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https://www.readbyqxmd.com/read/28185672/cariprazine-versus-risperidone-monotherapy-for-treatment-of-predominant-negative-symptoms-in-patients-with-schizophrenia-a-randomised-double-blind-controlled-trial
#1
György Németh, István Laszlovszky, Pál Czobor, Erzsébet Szalai, Balázs Szatmári, Judit Harsányi, Ágota Barabássy, Marc Debelle, Suresh Durgam, István Bitter, Stephen Marder, W Wolfgang Fleischhacker
BACKGROUND: Although predominant negative symptoms of schizophrenia can be severe enough to cause persistent impairment, effective treatment options are lacking. We aimed to assess the new generation antipsychotic cariprazine in adult patients with predominant negative symptoms. METHODS: In this randomised, double-blind, phase 3b trial, we enrolled adults aged 18-65 years with long-term (>2 year), stable schizophrenia and predominant negative symptoms (>6 months) at 66 study centres (mainly hospitals and university clinics, with a small number of private practices) in 11 European countries...
February 7, 2017: Lancet
https://www.readbyqxmd.com/read/28146324/psychiatric-comorbidity-in-new-daily-persistent-headache-a-cross-sectional-study
#2
R Uniyal, V K Paliwal, A Tripathi
BACKGROUND: New daily persistent headache (NDPH) is a type of chronic daily headache. NDPH can have migrainous (NDPH-CM) or tension-type character (NDPH-CTTH). Recently, NDPH patients have shown to have associated anxiety and depression. We compared anxiety, depressive symptoms, somatization and pain catastrophization among NDPH, healthy controls and patients with chronic low-back pain and between NDPH-CM and NDPH-CTTH. METHODS: We assessed the study population for depressive symptoms by Patient Health Questionnaire-9, anxiety by Generalized Anxiety Disorder Scale - 7, somatoform disorder using DSM IV (TR) criteria and pain catastrophizing by using Pain Catastrophizing Scale...
February 1, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28127753/a-prospective-cohort-study-of-outpatient-interdisciplinary-rehabilitation-of-chronic-headache-patients
#3
Steven J Krause, Mark J Stillman, Deborah E Tepper, Deborah Zajac
OBJECTIVE: To evaluate the efficacy of an intensive outpatient program designed to improve functioning and reduce psychological impairment in chronic headache patients. BACKGROUND: Chronic headaches, occurring 15 or more days per month, for three or more months, may arise from multiple International Classification of Headache Disorders diagnoses: Chronic Migraine, Chronic Tension Type Headache, New Daily Persistent Headache, Chronic Post Traumatic Headaches, and Medication Overuse Headache...
January 27, 2017: Headache
https://www.readbyqxmd.com/read/28124109/decompression-endoscopic-surgery-for-frontal-secondary-headache-attributed-to-supraorbital-and-supratrochlear-nerve-entrapment-a-comprehensive-review
#4
REVIEW
Boris Filipović, J Alexander de Ru, Rick van de Langenberg, Pepijn A Borggreven, Zdravko Lacković, Peter J F M Lohuis
In the last decade, a new surgical treatment modality was developed for frontal secondary headache, based on the assumption that the trigger of this pain entity is the entrapment of peripheral sensory nerves. The surgery entails a procedure, where an endoscopic approach is used to decompress the supraorbital and supratrochlear nerve branches, which are entrapped by the periosteum in the region of the corrugator supercilii muscle. Candidates for the surgery define their headache as moderate to severe persistent daily pressure or tension, localized in the frontal area, sometimes accompanied by symptoms of nausea and photophobia mimicking a primary headache-migraine...
January 25, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28025837/ketamine-infusions-for-treatment-refractory-headache
#5
Jared L Pomeroy, Michael J Marmura, Stephanie J Nahas, Eugene R Viscusi
BACKGROUND: Management of chronic migraine (CM) or new daily persistent headache (NDPH) in those who require aggressive outpatient and inpatient treatment is challenging. Ketamine has been suggested as a new treatment for this intractable population. METHODS: This is a retrospective review of 77 patients who underwent administration of intravenous, subanesthetic ketamine for CM or NDPH. All patients had previously failed aggressive outpatient and inpatient treatments...
