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https://www.readbyqxmd.com/read/29149281/seroreactivity-to-the-c6-peptide-in-borrelia-miyamotoi-infections-occurring-in-the-northeastern-united-states
#1
Phillip J Molloy, Karen E Weeks, Brittany Todd, Gary P Wormser
Background: There are no Food and Drug Administration (FDA) approved diagnostic tests for Borrelia miyamotoi infection, an emerging tick-borne illness in the United States. The purpose of this study was to evaluate whether the FDA-approved C6 peptide ELISA currently used to diagnose Lyme disease may potentially serve as a diagnostic test for B. miyamotoi infections. Methods: Serum specimens from 30 patients from the Northeastern United States with B. miyamotoi infection established by a polymerase chain reaction assay of a blood specimen were tested using the C6 ELISA...
November 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29149201/the-influence-of-filtering-and-downsampling-on-the-estimation-of-transfer-entropy
#2
Immo Weber, Esther Florin, Michael von Papen, Lars Timmermann
Transfer entropy (TE) provides a generalized and model-free framework to study Wiener-Granger causality between brain regions. Because of its nonparametric character, TE can infer directed information flow also from nonlinear systems. Despite its increasing number of applications in neuroscience, not much is known regarding the influence of common electrophysiological preprocessing on its estimation. We test the influence of filtering and downsampling on a recently proposed nearest neighborhood based TE estimator...
2017: PloS One
https://www.readbyqxmd.com/read/29148021/routine-adoption-of-timp2-and-igfbp7-biomarkers-in-cardiac-surgery-for-early-identification-of-acute-kidney-injury
#3
Chiara Levante, Fiorenza Ferrari, Chiara Manenti, Faeq Husain-Syed, Marta Scarpa, Tommaso Hinna Danesi, Massimo De Cal, Valentina Corradi, Grazia M Virzì, Alessandra Brendolan, Federico Nalesso, Pércia Bezerra, Salvador Lopez-Giacoman, Sara Samoni, Mara Senzolo, Davide Giavarina, Loris Salvador, Raffaele Bonato, Silvia De Rosa, Enrico Rettore, Claudio Ronco
BACKGROUND AND PURPOSE: Acute Kidney Injury (AKI) is a severe complication affecting many hospitalized patients after cardiac surgery, with negative impacts on short- and long-term clinical outcomes and on healthcare costs. Recently, clinical interest has been aimed at defining and classifying AKI, identifying risk factors and developing diagnostic strategies to identify patients at risk early on. Achieving an early and accurate diagnosis of AKI is a crucial issue, because prevention and timely detection may help to prevent negative clinical outcomes and avoid AKI-associated costs...
November 16, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29147162/high-preoperative-neutrophil-lymphocyte-ratio-nlr-and-red-blood-cell-distribution-width-rdw-as-independent-predictors-of-native-arteriovenous-fistula-failure
#4
Rashid Usman, Muhammad Jamil, Muhammad Naveed
Objective: To study the association between a high preoperative neutrophil lymphocyte ratio (NLR) and red cell distribution width (RDW) with arteriovenous fistula (AVF) failure, as well as to determine the cut-off values in a South Asian population. Materials and Methods: A total of 150 consecutive patients with a failed fistula who presented in the Department of Vascular Surgery between January 2014 and January 2016. Patients fulfilling the inclusion criteria were selected as defined as Case. They were compared with 150 patients who had matured fistulae (Control)...
September 25, 2017: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/29146521/hla-dq-gluten-tetramer-blood-test-accurately-identifies-patients-with-and-without-celiac-disease-in-absence-of-gluten-consumption
#5
Vikas K Sarna, Knut E A Lundin, Lars Mørkrid, Shuo-Wang Qiao, Ludvig M Sollid, Asbjørn Christophersen
BACKGROUND & AIMS: Celiac disease is characterized by HLA-DQ2/8-restricted responses of CD4+ T cells to cereal gluten proteins. A diagnosis of celiac disease based on serologic and histologic evidence and duodenal histology requires patients to be on gluten-containing diets. The growing number of individuals adhering to a gluten-free diet (GFD) without exclusion of celiac disease complicates its detection. HLA-DQ-gluten tetramers can be used to detect gluten-specific T cells in blood of patients with celiac disease, even if they are on a GFD...
