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https://www.readbyqxmd.com/read/29762825/the-prognostic-role-of-platelet-to-lymphocyte-ratio-and-mean-platelet-volume-in-critically-ill-patients
#1
A Yildiz, A Yigit, A R Benli
OBJECTIVE: The aim of this study was to identify the relationship between complete blood count parameters, mean platelet volume (MPV), and platelet to lymphocyte ratio (PLR) with mortality and hospitalization duration in critically ill patients. PATIENTS AND METHODS: A retrospective analysis was made of patients admitted to our tertiary adult i̇ntensive Care Unit (ICU) between January 2015 and January 2016. Hemoglobin (Hb), white blood cell (WBC), lymphocyte and platelet counts were obtained from the complete blood count performed at the time of admission...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760355/interventions-integrating-non-communicable-disease-prevention-and-reproductive-maternal-newborn-and-child-health-a-systematic-review
#2
Kimiyo Kikuchi, Rakesh Ayer, Sumiyo Okawa, Mariko Nishikitani, Fumihiko Yokota, Masamine Jimba, Naoki Nakashima
Reproductive, maternal, newborn, and child health (RMNCH) care services could be critical entry points for preventing non-communicable diseases in women and children. In high-income countries, non-communicable diseases screening has been integrated into both the medical and public health systems. To integrate these services in low- and middle-income countries, it is necessary to closely examine its effectiveness and feasibility. In this systematic review, we evaluated the effectiveness of integrating gestational and non-gestational non-communicable diseases interventions and RMNCH care among women and children in low- and middle-income countries...
2018: Bioscience Trends
https://www.readbyqxmd.com/read/29729652/critical-care-nurses-experiences-of-caring-for-a-dying-child-a-qualitative-evidence-synthesis
#3
REVIEW
Mitchell Grimston, Ashleigh E Butler, Beverley Copnell
AIM: To synthesise qualitative research examining the experience of critical care nurses caring for a dying child. BACKGROUND: Caring for a dying child remains one of the most difficult aspects of nursing, potentially leading to personal and professional distress. A thorough understanding of this experience for critical care nurses allows for improved delivery of care and support for the nurse. DESIGN: A qualitative evidence synthesis was undertaken, informed by Thomas and Harden's thematic synthesis methodology...
May 5, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29729501/the-impact-of-nurse-and-care-staff-education-on-the-functional-ability-and-quality-of-life-of-people-living-with-dementia-in-aged-care-a-systematic-review
#4
Michael Bauer, Deirdre Fetherstonhaugh, Emily Haesler, Elizabeth Beattie, Keith D Hill, Christopher J Poulos
OBJECTIVES: Educational initiatives can improve care delivery and the experience of living in residential aged care for people with dementia. This review aimed to determine the impact of nurse and care staff education on measures of functional ability and quality of life for older people with dementia living in care homes. DESIGN: Systematic review. DATA SOURCES: Search of on-line databases in English between January 2000 and January 2017...
April 23, 2018: Nurse Education Today
https://www.readbyqxmd.com/read/29716545/management-and-control-of-communicable-diseases-in-schools-and-other-child-care-settings-systematic-review-on-the-incubation-period-and-period-of-infectiousness
#5
Ida Czumbel, Chantal Quinten, Pierluigi Lopalco, Jan C Semenza
BACKGROUND: Information on the incubation period and period of infectiousness or shedding of infectious pathogens is critical for management and control of communicable diseases in schools and other childcare settings. METHODS: We performed a systematic literature review (Pubmed and Embase) to identify and critically appraise all relevant published articles using incubation, infectiousness or shedding, and exclusion period as parameters for the search. No language, time, geographical or study design restrictions were applied...
