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https://www.readbyqxmd.com/read/29755624/clinical-significance-of-skin-autofluorescence-in-patients-with-type-2-diabetes-mellitus-with-chronic-heart-failure
#1
Takashi Hitsumoto
Background: Recent clinical studies have shown that skin autofluorescence (AF) levels are significantly associated with diabetic complications. In contrast, data regarding the relationships between skin AF and chronic heart failure (CHF) are limited. The aim of this study was to clarify the clinical significance of skin AF in patients with type 2 diabetes mellitus (DM) with CHF. Methods: This cross-sectional study enrolled 257 outpatients with type 2 DM with CHF who were treated medically (96 men and 161 women; mean age, 79 ± 7 years)...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29753654/correlation-of-arterial-stiffness-with-left-atrial-volume-index-and-left-ventricular-mass-index-in-young-adults-evaluation-by-coronary-computed-tomography-angiography
#2
Kazuhiro Osawa, Rine Nakanishi, Toru Miyoshi, Sina Rahmani, Indre Ceponiene, Negin Nezarat, Mitsuru Kanisawa, Hong Qi, Eranthi Jayawardena, Nicholas Kim, Hiroshi Ito, Matthew J Budoff
BACKGROUND: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. METHODS: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA)...
April 26, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29615288/cardiac-effects-of-fish-oil-in-a-rat-model-of-streptozotocin-induced-diabetes
#3
F Mayyas, R Jaradat, K H Alzoubi
BACKGROUND AND AIMS: Fish oil (FO) is rich in omega-3 polyunsaturated fatty acids, which have cardio-protective effects. This study aims to evaluate effects of FO in a rat model of streptozotocin (STZ) induced diabetes. METHODS AND RESULTS: Adults male Wistar rats were assigned to control (4 μl corn oil/g corn oil given by oral gavage), FO (4 μl Menhaden FO/g body weight given by oral gavage), diabetes (DM, 35 mg/kg STZ single intraperitoneal injection, corn oil), and DM + FO groups for 8 weeks...
February 25, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29511422/clinical-significance-of-cardio-ankle-vascular-index-as-a-cardiovascular-risk-factor-in-elderly-patients-with-type-2-diabetes-mellitus
#4
Takashi Hitsumoto
Background: The cardio-ankle vascular index (CAVI) is a novel physiological marker of atherosclerosis that reflects systemic arterial stiffness. The aim of this study was to clarify the clinical significance of CAVI as a risk factor for cardiovascular diseases (CVDs) in elderly patients with type 2 diabetes mellitus. Methods: This cross-sectional study enrolled 216 elderly (≥ 65 years) outpatients with type 2 diabetes mellitus who were undergoing antidiabetic treatment (96 males and 120 females; mean age, 75 ± 7 years (mean ± standard deviation))...
April 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29479047/long-term-use-of-ipragliflozin-improved-cardiac-sympathetic-nerve-activity-in-a-patient-with-heart-failure-a-case-report
#5
Shunsuke Kiuchi, Shinji Hisatake, Takayuki Kabuki, Takahiro Fujii, Takashi Oka, Shintaro Dobashi, Hidenobu Hashimoto, Takanori Ikeda
Ipragliflozin is the first SGLT2 inhibitor approved in Japan. Reported here is a case where long-term administration of ipragliflozin decreased the rate of re-hospitalization due to heart failure (HF). An 83-year-old man with chronic HF and diabetes mellitus (DM) was hospitalized four times in the last five years. He was discharged six months after his last hospitalization, but he continued to have class III HF according to the New York Heart Association classification (NYHA), and his DM was also not properly managed...
March 19, 2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29259233/cardiovascular-disease-progression-in-female-zucker-diabetic-fatty-rats-occurs-via-unique-mechanisms-compared-to-males
#6
Kelly Lum-Naihe, Ryan Toedebusch, Abuzar Mahmood, Jamal Bajwa, Terry Carmack, Senthil A Kumar, Sivakumar Ardhanari, Vincent G DeMarco, Craig A Emter, Lakshmi Pulakat
Population studies have shown that compared to diabetic men, diabetic women are at a higher risk of cardiovascular disease. However, the mechanisms underlying this gender disparity are unclear. Our studies in young murine models of type 2 diabetes mellitus (T2DM) and cardiovascular disease show that diabetic male rats develop increased cardiac fibrosis and suppression of intracardiac anti-fibrotic cytokines, while premenopausal diabetic female rats do not. This protection from cardiac fibrosis in female rats can be an estrogen-related effect...
