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Uterine contraction

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https://www.readbyqxmd.com/read/29453654/uterine-electrical-activity-oxytocin-and-labor-translating-electrical-into-mechanical
#1
Anat Lavie, S Shinar, L Hiersch, E Ashwal, Y Yogev, A Aviram
PURPOSE: Uterine activity plays a crucial role in labor, especially when utero-tonic materials are administered. We aimed to determine the electrical responsiveness of the uterine musculature to labor augmentation with oxytocin using electrical uterine myography (EUM) technology, and to assess whether the kinetics of the EUM device may serve as a predictor for successful vaginal delivery. METHODS: EUM prospectively measured electrical uterine activity in women with singleton gestations at term (≥ 37 + 0 weeks) undergoing labor augmentation by oxytocin administration...
February 16, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29443077/contractility-measurements-of-human-uterine-smooth-muscle-to-aid-drug-development
#2
Sarah Arrowsmith, Peter Keov, Markus Muttenthaler, Christian W Gruber
Discovery and characterization of novel pharmaceutical compounds or biochemical probes rely on robust and physiologically relevant assay systems. We describe methods to measure ex vivo myometrium contractility. This assay can be used to investigate factors and molecules involved in the modulation of myometrial contraction and to determine their excitatory or inhibitory actions, and hence their therapeutic potential in vivo. Biopsies are obtained from women undergoing cesarean section delivery with informed consent...
January 26, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29430972/the-behaviour-of-pelvic-floor-muscles-during-uterine-contractions-in-spontaneous-and-oxytocin-induced-labour
#3
Nazan Karahan, Hediye Arslan, Çetin Çam
Term pregnant women were divided into oxytocin infusion and control groups. The electrical activities of pelvic floor muscles (PFM) were recorded at rest and during contractions electromyographically. The beginning and the end of each contraction were marked on the recorded electromyographic trace. A trace was regarded as 'negative' if no increase in electrical activity was observed and 'positive' if increased electrical activity was observed during the contractions. To evaluate the relative frequency of the areas of electrical activity during uterine contractions (UC) a 'positive electrical activity percentage' was used and calculated as: (total count of positive electrical activity areas)/(total count of UC) × 100...
February 12, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29428065/ectg-an-automatic-procedure-to-extract-digital-cardiotocographic-signals-from-digital-images
#4
Agnese Sbrollini, Angela Agostinelli, Ilaria Marcantoni, Micaela Morettini, Luca Burattini, Francesco Di Nardo, Sandro Fioretti, Laura Burattini
BACKGROUND AND OBJECTIVE: Cardiotocography (CTG), consisting in the simultaneous recording of fetal heart rate (FHR) and maternal uterine contractions (UC), is a popular clinical test to assess fetal health status. Typically, CTG machines provide paper reports that are visually interpreted by clinicians. Consequently, visual CTG interpretation depends on clinician's experience and has a poor reproducibility. The lack of databases containing digital CTG signals has limited number and importance of retrospective studies finalized to set up procedures for automatic CTG analysis that could contrast visual CTG interpretation subjectivity...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29425943/chlorinated-insecticides-toxaphene-and-endrin-affect-oxytocin-testosterone-oestradiol-and-prostaglandin-secretion-from-ovarian-and-uterine-cells-as-well-as-myometrial-contractions-in-cow-in%C3%A2-vitro
#5
Michael Hubert Wrobel, Jaroslaw Mlynarczuk
We examined the direct effects of toxaphene and endrin, chlorinated insecticides that are widespread in the environment, on myometrial contractions and on the secretion of hormones involved in regulating these contractions. Granulosa, luteal, endometrial and myometrial cells, and myometrial strips from non-pregnant cows were incubated with both insecticides at environmentally relevant doses. Toxaphene inhibited and endrin stimulated the secretion of testosterone and oestradiol from granulosa cells. Toxaphene also inhibited and endrin stimulated the expression of the mRNA encoding the precursor of oxytocin (OT), as well OT secretion in luteal cell cultures...