May 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29713205/pessary-use-in-stress-urinary-incontinence-a-review-of-advantages-complications-patient-satisfaction-and-quality-of-life
#6
REVIEW
Ghadeer Al-Shaikh, Sadiqa Syed, Somaia Osman, Abdulrahman Bogis, Ahmed Al-Badr
Stress urinary incontinnce (SUI) is a common condition among women. The usual approach to treatment of SUI is a stepwise plan from conservative to surgical procedures. A vaginal pessary is one of the commonly used conservative treatments that offer symptomatic improvement for women with incontinence. This review provides a critical analysis of the benefits and shortcomings offered by vaginal pessaries to patients affected by SUI, with a particular focus on indications, advantages, quality of life, patient satisfaction, and potential complications...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29686751/leadership-training-in-graduate-medical-education-a-systematic-review
#7
REVIEW
Brett Sadowski, Sarah Cantrell, Adam Barelski, Patrick G O'Malley, Joshua D Hartzell
Background : Leadership is a critical component of physician competence, yet the best approaches for developing leadership skills for physicians in training remain undefined. Objective : We systematically reviewed the literature on existing leadership curricula in graduate medical education (GME) to inform leadership program development. Methods : Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we searched MEDLINE, ERIC, EMBASE, and MedEdPORTAL through October 2015 using search terms to capture GME leadership curricula...
April 2018: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29653128/serotonin-specific-lesions-of-the-dorsal-raphe-disrupt-maternal-aggression-and-caregiving-in-postpartum-rats
#8
M Allie Holschbach, Erika V Vitale, Joseph S Lonstein
The behavioral modifications associated with early motherhood, including high aggression, caring for young, and low anxiety are all affected by acute pharmacological manipulation of serotonin signaling. However, the effects on these behaviors of permanently disrupting serotonin signaling at one of its primary sources, the dorsal raphe (DR), have not been examined in detail. To address this, serotonin-specific lesions centered on the dorsomedial DR (DRdm; subregion most implicated in emotional behaviors) were induced at mid-pregnancy (day 15) or early postpartum (day 2) in rats using a saporin-conjugated neurotoxin targeting the serotonin transporter (Anti-SERT-SAP)...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29615035/real-world-evidence-how-pragmatic-are-randomized-controlled-trials-labeled-as-pragmatic
#9
Rafael Dal-Ré, Perrine Janiaud, John P A Ioannidis
INTRODUCTION: Pragmatic randomized controlled trials (RCTs) mimic usual clinical practice and they are critical to inform decision-making by patients, clinicians and policy-makers in real-world settings. Pragmatic RCTs assess effectiveness of available medicines, while explanatory RCTs assess efficacy of investigational medicines. Explanatory and pragmatic are the extremes of a continuum. This debate article seeks to evaluate and provide recommendation on how to characterize pragmatic RCTs in light of the current landscape of RCTs...
April 3, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29582429/early-intervention-mobilization-or-active-exercise-for-critically-ill-adults-in-the-intensive-care-unit
#10
REVIEW
Katherine A Doiron, Tammy C Hoffmann, Elaine M Beller
BACKGROUND: Survivors of critical illness often experience a multitude of problems that begin in the intensive care unit (ICU) or present and continue after discharge. These can include muscle weakness, cognitive impairments, psychological difficulties, reduced physical function such as in activities of daily living (ADLs), and decreased quality of life. Early interventions such as mobilizations or active exercise, or both, may diminish the impact of the sequelae of critical illness. OBJECTIVES: To assess the effects of early intervention (mobilization or active exercise), commenced in the ICU, provided to critically ill adults either during or after the mechanical ventilation period, compared with delayed exercise or usual care, on improving physical function or performance, muscle strength and health-related quality of life...
March 27, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29569286/real-life-experiences-of-people-with-transient-ischaemic-attack-or-minor-stroke-a-qualitative-literature-review
#11
REVIEW
Gary Crowfoot, Pamela van der Riet, Jane Maguire
AIMS AND OBJECTIVES: To explore and present findings of qualitative studies exploring real-life experiences of people with transient ischaemic attack or minor stroke. BACKGROUND: Transient ischaemic attack and minor stroke significantly increase the risk of stroke. Primarily, literature has examined healthcare pathways, patient outcomes and models of care through quantitative methodologies. Several studies have explored patient experiences using qualitative approaches...
