keyword
https://read.qxmd.com/read/38383889/cost-effectiveness-of-latent-tuberculosis-infection-testing-and-treatment-with-6-week-regimen-among-key-population-in-rural-communities-in-china-a-decision-analysis-study
#21
JOURNAL ARTICLE
Xuefang Cao, Tonglei Guo, Henan Xin, Jiang Du, Chenlu Yang, Boxuan Feng, Yijun He, Lingyu Shen, Yuanzhi Di, Zihan Li, Yanxiao Chen, Jianguo Liang, Qi Jin, Li Wang, Lei Gao
PURPOSE: Several model studies suggested the implementation of latent tuberculosis infection (LTBI) testing and treatment could greatly reduce the incidence of tuberculosis (TB) and achieve the 2035 target of the "End TB" Strategy in China. The present study aimed to evaluate the cost-effectiveness of LTBI testing and TB preventive treatment among key population (≥ 50 years old) susceptible to TB at community level in China. METHODS: A Markov model was developed to investigate the cost-effectiveness of LTBI testing using interferon gamma release assay (IGRA) and subsequent treatment with 6-month daily isoniazid regimen (6H) (as a standard regimen for comparison) or 6-week twice-weekly rifapentine and isoniazid regimen (6-week H2 P2 ) in a cohort of 10,000 adults with an average initial age of 50 years...
February 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38377462/disseminated-mycobacterial-infection-with-reactive-polyarthritis-poncet-s-disease-during-immune-suppressive-treatment-including-ustekinumab-for-pediatric-crohn-s-disease
#22
JOURNAL ARTICLE
Chiara Minotti, Paola Costenaro, Daniele Donà, Monica Zuliani, Luca Bosa, Alberta Leon, Giorgio Perilongo, Paola Gaio, Giorgia Martini, Mara Cananzi
BACKGROUND: The incidence of pediatric inflammatory bowel disease is increasing. tumor necrosis factor alpha inhibitors medicines improved the prognosis of affected subjects. Nonetheless, a proportion of patients do not respond or lose response to treatment. Newer biologics, like ustekinumab, have been approved for adults. The pediatric off-label use of these drugs is increasing, despite limited safety evidence. We report a case of disseminated mycobacterial infection (MI) presenting with reactive polyarthritis (Poncet's disease, PD) in a girl with Crohn's disease receiving various immunosuppressants, including ustekinumab...
February 20, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38375844/t-lymphocyte-interferon-gamma-response-to-anaplasmataceae-related-major-surface-proteins-and-ankyrin-a-in-fibromyalgia
#23
JOURNAL ARTICLE
Basant K Puri, Rosemarie Preyer, Gary S Lee, Armin Schwarzbach
BACKGROUND: The aetiology of fibromyalgia is unknown; its symptoms may be related to a T-lymphocyte-mediated response to infectious organisms. OBJECTIVES: First, to test the hypothesis that fibromyalgia is associated with increased interferon (IFN)-γ-secreting T-lymphocytes after stimulation with Anaplasmataceae-related major surface proteins (MSFs) and the macromolecular translocation type IV secretion system effector ankyrin repeat domain-containing protein A (AnkA)...
February 16, 2024: CNS & Neurological Disorders Drug Targets
https://read.qxmd.com/read/38365178/quantifying-the-contribution-of-smear-negative-culture-positive-pulmonary-tuberculosis-to-nosocomial-transmission
#24
JOURNAL ARTICLE
Ya-Jen Yang, Sung-Ching Pan, Meng-Rui Lee, Che-Liang Chung, Chia-Ping Ku, Chi-Yu Liao, Tien-Yu Tsai, Jann-Yuan Wang, Chi-Tai Fang, Yee-Chun Chen
BACKGROUND: Despite current guidelines for tuberculosis (TB) control in healthcare settings, which focused on smear-positive cases, prevention of nosocomial TB transmission continues to be a challenge. Here, we report results of the first hospital-wide prospective study applying interferon-gamma release assay to investigate the role of smear-negative, culture-positive index cases in nosocomial TB transmission. METHODS: We prospectively identified cases of culture-confirmed smear-negative pulmonary TB receiving aerosol-generating procedures (AGPs) and cases of culture-confirmed smear-positive pulmonary TB admitted at a medical center...
