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interferon gamma release assay

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https://www.readbyqxmd.com/read/27887611/the-performance-of-interferon-gamma-release-assay-in-nontuberculous-mycobacterial-diseases-a-retrospective-study-in-china
#1
Mao-Shui Wang, Jun-Li Wang, Xin-Feng Wang
BACKGROUND: The interferon-gamma release assay (IGRA) is more specific than the tuberculin skin test to discriminate between tuberculosis (TB) and nontuberculous mycobacterial (NTM) diseases. Here we performed a retrospective study to evaluate the performance of the T-SPOT.TB in patients with NTM diseases. METHODS: Between March, 2013 and Nov, 2015, a total of 58 patients with NTM diseases had a T-SPOT.TB performed were enrolled, 30 patients had definite NTM diseases, 28 had probable diseases...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27871783/human-dental-pulp-stem-cells-suppress-alloantigen-induced-immunity-by-stimulating-t-cells-to-release-transforming-growth-factor-beta
#2
Kyu Hwan Kwack, Jung Min Lee, Sang Hyuk Park, Hyeon Woo Lee
INTRODUCTION: Human dental pulp stem cells (hDPSCs) are ideal candidates for regenerating damaged dental tissue. To examine the possibility that hDPSCs may be used to regenerate pulp, we tested their in vitro effects on acute allogeneic immune responses. METHODS: A peripheral blood mononuclear cell (PBMC) proliferation assay and immunoglobulin (Ig) production assay were performed to evaluate the immunosuppressive properties of hDPSCs. RESULTS: The mixed lymphocyte reaction was suppressed by incubation with hDPSCs...
November 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27855476/-tuberculosis-contact-investigation-eight-years-of-experience-with-the-quantiferon-tb%C3%A2-gold-in-tube-in-lower-saxony-germany
#3
M Scharlach, K Brakensiek
Since the beginning of the 21(st) century, beside tuberculin skin tests (TST) and chest X-rays, interferon-gamma release assays (IGRA) have become available for diagnosing latent tuberculosis infection. In 2006, the Governmental Institute of Public Health of Lower Saxony (NLGA) established the IGRA in its laboratory, using the QuantiFERON-TB(®)Gold In-Tube (QFT). A cohort of 19 309 contact persons who were investigated during contact tracing by local public health departments (LPHD) was analyzed. Within 3 years, 75% of LPHDs in Lower Saxony established the QFT for tuberculosis contact tracing...
November 17, 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27822960/limited-usefulness-of-the-interferon-gamma-release-assay-in-patients-with-hiv-infections-and-negative-tuberculin-skin-test-results-in-a-country-with-an-intermediate-tuberculosis-burden
#4
Min Jae Kim, Eun Young Nam, Kyoung Un Park, Pyeong Gyun Choe, Wan Beom Park, Kyoung-Ho Song, Eu Suk Kim, Hong Bin Kim, Myoung-Don Oh, Nam Joong Kim
No abstract text is available yet for this article.
November 8, 2016: Infectious Diseases
https://www.readbyqxmd.com/read/27798883/influence-of-circulating-tumour-cells-on-production-of-il-1%C3%AE-il-1%C3%AE-and-il-12-in-sera-of-patients-with-primary-diagnosis-of-breast-cancer-before-treatment
#5
Theresa Vilsmaier, Brigitte Rack, Alexander König, Klaus Friese, Wolfgang Janni, Udo Jeschke, Tobias Weissenbacher
BACKGROUND: Circulating tumour cells (CTCs) have been found to be a prognostic marker for reduced disease-free survival (DFS), distant DFS, breast cancer-specific survival, and overall survival (OS) before the start of systemic treatment. Determination of CTCs with the CellSearch System (Veridex, Raritan, NJ, USA) is a valuable but time-consuming and costly method. Therefore, the aim of this study was to evaluate cytokine profiles as a marker for CTC involvement. PATIENTS AND METHODS: Patients chosen for this study were defined as women with breast cancer who agreed to participate in the phase I SUCCESS study...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27784508/erythema-nodosum-and-the-risk-of-tuberculosis-in-a-high-incidence-setting
#6
REVIEW
Karen Bjorn-Mortensen, Karin Ladefoged, Jacob Simonsen, Sascha W Michelsen, Hans Christian F Sørensen, Anders Koch, Troels Lillebaek, Aase Bengaard Andersen, Bolette Soborg
OBJECTIVE: This study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with Mycobacterium tuberculosis infection (MTI) with or without EN. DESIGN: We estimated EN incidence rates (IRs) in East Greenland in 2010-2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register...
2016: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/27776586/controversies-in-tuberculous-infection-among-pediatric-infectious-disease-specialists-in-north-america
#7
A T Cruz, A L Hersh, J R Starke, S E Beekmann, P M Polgreen, R Banerjee
OBJECTIVE: To evaluate the extent to which advancements in the diagnosis and treatment of latent tuberculous infection (LTBI) have been integrated into practice by pediatric infectious disease (PID) specialists. DESIGN: We conducted an online survey of the Infectious Diseases Society of America's Emerging Infections Network (EIN) membership. RESULTS: Of the 323 members, 197 (61%) responded: 7% cared for ⩾5 children with TB disease and 34% for ⩾5 children with LTBI annually...