February 3, 2018: Chemosphere
https://www.readbyqxmd.com/read/29416642/progesterone-inhibits-contraction-and-increases-trek-1-potassium-channel-expression-in-late-pregnant-rat-uterus
#6
Zongzhi Yin, Yun Li, Wenzhu He, Dan Li, Hongyan Li, Yuanyuan Yang, Bing Shen, Xi Wang, Yunxia Cao, Raouf A Khalil
Objective: The aim of this study was to investigate the effect and mechanism by which progesterone regulates uterine contraction in late pregnant rats. Results: Progesterone caused concentration-dependent relaxation of uterine strips that was enhanced compared with control nontreated uterine strips. Uterine strips incubated with progesterone showed a significant increase in TREK-1 mRNA expression and protein level. TREK-1 inhibitor L-methionine partly reversed uterine relaxation caused by the progesterone, while TREK-1 activator arachidonic acid did not cause significant change in progesterone-induced relaxation...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29406317/electrohysterography-in-the-diagnosis-of-preterm-birth-a-review
#7
Javier Garcia-Casado, Yiyao Ye-Lin, Gema Prats-Boluda, Javier Mas-Cabo, José Alberola-Rubio, Alfredo Perales
Preterm birth (PTB) is one of the most common and serious complications in pregnancy. About 15 million preterm neonates are born every year, with ratios of 10-15% of total births. In industrialized countries, preterm delivery is responsible for 70% of mortality and 75% of morbidity in the neonatal period. Diagnostic means for its timely risk assessment are lacking and the underlying physiological mechanisms are unclear. Surface recording of the uterine myoelectrical activity (electrohysterogram, EHG) has emerged as a better uterine dynamics monitoring technique than traditional surface pressure recordings and provides information on the condition of uterine muscle in different obstetrical scenarios with the emphasis on predicting preterm deliveries...
February 6, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29404531/triage-by-cervical-length-sonographic-measurements-for-targeted-therapy-in-threatened-preterm-labor-a-double-blind-randomized-clinical-trial
#8
Homeira Vafaei, Neda Rahimirad, Seyedeh Marjan Hosseini, Maryam Kasraeian, Nasrin Asadi, Hadi Raeisi Shahraki, Khadijeh Bazrafshan
Background: Preterm labor and birth are associated with several neonatal complications including respiratory distress syndrome and intraventricular hemorrhage. Differentiating true and false labor pain is a dilemma to obstetricians. Objective: To elucidate the role of cervical length measurement in prediction of birth in pregnant women with threatened preterm labor. Materials and Methods: In this double blind randomized clinical trial, 120 women with gestational age <34 wk who presented painful uterine contractions randomly assigned to undergo measurement of cervical length...
November 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29402603/monosodium-glutamate-impairs-the-contraction-of-uterine-visceral-smooth-muscle-ex-vivo-of-rat-through-augmentation-of-acetylcholine-and-nitric-oxide-signaling-pathways
#9
Mukti Mondal, Kaushik Sarkar, Partha Pratim Nath, Ashma Khatun, Sanghamitra Pal, Goutam Paul
The aim of the study was to examine the toxic effects of Monosodium glutamate (MSG), an extensively used food additive, on the contraction of uterine visceral smooth muscle (UVSM) in rat and to elucidate the probable neurocrine mechanism involved in it. MSG produced significant potentiation of the force and inhibition of frequency of uterus recorded ex vivo in chronic MSG exposure and in single dose acute experiments. MSG also produced significant potentiation of force of acetylcholine induced contraction and no alterations in atropine induced contraction of uterus...
February 2, 2018: Reproductive Biology
https://www.readbyqxmd.com/read/29401080/the-effect-of-intermittent-oxytocin-pretreatment-on-oxytocin-induced-contractility-of-human-myometrium-in-vitro
#10
Chiraag Talati, Jose C A Carvalho, Alice Luca, Mrinalini Balki
BACKGROUND: Prolonged continuous oxytocin administration during labor may induce oxytocin receptor desensitization, which attenuates the response of the myometrium to further oxytocin, increasing the risk of postpartum hemorrhage. The literature comparing pulsatile (intermittent) versus continuous oxytocin administration for induction and augmentation of labor is inconsistent with regard to maternal outcomes. We aimed to determine the effect of intermittent versus continuous oxytocin preexposure on myometrial responsiveness to subsequent oxytocin...
