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https://www.readbyqxmd.com/read/27894787/safety-and-efficacy-of-liraglutide-treatment-in-japanese-type-2-diabetes-patients-after-acute-myocardial-infarction-a-non-randomized-interventional-pilot-trial
#1
Masataka Kajiwara, Atsushi Tanaka, Tomohiro Kawasaki, Koichi Nakao, Tomohiro Sakamoto, Shigeru Toyoda, Teruo Inoue, Nobuhiko Koga, Koichi Node
BACKGROUND: Glucagon-like peptide 1 analogs are expected to exert a cardio-protective action due to their effective glucose-lowering action and favorable potency on multifactorial metabolic pathways. However, the safety and tolerability of liraglutide treatment after a recent acute coronary syndrome (ACS) in Japanese patients with type 2 diabetes mellitus (T2DM) have yet to be fully established. METHODS: A total of eight T2DM patients were recruited within 2 weeks after the onset of a ST-elevation myocardial infarction (STEMI) followed by successful percutaneous coronary intervention (PCI)...
November 25, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27893829/sansevieria-roxburghiana-schult-schult-f-family-asparagaceae-attenuates-type-2-diabetes-and-its-associated-cardiomyopathy
#2
Niloy Bhattacharjee, Ritu Khanra, Tarun K Dua, Susmita Das, Bratati De, M Zia-Ul-Haq, Vincenzo De Feo, Saikat Dewanjee
BACKGROUND: Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) rhizome has been claimed to possess antidiabetic activity in the ethno-medicinal literature in India. Therefore, present experiments were carried out to explore the protective role of edible (aqueous) extract of S. roxburghiana rhizome (SR) against experimentally induced type 2 diabetes mellitus (T2DM) and its associated cardiomyopathy in Wistar rats. METHODS: SR was chemically characterized by GC-MS analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27629548/rationale-and-design-of-the-multidisciplinary-team-intervention-in-cardio-oncology-study-titan
#3
Edith Pituskin, Mark Haykowsky, Margaret McNeely, John Mackey, Neil Chua, Ian Paterson
BACKGROUND: Cancer is the leading cause of premature death in Canada. In the last decade, important gains in cancer survival have been achieved by advances in adjuvant treatment. However, many oncologic treatments also result in cardiovascular "toxicity". Furthermore, cardiac risk factors such as hypertension, dyslipidemia, and diabetes mellitus are known to contribute to the progression of cardiac damage and clinical cardiotoxicity. As such, for many survivors, the risk of death from cardiac disease exceeds that of recurrent cancer...
September 15, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27453255/relationship-between-arterial-stiffness-and-blood-pressure-drop-during-the-sit-to-stand-test-in-patients-with-diabetes-mellitus
#4
Yusuke Kobayashi, Tetsuya Fujikawa, Hideo Kobayashi, Koichiro Sumida, Shota Suzuki, Minako Kagimoto, Yuki Okuyama, Yosuke Ehara, Mari Katsumata, Megumi Fujita, Akira Fujiwara, Sanae Saka, Keisuke Yatsu, Tatsuo Hashimoto, Tadashi Kuji, Nobuhito Hirawa, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura
AIM: Patients with orthostatic hypotension (OH) have high arterial stiffness. Patients with diabetes mellitus (DM) often have cardiac autonomic neuropathy that leads to OH; however, whether OH is an indicator of arterial stiffness progression is unclear. We aimed to investigate whether the cardio-ankle vascular index (CAVI) varies between DM patients with and without OH using the sit-to-stand test (STST). METHODS: One hundred and fifty-nine patients with DM underwent CAVI assessment and blood pressure (BP) and heart rate change evaluation during the STST...
July 22, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27422625/research-into-the-effect-of-sglt2-inhibition-on-left-ventricular-remodelling-in-patients-with-heart-failure-and-diabetes-mellitus-reform-trial-rationale-and-design
#5
Jagdeep S S Singh, Amir Fathi, Keeran Vickneson, Ify Mordi, Mohapradeep Mohan, J Graeme Houston, Ewan R Pearson, Allan D Struthers, Chim C Lang
BACKGROUND: Heart failure (HF) and diabetes (DM) are a lethal combination. The current armamentarium of anti-diabetic agents has been shown to be less efficacious and sometimes even harmful in diabetic patients with concomitant cardiovascular disease, especially HF. Sodium glucose linked co-transporter type 2 (SGLT2) inhibitors are a new class of anti-diabetic agent that has shown potentially beneficial cardiovascular effects such as pre-load and after load reduction through osmotic diuresis, blood pressure reduction, reduced arterial stiffness and weight loss...
