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interferon gamma release assay

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https://www.readbyqxmd.com/read/29769377/-ex-vivo-cytokine-release-determined-by-a-multiplex-cytokine-assay-in-response-to-coccidioidal-antigen-stimulation-of-whole-blood-among-subjects-with-recently-diagnosed-primary-pulmonary-coccidioidomycosis
#1
Neil M Ampel, Ian Robey, Chinh T Nguyen, Brentin Roller, Jessica August, Kenneth S Knox, Demosthenes Pappagianis
The elements of the cellular immune response in human coccidioidomycosis remain undefined. We examined the ex vivo release of an array of inflammatory proteins in response to incubation with a coccidioidal antigen preparation to ascertain which of these might be associated with diagnosis and outcome. Patients with a recent diagnosis of primary pulmonary coccidioidomycosis and a control group of healthy subjects were studied. Blood samples were incubated for 18 h with T27K, a soluble coccidioidal preparation containing multiple glycosylated antigens, and the supernatant was assayed for inflammatory proteins using the multiplex Luminex system...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29769160/cross-border-outbreak-of-extensively-drug-resistant-tuberculosis-linked-to-a-university-in-romania
#2
O Popovici, Ph Monk, D Chemtob, D Chiotan, P J Freidlin, R Groenheit, M Haanperä, D Homorodean, M Mansjö, E Robinson, E Rorman, G Smith, H Soini, M J Van Der Werf
Extensively drug-resistant (XDR) tuberculosis (TB) poses a threat to public health due to its complicated, expensive and often unsuccessful treatment. A cluster of three XDR TB cases was detected among foreign medical students of a Romanian university. The contact investigations included tuberculin skin testing or interferon gamma release assay, chest X-ray, sputum smear microscopy, culture, drug susceptibility testing, genotyping and whole-genome sequencing (WGS), and were addressed to students, personnel of the university, family members or other close contacts of the cases...
May 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29764958/diabetes-mellitus-and-latent-tuberculosis-infection-baseline-analysis-of-a-large-uk-cohort
#3
Charlotte Jackson, Jo Southern, Ajit Lalvani, Francis Drobniewski, Chris J Griffiths, Marc Lipman, Graham H Bothamley, Jonathan J Deeks, Ambreen Imran, Onn Min Kon, Sithembinkosi Mpofu, Vladyslav Nikolayevskyy, Melanie Rees-Roberts, Alice Sitch, Saranya Sridhar, Chuen-Yan Tsou, Hilary Whitworth, Ibrahim Abubakar
We conducted a cross-sectional analysis of baseline data from a UK cohort study which enrolled participants at risk of latent tuberculosis infection (LTBI, defined as a positive result for either of the two interferon gamma release assays). Binomial regression with a log link was used to estimate crude and adjusted prevalence ratios (PRs) and 95% CIs for the relationship between diabetes mellitus (DM) and LTBI. Adjusted for age, sex, ethnicity, body mass index and the presence of other immunocompromising conditions, DM was associated with a 15% higher prevalence of LTBI (adjusted PR=1...
May 15, 2018: Thorax
https://www.readbyqxmd.com/read/29758245/validation-and-comparison-of-elisa-kits-to-measure-interferon-gamma-responses-in-quantiferon-cultural-supernatants-for-diagnosis-of-tuberculosis
#4
Jungho Kim, Sungyoung Bong, Deok-Ryun Kim, Sang-Nae Cho, Hyejon Lee
Much effort has been made to reduce the cost of LTBI diagnosis with equivalent efficacy and efficiency of interferon-γ release assay (IGRA). This study showed that repeatability, intermediate precision, and accuracy of the Bionote-ELISA were comparable to QFT-ELISA. The Bionote-ELISA could provide the alternative method.
May 11, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29757355/a-prospective-study-to-monitor-for-tuberculosis-during-anti-tumour-necrosis-factor-therapy-in-patients-with-inflammatory-bowel-disease-and-immune-mediated-inflammatory-diseases
#5
Choon Kin Lee, Sunny H Wong, Grace Lui, Whitney Tang, Lai San Tam, Margaret Ip, Esther Hung, Minhu Chen, Justin C Wu, Siew C Ng
Background: Biologic therapies have revolutionised the treatment of immune- mediated diseases including inflammatory bowel disease (IBD) and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data of regular monitoring for latent tuberculosis infection (LTBI) during biologic treatment are lacking. Methods: Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed-up for 3 years...