February 2, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29390463/a-double-blinded-randomized-placebo-controlled-trial-assessing-the-effects-of-nifedipine-on-embryo-transfer-study-protocol
#11
RANDOMIZED CONTROLLED TRIAL
Kelvin Kl Ng, Genia Rozen, Tanya Stewart, Franca Agresta, Alex Polyakov
INTRODUCTION: Implantation failure is the main factor affecting the success rate of in vitro fertilization (IVF) procedures. Studies have reported that uterine contractions (UCs) at the time of embryo transfer (ET) were inversely related to implantation and pregnancy rate, hence reducing the success of IVF treatment. Various pharmacological agents, with the exception of calcium channel blocker (CCB), have been investigated to reduce UC. In this regard, we are presenting a proposal for a double-blind randomized placebo-controlled trial...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383894/-effects-of-transcutaneous-electrical-acupoint-stimulation-for-depression-in-late-pregnancy-and-impacts-on-inflammatory-cytokines
#12
Wei-Ye Chen, Li Li, Hui-Yuan Wang, Nan Jiang
OBJECTIVE: To assess the safety and efficacy of transcutaneous electrical acupoint stimulation (TEAS) for depression in late pregnancy and impacts on inflammatory cytokines. METHODS: A total of 150 pregnant women with depression in late pregnancy were randomized into a high intensity group (n=52), a low intensity group (n=49) and a control group (n=49). TEAS was applied at bilateral Neiguan (PC 6) and Shenmen (HT 7) for 6 weeks. The intensities of TEAS in the high intensity group, the low intensity group and the control group were 10, 5 and 0 mA, respectively...
January 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29372145/effects-of-corticotropin-releasing-hormone-on-the-expression-of-adenosine-triphosphate-sensitive-potassium-channels-kir6-1-sur2b-in-human-term-pregnant-myometrium
#13
Joo Young Kim, Wen Hao Wu, Jin Hyun Jun, Jeenah Sohn, Yong Soo Seo
Objective: Corticotropin-releasing hormone (CRH) is a crucial regulator of human pregnancy and parturition. Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels are important for regulating myometrial quiescence during pregnancy. We investigated regulatory effects of different concentrations of CRH on KATP channel expression in human myometrial smooth muscle cells (HSMCs) in in vitro conditions. Methods: After treating HSMCs with different concentrations of CRH (1, 10, 102, 103, 104 pmol/L), mRNA and protein expression of KATP channel subunits (Kir6...
January 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29356563/oxytocin-receptor-antagonist-atosiban-in-the-threat-of-preterm-birth-does-it-have-any-effect-on-breastfeeding-in-the-term-newborn
#14
Lucía López Gómez, Miguel A Marín Gabriel, Begoña Encinas, Juan J de la Cruz Troca, Belén Rodríguez Marrodán
AIM: Oxytocin is a hormone involved in the mechanism of breastfeeding, uterine contractions, and social relationships. Atosiban (competitive oxytocin antagonist) is one of the most commonly used tocolytics for the threat of preterm labor in Europe. The aim of this study is to determinate if the administration of atosiban has any influence in the type of feeding in the term newborn at discharge. The secondary objective is to verify its effectiveness for the prevention of preterm delivery and in the possibility of applying treatment to complete lung maturation...
January 22, 2018: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
https://www.readbyqxmd.com/read/29350194/detection-rate-of-fetal-distress-using-contraction-dependent-fetal-heart-rate-variability-analysis
#15
Guy J J Warmerdam, Rik Vullings, Judith O E H Van Laar, M Beatrijs Van der Hout-Van der Jagt, Jan W M Bergmans, Lars Schmitt, S Guid Oei
Monitoring of the fetal condition during labor is currently performed by cardiotocography (CTG). Despite the use of CTG in clinical practice, CTG interpretation suffers from a high inter- and intra-observer variability and a low specificity. In addition to CTG, analysis of fetal heart rate variability (HRV) has been shown to provide information on fetal distress. However, fetal HRV can be strongly influenced by uterine contractions, particularly during the second stage of labor. Therefore, the aim of this study is to examine if distinguishing contractions from rest periods can improve the detection rate of HRV features for fetal distress during the second stage of labor...
