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https://www.readbyqxmd.com/read/28633107/effects-of-chemical-and-physical-enhancement-techniques-on-transdermal-delivery-of-3-fluoroamphetamine-hydrochloride
#1
Ashana Puri, Kevin S Murnane, Bruce E Blough, Ajay K Banga
The present study investigated the passive transdermal delivery of 3-fluoroamphetamine hydrochloride (PAL-353) and evaluated the effects of chemical and physical enhancement techniques on its permeation through human skin. In vitro drug permeation studies through dermatomed human skin were performed using Franz diffusion cells. Passive permeation of PAL-353 from propylene glycol and phosphate buffered saline as vehicles was studied. Effect of oleic acid, maltose microneedles, ablative laser, and anodal iontophoresis on its transdermal permeation was investigated...
June 17, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28624872/abaloparatide-first-global-approval
#2
Matt Shirley
Abaloparatide (Tymlos™) is a synthetic peptide analogue of human parathyroid hormone-related protein that was developed by Radius Health as an osteoanabolic agent for the treatment of postmenopausal osteoporosis. Abaloparatide acts through selective activation of the parathyroid hormone type 1 receptor signalling pathway. In April 2017, subcutaneous abaloparatide received its first global approval, in the USA, for the treatment of postmenopausal women with osteoporosis at high risk for fracture, defined as a history of osteoporotic fracture, multiple risk factors for fracture, or patients who have failed or are intolerant to other available osteoporosis therapy...
June 17, 2017: Drugs
https://www.readbyqxmd.com/read/28620730/advances-towards-painless-vaccination-and-newer-modes-of-vaccine-delivery
#3
Neha Garg, Anju Aggarwal
Vaccines have been successful in reducing the mortality and morbidity, but most of them are delivered by intramuscular or intravenous route. They are associated with pain to the baby and bring lot of anxiety for the parents. There has been a marked increase in the number of injections required in first two years of life for completing the vaccination schedule. Hence, there is a need to have a painless vaccine delivery system. Numerous new routes of vaccination like, oral, nasal and transdermal routes are being tried...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28618841/assessment-of-solid-microneedle-rollers-to-enhance-transmembrane-delivery-of-doxycycline-and-inhibition-of-mmp-activity
#4
Abbie Omolu, Maryse Bailly, Richard M Day
Many chronic wounds exhibit high matrix metalloproteinase (MMP) activity that impedes the normal wound healing process. Intradermal delivery (IDD) of sub-antimicrobial concentrations of doxycycline, as an MMP inhibitor, could target early stages of chronic wound development and inhibit further wound progression. To deliver doxycycline intradermally, the skin barrier must be disrupted. Microneedle rollers offer a minimally invasive technique to penetrate the skin by creating multiple microchannels that act as temporary conduits for drugs to diffuse through...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28595555/microdialysis-assessed-adipose-tissue-metabolism-in-critically-ill-patients
#5
Ioannis Ilias, Nikitas Nikitas, Maria Theodorakopoulou, Ioanna Dimopoulou
BACKGROUND: Microdialysis is a minimally invasive technique that allows direct in situ and in vivo sampling, studies and manipulations of the interstitial/extracellular fluid/space. It has been shown to be of use mainly in acute brain injury/neurocritical care. METHODS: Microdialysis has been used to study obesity, diabetes mellitus, inflammation and pharmacokinetics at the adipose tissue level. In critically ill patients (and particularly in those with sepsis or septic shock), within days to weeks, adipose tissue shows profound alterations; under such conditions the implementation of microdialysis can provide researchers with interesting findings...
June 8, 2017: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
https://www.readbyqxmd.com/read/28594434/a-facile-method-and-novel-mechanism-using-microneedle-structured-pdms-for-triboelectric-generator-applications
#6
Van-Long Trinh, Chen-Kuei Chung
The triboelectric generator (TEG) is a cost-effective, multi-fabricated, friendly mechanical-energy-harvesting device. The traditional TEG, generally formed by two triboelectric materials in multilayers or a simple pattern, generated triboelectricity as it worked in the cycling contact-separation operation. This paper demonstrates a novel, high-aspect-ratio, microneedle (MN)-structured polydimethylsiloxane (PDMS)-based triboelectric generator (MN-TEG) by means of a low-cost, simple fabrication using CO2 laser ablation on the polymethyl methacrylate substrate and a molding process...
