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https://www.readbyqxmd.com/read/29680082/no-197a-fetal-health-surveillance-antepartum-consensus-guideline
#1
Robert Liston, Diane Sawchuck, David Young
OBJECTIVE: This guideline provides new recommendations pertaining to the application and documentation of fetal surveillance in the antepartum period that will decrease the incidence of birth asphyxia while maintaining the lowest possible rate of obstetrical intervention. Pregnancies with and without risk factors for adverse perinatal outcomes are considered. This guideline presents an alternative classification system for antenatal fetal non-stress testing to what has been used previously...
April 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29673669/rupture-of-the-scarred-and-unscarred-gravid-uterus-outcomes-and-risk-factors-analysis
#2
Shu-Han You, Yao-Lung Chang, Chih-Feng Yen
OBJECTIVE: To study the maternal and fetal outcomes and assess the risk factors in patients with rupture at the lower-segment or non-lower-segment scarred, or unscarred gravid uterus. MATERIALS AND METHODS: Gravid patients with uterine rupture were retrospectively collected in Chang-Gung Memorial Hospital from November 2004 to July 2017. The rupture timing and location in association with maternal and fetal outcomes were collected as well as the possible risk factors including surgical history and interval prior to conception were analyzed...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29664053/labor-onset-oxytocin-use-and-epidural-anesthesia-for-vaginal-birth-after-cesarean-section-and-associated-effects-on-maternal-and-neonatal-outcomes-in-a-tertiary-hospital-in-china-a-retrospective-study
#3
Shao-Wen Wu, He Dian, Wei-Yuan Zhang
Background: In the mainland of China, the trial of labor after cesarean section is still a relatively new technique. In this study, we aimed to investigate the effects of labor onset, oxytocin use, and epidural anesthesia on maternal and neonatal outcomes for vaginal birth after cesarean section (VBAC) in a tertiary hospital in China. Methods: This was a retrospective study carried out on 212 VBAC cases between January 2015 and June 2017 in Beijing Obstetrics and Gynecology Hospital, Capital Medical University...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29658433/feasibility-of-transabdominal-electrohysterography-for-analysis-of-uterine-activity-in-nonpregnant-women
#4
Federica Sammali, Nienke Pertronella Maria Kuijsters, Benedictus Christiaan Schoot, Massimo Mischi, Chiara Rabotti
PURPOSE: Uterine activity plays a key role in reproduction, and altered patterns of uterine contractility have been associated with important physiopathological conditions, such as subfertility, dysmenorrhea, and endometriosis. However, there is currently no method to objectively quantify uterine contractility outside pregnancy without interfering with the spontaneous contraction pattern. Transabdominal electrohysterography has great potential as a clinical tool to characterize noninvasively uterine activity, but results of this technique in nonpregnant women are poorly documented...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29618799/s-nitrosoglutathione-reductase-underlies-the-dysfunctional-relaxation-to-nitric-oxide-in-preterm-labor
#5
Scott D Barnett, Christina R Smith, Craig C Ulrich, Josh E Baker, Iain L O Buxton
Tocolytics show limited efficacy to prevent preterm delivery. In uterine smooth muscle cGMP accumulation following addition of nitric oxide (NO) has little effect on relaxation suggesting a role for protein S-nitrosation. In human myometrial tissues from women in labor at term (TL), or spontaneously in labor preterm (sPTL), direct stimulation of soluble guanylyl cyclase (sGC) fails to relax myometrium, while the same treatment relaxes vascular smooth muscle completely. Unlike term myometrium, effects of NO are not only blunted in sPTL, but global protein S-nitrosation is also diminished, suggesting a dysfunctional response to NO-mediated protein S-nitrosation...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614445/exploring-full-cervical-dilatation-caesarean-sections-a-retrospective-cohort-study
#6
Edward M A Corry, Meenakshi Ramphul, Ann M Rowan, Ricardo Segurado, Rhona M Mahony, Declan P Keane
BACKGROUND: The rate of caesarean sections at full cervical dilatation with their high risk of morbidity continues to rise mirroring the overall increase in caesarean section rates internationally. OBJECTIVES: The objectives of this study were to determine the rate of full dilatation caesarean section in a tertiary referral unit and evaluate key labour, maternal and fetal factors potentially linked to those deliveries. We also assessed maternal and fetal morbidity at full dilatation sections...