November 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27763261/latent-mycobacterium-tuberculosis-infection-and-interferon-gamma-release-assays
#8
Madhukar Pai, Marcel Behr
The identification of individuals with latent tuberculosis infection (LTBI) is useful for both fundamental understanding of the pathogenesis of disease and for clinical and public health interventions (i.e., to prevent progression to disease). Basic research suggests there is a pathogenetic continuum from exposure to infection to disease, and individuals may advance or reverse positions within the spectrum, depending on changes in the host immunity. Unfortunately, there is no diagnostic test that resolves the various stages within the spectrum of Mycobacterium tuberculosis infection...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27756230/circulating-granulysin-levels-in-healthcare-workers-and-latent-tuberculosis-infection-estimated-using-interferon-gamma-release-assays
#9
Pham Huu Thuong, Do Bang Tam, Shinsaku Sakurada, Nguyen Thi Le Hang, Minako Hijikata, Le Thi Hong, Phan Thi Minh Ngoc, Pham Thu Anh, Vu Cao Cuong, Ikumi Matsushita, Luu Thi Lien, Naoto Keicho
BACKGROUND: Granulysin (GNLY) is produced by human lymphocyte subpopulations and exhibits antimicrobial activity against Mycobacterium tuberculosis. We examined the association between GNLY levels in blood and latent tuberculosis (TB) infection. METHODS: Latency of TB infection among Vietnamese healthcare workers was estimated using interferon-gamma release assays (IGRA), and serum GNLY concentrations were measured using enzyme-linked immunosorbent assays. The levels of GNLY expression in whole blood and the presence of GNLY alleles with the exon-4 polymorphism rs11127 were also determined using PCR-based methods...
October 18, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27755606/correction-the-clinical-usefulness-of-tuberculin-skin-test-versus-interferon-gamma-release-assays-for-diagnosis-of-latent-tuberculosis-in-hiv-patients-a-meta-analysis
#10
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0161983.].
2016: PloS One
https://www.readbyqxmd.com/read/27753763/pediatric-extrapulmonary-tuberculosis-clinical-spectrum-risk-factors-and-diagnostic-challenges-in-a-low-prevalence-region
#11
Begoña Santiago-García, Daniel Blázquez-Gamero, Fernando Baquero-Artigao, Jesús Ruíz-Contreras, Jose M Bellón, Maria A Muñoz-Fernández, María J Mellado-Peña
BACKGROUND: Children are at higher risk of tuberculosis (TB) dissemination and extrapulmonary disease, contributing greatly to TB-associated morbidity and long-term sequelae. However, there are very few studies that assess the impact and clinical spectrum of pediatric extrapulmonary TB (EPTB) in low-prevalence regions. METHODS: Children <18 years of age diagnosed with TB in Madrid region (2005-2013) were reviewed. We compared the epidemiology, clinical characteristics and the performance of diagnostic tests in childhood extrapulmonary and pulmonary disease...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27740453/human-immunology-of-tuberculosis
#12
Thomas J Scriba, Anna K Coussens, Helen A Fletcher
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human infection with Mycobacterium tuberculosis is dependent on the ability of the immune response to clear or contain the infection.In cases where this fails, the bacterium replicates, disseminates within the host, and elicits a pathologic inflammatory response, and disease ensues. Clinical presentation of TB disease is remarkably heterogenous, and the disease phenotype is largely dependent on host immune status. Onward transmission of M...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27733126/comparison-of-characteristics-of-culture-negative-pyogenic-spondylitis-and-tuberculous-spondylitis-a-retrospective-study
#13
Chung-Jong Kim, Eun Jung Kim, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Hong-Bin Kim, Myoung-Don Oh, Nam Joong Kim
BACKGROUND: Differences between the characteristics of culture positive pyogenic spondylitis (CPPS) and tuberculous spondylitis (TS) are well known. However, differences between the characteristics of culture negative pyogenic spondylitis (CNPS) and TS have not been reported; these would be more helpful in clinical practice especially when initial microbiologic examination of blood and/or biopsy tissue did not reveal the causative bacteria in patients with infectious spondylitis. METHODS: We performed a retrospective review of the medical records of patients with CNPS and TS...