February 14, 2024: American Journal of Infection Control
https://read.qxmd.com/read/38346360/quantiferon-cmv-assay-by-chemiluminescence-immunoassay-is-it-more-suitable-for-real-live-monitoring-of-transplant-patients
#25
JOURNAL ARTICLE
Raquel Fernández-Moreno, Aurora Páez-Vega, Diego Rodríguez-Cano, Ana Salinas, Fernando Rodríguez-Cantalejo, Aurora Jurado, Julián Torre-Cisneros, Sara Cantisán
BACKGROUND: The QuantiFERONCMV (QF-CMV) assay is an interferon-gamma release assay (IGRA) used to monitor CMV-specific cell-mediated immunity (CMV-CMI) by ELISA in transplant patients. However, a chemiluminescent immunoassay (CLIA) has been developed to quantify IFNG in the QuantiFERON-Tuberculosis (TB) to detect latent TB infection. OBJECTIVES: The aim of this work is to compare the results of QF-CMV by ELISA with those obtained by CLIA in an automated Liaison XL analyzer using the QuantiFERON-TB Gold Plus reagents...
February 8, 2024: Journal of Clinical Virology
https://read.qxmd.com/read/38310564/leaf-extracts-of-eight-selected-southern-african-medicinal-plants-modulate-pro-inflammatory-cytokine-secretion-in-lps-stimulated-raw-264-7-macrophages
#26
JOURNAL ARTICLE
Gugulethu P Khumalo, Wendy Loa-Kum-Cheung, Ben-Erik Van Wyk, Yunjiang Feng, Ian E Cock
This study investigates the anti-inflammatory properties of extracts prepared from the leaves of eight southern African medicinal plants used traditionally to treat inflammation and pain. The inhibitory effect of aqueous and ethanol extracts on the release of pro-inflammatory cytokines was determined in lipopolysaccharide (LPS) stimulated and unstimulated RAW 264.7 murine macrophage cells. The levels of interleukin (IL)-1β, IL-6, tumour necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein 1 (MCP-1) and macrophage inflammatory protein (MIP)-2 release were determined using cytokine multiplex-bead assays...
February 4, 2024: Inflammopharmacology
https://read.qxmd.com/read/38299916/a-retrospective-study-of-factors-contributing-to-the-performance-of-an-interferon-gamma-release-assay-blood-test-for-tuberculosis-infection
#27
JOURNAL ARTICLE
Junhyup Song, Sinyoung Kim, Younhee Park
BACKGROUND: Tuberculosis (TB) remains a significant global health concern. Accurate detection of latent TB infection is crucial for effective control and prevention. We aimed to assess the performance of an interferon-gamma release assay blood test (QuantiFERON-TB Gold Plus [QFT-Plus]) in various clinical contexts and identify conditions that affect its results. METHODS: We conducted a retrospective analysis of 31 000 QFT-Plus samples collected from 26 000 subjects at a tertiary hospital in South Korea over a 4-year period and compared the rates of positivity and indeterminate results across diverse clinical situations...
February 1, 2024: Clinical Chemistry
https://read.qxmd.com/read/38297023/temporal-dynamics-of-the-early-immune-response-following-mycobacterium-bovis-infection-of-cattle
#28
JOURNAL ARTICLE
Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur
Bovine tuberculosis is an infectious disease of global significance that remains endemic in many countries. Mycobacterium bovis infection in cattle is characterized by a cell-mediated immune response (CMI) that precedes humoral responses, however the timing and trajectories of CMI and antibody responses determined by newer generation assays remain undefined. Here we used defined-antigen interferon-gamma release assays (IGRA) and an eleven-antigen multiplex ELISA (Enferplex TB test) alongside traditional tuberculin-based IGRA and IDEXX M...