March 20, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29604081/the-peripheral-chemoreflex-indefatigable-guardian-of-fetal-physiological-adaptation-to-labour
#7
Christopher A Lear, Guido Wassink, Jenny A Westgate, Jan G Nijhuis, Austin Ugwumadu, Robert Galinsky, Laura Bennet, Alistair J Gunn
The fetus is consistently exposed to repeated periods of impaired oxygen (hypoxaemia) and nutrient supply in labour. This is balanced by the healthy fetus's remarkable anaerobic tolerance, and impressive ability to mount protective adaptations to hypoxaemia. The most important mediator of fetal adaptations to brief repeated hypoxaemia is the peripheral chemoreflex, a rapid reflex response to acute falls in arterial oxygen tension. The overwhelming majority of fetuses are able to respond to repeated uterine contractions without developing hypotension or hypoxic-ischaemic injury...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29599898/the-effects-of-ibogaine-on-uterine-smooth-muscle-contractions-relation-to-the-activity-of-antioxidant-enzymes
#8
Zorana Oreščanin-Dušić, Nikola Tatalović, Teodora Vidonja-Uzelac, Jelena Nestorov, Aleksandra Nikolić-Kokić, Ana Mijušković, Mihajlo Spasić, Roman Paškulin, Mara Bresjanac, Duško Blagojević
Ibogaine is an indole alkaloid originally extracted from the root bark of the African rainforest shrub Tabernanthe iboga . It has been explored as a treatment for substance abuse because it interrupts drug addiction and relieves withdrawal symptoms. However, it has been shown that ibogaine treatment leads to a sharp and transient fall in cellular ATP level followed by an increase of cellular respiration and ROS production. Since contractile tissues are sensitive to changes in the levels of ATP and ROS, here we investigated an ibogaine-mediated link between altered redox homeostasis and uterine contractile activity...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29593128/selective-inhibition-of-smooth-muscle-plasma-membrane-transport-%C3%B0-%C3%B0-2-mg2-%C3%B0-%C3%B0-%C3%B0-ase-by-calixarene-c-90-and-its-activation-by-ipt-35-compound
#9
Iuliia I Mazur, Tetyana O Veklich, Oleksandr A Shkrabak, Nikolai A Mohart, Anatoly M Demchenko, Inna V Gerashchenko, Roman V Rodik, Vitaly I Kalchenko, Sergiy O Kosterin
We investigated the influence of calixarene C-90 and IPT-35 on plasma membrane Ca2+- pumping АТРase (PMCA), intracellular calcium homeostasis and myometrium smooth muscle strain contractions. It has been shown that both effectors (100 μM) affect PMCA enzymatic activity: calixarene C-90 inhibits it by 75% and IPT-35 activates it by 40%. These compounds don't affect the Mg2+-АТРase, Mg2+-independent Са2+-АТРase and Na+,K+-АТРase enzymatic activities. C-90 inhibition coefficient I0.5 magnitude was approximately 20 μM and the Hill coefficient nH was 0...
March 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29588826/relationship-between-behavioral-indices-of-pain-during-labor-pain-with-pain-intensity-and-duration-of-delivery
#10
Bibi Marziyeh Hashemi Asl, Atiyeh Vatanchi, Nahid Golmakani, Alireza Najafi
Background: Certain behaviors can be adopted by women to cope with labor pain according to their individual characteristics, which are currently called behavioral indicators during labor pain, and include facial expressions, verbal expressions, tone of voice, body movements, degree of relaxation, and respiratory system functioning during delivery. Moreover, severity of pain and duration of labor can vary due to several factors including individual characteristics. Objective: The purpose of the present study was to determine the relationship between behavioral indicators during labor pain, severity of pain, and delivery duration...