February 2017: Headache
https://www.readbyqxmd.com/read/28025831/new-daily-persistent-headache-caused-by-a-multinodular-goiter-and-headaches-associated-with-thyroid-disease
#6
Randolph W Evans, Josefine S Timm
A 33-year-old female is presented with the first case to our knowledge of new daily persistent headache (NDPH) with a large right benign non-toxic multinodular goiter causing carotid and vertebral compression with complete resolution of the headache immediately after thyroidectomy. Although this may be quite rare, hypothyroidism or hyperthyroidism causing NDPH, migraine, or an exacerbation of pre-existing migraine is not. Clinicians should consider routinely obtaining serum thyroid-stimulating hormone (TSH) and free T4 in patients with new onset frequent headaches or an exacerbation of prior primary headaches...
February 2017: Headache
https://www.readbyqxmd.com/read/27998893/management-of-children-and-young-people-with-headache
#7
William P Whitehouse, Shakti Agrawal
Headache is very common in children and young people. The correct advice and treatment requires consideration of a wide differential diagnosis between primary and secondary headaches, and also of the different types of primary headache. The International Classification of Headache Disorders gives useful descriptions and diagnostic criteria that are especially useful for primary headaches. The National Institute for Health and Care Excellence (NICE) Clinical Guideline 150 provides evidence-based recommendations on treatments for adults and young people from age 12 years...
April 2017: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27901275/peripheral-nerve-blocks-for-the-treatment-of-headache-in-older-adults-a-retrospective-study
#8
Jacob R Hascalovici, Matthew S Robbins
OBJECTIVE: The objective of this study is to provide demographical and clinical descriptions of patients age 65 years old and older who were treated with peripheral nerve blocks (PNBs) at our institution and evaluate the safety and efficacy of this treatment. BACKGROUND: Headache disorders are common, disabling chronic neurological diseases that often persist with advancing age. Geriatric headache management poses unique therapeutic challenges because of considerations of comorbidity, drug interactions, and adverse effects...
January 2017: Headache
https://www.readbyqxmd.com/read/27775149/amitriptyline-dose-and-treatment-outcomes-in-specialty-headache-practice-a-retrospective-cohort-study
#9
Lauren Doyle Strauss, Emma Weizenbaum, Elizabeth W Loder, Paul B Rizzoli
OBJECTIVE: To characterize treatment patterns and real world outcomes in headache patients treated with amitriptyline in an academic headache center. DESIGN AND METHODS: A retrospective chart review identified 178 patients in our center who were given a new prescription for amitriptyline in treatment of headache, and who were seen in follow-up within one year. Charts were reviewed to identify dosing patterns (initial and maximum dose) and persistence, patient-reported headache benefit, and reported side effects...
November 2016: Headache
https://www.readbyqxmd.com/read/27770403/characterising-the-premonitory-stage-of-migraine-in-children-a-clinic-based-study-of-100-patients-in-a-specialist-headache-service
#10
N Karsan, P Prabhakar, P J Goadsby
BACKGROUND: The premonitory stage of migraine attacks, when symptomatology outside of pain can manifest hours to days before the onset of the headache, is well recognised. Such symptoms have been reported in adults in a number of studies, and have value in predicting an impending headache. These symptoms have not been extensively studied in children. We aimed to characterise which, if any, of these symptoms are reported in children seen within a Specialist Headache Service. METHODS: We reviewed clinic letters from the initial consultation of children and adolescents seen within the Specialist Headache Service at Great Ormond Street Hospital between 1999 and 2015 with migraine in whom we had prospectively assessed clinical phenotype data...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27731894/patterns-of-use-of-peripheral-nerve-blocks-and-trigger-point-injections-for-pediatric-headache-results-of-a-survey-of-the-american-headache-society-pediatric-and-adolescent-section
#11
Christina L Szperka, Amy A Gelfand, Andrew D Hershey
OBJECTIVE: To describe current patterns of use of nerve blocks and trigger point injections for treatment of pediatric headache. BACKGROUND: Peripheral nerve blocks are often used to treat headaches in adults and children, but the available studies and practice data from adult headache specialists have shown wide variability in diagnostic indications, sites injected, and medication(s) used. The purpose of this study was to describe current practice patterns in the use of nerve blocks and trigger point injections for pediatric headache disorders...