January 31, 2024: Scientific Reports
https://read.qxmd.com/read/38291882/advancing-cytomegalovirus-prevention-in-solid-organ-transplant-recipients-the-promise-of-cell-mediated-immune-assays
#29
REVIEW
Vivek B Beechar, Varun K Phadke, Stephanie M Pouch, Michael H Woodworth
Cytomegalovirus (CMV) infections are a major source of morbidity and mortality in solid organ transplant recipients. Prophylactic, preemptive, and hybrid prevention strategies have traditionally been the mainstay of CMV prevention but there is growing interest in the use of CMV cell-mediated immune assays to inform novel approaches to risk stratification. Recent evidence suggests that CMV interferon-gamma release assays can offer predictive insights into the risk for CMV-related illnesses, raising the potential for tailored CMV prevention strategies anchored to each individual's unique CMV immune profile...
January 31, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/38290379/determination-of-latent-tuberculosis-infection-from-plasma-samples-via-label-free-sers-sensors-and-machine-learning
#30
JOURNAL ARTICLE
Pitak Eiamchai, Chadatan Juntagran, Pacharamon Somboonsaksri, Uraiwan Waiwijit, Jukgarin Eisiri, Janejira Samarnjit, Benjawan Kaewseekhao, Saksorn Limwichean, Mati Horprathum, Wipa Reechaipichitkul, Noppadon Nuntawong, Kiatichai Faksri
Effective diagnostic tools for screening of latent tuberculosis infection (LTBI) are lacking. We aim to investigate the performance of LTBI diagnostic approaches using label-free surface-enhanced Raman spectroscopy (SERS). We used 1000 plasma samples from Northeast Thailand. Fifty percent of the samples had tested positive in the interferon-gamma release assay (IGRA) and 50 % negative. The SERS investigations were performed on individually prepared protein specimens using the Raman-mapping technique over a 7 × 7 grid area under measurement conditions that took under 10 min to complete...
January 27, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38290139/estimated-rates-of-progression-to-tuberculosis-disease-for-persons-infected-with-mycobacterium-tuberculosis-in-the-united-states
#31
JOURNAL ARTICLE
Mina Ekramnia, Yunfei Li, Maryam B Haddad, Suzanne M Marks, J Steve Kammerer, Nicole A Swartwood, Ted Cohen, Jeffrey W Miller, C Robert Horsburgh, Joshua A Salomon, Nicolas A Menzies
BACKGROUND: In the United States, over 80% of tuberculosis (TB) disease cases are estimated to result from reactivation of latent TB infection (LTBI) acquired more than 2 years previously ("reactivation TB"). We estimated reactivation TB rates for the US population with LTBI, overall, by age, sex, race-ethnicity, and US-born status, and for selected comorbidities (diabetes, end-stage renal disease, and HIV). METHODS: We collated nationally representative data for 2011-2012...
March 1, 2024: Epidemiology
https://read.qxmd.com/read/38279837/high-vaccination-coverage-and-infection-rate-result-in-a-robust-sars-cov-2-specific-immunity-in-the-majority-of-liver-cirrhosis-and-transplant-patients-a-single-center-cross-sectional-study
#32
JOURNAL ARTICLE
P von der Schulenburg, A Herting, A Harberts, M Lütgehetmann, J Jahnke-Triankowski, S Pischke, F Piecha, A Drolz, V Jörg, P Hübener, M Wehmeyer, M M Addo, L Fischer, A W Lohse, J Schulze Zur Wiesch, M Sterneck
BACKGROUND: In the third year of the SARS-CoV-2 pandemic, little is known about the vaccine- and infection-induced immune response in liver transplant recipients (LTR) and liver cirrhosis patients (LCP). OBJECTIVE: This cross-sectional study assessed the vaccination coverage, infection rate, and the resulting humoral and cellular SARS-CoV-2-specific immune responses in a cohort of LTR and LCP at the University Medical Center Hamburg-Eppendorf, Germany between March and May 2023...