November 13, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29145895/comparative-analysis-of-high-sensitivity-cardiac-troponin-i-and-t-for-their-association-with-coronary-computed-tomography-assessed-calcium-scoring-represented-by-the-agatston-score
#6
Jonas Rusnak, Michael Behnes, Thomas Henzler, Nadine Reckord, Nils Vogler, Mathias Meyer, Ursula Hoffmann, Michele Natale, Julia Hoffmann, Sonja Hamed, Kathrin Weidner, Siegfried Lang, Agnibh Mukherji, Holger Haubenreisser, Stefan O Schoenberg, Martin Borggrefe, Thomas Bertsch, Ibrahim Akin
BACKGROUND: This study evaluates the association between high-sensitivity cardiac troponin I (hs-cTnI) and T (hs-cTnT) and coronary calcium concentration (CAC) detected by coronary computed tomography (CCT) and evaluated with the Agatston score in patients with suspected coronary artery disease (CAD). METHODS: Patients undergoing CCT during routine clinical care were enrolled prospectively. CCT was indicated for patients with a low to intermediate pretest probability for CAD...
November 16, 2017: European Journal of Medical Research
https://www.readbyqxmd.com/read/29145844/development-and-evaluation-of-an-interferon-gamma-assay-for-the-diagnosis-of-tuberculosis-in-red-deer-experimentally-infected-with-mycobacterium-bovis
#7
María Ángeles Risalde, Jobin Thomas, Iker Sevilla, Miriam Serrano, Jose Antonio Ortíz, Joseba Garrido, Mercedes Domínguez, Lucas Domínguez, Christian Gortázar, Jose Francisco Ruíz-Fons
BACKGROUND: Red deer (Cervus elaphus) is regarded as an epidemiologically relevant host for Mycobacterium bovis (M. bovis) and closely related members of the Mycobacterium tuberculosis complex that cause animal tuberculosis (TB). The standard antemortem screening test for the detection of TB in deer is the intradermal tuberculin skin test, but the detection of interferon-gamma (IFNγ) produced by white blood cells exposed to M. bovis antigens can be used as an alternative or supplemental assay in most TB eradication/control programs...
November 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29145836/clinical-utility-of-computed-tomography-hounsfield-characterization-for-percutaneous-nephrolithotomy-a-cross-sectional-study
#8
Andrea Gallioli, Elisa De Lorenzis, Luca Boeri, Maurizio Delor, Stefano Paolo Zanetti, Fabrizio Longo, Alberto Trinchieri, Emanuele Montanari
BACKGROUND: Computed Tomography (CT) is considered the gold-standard for the pre-operative evaluation of urolithiasis. However, no Hounsfield (HU) variable capable of differentiating stone types has been clearly identified. The aim of this study is to assess the predictive value of HU parameters on CT for determining stone composition and outcomes in percutaneous nephrolithotomy (PCNL). METHODS: Seventy seven consecutive cases of PCNL between 2011 and 2016 were divided into 4 groups: 40 (52%) calcium, 26 (34%) uric acid, 5 (6%) struvite and 6 (8%) cystine stones...
November 16, 2017: BMC Urology
https://www.readbyqxmd.com/read/29145044/image-processing-for-precise-three-dimensional-registration-and-stitching-of-thick-high-resolution-laser-scanning-microscopy-image-stacks
#9
Chloé Murtin, Carole Frindel, David Rousseau, Kei Ito
The possible depth of imaging of laser-scanning microscopy is limited not only by the working distances of objective lenses but also by image degradation caused by attenuation and diffraction of light passing through the specimen. To tackle this problem, one can either flip the sample to record images from both sides of the specimen or consecutively cut off shallow parts of the sample after taking serial images of certain thickness. Multiple image substacks acquired in these ways should be combined afterwards to generate a single stack...
November 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29144965/role-of-serum-1-3%C3%AE-d-glucan-assay-in-early-diagnosis-of-invasive-fungal-infections-in-a-neonatal-intensive-care-unit
#10
Abd Elazeez Shabaan, Lobna Mahmoud Elbaz, Wafaa M El-Emshaty, Basma Shouman
OBJECTIVES: To study the microbiological pattern of late onset neonatal sepsis cultures and to assess the diagnostic performance of serum (1,3)-β-d-glucan level for early diagnosis of invasive fungemia in high-risk infants admitted to a neonatal intensive care unit. METHODS: A prospective multicenter clinical trial conducted on infants at high risk for invasive fungal infections, with suspected late onset sepsis, admitted to a neonatal intensive care unit at Mansoura University Children's Hospital and Mansoura General Hospital between March 2014 and February 2016...