May 11, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29755013/screening-for-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-can-interferon-gamma-release-assays-replace-the-tuberculin-skin-test
#6
José Luis Cabriada, Rafael Ruiz-Zorrilla, Jesús Barrio, Ramón Atienza, Alain Huerta, Iago Rodríguez-Lago, Antonio Bernal, César Herrero
BACKGROUND/AIMS: Screening for latent tuberculosis infection is mandatory before starting anti-tumor necrosis factor therapy. New assays based on interferon-γ (IFN-γ) release have recently become available and may be more accurate. The aim of this study was to compare QuantiFERON-TB and tuberculin skin test in screening for latent infection in patients with inflammatory bowel disease. MATERIALS AND METHODS: We prospectively screened 138 patients with inflammatory bowel disease for latent tuberculosis infection with chest X-ray, tuberculin skin test, and a third-generation QuantiFERON-TB test...
May 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29743310/comparison-of-the-quantiferon-tb-gold-plus-and-quantiferon-tb-gold-in-tube-interferon-%C3%AE-release-assays-in-patients-at-risk-for-tuberculosis-and-in-healthcare-workers
#7
Elitza S Theel, Heather Hilgart, Margaret Breen-Lyles, Kevin McCoy, Rhiannon Flury, Laura E Breeher, John Wilson, Irene G Sia, Jennifer A Whitaker, Jeremy Clain, Timothy R Aksamit, Patricio Escalante
The QuantiFERON-TB Gold Plus (QFT-Plus; Qiagen, Germantown, MD) interferon-gamma release assay (IGRA) received FDA-clearance in 2017 and will replace the prior version of the assay, the QFT-Gold In Tube (QFT-GIT). Here, we compared performance of the QFT-Plus assay to the QFT-GIT version in a diverse patient population, including patients undergoing evaluation for or follow-up of latent tuberculosis infection (LTBI; n=39) or active TB (n=3), and in healthcare workers (HCWs; n=119) at Mayo Clinic (Rochester, MN)...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29731933/latent-tuberculosis-infection-diagnosis-and-treatment
#8
Biljana Ilievska-Poposka, Marija Metodieva, Maja Zakoska, Cveta Vragoterova, Dejan Trajkov
INTRODUCTION: Latent tuberculosis infection (LTBI) is defined as a state of persistent immune response to stimulation by Mycobacterium tuberculosis antigens without evidence of clinically manifested active tuberculosis (TB). Diagnosis and treatment for LTBI are important for TB, especially in high-risk populations. Tuberculin skin test (TST) and interferon-gamma release assays (IGRAs) are used to diagnose LTBI. AIM: The study aims to present the first results with IGRA test compared with TST in the screening of LTBI and the treatment results in the cases with LTBI in Macedonia...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29721337/influence-of-seasonality-and-circulating-cytokines-on-serial-quantiferon-discordances
#9
Marsha L Griffin, Saroochi Agarwal, Melissa Zhu Murphy, Larry D Teeter, Edward A Graviss
Objectives. An 18-month prospective study serially tested healthcare workers (HCWs) for tuberculosis infection (TBI) and reported discordant QuantiFERON Gold In-Tube® (QFT) results in some participants. The purpose of the current study was to investigate whether the interferon-gamma (IFN- γ ) measured by QFT in discordant individuals could be influenced by other circulating cytokines that vary seasonally at the time of phlebotomy. Methods. The CDC funded TBESC Task Order 18 (TO18) project to assess the use of Interferon Gamma Release Assays (IGRAs), T-SPOT...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29718223/outcomes-of-treatment-for-latent-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-receiving-biologic-therapy
#10
Guilherme P Ramos, Gregory Stroh, Badr Al-Bawardy, William A Faubion, Konstantinos A Papadakis, Patricio Escalante
Background: Treatment for latent tuberculosis infection (LTBI) is of particular concern in patients with inflammatory bowel disease (IBD) initiating biologic therapies to prevent tuberculosis (TB) reactivation. This study aimed to evaluate the effectiveness of LTBI treatment in IBD patients receiving biologic therapy. Methods: There was a retrospective review of all IBD patients diagnosed with LTBI following a tuberculin skin test (TST) and/or interferon gamma release assay (IGRA) and who received biologic therapy between 2002 and 2016...