January 27, 2024: United European Gastroenterology Journal
https://read.qxmd.com/read/38278794/identification-of-differentially-recognized-t-cell-epitopes-in-the-spectrum-of-tuberculosis-infection
#33
JOURNAL ARTICLE
Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G Catanzaro, Antonino Catanzaro, Timothy Rodwell, Judy S B Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D DeSilva, Bjoern Peters, Alessandro Sette, Cecilia S Lindestam Arlehamn
There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-treatment for active tuberculosis (ATB) reveals IFNγ-specific T cell responses against 137 unique epitopes. Of these, 16% are recognized by two or more participants and predominantly derived from cell wall and cell processes antigens. There is differential recognition of antigens, including TB vaccine candidate antigens, between ATB participants and interferon-gamma release assay (IGRA + /-) individuals...
January 26, 2024: Nature Communications
https://read.qxmd.com/read/38272735/zika-virus-precursor-membrane-peptides-induce-immune-response-in-peripheral-blood-mononuclear-cells
#34
JOURNAL ARTICLE
Yogita Gupta, Manoj Baranwal, Bhupendra Chudasama
Zika virus is a re-merging flavivirus allied to serious mental health conditions in the fetuses. There is currently no preventives or treatment available for Zika infection. In this work, we have extended the in silico analysis by performing the molecular docking of previous reported three conserved Zika virus precursor membrane (prM) peptides (MP1, MP2 and MP3) with HLA complex (pHLA) and T cell receptors (TCR) and also evaluated the peptide specific immune response in human peripheral blood mononuclear cells (PBMC)...
January 24, 2024: Human Immunology
https://read.qxmd.com/read/38265746/treatment-of-psoriasis-patients-with-latent-tuberculosis-using-il-17-and-il-23-inhibitors-a-retrospective-multinational-multicentre-study
#35
MULTICENTER STUDY
Tiago Torres, Andrea Chiricozzi, Luis Puig, Ana Maria Lé, Angelo Valerio Marzano, Paolo Dapavo, Esteban Dauden, Jόse-Manuel Carrascosa, Elizabeth Lazaridou, Gleison Duarte, André V E Carvalho, Ricardo Romiti, Natalia Rompoti, Laetitia Teixeira, Miguel Abreu, Elena Ippoliti, Carlo Alberto Maronese, Mar Llamas-Velasco, Eva Vilarrasa, Elena Del Alcázar, Athina-Ioanna Daponte, Marina Papoutsaki, Andrea Carugno, Francesco Bellinato, Paolo Gisondi
BACKGROUND: Tuberculosis has a major global impact. Immunocompetent hosts usually control this disease, resulting in an asymptomatic latent tuberculosis infection (LTBI). Because TNF inhibitors increase the risk of tuberculosis reactivation, current guidelines recommend tuberculosis screening before starting any biologic drug, and chemoprophylaxis if LTBI is diagnosed. Available evidence from clinical trials and real-world studies suggests that IL-17 and IL-23 inhibitors do not increase the risk of tuberculosis reactivation...
March 2024: American Journal of Clinical Dermatology
https://read.qxmd.com/read/38260110/central-nervous-system-tuberculosis-in-immunocompromised-patients-a-case-report-emphasizing-immune-status-and-early-recognition-and-treatment
#36
Marta Quaresma, Madalena Paulino, Ana Oliveira, Ana Nunes
Tuberculosis (TB) remains a global health challenge. Although pulmonary TB is the most frequent presentation, extrapulmonary involvement can occur, especially in immunocompromised patients. HIV-positive individuals are particularly vulnerable to opportunistic infections, such as TB, and CNS involvement is more prevalent in these patients, often leading to a poorer prognosis. CNS TB management is challenging due to nonspecific symptoms and delayed diagnosis, contributing to high mortality. It can manifest diffusely as tuberculous meningitis (TBM), localized as tuberculoma or tuberculous abscess, or as extradural and intradural spinal infections...
