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https://www.readbyqxmd.com/read/29451433/populations-of-phytophthora-rubi-show-little-differentiation-and-high-rates-of-migration-among-states-in-the-western-united-states
#1
Javier F Tabima, Michael D Coffey, Inga Zasada, Niklaus J Grünwald
Population genetics is a powerful tool to understand patterns and evolutionary processes that are involved in plant pathogen emergence and adaptation to agricultural ecosystems. We are interested in studying the population dynamics of Phytophthora rubi, the causal agent of Phytophthora root rot in raspberry. P. rubi is found in the western U.S., where the majority of the fresh and processed raspberries are produced. We used genotyping-by-sequencing to characterize genetic diversity in populations of P. rubi sampled in the U...
February 16, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29440177/ponatinib-shows-potent-antitumor-activity-in-small-cell-carcinoma-of-the-ovary-hypercalcemic-type-sccoht-through-multi-kinase-inhibition
#2
Jessica D Lang, William P D Hendricks, Krystal A Orlando, Hongwei Yin, Jeffrey Kiefer, Pilar Ramos, Ritin Sharma, Patrick Pirrotte, Elizabeth A Raupach, Chris Sereduk, Nanyun Tang, Winnie S Liang, Megan Washington, Salvatore J Facista, Victoria L Zismann, Emily M Cousins, Michael B Major, Yemin Wang, Anthony N Karnezis, Aleksandar Sekulic, Ralf Hass, Barbara C Vanderhyden, Praveen Nair, Bernard E Weissman, David G Huntsman, Jeffrey M Trent
PURPOSE: Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the SWI/SNF ATPase subunits SMARCA4 and SMARCA2. A great need exists for effective targeted therapies for SCCOHT. EXPERIMENTAL DESIGN: To identify underlying therapeutic vulnerabilities in SCCOHT, we conducted high-throughput siRNA and drug screens. Complementary proteomics approaches profiled kinases inhibited by ponatinib...
February 9, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29438954/dietary-intake-and-urinary-metals-among-pregnant-women-in-the-pacific-northwest
#3
Citlalli Osorio-Yáñez, Bizu Gelaye, Daniel A Enquobahrie, Chunfang Qiu, Michelle A Williams
Pregnancy is a period when the mother and her offspring are susceptible to the toxic effects of metals. We investigated associations of intake of frequently consumed foods with urinary metals concentrations among pregnant women in the Pacific Northwest. We measured urinary cadmium (U-Cd), arsenic (U-As) and molybdenum (U-Mo) concentrations from spot urine samples in early pregnancy (15 weeks of gestation, on average) among 558 women from Seattle and Tacoma, Washington. We assessed periconceptional dietary intake using a semi-quantitative food frequency questionnaire (FFQ)...
February 10, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29438537/irrigation-and-grass-cover-effects-on-pupal-survival-rates-in-soil-and-adult-emergence-patterns-of-rhagoletis-indifferens-diptera-tephritidae
#4
Wee L Yee, Peter S Chapman
Western cherry fruit fly, Rhagoletis indifferens (Curran; Diptera: Tephritidae), occurs in unmanaged cherries (Prunus spp.) across dry climates in Washington State and other regions in western United States and Canada. To help explain the fly's distribution in arid climates, we determined the effects of adding water to bare and grass-covered soils on pupal survival rates and adult emergence patterns of R. indifferens in central Washington. Water was added ('irrigated') or not to bare soil and grass-covered soil in cylinders pressed into the ground...
February 9, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29438334/changing-the-paradigm-in-public-health-and-disability-through-a-knowledge-translation-center
#5
Kerri A Vanderbom, Yochai Eisenberg, Allison H Tubbs, Teneasha Washington, Alex X Martínez, Amy Rauworth
People with disabilities are a health disparity population that face many barriers to health promotion opportunities in their communities. Inclusion in public health initiatives is a critical approach to address the health disparities that people with disabilities experience. The National Center on Health, Physical Activity and Disability (NCHPAD) is tackling health disparities in the areas of physical activity, healthy nutrition, and healthy weight management. Using the NCHPAD Knowledge Adaptation, Translation, and Scale-up Framework, NCHPAD is systematically facilitating, monitoring, and evaluating inclusive programmatic, policy, systems, and environmental (PPSE) changes in communities and organizations at a local and national level...