November 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/29143699/are-there-distinct-cognitive-and-motivational-sub-groups-of-children-with-adhd
#11
Rikke Lambek, Edmund Sonuga-Barke, Rosemary Tannock, Anne Virring Sørensen, Dorte Damm, Per Hove Thomsen
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is proposed to be a neuropsychologically heterogeneous disorder that encompasses two distinct sub-groups, one with executive function (EF) deficits and one with delay aversion (DA). However, such claims have often been based on studies that have operationalized neuropsychological deficits using a categorical approach - using intuitive but rather arbitrary, clinical cut-offs. The current study applied an alternative empirical approach to sub-grouping in ADHD, latent profile analysis (LPA), and attempted to validate emerging subgroups through clinically relevant correlates...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29143616/diagnostic-accuracy-of-detection-and-quantification-of-hbv-dna-and-hcv-rna-using-dried-blood-spot-dbs-samples-a-systematic-review-and-meta-analysis
#12
Berit Lange, Teri Roberts, Jennifer Cohn, Jamie Greenman, Johannes Camp, Azumi Ishizaki, Luke Messac, Edouard Tuaillon, Philippe van de Perre, Christine Pichler, Claudia M Denkinger, Philippa Easterbrook
BACKGROUND: The detection and quantification of hepatitis B (HBV) DNA and hepatitis C (HCV) RNA in whole blood collected on dried blood spots (DBS) may facilitate access to diagnosis and treatment of HBV and HCV infection in resource-poor settings. We evaluated the diagnostic performance of DBS compared to venous blood samples for detection and quantification of HBV-DNA and HCV-RNA in two systematic reviews and meta-analyses on the diagnostic accuracy of HBV DNA and HCV RNA from DBS compared to venous blood samples...
November 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29143334/pk-pd-modeling-of-flunixin-meglumine-in-a-kaolin-induced-inflammation-model-in-piglets
#13
O L Levionnois, T K Fosse, B Ranheim
Flunixin is marketed in several countries for analgesia in adult swine but little is known about its efficacy in piglets. Thirty-two piglets (6-8 days old) were randomized to receive placebo saline (n = 11, group CONTROL) or flunixin meglumine intravenously at 2.2 (n = 11, group MEDIUM) or 4.4 (n = 10, group HIGH) mg/kg, 10 hr after subcutaneous injection of kaolin in the left metacarpal area. A hand-held algometer was used to determine each piglet's mechanical nociceptive threshold (MNT) from both front feet up to 50 hr after treatment (cut-off value of 24...
November 16, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29143195/normal-values-of-high-resolution-manometry-in-supine-and-upright-positions-in-a-thai-population
#14
Pitichote Hiranyatheb, Suriya Chakkaphak, Supphamat Chirnaksorn, Pattaraporn Lekhaka, Kaimuk Petsrikun, Kornkanok Somboonpun
BACKGROUND: Although cut-off values used in high-resolution manometry (HRM) to diagnose esophageal motility disorders are based on representative samples of the US population and assume a supine position, differences in population and body positioning can reportedly affect results. AIMS: To establish normal HRM values for Thai people in both supine and upright positions. METHODS: Forty-one healthy subjects were recruited, each of whom underwent solid-state HRM with ten 5-mL swallows of water in both the supine and upright positions...
November 15, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29143102/diagnostic-performance-of-hpv-e6-e7-mrna-assay-for-detection-of-cervical-high-grade-intraepithelial-neoplasia-and-cancer-among-women-with-ascus-papanicolaou-smears
#15
Chenchen Ren, Yuanhang Zhu, Li Yang, Xiaoan Zhang, Ling Liu, Chunying Ren
PURPOSE: The aim of this study was to investigate the clinical performance of high risk (HR) HPV E6/E7 mRNA assay in detecting cervical high-grade intraepithelial neoplasia and cancer among women with atypical squamous cells of undetermined significance (ASCUS) Papanicolaou (Pap) smears. METHODS: A total of 160 patients with ASCUS who underwent HR-HPV DNA assay, HR-HPV E6/E7 mRNA assay and colposcopy biopsy at Third Affiliated Hospital of Zhengzhou University, China, from December 2015 to March 2017, were enrolled...