March 22, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29502073/impact-of-acute-otitis-media-clinical-practice-guidelines-on-antibiotic-and-analgesic-prescriptions-a-systematic-review
#12
REVIEW
Yelin Deniz, Rick T van Uum, Marieke L A de Hoog, Anne G M Schilder, Roger A M J Damoiseaux, Roderick P Venekamp
BACKGROUND: Clinical practice guidelines focusing on judicious use of antibiotics for childhood acute otitis media (AOM) have been introduced in many countries around the world. OBJECTIVE: To systematically review the effects of these guidelines on the prescription of antibiotics and analgesics for children with AOM. METHODS: Systematic searches of PubMed, Embase and Cochrane Library from inception to 6 June 2017 using broad search terms. Studies specifically aimed at evaluating the effects of introduction of national AOM practice guidelines on type of antibiotic and/or analgesic prescriptions were included, irrespective of design, setting or language...
June 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29497170/whither-systems-medicine
#13
REVIEW
Rolf Apweiler, Tim Beissbarth, Michael R Berthold, Nils Blüthgen, Yvonne Burmeister, Olaf Dammann, Andreas Deutsch, Friedrich Feuerhake, Andre Franke, Jan Hasenauer, Steve Hoffmann, Thomas Höfer, Peter Lm Jansen, Lars Kaderali, Ursula Klingmüller, Ina Koch, Oliver Kohlbacher, Lars Kuepfer, Frank Lammert, Dieter Maier, Nico Pfeifer, Nicole Radde, Markus Rehm, Ingo Roeder, Julio Saez-Rodriguez, Ulrich Sax, Bernd Schmeck, Andreas Schuppert, Bernd Seilheimer, Fabian J Theis, Julio Vera, Olaf Wolkenhauer
New technologies to generate, store and retrieve medical and research data are inducing a rapid change in clinical and translational research and health care. Systems medicine is the interdisciplinary approach wherein physicians and clinical investigators team up with experts from biology, biostatistics, informatics, mathematics and computational modeling to develop methods to use new and stored data to the benefit of the patient. We here provide a critical assessment of the opportunities and challenges arising out of systems approaches in medicine and from this provide a definition of what systems medicine entails...
March 2, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29492717/the-global-spine-care-initiative-a-systematic-review-for-the-assessment-of-spine-related-complaints-in-populations-with-limited-resources-and-in-low-and-middle-income-communities
#14
REVIEW
Margareta Nordin, Kristi Randhawa, Paola Torres, Hainan Yu, Scott Haldeman, O'Dane Brady, Pierre Côté, Carlos Torres, Michael Modic, Rajani Mullerpatan, Christine Cedraschi, Roger Chou, Emre Acaroğlu, Eric L Hurwitz, Nadège Lemeunier, Jean Dudler, Anne Taylor-Vaisey, Erkin Sönmez
PURPOSE: The purpose of this systematic literature review was to develop recommendations for the assessment of spine-related complaints in medically underserved areas with limited resources. METHODS: We conducted a systematic review and best evidence synthesis of guidelines on the assessment of spine-related complaints. Independent reviewers critically appraised eligible guidelines using the Appraisal of Guidelines for Research and Evaluation-II criteria. Low risk of bias clinical practice guidelines was used to develop recommendations...
February 28, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29434521/nursing-education-challenges-and-solutions-in-sub-saharan-africa-an-integrative-review
#15
Thokozani Bvumbwe, Ntombifikile Mtshali
Background: The Lancet Commission and the Global Health Workforce Alliance reported that professional education has generally not kept up the pace of health care challenges. Sub Saharan Africa needs an effective and efficient nursing education system to build an adequate, competent and relevant nursing workforce necessary for the achievement of Sustainable Development Goals. The Plan of Action for Scaling up Quality Nursing and Midwifery Education and Practice for the African Region 2012 - 2022 provided a framework for scale up of nurses and midwives...