February 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29437965/ctcf-binding-sites-in-the-hsv-1-genome-display-site-specific-ctcf-occupation-protein-recruitment-and-insulator-function
#6
Shannan D Washington, Farhana Musarrat, Monica K Ertel, Gregory L Backes, Donna M Neumann
There are seven conserved CTCF binding domains in the HSV-1 genome. These binding sites individually flank the LAT and the IE gene regions, suggesting that CTCF insulators differentially control transcriptional domains in HSV-1 latency. In this work, we show that two CTCF binding motifs in HSV-1 display enhancer-blocking in a cell-type specific manner. We found that CTCF binding to the latent HSV-1 genome was LAT-dependent and the quantity of bound CTCF was site-specific. Following reactivation, CTCF eviction was dynamic suggesting each CTCF site was independently regulated...
February 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29436048/home-birth-integration-into-the-health-care-systems-of-eleven-international-jurisdictions
#7
Amanda Comeau, Eileen K Hutton, Julia Simioni, Ella Anvari, Megan Bowen, Samantha Kruegar, Elizabeth K Darling
BACKGROUND: The purpose of this study was to develop assessment criteria that could be used to examine the level of integration of home birth within larger health care systems in developed countries across 11 international jurisdictions. METHODS: An expert panel developed criteria and a definition to assess home birth integration within health care systems. We selected jurisdictions based on the publications that were eligible for inclusion in our systematic review and meta-analysis on planned place of birth...
February 13, 2018: Birth
https://www.readbyqxmd.com/read/29435862/disparities-in-the-treatment-of-substance-use-disorders-does-where-you-live-matter
#8
Andrea Acevedo, Lee Panas, Deborah Garnick, Dolores Acevedo-Garcia, Jennifer Miles, Grant Ritter, Kevin Campbell
This study focused on (1) whether disparities in timely receipt of substance use services can be explained in part by the characteristics of the community in which the clients reside and (2) whether the effect of community characteristics on timely receipt of services was similar across racial/ethnic groups. The sample was composed of adults receiving publicly funded outpatient treatment in Washington State. Treatment data were linked to data from the US census. The outcome studied was "Initiation and Engagement" in treatment (IET), a measure noting timely receipt of services at the beginning of treatment...
February 12, 2018: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/29435563/family-history-and-breast-cancer-risk-among-older-women-in-the-breast-cancer-surveillance-consortium-cohort
#9
Dejana Braithwaite, Diana L Miglioretti, Weiwei Zhu, Joshua Demb, Amy Trentham-Dietz, Brian Sprague, Jeffrey A Tice, Tracy Onega, Louise M Henderson, Diana S M Buist, Elad Ziv, Louise C Walter, Karla Kerlikowske
Importance: First-degree family history is a strong risk factor for breast cancer, but controversy exists about the magnitude of the association among older women. Objective: To determine whether first-degree family history is associated with increased risk of breast cancer among older women, and identify whether the association varies by breast density. Design, Setting, and Participants: Prospective cohort study between 1996 and 2012 from 7 Breast Cancer Surveillance Consortium (BCSC) registries located in New Hampshire, North Carolina, San Francisco Bay area, western Washington state, New Mexico, Colorado, and Vermont...
February 12, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29432790/neighborhood-built-environment-and-socioeconomic-status-in-relation-to-physical-activity-sedentary-behavior-and-weight-status-of-adolescents
#10
James F Sallis, Terry L Conway, Kelli L Cain, Jordan A Carlson, Lawrence D Frank, Jacqueline Kerr, Karen Glanz, James E Chapman, Brian E Saelens
INTRODUCTION: The study examined the association of neighborhood walkability to multiple activity-related outcomes and BMI among adolescents and evaluated socioeconomic status as an effect modifier. METHOD: Cross-sectional study, with adolescents recruited from neighborhoods that met criteria for a 2 × 2 matrix defined by high/low GIS-defined walkability and high/low median income. Adolescents aged 12-16 years (n = 928) were recruited from selected neighborhoods in Maryland and King County, Washington regions in 2009-2011...