December 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28856781/cellular-apoptosis-and-cardiac-dysfunction-in-stz-induced-diabetic-rats-attenuated-by-anthocyanins-via-activation-of-igfi-r-pi3k-akt-survival-signaling
#7
Pei-Chen Huang, Guei-Jane Wang, Ming-Jen Fan, Marthandam Asokan Shibu, Yin-Tso Liu, Vijaya Padma Viswanadha, Yi-Lin Lin, Chao-Hung Lai, Yu-Feng Chen, Hung-En Liao, Chih-Yang Huang
Anthocyanins are known cyto-protective agents against various stress conditions. In this study cardio-protective effect of anthocyanins from black rice against diabetic mellitus (DM) was evaluated using a streptozotocin (STZ)-induced DM rat model. Five-week-old male Wistar rats were administered with STZ (55 mg kg-1 , IP) to induce DM; rats in the treatment group received 250 mg oral anthocyanin/kg/day during the 4-week treatment period. DM and the control rats received normal saline through oral gavage. The results reveal that STZ-induced DM elevates myocardial apoptosis and associated proapoptotic proteins but down-regulates the proteins of IGF1R mediated survival signaling mechanism...
December 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28746811/the-acute-effects-of-different-spironolactone-doses-on-cardiac-function-in-streptozotocin-induced-diabetic-rats
#8
Aleksandra Vranic, Stefan Simovic, Petar Ristic, Tamara Nikolic, Isidora Stojic, Ivan Srejovic, Vladimir Zivkovic, Vladimir Jakovljevic, Dusan Djuric
Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts...
November 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28571189/evaluation-of-ecg-abnormalities-in-patients-with-asymptomatic-type-2-diabetes-mellitus
#9
Sahil Gupta, Rajeev Kumar Gupta, Malini Kulshrestha, Rajib Ratna Chaudhary
INTRODUCTION: Diabetes Mellitus (DM) is the most common chronic disease. DM is considered a Cardiovascular Disease (CVD) risk equivalent. Its macrovascular complications are associated with two-fold increased risk of premature atherosclerotic CVD. Most of the diabetics with cardiovascular involvement are asymptomatic. Electro Cardio Graph (ECG) abnormalities are found to be predictors of silent ischaemia in asymptomatic persons. An abnormal ECG response is associated with statistically significant high risk for cardiac mortality and morbidity...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27957254/outcomes-and-long-term-survival-of-coronary-artery-surgery-the-controversial-role-of-opium-as-risk-marker
#10
Mahdi Najafi, Leila Jahangiry, Seyedeh Hamideh Mortazavi, Arash Jalali, Abbasali Karimi, Ali Bozorgi
AIM: To study survival in isolated coronary artery bypass graft (CABG) patients and to evaluate the impact of preoperative chronic opium consumption on long-term outcome. METHODS: Cohort of 566 isolated CABG patients as Tehran Heart Center cardiac output measurement was conducted. Daily evaluation until discharge as well as 4- and 12-mo and 6.5-year follow-up information for survival status were fulfilled for all patients. Long-term 6.5-year overall and opium-stratified survival, adjusted survival curves based on opium consumption as well as possible predictors of all-cause mortality using multiple cox regression were determined by statistical analysis...
November 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27894787/safety-and-efficacy-of-liraglutide-treatment-in-japanese-type-2-diabetes-patients-after-acute-myocardial-infarction-a-non-randomized-interventional-pilot-trial
#11
Masataka Kajiwara, Atsushi Tanaka, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Shigeru Toyoda, Teruo Inoue, Nobuhiko Koga, Koichi Node
BACKGROUND: Glucagon-like peptide 1 analogs are expected to exert a cardio-protective action due to their effective glucose-lowering action and favorable potency on multifactorial metabolic pathways. However, the safety and tolerability of liraglutide treatment after a recent acute coronary syndrome (ACS) in Japanese patients with type 2 diabetes mellitus (T2DM) have yet to be fully established. METHODS: A total of eight T2DM patients were recruited within 2 weeks after the onset of a ST-elevation myocardial infarction (STEMI) followed by successful percutaneous coronary intervention (PCI)...