April 26, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29717989/-screening-for-tuberculosis-before-tnf%C3%AE-treatment-in-routine-rheumatic-care-in-iceland-result-from-the-nationwide-icebio-registry
#11
Thorir Mar Bjorgulfsson, Gerdur Gröndal, Thorsteinn Blondal, Bjorn Gudbjornsson
INTRODUCTION: Treatment with TNFα inhibitors (TNFαi) greatly increases the risk of reactivation of tuberculosis in rheumatic patients. Therefore, it is recommended to screen patients for tuberculosis before initiating TNFαi treatment. Iceland has a low prevalence of tuberculosis and BCG vaccination is not routine praxis. The purpose of this study was to review the results from TB-screening in routine praxis and to analyze whether changes in the screening process are to be recommended...
May 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29695324/detection-of-mycobacterium-bovis-infection-in-african-buffaloes-syncerus-caffer-using-quantiferon-%C3%A2-tb-gold-qft-tubes-and-the-qiagen-cattletype-%C3%A2-ifn-gamma-elisa
#12
Netanya Bernitz, Charlene Clarke, Eduard O Roos, Wynand J Goosen, David Cooper, Paul D van Helden, Sven D C Parsons, Michele A Miller
African buffaloes (Syncerus caffer) are wildlife maintenance hosts of Mycobacterium bovis, the cause of bovine tuberculosis. Consequently, M. bovis infected buffaloes pose a transmission risk for cattle and other wildlife species. Previously, a modification to the Qiagen QuantiFERON® -TB Gold (QFT) system, using QFT tubes and an in-house bovine interferon-gamma (IFN-γ) ELISA, was evaluated for the detection of M. bovis infection in buffaloes. Subsequently, Qiagen has developed a commercially available cattletype® IFN-gamma ELISA for the detection of antigen-specific IFN-γ release in ruminants...
February 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29695323/evaluation-of-mycobacteria-specific-gamma-interferon-and-antibody-responses-before-and-after-a-single-intradermal-skin-test-in-cattle-naturally-exposed-to-m-avium-subsp-paratuberculosis-and-experimentally-infected-with-m-bovis
#13
Virginie Roupie, Elena Alonso-Velasco, Sarah Van Der Heyden, Sébastien Holbert, Lucille Duytschaever, Patricia Berthon, Iris Van Dosselaer, Willem Van Campe, Laurent Mostin, Franck Biet, Stefan Roels, Kris Huygen, David Fretin
This study reports on the diagnostic potential of IFN-γ release assays and serology for Mycobacterium bovis in six naturally M. avium subsp. paratuberculosis (Map) exposed bulls of which four were intratracheally infected with a Belgian field strain of M. bovis. Heparinized blood, serum and fecal samples were collected at regular time intervals for mycobacteria-specific IFN-γ release assays, antibody analysis and for Map culture respectively. Single intradermal skin test (SIT) with bovine tuberculin (PPD-B) was performed on day 115 and animals were sacrificed on day 133 after M...
February 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29663956/paradox-of-serial-interferon-gamma-release-assays-variability-width-more-important-than-specificity-size
#14
J E Stout, R Belknap, Y-J Wu, C S Ho
SETTING: Serial screening for latent tuberculous infection (LTBI) is commonly performed in certain populations, such as health care workers. The high apparent conversion rate in some studies of interferon-gamma release assays is puzzling given the claimed high specificity of these tests. OBJECTIVE: To understand how test-retest variability, specificity, and underlying LTBI prevalence affect observed outcomes of repeated testing for LTBI. DESIGN: Mathematical model assuming constant test sensitivity and specificity over time and no new infections...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29663954/characteristics-of-a-large-latent-tuberculous-infection-screening-programme-using-quantiferon-%C3%A2-tb-gold-in-korea
#15
H-J Hwang, J-H Park, S Nam, H-J Lee, H-J Kim, S Yu, S-Y Shin
BACKGROUND: As mentioned in the 'Action Strategy for TB Safe Korea' in March 2017, almost 2 million Koreans were screened for latent tuberculous infection (LTBI) in 2017. As a preliminary step, the Korean Institute of Tuberculosis (KIT) screened 23 824 individuals from various population groups. The present study aimed to characterise the data collected from the screening programme using the QuantiFERON®-TB Gold In-Tube (QFT) assay. METHODS: Interferon-gamma release assays were performed using the manual QFT or automated DS2 instruments...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29660203/mycobacterium-tuberculosis-active-disease-and-latent-infection-in-a-renal-transplant-cohort
#16
Nastaran Rafiei, Jackie Williams, William R Mulley, James M Trauer, Grant A Jenkin, Benjamin A Rogers
BACKGROUND: Tuberculosis (TB) is a serious opportunistic infection in renal transplant recipients associated with high mortality. Screening and treatment of latent Mycobacterium tuberculosis infection (LTBI) offers an opportunity to prevent subsequent active disease. METHODS: We retrospectively reviewed the records of all adult patients who underwent renal transplantation at our centre from 2005 to 2014 to assess current screening practices, the risks for and burden of active TB...