February 9, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29432516/survey-estimates-of-changes-in-alcohol-use-patterns-following-the-2012-privatization-of-the-washington-liquor-monopoly
#11
William C Kerr, Edwina Williams, Yu Ye, Meenakshi Sabina Subbaraman, Thomas K Greenfield
Aims: The US state of Washington's 333 state-run liquor stores were privatized on 1 June 2012 and purchases began in ~1500 licensed stores of a variety of types. A regime of taxes and fees was implemented to replace the revenues generated by the state stores and, 1 year later, the beer tax was reduced by two thirds. This study evaluates the impact of these changes on total alcohol and spirits consumption in a retrospective pre-test design. Methods: The study sample consists of 2289 adults recruited in three cross-sectional surveys during 2014 and 2015...
February 8, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29429804/clinical-outcome-of-prostate-cancer-patients-with-germline-dna-repair-mutations-retrospective-analysis-from-an-international-study
#12
Joaquin Mateo, Heather H Cheng, Himisha Beltran, David Dolling, Wen Xu, Colin C Pritchard, Helen Mossop, Pasquale Rescigno, Raquel Perez-Lopez, Verena Sailer, Michael Kolinsky, Ada Balasopoulou, Claudia Bertan, David M Nanus, Scott T Tagawa, Heather Thorne, Bruce Montgomery, Suzanne Carreira, Shahneen Sandhu, Mark A Rubin, Peter S Nelson, Johann S de Bono
BACKGROUND: Germline DNA damage repair gene mutation (gDDRm) is found in >10% of metastatic prostate cancer (mPC). Their prognostic and predictive impact relating to standard therapies is unclear. OBJECTIVE: To determine whether gDDRm status impacts benefit from established therapies in mPC. DESIGN, SETTING, AND PARTICIPANTS: This is a retrospective, international, observational study. Medical records were reviewed for 390 mPC patients with known gDDRm status...
January 29, 2018: European Urology
https://www.readbyqxmd.com/read/29427695/food-insecurity-is-associated-with-high-risk-glycemic-control-and-higher-health-care-utilization-among-youth-and-young-adults-with-type-1-diabetes
#13
Jason A Mendoza, Wren Haaland, Ralph B D'Agostino, Lauren Martini, Catherine Pihoker, Edward A Frongillo, Elizabeth J Mayer-Davis, Lenna L Liu, Dana Dabelea, Jean M Lawrence, Angela D Liese
AIMS: Household food insecurity (FI), i.e., limited availability of nutritionally adequate foods, is associated with poor glycemic control among adults with type 2 diabetes. We evaluated the association of FI among youth and young adults (YYA) with type 1 diabetes to inform recent clinical recommendations from the American Diabetes Association for providers to screen all patients with diabetes for FI. METHODS: Using data from the Washington and South Carolina SEARCH for Diabetes in Youth Study sites, we conducted an observational, cross-sectional evaluation of associations between FI and glycemic control, hospitalizations, and emergency department (ED) visits among YYA with type 1 diabetes...
February 7, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29422983/3rd-american-traditional-chinese-medicine-association-congress-goes-to-washington
#14
EDITORIAL
Stephanie Pina
No abstract text is available yet for this article.
February 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29422165/evaluating-the-effectiveness-of-pre-operative-platelet-inhibition-testing-to-reduce-costs-and-pre-operative-length-of-stay
#15
Jennifer Bobbitt, Kathleen Petro, Michael Martin
This was a retrospective study to assess the effectiveness of Society of Thoracic Surgeons (STS) Guidelines in reducing resource utilization at Washington Adventist Hospital, Takoma Park, Maryland. Pre and post operative stay (days), platelets and other blood product use, along with hospital costs were compared in elective Cardiac Surgical patients receiving P2Y12 inhibitors in the year prior to and year following the implementation of the STS guidelines of preoperative monitoring of platelet inhibition with VerifyNow...