June 8, 2017: Small
https://www.readbyqxmd.com/read/28585801/microneedle-ph-sensor-direct-label-free-real-time-detection-of-cerebrospinal-fluid-and-bladder-ph
#7
Ganesh Kumar Mani, Kousei Miyakoda, Asuka Saito, Yutaka Yasoda, Kagemasa Kajiwara, Minoru Kimura, Kazuyoshi Tsuchiya
Acid-base homeostasis (body pH) inside the body is precisely controlled by the kidneys and lungs and buffer systems, such that even a minor pH change could severely affect many organs. Blood and urine pH tests are common in day-to-day clinical trials and require little effort for diagnosis. There is always a great demand for in vivo testing to understand more about body metabolism and to provide effective diagnosis and therapy. In this article, we report the simple fabrication of microneedle-based direct, label-free, and real-time pH sensors...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28574158/efficacy-and-safety-of-a-new-microneedle-patch-for-skin-brightening-a-randomized-split-face-single-blind-study
#8
Kui Young Park, Hyun Jung Kwon, Changjin Lee, Daegun Kim, Jun Jin Yoon, Myeong Nam Kim, Beom Joon Kim
BACKGROUND: Although microneedles are one of the best transdermal drug delivery systems for active compounds, few clinical trials have examined the safety and efficacy of brightening microneedle patches. AIMS: To determine the efficacy and safety of a newly developed whitening microneedle patch. PATIENTS/METHODS: A split-face study was designed for efficacy assessment with 34 Korean women applying the tested product (a whitening microneedle patch) on one cheek and a control whitening essence on the other...
June 2, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28561892/microneedle-assisted-dc-targeted-codelivery-of-ptrp-2-and-adjuvant-of-paclitaxel-for-transcutaneous-immunotherapy
#9
Jiaojiao Xu, Beihua Xu, Jin Tao, Yunxu Yang, Ying Hu, Yongzhuo Huang
This work aims at developing an immunotherapeutic strategy to deliver a cancer DNA vaccine targeting dendritic cells (DCs), to trigger their maturation and antitumor function, and reduce immune escape using a polymeric nanocomplex of paclitaxel (PTX)-encapsulated sulfobutylether-β-cyclodextrin (SBE)/mannosylated N,N,N-trimethylchitosan (mTMC)/DNA. To enhance DC-targeting and revoke immunosuppression is the major challenge for eliciting effective antitumor immunity. This codelivery system is characterized by using low-dose PTX as an adjuvant that is included inside SBE, and the PTX/SBE further serves as an anionic crosslinker to self-assemble with the cationic mTMC/DNA polyplexes...
May 31, 2017: Small
https://www.readbyqxmd.com/read/28552053/microneedle-patches-as-drugs-and-vaccine-delivery-platform
#10
Junwei Li, Mingtao Zeng, Hu Shan, Chunyi Tong
BACKGROUND: Transcutaneous delivery is the ideal method for delivering therapeutic reagents or vaccines into skin. With their promise of self-administration, cost-effective and high efficiency, microneedle patches have been studied intensively as therapeutic and vaccination delivery platform that replaces injection by syringe. This review aims to summarize the recent advancements of microneedle patches in application for drugs and vaccine delivery. METHODS: We review the most of recently published papers on microneedle patches, summarized their evolution, classification, state- of the-art capabilities and discuss promising application in drugs and vaccine delivery...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28549948/microneedles-in-the-clinic
#11
REVIEW
Shubhmita Bhatnagar, Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Especially, microneedles have been widely studied and developed for cosmetic and therapeutic applications...
May 23, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28544329/dissolving-microneedle-arrays-for-transdermal-delivery-of-amphiphilic-vaccines
#12
Myunggi An, Haipeng Liu
Amphiphilic vaccine based on lipid-polymer conjugates is a new type of vaccine capable of self-delivering to the immune system. When injected subcutaneously, amphiphilic vaccines efficiently target antigen presenting cells in the lymph nodes (LNs) via a unique albumin-mediated transport and uptake mechanism and induce potent humoral and cellular immune responses. However, whether this new type of vaccine can be administrated via a safe, convenient microneedle-based transdermal approach remains unstudied. For such skin barrier-disruption systems, a simple application of microneedle arrays (MNs) is desired to disrupt the stratum corneum, and for rapid and pain-free self-administration of vaccines into the skin, the anatomic place permeates with an intricate mesh of lymphatic vessels draining to LNs...