July 15, 2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27000825/phytochemicals-as-prototypes-for-pharmaceutical-leads-towards-drug-development-against-diabetic-cardiomyopathy
#6
Shreesh Ojha, Amani Kurdi, Bassem Sadek, M Kaleem, Lu Cai, M A Kamal, Mohanraj Rajesh
Globally diabetes mellitus (DM) is swiftly reaching epidemic proportions and impose major health care and socio-economic challenges that are associated with its complications. DM is considered as the major risk factor for the development of debilitating micro & macro vascular complications. Clinical studies have revealed that development of diabetic cardiomyopathy (DCM) in subjects with diabetes can occur both- dependent and independent of pre-existing increased risk factors such as poor glycemic control, hyperlipidemia, and or hypertension...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/26813369/-effectiveness-analysis-of-carotid-endarterectomy-in-diabetic-patients-suffering-from-carotid-stenosis
#7
Keqiang Zhao, Weiwei Wu, Junlai Zhao, Zhanjiang Cao, Yu Yang
OBJECTIVE: To evaluate the perioperative complications and effectiveness of carotid endarterectomy (CEA) with diabetes mellitus (DM). METHODS: A total of 148 patients with carotid stenosis undergone CEA from December 2010 to December 2013 were collected and analyzed retrospectively. The patients were distributed into DM group (n=83) and the control group (n=65) according to the comorbidities. Age, gender, risk factors, stenosis degree, cerebral ischemic symptom, shunt in operation, perioperative complications and restenosis after one year in the two groups were analyzed and compared...
November 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26665231/preventing-cardiac-diseases-in-childhood
#8
Andreas Petropoulos, Doris Ehringer-Schetitska, Peter Fritsch, Eero Jokinen, Robert Dalla Pozza, Renate Oberhoffer
OBJECTIVE: The burden of cardiac disease in childhood is unknown. It will be a sum of 1% of living births in the general population, suffering from Congenital Heart Disease (CHD) + approximately 2.5% of the general population suffering from bicuspid aortic valve diseases + an unknown higher prevalence of acquired diseases. Cardiomyopathies, arrhythmias - sudden cardiac death (SCD), rheumatic heard disease, hypertension and accelerating atherosclerosis are among the most frequent. Adding on, genetic syndromes including cardiac defects, endocarditis and myocarditis we can address a large pediatric population worldwide, suffering from heart disease...
September 2015: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/26631237/combined-angiotensin-receptor-modulation-in-the-management-of-cardio-metabolic-disorders
#9
REVIEW
Ludovit Paulis, Sébastien Foulquier, Pawel Namsolleck, Chiara Recarti, Ulrike Muscha Steckelings, Thomas Unger
Cardiovascular and metabolic disorders, such as hypertension, insulin resistance, dyslipidemia or obesity are linked with chronic low-grade inflammation and dysregulation of the renin-angiotensin system (RAS). Consequently, RAS inhibition by ACE inhibitors or angiotensin AT1 receptor (AT1R) blockers is the evidence-based standard for cardiovascular risk reduction in high-risk patients, including diabetics with albuminuria. In addition, RAS inhibition reduces the new onset of diabetes mellitus. Yet, the high and increasing prevalence of metabolic disorders, and the high residual risk even in properly treated patients, calls for additional means of pharmacological intervention...
January 2016: Drugs
https://www.readbyqxmd.com/read/26587461/the-role-of-monitoring-arterial-stiffness-with-cardio-ankle-vascular-index-in-the-control-of-lifestyle-related-diseases
#10
REVIEW
Kohji Shirai, Atsuhito Saiki, Daiji Nagayama, Ichiro Tatsuno, Kazuhiro Shimizu, Mao Takahashi
Arteriosclerosis is a major contributor to cardiovascular diseases. One of the difficulties in controlling those diseases is the lack of a suitable indicator of arteriosclerosis or arterial injury in routine clinical practice. Arterial stiffness was supposed to be one of the monitoring indexes of arteriosclerosis. Cardio-ankle vascular index (CAVI) is reflecting the stiffness of the arterial tree from the origin of the aorta to the ankle, and one of the features of CAVI is independency from blood pressure at a measuring time...