2018: BMC Nursing
https://www.readbyqxmd.com/read/29433862/three-dimensionally-printed-bioactive-ceramic-scaffold-osseoconduction-across-critical-sized-mandibular-defects
#16
Christopher D Lopez, J Rodrigo Diaz-Siso, Lukasz Witek, Jonathan M Bekisz, Bruce N Cronstein, Andrea Torroni, Roberto L Flores, Eduardo D Rodriguez, Paulo G Coelho
BACKGROUND: Vascularized bone tissue transfer, commonly used to reconstruct large mandibular defects, is challenged by long operative times, extended hospital stay, donor-site morbidity, and resulting health care. 3D-printed osseoconductive tissue-engineered scaffolds may provide an alternative solution for reconstruction of significant mandibular defects. This pilot study presents a novel 3D-printed bioactive ceramic scaffold with osseoconductive properties to treat segmental mandibular defects in a rabbit model...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29422722/sleeping-in-a-brave-new-world-opportunities-for-improving-learning-and-clinical-outcomes-through-targeted-memory-reactivation
#17
Ken A Paller
Neuroscientific insights into learning and memory have mostly concerned input and output, but intervening processing during the time between acquisition and retrieval is also critical. Indeed, intervening memory reactivation may regulate memory longevity, and a growing body of evidence implicates sleep in changing memory storage. For example, subtle auditory stimulation can be used experimentally to selectively encourage memory reactivation during sleep, which thereby improves learning. Much remains to be elucidated about how learning depends on sleep...
December 2017: Current Directions in Psychological Science
https://www.readbyqxmd.com/read/29418050/the-process-of-incorporating-insulin-pumps-into-the-everyday-lives-of-people-with-type-1-diabetes-a-critical-interpretive-synthesis
#18
REVIEW
Claire Reidy, Mike Bracher, Claire Foster, Ivaylo Vassilev, Anne Rogers
BACKGROUND: Insulin pump therapy (IPT) is a technological advancement that has been developed to help people manage Type 1 diabetes (T1D). However, ways of managing diabetes requiring the implementation of health technologies bring new complexities and a need to understand the factors which enable people with T1D to incorporate a novel device. This new comprehension could provide an exemplar for people with long-term conditions to incorporate new technologies more generally. OBJECTIVE: To determine what influences the incorporation, adaptation and use of IPT into the everyday lives of people living with diabetes...
February 8, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29415004/facilitators-and-barriers-for-hiv-testing-in-zambia-a-systematic-review-of-multi-level-factors
#19
REVIEW
Shan Qiao, Yao Zhang, Xiaoming Li, J Anitha Menon
It was estimated that 1.2 million people live with HIV/AIDS in Zambia by 2015. Zambia has developed and implemented diverse programs to reduce the prevalence in the country. HIV-testing is a critical step in HIV treatment and prevention, especially among all the key populations. However, there is no systematic review so far to demonstrate the trend of HIV-testing studies in Zambia since 1990s or synthesis the key factors that associated with HIV-testing practices in the country. Therefore, this study conducted a systematic review to search all English literature published prior to November 2016 in six electronic databases and retrieved 32 articles that meet our inclusion criteria...
2018: PloS One
https://www.readbyqxmd.com/read/29406372/epidemiology-of-pediatric-critical-care-transport-in-northern-alberta-and-the-western-arctic
#20
Atsushi Kawaguchi, Charlene C Nielsen, Gonzalo G Guerra, L Duncan Saunders, Yutaka Yasui, Allan DeCaen
OBJECTIVE: Specialized pediatric critical care transport teams are essential to pediatric retrieval systems. This study aims to describe the contemporary transports performed by a Canadian pediatric critical care transport team and to compare the treatment and outcomes of children referred from high-level care (hospitals offering pediatric services where an adult ICU exists) and nonhigh-level care (all other hospitals) hospitals. DESIGN: A descriptive cohort study...
February 5, 2018: Pediatric Critical Care Medicine
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