January 2018: Electronic Physician
https://www.readbyqxmd.com/read/29577872/adaptive-reduction-of-human-myometrium-contractile-activity-in-response-to-prolonged-uterine-stretch-during-term-and-twin-pregnancy-role-of-trek-1-channel
#11
Zongzhi Yin, Wenzhu He, Yun Li, Dan Li, Hongyan Li, Yuanyuan Yang, Zhaolian Wei, Bing Shen, Xi Wang, Yunxia Cao, Raouf A Khalil
Quiescence of myometrium contractile activity allows uterine expansion to accommodate the growing fetus and prevents preterm labor particularly during excessive uterine stretch in multiple pregnancy. However, the mechanisms regulating uterine response to stretch are unclear. We tested the hypothesis that prolonged uterine stretch is associated with decreased myometrium contractile activity via activation of TWIK-related K+ channel (TREK-1). Pregnant women at different gestational age (preterm and term) and uterine stretch (singleton and twin pregnancy) were studied, and uterine strips were isolated for measurement of contractile activity and TREK-1 channel expression/activity...
March 22, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29557685/magnesium-sulfate-and-calcium-channel-blocking-drugs-as-antidotes-for-acute-organophosphorus-insecticide-poisoning-a-systematic-review-and-meta-analysis
#12
Miran Brvar, Ming Yin Chan, Andrew H Dawson, Richard R Ribchester, Michael Eddleston
INTRODUCTION: Treatment of acute organophosphorus or carbamate insecticide self-poisoning is often ineffective, with tens of thousands of deaths occurring every year. Researchers have recommended the addition of magnesium sulfate or calcium channel blocking drugs to standard care to reduce acetylcholine release at cholinergic synapses. OBJECTIVE: We aimed to review systematically the evidence from preclinical studies in animals exposed to organophosphorus or carbamate insecticides concerning the efficacy of magnesium sulfate and calcium channel blocking drugs as therapy compared with placebo in reducing mortality or clinical features of poisoning...
March 20, 2018: Clinical Toxicology
https://www.readbyqxmd.com/read/29537114/blood-calcium-glucose-and-haematology-profiles-of-parturient-bitches-diagnosed-with-uterine-inertia-or-obstructive-dystocia
#13
B L Frehner, I M Reichler, S Keller, S Goericke-Pesch, O Balogh
Bitches with dystocia most often present with clinical signs of uterine inertia (UI). The aetiology of myometrial dysfunction in most of these cases is still not elucidated. We compared blood ionized calcium (iCa) and glucose concentrations in bitches diagnosed with primary UI (PUI, n = 14), secondary UI (SUI, n = 6) or obstructive dystocia (OD, n = 6), and we described their haematology profiles. Bitches diagnosed with UI had a patent birth canal and delivered no puppies yet (PUI) or only part of the whole litter (SUI)...
March 14, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29536649/hyperbaric-oxygenation-and-glucose-amino-acids-substitution-in-human-severe-placental-insufficiency
#14
Michael Tchirikov, Erich Saling, Gauri Bapayeva, Michael Bucher, Oliver Thews, Gregor Seliger
In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O2 ) with 1.4 atmospheres absolute for 50 min for 7 days. At 31+4  weeks' gestation, the patient gave birth spontaneously to a newborn weighing 1378 g, pH 7.33, APGAR score 4/6/intubation. In follow-up examinations at 5 years of age, the boy was doing well without any neurological disturbance or developmental delay...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29524518/changes-in-expression-of-p2x7-receptors-in-rat-myometrium-at-different-gestational-stages-and-the-mechanism-of-atp-induced-uterine-contraction
#15
Mohammed Alotaibi
AIMS: Given the importance of ATP in the control of uterine activity for successful labor and involution, this study was performed to measure the level of P2X7 receptors (P2X7Rs) in rat myometrium at different gestational stages and to investigate the mechanisms of ATP-induced uterine contraction. MATERIALS AND METHODS: Myometrial tissues were obtained from rats at different gestational stages and the level of P2X7Rs was measured by ELISA. In other experiments, the effect of 1 mM ATP was applied on spontaneous contraction and the underlying mechanisms were investigated...