March 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27893829/sansevieria-roxburghiana-schult-schult-f-family-asparagaceae-attenuates-type-2-diabetes-and-its-associated-cardiomyopathy
#12
Niloy Bhattacharjee, Ritu Khanra, Tarun K Dua, Susmita Das, Bratati De, M Zia-Ul-Haq, Vincenzo De Feo, Saikat Dewanjee
BACKGROUND: Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) rhizome has been claimed to possess antidiabetic activity in the ethno-medicinal literature in India. Therefore, present experiments were carried out to explore the protective role of edible (aqueous) extract of S. roxburghiana rhizome (SR) against experimentally induced type 2 diabetes mellitus (T2DM) and its associated cardiomyopathy in Wistar rats. METHODS: SR was chemically characterized by GC-MS analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27629548/rationale-and-design-of-the-multidisciplinary-team-intervention-in-cardio-oncology-study-titan
#13
Edith Pituskin, Mark Haykowsky, Margaret McNeely, John Mackey, Neil Chua, Ian Paterson
BACKGROUND: Cancer is the leading cause of premature death in Canada. In the last decade, important gains in cancer survival have been achieved by advances in adjuvant treatment. However, many oncologic treatments also result in cardiovascular "toxicity". Furthermore, cardiac risk factors such as hypertension, dyslipidemia, and diabetes mellitus are known to contribute to the progression of cardiac damage and clinical cardiotoxicity. As such, for many survivors, the risk of death from cardiac disease exceeds that of recurrent cancer...
September 15, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27453255/relationship-between-arterial-stiffness-and-blood-pressure-drop-during-the-sit-to-stand-test-in-patients-with-diabetes-mellitus
#14
COMPARATIVE STUDY
Yusuke Kobayashi, Tetsuya Fujikawa, Hideo Kobayashi, Koichiro Sumida, Shota Suzuki, Minako Kagimoto, Yuki Okuyama, Yosuke Ehara, Mari Katsumata, Megumi Fujita, Akira Fujiwara, Sanae Saka, Keisuke Yatsu, Tatsuo Hashimoto, Tadashi Kuji, Nobuhito Hirawa, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura
AIM: Patients with orthostatic hypotension (OH) have high arterial stiffness. Patients with diabetes mellitus (DM) often have cardiac autonomic neuropathy that leads to OH; however, whether OH is an indicator of arterial stiffness progression is unclear. We aimed to investigate whether the cardio-ankle vascular index (CAVI) varies between DM patients with and without OH using the sit-to-stand test (STST). METHODS: One hundred and fifty-nine patients with DM underwent CAVI assessment and blood pressure (BP) and heart rate change evaluation during the STST...
February 1, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27422625/research-into-the-effect-of-sglt2-inhibition-on-left-ventricular-remodelling-in-patients-with-heart-failure-and-diabetes-mellitus-reform-trial-rationale-and-design
#15
RANDOMIZED CONTROLLED TRIAL
Jagdeep S S Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J Graeme Houston, Ewan R Pearson, Allan D Struthers, Chim C Lang
BACKGROUND: Heart failure (HF) and diabetes (DM) are a lethal combination. The current armamentarium of anti-diabetic agents has been shown to be less efficacious and sometimes even harmful in diabetic patients with concomitant cardiovascular disease, especially HF. Sodium glucose linked co-transporter type 2 (SGLT2) inhibitors are a new class of anti-diabetic agent that has shown potentially beneficial cardiovascular effects such as pre-load and after load reduction through osmotic diuresis, blood pressure reduction, reduced arterial stiffness and weight loss...