September 2015: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/26297226/relationship-of-hyperuricemia-with-mortality-in-heart-failure-patients-with-preserved-ejection-fraction
#11
Takeshi Shimizu, Akiomi Yoshihisa, Yuki Kanno, Mai Takiguchi, Akihiko Sato, Shunsuke Miura, Yuichi Nakamura, Hiroyuki Yamauchi, Takashi Owada, Satoshi Abe, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Takayoshi Yamaki, Koichi Sugimoto, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Yasuchika Takeishi
Serum uric acid is a predictor of cardiovascular mortality in heart failure with reduced ejection fraction. However, the impact of uric acid on heart failure with preserved ejection fraction (HFpEF) remains unclear. Here, we investigated the association between hyperuricemia and mortality in HFpEF patients. Consecutive 424 patients, who were admitted to our hospital for decompensated heart failure and diagnosed as having HFpEF, were divided into two groups based on presence of hyperuricemia (serum uric acid ≥7 mg/dl or taking antihyperuricemic agents)...
October 2015: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26021501/early-results-of-coronary-endarterectomy-combined-with-coronary-artery-bypass-grafting-in-patients-with-diffused-coronary-artery-disease
#12
Li-Qun Chi, Jian-Qun Zhang, Qing-Yu Kong, Wei Xiao, Lin Liang, Xin-Liang Chen
BACKGROUND: It is still a challenge for the cardiac surgeons to achieve adequate revascularization for diffused coronary artery disease (CAD). Coronary endarterectomy (CE) offers an alternative choice of coronary artery reconstruction and revascularization. In this study, short-term result of CE combined with coronary artery bypass graft (CABG) was discussed in the treatment for the diffused CAD. METHODS: From January 2012 to April 2014, 221 cases of CABG were performed by the same surgeon in our unit...
June 5, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/25853841/cardio-ankle-vascular-index-is-associated-with-cardiovascular-target-organ-damage-and-vascular-structure-and-function-in-patients-with-diabetes-or-metabolic-syndrome-lod-diabetes-study-a-case-series-report
#13
MULTICENTER STUDY
Manuel Ángel Gómez-Marcos, José Ignacio Recio-Rodríguez, María Carmen Patino-Alonso, Cristina Agudo-Conde, Leticia Gómez-Sánchez, Marta Gomez-Sanchez, Emiliano Rodríguez-Sanchez, Jose Angel Maderuelo-Fernandez, Luís García-Ortiz
BACKGROUND: The cardio ankle vascular index (CAVI) is a new index of the overall stiffness of the artery from the origin of the aorta to the ankle. This index can estimate the risk of atherosclerosis. We aimed to find the relationship between CAVI and target organ damage (TOD), vascular structure and function, and cardiovascular risk factors in Caucasian patients with type 2 diabetes mellitus or metabolic syndrome. METHODS: We included 110 subjects from the LOD-Diabetes study, whose mean age was 61 ± 11 years, and 37...
January 16, 2015: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/25711144/-prognostic-value-of-cardiovascular-mri-in-diabetics
#14
C L Schlett, R C Bertheau, H-U Kauczor, S Weckbach
CLINICAL/METHODICAL ISSUE: Despite an increased cardiovascular risk in patients with diabetes mellitus they are a heterogeneous population with very different individual manifestation of diseases; therefore, a profound stratification is recommended. STANDARD METHODS: Clinical examinations and blood biomarkers are typically used in diabetic patients to determine the risk for developing cardio-cerebrovascular events. METHODICAL INNOVATIONS: Cardiac as well as whole-body magnetic resonance imaging (MRI) including cardiovascular sequences are established methods for clinical diagnostics...
April 2015: Der Radiologe
https://www.readbyqxmd.com/read/25591455/abroma-augusta-l-malvaceae-leaf-extract-attenuates-diabetes-induced-nephropathy-and-cardiomyopathy-via-inhibition-of-oxidative-stress-and-inflammatory-response
#15
Ritu Khanra, Saikat Dewanjee, Tarun K Dua, Ranabir Sahu, Moumita Gangopadhyay, Vincenzo De Feo, Muhammad Zia-Ul-Haq
BACKGROUND: Abroma augusta L. (Malvaceae) leaf is traditionally used to treat diabetes in India and Southern Asia. Therefore, current study was performed to evaluate the protective effect of defatted methanol extract of A. augusta leaves (AA) against type 2 diabetes mellitus (T2DM) and its associated nephropathy and cardiomyopathy in experimental rats. METHODS: Antidiabetic activity of AA extracts (100 and 200 mg/kg, p.o.) was measured in streptozotocin-nicotinamide induced type 2 diabetic (T2D) rat...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/25577519/the-pathophysiology-of-the-chronic-cardiorenal-syndrome-a-magnetic-resonance-imaging-study
#16
Tobias Breidthardt, Eleanor F Cox, Iain Squire, Aghogho Odudu, Nur Farhayu Omar, Mohamed Tarek Eldehni, Susan T Francis, Christopher W McIntyre
OBJECTIVE: To study the association of renal function with renal perfusion and renal parenchymal structure (T1 relaxation) in patients with chronic heart failure (HF). METHODS: After IRB approval, 40 participants were enrolled according to HF and renal function status [10 healthy volunteers < 40 years; 10 healthy age-matched volunteers; 10 HF patients eGFR > 60 ml/min/1.73 m(2); 10 HF patients eGFR < 60 ml/min/1.73 m(2)] and assessed by MRI...