January 2024: Curēus
https://read.qxmd.com/read/38244813/igra-based-inh-regimen-for-prevention-of-active-tuberculosis-after-kidney-transplantation-a-single-center-retrospective-study
#37
JOURNAL ARTICLE
Jun Zeng, Daiwen Zhu, Haohan Zhang, Tao Lin, Turun Song
OBJECTIVES: To evaluate the effectiveness and safety of Interferon-gamma release Assay (IGRA)-based isoniazid (INH) prophylaxis strategy to prevent tuberculosis (TB) infection in kidney transplantation (KT) with a risk of TB occurrence. METHODS: Adult KT recipients (KTRs) between June 2014 and July 2021 were retrospectively enrolled. The development of active TB after KT was evaluated. RESULTS: Of 925 KTRs, 111 (12.0%) developed active TB...
January 18, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38227604/increased-tuberculosis-reactivation-risk-in-patients-receiving-immune-checkpoint-inhibitor-based-therapy
#38
JOURNAL ARTICLE
Hsing-Wu Chen, Yao-Wen Kuo, Chung-Yu Chen, Chin-Hao Chang, Su-Mei Wang, Ying-Chun Chien, Wei-Chen Lu, Jo-Pai Chen, Cheng-Yu Chang, Yu-Feng Wei, Shih-Chieh Chang, Chin-Chung Shu, Jann-Yuan Wang, Wei-Yu Liao, Hao-Chien Wang, Chong-Jen Yu
OBJECTIVE: Reports of tuberculosis (TB) during anticancer treatment with immune checkpoint inhibitors (ICIs) are increasing. However, it is not clear whether the use of ICIs is a significant risk factor for TB, including reactivation or latent TB infection (LTBI). METHODS: To determine the risk of TB reactivation in patients with lung cancer who use ICIs or tyrosine kinase inhibitors (TKIs), we conducted a retrospective study using a hospital-based cancer registry...
January 16, 2024: Oncologist
https://read.qxmd.com/read/38222988/cerebral-tuberculosis-after-therapy-with-adalimumab-for-hidradenitis-suppurativa-a-rare-case
#39
Francisca Martins, Alexandra Rodrigues, João Fonseca Oliveira, Rui Malheiro, Luís Cerqueira
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with limited therapeutic options. Adalimumab, an anti-tumor necrosis factor-alpha (TNF-α) monoclonal antibody, was the first biological agent approved for the treatment of moderate to severe HS. Tuberculosis (TB) is a highly prevalent global public health problem, affecting individuals worldwide. Continuous immunosuppression from TNF-α treatment increases the risk of TB development. Isolated neurotuberculosis, in the absence of other symptoms, emerges as a rarely observed infection pattern in such patients...
January 2024: Curēus
https://read.qxmd.com/read/38222154/prevalence-of-latent-tuberculosis-infection-among-rheumatology-patients-and-management-practices-in-the-united-arab-emirates-a-single-center-retrospective-cohort-study
#40
JOURNAL ARTICLE
Shamma Al Nokhatha, Fatima AlKindi, Maryam Alfalasi, Merna Abdelsalhen, Fatima AlKhyeli, Ahmad R Alsaber
Introduction Prior to immunosuppression, rheumatology patients are routinely screened for latent tuberculosis (TB) infection using interferon-gamma release assays (IGRAs). Variability in the management of latent and indeterminate IGRA results across institutions limited long-term outcome data. A retrospective study was conducted at Tawam Hospital, United Arab Emirates, to investigate the incidence and management protocols associated with positive and indeterminate IGRA results, as well as TB infection, among patients with rheumatic conditions...
December 2023: Curēus
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