January 19, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29335190/phytochemistry-and-pharmacology-of-the-genus-leonurus-the-herb-to-benefit-the-mothers-and-more
#16
REVIEW
Rui-Han Zhang, Zhi-Ke Liu, Da-Song Yang, Xing-Jie Zhang, Han-Dong Sun, Wei-Lie Xiao
Plants belonging to the genus Leonurus, also named motherwort, are traditionally used for anti-gynecological disorder in East Asia, and for sedative in Europe. Chemical investigation of the genus Leonurus not only enriched the natural products library, but also enlarged the pharmacological application of this traditional herb. In this review, we systematically summarized the structures of 259 compounds isolated from the genus Leonurus, featured with 147 labdane diterpenoids. The reported bioactivity studies up to 2017 are presented in the second part, with the main focus on the isolated compounds and also concerning the extracts...
January 12, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29331998/torsion-and-rupture-of-a-non-communicating-rudimentary-horn-in-a-17-week-gestation-in-a-16-year-old-girl-lessons-learnt
#17
Namrata Kumar, Vinita Das, Amita Pandey, Smriti Agrawal
A unicornuate uterus with non-communicating rudimentary horn has always been notorious and poses threat to continuation of pregnancy with dismal consequences. We are reporting an interesting case of uterine malformation with a 90° rotation of uterine axis which ultimately ruptured during termination of pregnancy. The rarity in our case was not only conception in non-communicating horn but also the complete twisting of axis which made the pregnant horn come in front of the non-gravid unicornuate uterus, mimicking normal pregnancy...
January 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29330113/runt-related-transcription-factor-1-runx1-deficiency-attenuates-inflammation-induced-pro-inflammatory-and-pro-labour-mediators-in-myometrium
#18
Martha Lappas
Identifying new targets that regulate myometrial activation are required to develop effective treatments to stop preterm labor. Inflammation, which can be induced by sterile or infective insults, plays a role in initiating and maintaining uterine contractions. Several high throughput transcription screening studies have identified an upregulation of runt-related transcription factor 1 (RUNX1) mRNA expression in myometrium with labor. The role of RUNX1 in labor, however, is not known. We report increased RUNX1 during late gestation which was further augmented in labor, suggesting that RUNX1 may be involved in the transition of the myometrium from a quiescent into a contractile state in preparation for labor...
January 9, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29329366/delineating-differential-regulatory-signatures-of-the-human-transcriptome-in-the-choriodecidua-and-myometrium-at-term-labor
#19
Sylvia Lui, Cyntia Duval, Farkhondeh Farrokhnia, Sylvie Girard, Lynda K Harris, Clare L Tower, Adam Stevens, Rebecca L Jones
Background: Preterm deliveries remain the leading cause of neonatal morbidity and mortality. Current therapies target only myometrial contractions and are largely ineffective. As labor involves multiple coordinated events across maternal and fetal tissues, identifying fundamental regulatory pathways of normal term labor is vital to understanding successful parturition and consequently labor pathologies. We aimed to identify transcriptomic signatures of human normal term labor of two tissues: in the fetal-facing choriodecidua and the maternal myometrium...
January 10, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29324609/outcomes-of-planned-compared-with-urgent-deliveries-using-a-multidisciplinary-team-approach-for-morbidly-adherent-placenta
#20
Alireza A Shamshirsaz, Karin A Fox, Hadi Erfani, Steven L Clark, Amir A Shamshirsaz, Ahmed A Nassr, Nathan C Sundgren, Jeffery A Jones, Matthew L Anderson, Elias Kassir, Bahram Salmanian, Alexandra W Buffie, Shiu-Ki Hui, Jimmy Espinoza, Lynda A Tyer-Viola, Martha Rac, Niloofar Karbasian, Jerasimos Ballas, Gary A Dildy, Michael A Belfort
OBJECTIVE: To compare outcomes between planned and urgent cesarean hysterectomy for morbidly adherent placenta managed by a multidisciplinary team. METHODS: This is a retrospective case-control study of women with singleton pregnancies with antenatally suspected and pathologically confirmed morbidly adherent placenta who underwent cesarean hysterectomy between January 1, 2011, and February 30, 2017. Timing of delivery was classified as either planned (delivery at 34-35 weeks of gestation) or urgent (need for urgent delivery as a result of uterine contractions, bleeding, or both)...
February 2018: Obstetrics and Gynecology
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