October 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27733123/cost-analysis-of-tuberculin-skin-test-and-the-quantiferon-tb-gold-in-tube-test-for-tuberculosis-screening-in-a-correctional-setting-in-dallas-texas-usa
#14
Ank E Nijhawan, Princess A Iroh, Larry S Brown, Daniel Winetsky, Esmaeil Porsa
BACKGROUND: Tuberculosis (TB) disproportionately affects immigrants, HIV-infected individuals, and those living in crowded settings such as homeless shelters and correctional facilities. Although the majority of jails and prisons use a tuberculin skin test (TST) for latent tuberculosis infection (LTBI) screening, limited data exist on the clinical performance and costs of the TST compared to interferon gamma release assays (IGRAs) in this setting. METHODS: A prospective pilot study comparing cost between TST and an IGRA (QuantiFERON Gold In-tube, QFT-GIT) for the detection of LTBI in a convenience sample of inmates entering the Dallas County Jail (DCJ) was conducted June-October 2014...
October 12, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27727132/comparing-tspot-assay-results-between-an-elispot-reader-and-manual-counts
#15
Saroochi Agarwal, Duc T Nguyen, Justin D Lew, Larry D Teeter, Jose-Miguel Yamal, Blanca I Restrepo, Eric L Brown, Susan E Dorman, Edward A Graviss
BACKGROUND: The interferon gamma release assay, TSPOT.TB (TSPOT) can be read by several methodologies, including an Elispot reader or manually by technician. We compared the results from these two counting methods. METHODS: Automated and manual TSPOT results among 2481 United States health care workers were compared. Cohen's kappa coefficient was used to determine the inter-rater agreement. Univariate and multiple logistic regression were used to investigate selected variable contributions...
September 28, 2016: Tuberculosis
https://www.readbyqxmd.com/read/27726808/mycobacteria
#16
Patricia J Simner, Gail L Woods, Nancy L Wengenack
The immunocompromised host is at increased risk of Mycobacterium tuberculosis complex and nontuberculous mycobacteria infection. Although Mycobacterium tuberculosis complex is a significant mycobacterial pathogen, nontuberculous mycobacteria causes substantial disease in those with suppressed immune responses. Mycobacterial infections can cause significant morbidity and mortality in this patient population, and rapid identification and susceptibility testing of the mycobacterial species is paramount to patient management and outcomes...
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27726784/human-immunology-of-tuberculosis
#17
Thomas J Scriba, Anna K Coussens, Helen A Fletcher
Immunology is a central theme when it comes to tuberculosis (TB). The outcome of human infection with Mycobacterium tuberculosis is dependent on the ability of the immune response to clear or contain the infection.In cases where this fails, the bacterium replicates, disseminates within the host, and elicits a pathologic inflammatory response, and disease ensues. Clinical presentation of TB disease is remarkably heterogenous, and the disease phenotype is largely dependent on host immune status. Onward transmission of M...
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27725037/european-shortage-of-purified-protein-derivative-and-its-impact-on-tuberculosis-screening-practices
#18
M Tebruegge, D Buonsenso, F Brinkmann, A Noguera-Julian, I Pavić, A Sorete Arbore, Z Vančíková, S Velizarova, S B Welch, N Ritz
SETTING: In June 2014, we became aware that shortages of purified protein derivative (PPD), the test substance used for the tuberculin skin test (TST), had occurred in several European health care institutions providing care for children with tuberculosis (TB). OBJECTIVE: To establish the extent of the shortage, a survey was performed. DESIGN: Survey conducted over a 1-month period (June-July 2014) among members of the Paediatric Tuberculosis Network European Trials Group (ptbnet)...
October 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27716176/relation-between-bcg-vaccine-scar-and-an-interferon-gamma-release-assay-in-immigrant-children-with-positive-tuberculin-skin-test-%C3%A2-10%C3%A2-mm
#19
Margret Johansson Gudjónsdóttir, Karsten Kötz, Ruth Stangebye Nielsen, Philip Wilmar, Sofia Olausson, Daniel Wallmyr, Birger Trollfors
BACKGROUND: Immigrants from countries with high incidence of tuberculosis (TB) are usually offered screening when they arrive to low incidence countries. The tuberculin skin test (TST) is often used. The interferon gamma release assays (IGRAs) are more specific and not affected by BCG vaccination. The aims of this study were 1. To see if there if there is a correlation between a positive IGRA (QFT) and presence of a BCG scar in children with TST ≥10 mm, 2. To compare the TST diameter with QFT result, 3...
October 6, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27703202/inflammatory-markers-and-clinical-characteristics-for-predicting-persistent-positivity-of-interferon-gamma-release-assay-in-dialysis-population
#20
Chin-Chung Shu, Chia-Lin Hsu, Chih-Yuan Lee, Vin-Cent Wu, Feng-Jung Yang, Jann-Yuan Wang, Chong-Jen Yu, Li-Na Lee
The interferon-gamma release assay (IGRA) is useful for diagnosing latent tuberculosis infection (LTBI), however the rate of negative conversion is high, especially in dialysis patients. Few studies have focused on predicting persistently positive patients who are at high risk of tuberculosis reactivation. We screened dialysis patients, and used QuantiFERON-TB Gold In-tube (QFT-GIT) to identify LTBI. Of the 157 participants who had initially positive QFT-GIT, 82 had persistently positivity and 75 had negative conversion...
October 5, 2016: Scientific Reports
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