November 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29141603/detect-i-detect-ii-a-study-protocol-for-a-prospective-multicentre-observational-study-to-validate-the-uromark-assay-for-the-detection-of-bladder-cancer-from-urinary-cells
#16
Wei Shen Tan, Andrew Feber, Liqin Dong, Rachael Sarpong, Sheida Rezaee, Simon Rodney, Pramit Khetrapal, Patricia de Winter, Frelyn Ocampo, Rumana Jalil, Norman R Williams, Chris Brew-Graves, John D Kelly
BACKGROUND: Haematuria is a common finding in general practice which requires visual inspection of the bladder by cystoscopy as well as upper tract imaging. In addition, patients with non-muscle invasive bladder cancer (NMIBC) often require surveillance cystoscopy as often as three monthly depending on disease risk. However, cystoscopy is an invasive procedure which is uncomfortable, requires hospital attendance and is associated with a risk of urinary tract infection. We have developed the UroMark assay, which can detect 150 methylation specific alteration specific to bladder cancer using DNA from urinary sediment cells...
November 15, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29140454/gestational-age-specific-perinatal-mortality-rates-for-assisted-reproductive-technology-art-and-other-births
#17
Abrar A Chughtai, Alex Y Wang, Lisa Hilder, Zhuoyang Li, Kei Lui, Cindy Farquhar, Elizabeth A Sullivan
STUDY QUESTION: Is perinatal mortality rate higher among births born following assisted reproductive technology (ART) compared to non-ART births? SUMMARY ANSWER: Overall perinatal mortality rates in ART births was higher compared to non-ART births, but gestational age-specific perinatal mortality rate of ART births was lower for very preterm and moderate to late preterm births. WHAT IS KNOWN ALREADY: Births born following ART are reported to have higher risk of adverse perinatal outcomes compared to non-ART births...
November 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29138434/generating-localized-plasmonic-fields-on-an-integrated-photonic-platform-using-tapered-couplers-for-biosensing-applications
#18
Gurpreet Singh, Renzhe Bi, U S Dinish, Malini Olivo
A theoretical design and analysis of a tapered-coupler structure on a silicon nitride integrated-photonic platform for coupling optical energy from a dielectric waveguide to a plasmonic tip is presented. The proposed design can be considered as a hybrid photonic-plasmonic structure that generally supports hybrid symmetric and asymmetric modes. Along the taper, one of the hybrid modes approaches the cut-off, while the other approaches the short-range surface plasmon mode that generates localized fields. Potential use of the proposed novel tapered-coupler plasmonic structure for highly sensitive biosensing applications using surface enhanced Raman scattering (SERS) and metal enhanced fluorescence (MEF) techniques is discussed...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137442/prognostic-value-of-long-noncoding-rna-zfas1-in-various-carcinomas-a-meta-analysis
#19
Dan Dong, Zhongyi Mu, Wei Wang, Na Xin, Xiaowen Song, Yue Shao, Chenghai Zhao
A number of studies have revealed that zinc finger antisense 1 (ZFAS1), a long noncoding RNA (lncRNA), is aberrantly regulated in various cancers, and high ZFAS1 expression is associated with poor prognosis and increased risk of lymph node metastasis (LNM). This meta-analysis was conducted to identify the potential value of ZFAS1 as a biomarker for cancer prognosis. We searched electronic database PubMed, Web of Science, and China Wanfang Data (up to June 1, 2017) to collect all relevant studies and explore the association of ZFAS1 expression with overall survival (OS) and LNM...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137438/prognostic-value-of-bone-scan-index-as-an-imaging-biomarker-in-metastatic-prostate-cancer-a-meta-analysis
#20
Dongyang Li, Hang Lv, Xuanyu Hao, Yudi Dong, Huixu Dai, Yongsheng Song
Background: The prognostic value of the bone scan index (BSI) in metastatic prostate cancer (mPCa) remained controversial. Therefore, we performed a meta-analysis to determine the predictive value of BSI and survival in patients with mPCa. Materials and Methods: A literature search was performed in PubMed, Embase, Web of Science and Cochrane library databases. Hazard ratios (HRs), concordance indices (C-indices) were extracted to estimate the relationship between BSI and survival in patients with mPCa...
October 13, 2017: Oncotarget
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