasing worldwide.However, both in high- and low-income countries, secondary prevention after an acute myocardial infarction or stroke has been implemented in less than a half of eligible patients...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29433517/quality-of-life-of-patients-with-first-time-ami-a-descriptive-study
#18
Mandreker Bahall, Katija Khan
BACKGROUND: Outcomes following acute myocardial infarction (AMI) may result in death, increased morbidity, and change in quality of life (QOL). This study explores health-related QOL of first-time patients following AMI. METHODS: This cross-sectional study used a sample of patients with first-time AMI experienced between April 2011 and March 2015 at a tertiary health institution. Recruited patients belonged to different post-AMI periods: 2-10 weeks, 5-22 months, and > 22 months to 4 years post AMI...
February 13, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29408714/effect-of-exercise-training-on-left-ventricular-mechanics-after-acute-myocardial-infarction-an-exploratory-study
#19
Gordon McGregor, Eric J Stöhr, David Oxborough, Peter Kimani, Rob Shave
BACKGROUND: Cardiac rehabilitation (CR) exercise training is beneficial after myocardial infarction (MI). Whilst the peripheral adaptations to training are well defined, little is known regarding the effect on left ventricular (LV) remodelling, particularly LV function. Efficient LV ejection and filling is achieved through deformation and rotation of the myocardium in systole and diastole - LV mechanics. The response of LV mechanics to CR exercise training in MI patients is unknown. METHODS: In this observational exploratory study, 36 (of 40 enrolled) male, MI patients completed either 10-weeks of twice-weekly gym based cardiovascular exercise at 60-80% VO2peak (n=18), or a non-exercise control period (n=18)...
January 31, 2018: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29380285/stronger-correlation-with-myocardial-ischemia-of-high-sensitivity-troponin-t-than-other-biomarkers
#20
Theodore Pipikos, Alkistis Kapelouzou, Diamantis I Tsilimigras, Yannis Fostinis, Marina Pipikou, Athanassios Theodorakos, Antonis N Pavlidis, Christos Kontogiannis, Dennis V Cokkinos, Maria Koutelou
BACKGROUND: Acute myocardial infarction (AMI) is considered a major cause of death and disability. Myocardial perfusion scintigraphy (MPS) as a non-invasive diagnostic imaging procedure and certain biomarkers associated with myocardial ischemia (ISCH), such as ischemia-modified albumin (IMA), neuropeptide Y (NPY), N-terminal pro b-type natriuretic peptide (NT-proBNP), and high-sensitivity troponin T (hsTnT) could probably aid in the detection of myocardial infarction. METHODS: Between December 2011 and June 2012, we prospectively analyzed patients who underwent a MPS study with the clinical question of myocardial ISCH...
January 29, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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