February 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29420716/racial-ethnic-disparities-in-the-lifetime-risk-of-chlamydia-trachomatis-diagnosis-and-adverse-reproductive-health-outcomes-among-women-in-king-county-washington
#16
Laura C Chambers, Christine M Khosropour, David A Katz, Julia C Dombrowski, Lisa E Manhart, Matthew R Golden
Background: Chlamydia trachomatis is the most common reportable infection in the US and can cause pelvic inflammatory disease (PID) and tubal factor infertility (TFI). Methods: We created lifetables to estimate the "lifetime" risk of chlamydia diagnosis among women age 15-34 in King County, Washington, US, 1992-2014. We estimated the lifetime risk of chlamydia-associated PID and TFI, incorporating published estimates of the risk of sequelae by chlamydia testing history...
February 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29414565/current-state-of-the-union-of-epilepsy-care-in-the-united-states-antiepileptic-drugs-an-introduction-to-the-connectors-project
#17
Joseph I Sirven, Patricia O Shafer, Linda Kalilani, Imane Wild, Jesse Fishman, Steve Owens
PURPOSE: How antiepileptic drugs (AEDs) are used in the United States (US) is one proxy public health indicator for the current state of epilepsy management. The use of phenytoin, other older AEDs, and newer AEDs may act as an indicator for the quality of epilepsy practice in addition to the current American Academy of Neurology quality measures. Data on AED used by states and populations can help identify which public health interventions are necessary to improve the status of epilepsy care...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414426/investigating-connectivity-in-the-urban-food-landscapes-of-migrant-women-facing-food-insecurity-in-washington-dc
#18
Colleen Hammelman
The survival strategies of migrant women living in urban poverty are embedded in urban food landscapes ('foodscapes') characterized by dynamic social relationships and mobility. Relying on interviews with 31 migrant women in Washington, DC, this paper traces the socio-spatial conditions of their urban foodscapes to show that urban environments inhabited by low-income migrants are dynamic, stretching across multiple neighborhoods as they move throughout the city with social networks to obtain affordable, quality, and culturally appropriate food...
January 31, 2018: Health & Place
https://www.readbyqxmd.com/read/29410142/a-randomized-multi-center-study-assessing-the-educational-impact-of-a-computerized-interactive-hysterectomy-trainer-on-gynecology-residents
#19
Allan S Lichtman, William Parker, Barbara Goff, Neeraj Mehra, Eliane M Shore, Guylaine Lefebvre, Alexander Chiang, John Lenihan, Henk W R Schreuder
STUDY OBJECTIVE: To assess improvement of cognitive surgical knowledge of laparoscopic hysterectomy in post-graduate year (PGY) 1 and 2 gynecology residents who used an interactive computer-based Laparoscopic Hysterectomy Trainer. DESIGN: Multicenter prospective, randomized, controlled study (Canadian Taskforce Classification I). SETTING: Five Departments of Obstetrics and Gynecology: Keck School of Medicine of USC; University of California-Los Angeles; University of Washington; University of British Columbia; University of Toronto...
February 1, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29409555/seattle-s-minimum-wage-ordinance-did-not-affect-supermarket-food-prices-by-food-processing-category
#20
Amanda L Spoden, James H Buszkiewicz, Adam Drewnowski, Mark C Long, Jennifer J Otten
OBJECTIVE: To examine the impacts of Seattle's minimum wage ordinance on food prices by food processing category. DESIGN: Supermarket food prices were collected for 106 items using a University of Washington Center for Public Health Nutrition market basket at affected and unaffected supermarket chain stores at three times: March 2015 (1-month pre-policy enactment), May 2015 (1-month post-policy enactment) and May 2016 (1-year post-policy enactment). Food items were categorized into four food processing groups, from minimally to ultra-processed...
February 7, 2018: Public Health Nutrition
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