March 7, 2018: Life Sciences
https://www.readbyqxmd.com/read/29508063/labor-estimation-by-informational-objective-assessment-leioa-for-preterm-delivery-prediction
#16
Iker Malaina, Larraitz Aranburu, Luis Martínez, Luis Fernández-Llebrez, Carlos Bringas, Ildefonso M De la Fuente, Martín Blás Pérez, Leire González, Itziar Arana, Roberto Matorras
PURPOSE: To introduce LEIOA, a new screening method to forecast which patients admitted to the hospital because of suspected threatened premature delivery will give birth in < 7 days, so that it can be used to assist in the prognosis and treatment jointly with other clinical tools. METHODS: From 2010 to 2013, 286 tocographies from women with gestational ages comprehended between 24 and 37 weeks were collected and studied. Then, we developed a new predictive model based on uterine contractions which combine the Generalized Hurst Exponent and the Approximate Entropy by logistic regression (LEIOA model)...
March 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29500186/monitoring-uterine-contractility-in-mice-with-a-transcervical-intrauterine-pressure-catheter
#17
Michael F Robuck, Christine M O'Brien, Kelsi M Knapp, Sheila Shay, James D West, J M Newton, James C Slaughter, Bibhash Paria, Jeff Reese, Jennifer L Herington
In mouse models used to study parturition or pre-clinical therapeutic testing, measurement of uterine contractions is limited to either ex vivo isometric tension or operative IUP. The goal of this study was to: 1) develop a method for transcervical insertion of a pressure catheter to measure in vivo intrauterine contractile pressure during mouse pregnancy, 2) determine whether this method can be utilized numerous times in a single mouse pregnancy without affecting the timing of delivery or fetal outcome, and 3) compare the in vivo contractile activity between mouse models of term and preterm labor (PTL)...
March 2, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29489066/confirmation-of-the-cardiac-safety-of-pgf-2%C3%AE-receptor-antagonist-obe022-in-a-first-in-human-study-in-healthy-subjects-using-intensive-ecg-assessments
#18
Jörg Täubel, Ulrike Lorch, Simon Coates, Sara Fernandes, Paul Foley, Georg Ferber, Jean-Pierre Gotteland, Oliver Pohl
OBE022, a new orally active prostaglandin F2α  receptor antagonist (OBE022) with myometrial selectivity is being developed to reduce uterine contractions during preterm labor. This first-in-human study evaluated the effect of OBE022 following multiple doses on the QT interval in 23 healthy postmenopausal women, using the effect of a meal on QTc to demonstrate assay sensitivity. We report the cardiac safety outcome performed during the multiple ascending part of this trial. OBE022 was administered after a standardized breakfast on day 1 and in the fasted state from day 3 to day 9 wth a standardized lunch 4 hours after administration...
February 28, 2018: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/29485241/effects-of-fetal-hypothyroidism-on-uterine-smooth-muscle-contraction-and-structure-of-offspring-rats
#19
Fatemeh Bagheripuor, Mahboubeh Ghanbari, Abass Piryaei, Asghar Ghasemi
NEW FINDINGS: What is the central question of this study? Does fetal hypothyroidism in rats alter uterine contractions and structure in the adult offspring? What is the main finding and its importance? Our study indicated that maternal hypothyroidism during pregnancy increased gestational length and decreased litter size as well as delayed puberty onset; in addition, maternal hypothyroidism caused irregular uterine contractions and histological changes in the uterus in the female offspring...
February 27, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29482570/factors-contributing-to-the-decision-to-perform-a-cesarean-section-in-labrador-retrievers
#20
Gaudenz Dolf, Claude Gaillard, Jane Russenberger, Lou Moseley, Claude Schelling
BACKGROUND: In the past 10 years, the frequency of unplanned cesarean sections in the Labrador Retriever breeding colony at Guiding Eyes for the Blind stayed around 10% (range 5% to 28%). To reduce the number of cesarean sections, factors influencing the occurrence of a cesarean section need to be known. The goal of this study was to identify factors that contribute to the decision to perform a cesarean section. RESULTS: Of the 688 Labrador Retriever litters whelped between 2003 and 2016, 667 litters had sufficient data and remained in the analysis...
February 27, 2018: BMC Veterinary Research
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