May 19, 2017: Small
https://www.readbyqxmd.com/read/28536970/mesoporous-silica-nanoparticle-coated-microneedle-arrays-for-intradermal-antigen-delivery
#13
Jing Tu, Guangsheng Du, M Reza Nejadnik, Juha Mönkäre, Koen van der Maaden, Paul H H Bomans, Nico A J M Sommerdijk, Bram Slütter, Wim Jiskoot, Joke A Bouwstra, Alexander Kros
PURPOSE: To develop a new intradermal antigen delivery system by coating microneedle arrays with lipid bilayer-coated, antigen-loaded mesoporous silica nanoparticles (LB-MSN-OVA). METHODS: Synthesis of MSNs with 10-nm pores was performed and the nanoparticles were loaded with the model antigen ovalbumin (OVA), and coated with a lipid bilayer (LB-MSN-OVA). The uptake of LB-MSN-OVA by bone marrow-derived dendritic cells (BDMCs) was studied by flow cytometry. The designed LB-MSN-OVA were coated onto pH-sensitive pyridine-modified microneedle arrays and the delivery of LB-MSN-OVA into ex vivo human skin was studied...
May 23, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#14
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530093/iron-oxide-nanoparticle-powered-micro-optical-coherence-tomography-for-in-situ-imaging-the-penetration-and-swelling-of-polymeric-microneedles-in-the-skin
#15
Razina Z Seeni, Xiaojun Yu, Hao Chang, Peng Chen, Linbo Liu, Chenjie Xu
In recent years, polymeric microneedles (MNs) have attracted keen interests among researchers because of their applicability in transdermal drug delivery and interstitial skin fluid (ISF) extraction. When designing and characterizing such devices, it is critical to monitor their real-time in vitro and in vivo performances to optimize the desired effects, yet most of the existing methods are incapable of such functions. To address this unmet need, we develop a real-time noninvasive imaging methodology by integrating iron oxide (Fe3O4) nanoparticles into polymeric MNs to enhance image contrast for micro-optical coherence tomography (μOCT) imaging...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28514466/how-microneedles-can-change-cutaneous-drug-delivery-small-needles-make-a-big-difference
#16
Hadar Lev-Tov
No abstract text is available yet for this article.
May 17, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28514458/effect-of-expedited-microneedle-assisted-photodynamic-therapy-for-field-treatment-of-actinic-keratoses-a-randomized-clinical-trial
#17
Tatyana A Petukhova, Lauren A Hassoun, Negar Foolad, Mayanka Barath, Raja K Sivamani
Importance: Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK. Objective: To evaluate efficacy and pain associated with microneedle expedited PDT. Design, Setting, and Participants: The Microneedle Photodynamic Therapy II (MNPDT-II) study was a randomized, single-blinded, split-face controlled, 2-arm clinical trial...
May 17, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28508376/in-vivo-and-qualitative-studies-investigating-the-translational-potential-of-microneedles-for-use-in-the-older-population
#18
Helen L Quinn, Carmel M Hughes, Ryan F Donnelly
Microneedles (MNs) are a novel transdermal drug delivery platform, rapidly progressing from a substantive evidence base, towards commercialisation. As part of this transition, it is important to consider the future use of MNs by older people in order to ensure optimal therapeutic outcomes for this unique and increasing population group. This paper, therefore, considers the use of MNs by those aged over 65 years, investigating insertion parameters in ageing skin, alongside the feasibility and acceptability of the technology...
May 15, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28504480/therapeutic-effect-of-microneedling-and-autologous-platelet-rich-plasma-in-the-treatment-of-atrophic-scars-a-randomized-study
#19
Zeinab A Ibrahim, Amal A El-Ashmawy, Ola A Shora
BACKGROUND: New treatments and techniques were being added over the last few years to treat atrophic scars with variable results and adverse effects. AIM OF THE WORK: The aim of this study was to evaluate and compare the therapeutic efficacy and safety of microneedling, autologous platelet-rich plasma, and combination of both procedures in the treatment of atrophic scars. PATIENTS AND METHODS: This study included 90 patients with atrophic scars and were classified randomly into three groups: I: 28 patients treated with microneedling, one session every 4 weeks; II: 34 patients treated with intradermal injection of platelet-rich plasma, one session every 2 weeks; and III: 28 patients treated with alternative sessions of each microneedling and platelet-rich plasma, 2 weeks between each session, for a maximum of six sessions...
May 14, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28494734/recent-advances-in-skin-penetration-enhancers-for-transdermal-gene-and-drug-delivery
#20
Morteza Amjadi, Babak Mostaghaci, Metin Sitti
There is a growing interest in transdermal delivery systems because of their noninvasive, targeted, and on-demand delivery of gene and drugs. However, efficient penetration of therapeutic compounds into the skin is still challenging largely due to the impermeability of the outermost layer of the skin, known as stratum corneum. Recently, there have been major research activities to enhance the skin penetration depth of pharmacological agents. This article reviews recent advances in the development of various strategies for skin penetration enhancement...
May 10, 2017: Current Gene Therapy
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