July 15, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27000825/phytochemicals-as-prototypes-for-pharmaceutical-leads-towards-drug-development-against-diabetic-cardiomyopathy
#16
REVIEW
Shreesh Ojha, Amani Kurdi, Bassem Sadek, M Kaleem, Lu Cai, M A Kamal, Mohanraj Rajesh
Globally diabetes mellitus (DM) is swiftly reaching epidemic proportions and impose major health care and socio-economic challenges that are associated with its complications. DM is considered as the major risk factor for the development of debilitating micro & macro vascular complications. Clinical studies have revealed that development of diabetic cardiomyopathy (DCM) in subjects with diabetes can occur both- dependent and independent of pre-existing increased risk factors such as poor glycemic control, hyperlipidemia, and or hypertension...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26813369/-effectiveness-analysis-of-carotid-endarterectomy-in-diabetic-patients-suffering-from-carotid-stenosis
#17
Keqiang Zhao, Weiwei Wu, Junlai Zhao, Zhanjiang Cao, Yu Yang
OBJECTIVE: To evaluate the perioperative complications and effectiveness of carotid endarterectomy (CEA) with diabetes mellitus (DM). METHODS: A total of 148 patients with carotid stenosis undergone CEA from December 2010 to December 2013 were collected and analyzed retrospectively. The patients were distributed into DM group (n=83) and the control group (n=65) according to the comorbidities. Age, gender, risk factors, stenosis degree, cerebral ischemic symptom, shunt in operation, perioperative complications and restenosis after one year in the two groups were analyzed and compared...
November 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26665231/preventing-cardiac-diseases-in-childhood
#18
Andreas Petropoulos, Doris Ehringer-Schetitska, Peter Fritsch, Eero Jokinen, Robert Dalla Pozza, Renate Oberhoffer
OBJECTIVE: The burden of cardiac disease in childhood is unknown. It will be a sum of 1% of living births in the general population, suffering from Congenital Heart Disease (CHD) + approximately 2.5% of the general population suffering from bicuspid aortic valve diseases + an unknown higher prevalence of acquired diseases. Cardiomyopathies, arrhythmias - sudden cardiac death (SCD), rheumatic heard disease, hypertension and accelerating atherosclerosis are among the most frequent. Adding on, genetic syndromes including cardiac defects, endocarditis and myocarditis we can address a large pediatric population worldwide, suffering from heart disease...
September 2015: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26631237/combined-angiotensin-receptor-modulation-in-the-management-of-cardio-metabolic-disorders
#19
REVIEW
Ludovit Paulis, Sébastien Foulquier, Pawel Namsolleck, Chiara Recarti, Ulrike Muscha Steckelings, Thomas Unger
Cardiovascular and metabolic disorders, such as hypertension, insulin resistance, dyslipidemia or obesity are linked with chronic low-grade inflammation and dysregulation of the renin-angiotensin system (RAS). Consequently, RAS inhibition by ACE inhibitors or angiotensin AT1 receptor (AT1R) blockers is the evidence-based standard for cardiovascular risk reduction in high-risk patients, including diabetics with albuminuria. In addition, RAS inhibition reduces the new onset of diabetes mellitus. Yet, the high and increasing prevalence of metabolic disorders, and the high residual risk even in properly treated patients, calls for additional means of pharmacological intervention...
January 2016: Drugs
https://www.readbyqxmd.com/read/26587461/the-role-of-monitoring-arterial-stiffness-with-cardio-ankle-vascular-index-in-the-control-of-lifestyle-related-diseases
#20
REVIEW
Kohji Shirai, Atsuhito Saiki, Daiji Nagayama, Ichiro Tatsuno, Kazuhiro Shimizu, Mao Takahashi
Arteriosclerosis is a major contributor to cardiovascular diseases. One of the difficulties in controlling those diseases is the lack of a suitable indicator of arteriosclerosis or arterial injury in routine clinical practice. Arterial stiffness was supposed to be one of the monitoring indexes of arteriosclerosis. Cardio-ankle vascular index (CAVI) is reflecting the stiffness of the arterial tree from the origin of the aorta to the ankle, and one of the features of CAVI is independency from blood pressure at a measuring time...
September 2015: Pulse (Basel, Switzerland)
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