Rosana Banzato, Nathalia M Pinheiro-Menegasso, Fernanda Paula Roncon Santana Novelli, Clarice R Olivo, Laura Taguchi, Stheffany de Oliveira Santos, Silvia Fukuzaki, Walcy Paganelli Rosolia Teodoro, Fernanda D T Q S Lopes, Iolanda F L C Tibério, Alessandra Choqueta de Toledo-Arruda, Marco Antônio M Prado, Vânia F Prado, Carla M Prado
Pulmonary emphysema is a primary component of chronic obstructive pulmonary disease (COPD), a life-threatening disorder characterized by lung inflammation and restricted airflow, primarily resulting from the destruction of small airways and alveolar walls. Cumulative evidence suggests that nicotinic receptors, especially the α7 subtype (α7nAChR), is required for anti-inflammatory cholinergic responses. We postulated that the stimulation of α7nAChR could offer therapeutic benefits in the context of pulmonary emphysema...
January 16, 2024: Inflammation