April 16, 2018: Nephrology
https://www.readbyqxmd.com/read/29650047/care-cascade-for-targeted-tuberculosis-testing-and-linkage-to-care-in-homeless-populations-in-the-united-states-a-meta-analysis
#17
Andrea Parriott, Mohsen Malekinejad, Amanda P Miller, Suzanne M Marks, Hacsi Horvath, James G Kahn
BACKGROUND: Homelessness increases the risk of tuberculosis (TB) disease and latent TB infection (LTBI), but persons experiencing homelessness often lack access to testing and treatment. We assessed the yield of TB testing and linkage to care for programs targeting homeless populations in the United States. METHODS: We conducted a comprehensive search of peer-reviewed and grey literature, adapting Cochrane systematic review methods. Two reviewers independently assessed study eligibility and abstracted key data on the testing to care cascade: number of persons reached, recruited for testing, tested for LTBI, with valid test results, referred to follow-up care, and initiating care...
April 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29642834/-risk-of-travel-associated-tuberculosis
#18
Süheyla Sürücüoğlu
Tuberculosis has spread by human movements throughout history. There have been reports indicating tuberculosis transmission on all travel vehicles, including aircrafts, ground vehicles and vessels until today. However, due to the ever increasing of air transportation and air travelling among countries with low and high tuberculosis incidence, transmission risk especially in aircrafts has become an important issue worldwide. But in many of the studies conducted in this regard, transmission of tuberculosis in aircrafts was found very low...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29642833/-management-and-treatment-difficulties-of-multi-drug-resistant-pulmonary-tuberculosis-in-a-pediatric-case
#19
Selda Hançerli Törün, Emine Manolya Acar, Ayper Somer, Gonca Erköse, Dilek Şatana, Zuhal Bayramoğlu, Emine Çalışkan, Zeki Kılıçaslan
Tuberculosis continues to be a major health problem worldwide. Multidrug resistant tuberculosis (MDR-TB) infection that occurs in childhood is caused by adult MDR-TB agents which are in circulation and resistant to primary drugs. In this case report a 17-month-old child with MDR-TB who was cured after a 24-month therapy regimen was presented. Physical examination of a 17-month-old girl admitted to the hospital with the cause of recurrent pneumonia revealed a rubbery lymphadenopathy less than 2 cm in the right upper cervical region...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29620541/screening-of-latent-tuberculosis-infection-among-health-care-workers-working-in-hajj-pilgrimage-area-in-saudi-arabia-using-interferon-gamma-release-assay-and-tuberculin-skin-test
#20
Zakeya A Bukhary, Soliman M Amer, Magdy M Emara, Mohammad E Abdalla, Sahar A Ali
BACKGROUND: Interferon gamma release assays (IGRA) is highly specific for Mycobacterium tuberculosis and is the preferred test in BCG-vaccinated individuals. The few studies that have screened health care workers (HCWs) in Saudi Arabia for latent tuberculosis infection (LTBI) using IGRA have varied in agreement with the traditional tuberculin skin test (TST). OBJECTIVE: Assess the prevalence of LTBI among HCWs working in the Hajj pilgrimage using IGRA and TST and measuring their agreement...
March 2018: Annals of Saudi Medicine
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