June 2015: European Radiology
https://www.readbyqxmd.com/read/25573882/cardiac-autonomic-dysfunction-is-associated-with-high-risk-albumin-to-creatinine-ratio-in-young-adolescents-with-type-1-diabetes-in-addit-adolescent-type-1-diabetes-cardio-renal-interventional-trial
#17
RANDOMIZED CONTROLLED TRIAL
Yoon Hi Cho, Maria E Craig, Elizabeth A Davis, Andrew M Cotterill, Jennifer J Couper, Fergus J Cameron, Paul Z Benitez-Aguirre, R Neil Dalton, David B Dunger, Timothy W Jones, Kim C Donaghue
OBJECTIVE: This study examined the association between cardiac autonomic dysfunction and high albumin-to-creatinine ratio (ACR) in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS: Adolescents recruited as part of a multicenter screening study (n = 445, 49% female, aged 10-17 years, mean duration 6.9 years; mean HbA1c 8.4%, 68 mmol/mol) underwent a 10-min continuous electrocardiogram recording for heart rate variability analysis. Time-domain heart rate variability measures included baseline heart rate, SD of the R-R interval (SDNN), and root mean squared difference of successive R-R intervals (RMSSD)...
April 2015: Diabetes Care
https://www.readbyqxmd.com/read/25558036/sleep-cardiac-autonomic-function-and-carotid-atherosclerosis-in-patients-with-cardiovascular-risks-hscaa-study
#18
Manabu Kadoya, Hidenori Koyama, Masafumi Kurajoh, Akinori Kanzaki, Miki Kakutani-Hatayama, Hirokazu Okazaki, Takuhito Shoji, Yuji Moriwaki, Tetsuya Yamamoto, Masanori Emoto, Masaaki Inaba, Mitsuyoshi Namba
OBJECTIVES: Behavioral and psychosocial factors have been gaining increased attention in regard to cardiovascular diseases. We evaluated sleep conditions, cardiac autonomic function, and carotid atherosclerosis in subjects who participated in the Hyogo Sleep Cardio-Autonomic Atherosclerosis (HSCAA) Study. METHODS: This cross-sectional study included 330 serial patients registered in the HSCAA study who were free from past cardiovascular diseases, and prescribing α- or β-blockers...
February 2015: Atherosclerosis
https://www.readbyqxmd.com/read/25153796/plasma-brain-derived-neurotrophic-factor-and-reverse-dipping-pattern-of-nocturnal-blood-pressure-in-patients-with-cardiovascular-risk-factors
#19
Manabu Kadoya, Hidenori Koyama, Akinori Kanzaki, Masafumi Kurajoh, Miki Hatayama, Jun Shiraishi, Hirokazu Okazaki, Takuhito Shoji, Yuji Moriwaki, Tetsuya Yamamoto, Masaaki Inaba, Mitsuyoshi Namba
CONTEXT: Basic studies have shown that brain-derived neurotrophic factor (BDNF) has critical roles in the survival, growth, maintenance, and death of central and peripheral neurons, while it is also involved in regulation of the autonomic nervous system. Furthermore, recent clinical studies have suggested potential role of plasma BDNF in the circulatory system. OBJECTIVE: We investigated the mutual relationships among plasma BDNF, patterns of nocturnal blood pressure changes (dippers, non-dippers, extra-dippers, and reverse-dippers), and cardiac autonomic function as determined by heart rate variability (HRV)...
2014: PloS One
https://www.readbyqxmd.com/read/25120987/red-cell-distribution-width-and-serum-bnp-level-correlation-in-diabetic-patients-with-cardiac-failure-a-cross-sectional-study
#20
Subhashree A R
INTRODUCTION: Red cell distribution width (RDW) is a red cell measurement given by fully automated hematology analyzers. It is a measure of heterogeneity in the size of circulating erythrocytes. Studies have shown that it is a prognostic marker in non - anemic diabetic patients with symptomatic cardiovascular disease but its correlation with cardiac failure in diabetics has not been studied so far. Moreover, studies have also shown that a higher RDW may reflect an underlying inflammatory state...
June 2014: Journal of Clinical and Diagnostic Research: JCDR
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