November 2016: Headache
https://www.readbyqxmd.com/read/27629088/aprepitant-for-the-management-of-nausea-with-inpatient-iv-dihydroergotamine
#12
Denise E Chou, Amy R Tso, Peter J Goadsby
OBJECTIVE: To assess the efficacy and tolerability of oral aprepitant, a substance P/neurokinin A receptor antagonist, in controlling nausea associated with IV dihydroergotamine (DHE) administered for medically refractory migrainous headache in patients not responding to standard antiemetics or with a history of uncontrolled nausea with DHE. METHODS: This was a retrospective chart review of prospectively collected hourly diary data and clinical notes of patients hospitalized between 2011 and 2015 for inpatient treatment with DHE...
October 11, 2016: Neurology
https://www.readbyqxmd.com/read/27449912/chronic-daily-headache-and-medication-overuse-headache-in-first-visit-headache-patients-in-korea-a-multicenter-clinic-based-study
#13
Myoung Jin Cha, Heui Soo Moon, Jong Hee Sohn, Byung Su Kim, Tae Jin Song, Jae Moon Kim, Jeong Wook Park, Kwang Yeol Park, Soo Kyoung Kim, Byung Kun Kim, Soo Jin Cho
BACKGROUND AND PURPOSE: Chronic daily headache (CDH) is defined as a headache disorder in which headaches occur on a daily or near-daily basis (at least 15 days/month) for more than 3 months. Chronic migraine (CM) and medication overuse headache (MOH) are very disabling headaches that remain underdiagnosed. The aim of this study was to establish the frequency of CDH and its various subtypes, and examine the associations with MOH among first-visit headache patients presenting at neurology outpatient clinics in Korea...
July 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27432630/new-daily-persistent-headache
#14
Deborah Tepper
No abstract text is available yet for this article.
July 2016: Headache
https://www.readbyqxmd.com/read/27272563/increased-versus-stable-doses-of-inhaled-corticosteroids-for-exacerbations-of-chronic-asthma-in-adults-and-children
#15
REVIEW
Kayleigh M Kew, Michael Quinn, Bradley S Quon, Francine M Ducharme
BACKGROUND: People with asthma may experience exacerbations or "attacks" during which their symptoms worsen and additional treatment is required. Written action plans may advocate doubling the dose of inhaled steroids in the early stages of an asthma exacerbation to reduce the severity of the attack and to prevent the need for oral steroids or hospital admission. OBJECTIVES: To compare the clinical effectiveness and safety of increased versus stable doses of inhaled corticosteroids (ICS) as part of a patient-initiated action plan for home management of exacerbations in children and adults with persistent asthma...
June 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27080086/update-on-new-daily-persistent-headache
#16
REVIEW
Hida Nierenburg, Lawrence C Newman
New daily persistent headache (NDPH) is an uncommon and under-recognized primary headache disorder. Clinically, NDPH may resemble migraine or tension-type headache. Unlike migraine or tension-type headaches, however, a distinguishing feature of NDPH is that the majority of patients with NDPH can pinpoint the exact date of onset of symptoms. While cases can arise de novo, in multiple reports, a viral illness precedes the onset of headache. NDPH has two temporal profiles: a self-limited form that resolves spontaneously without treatment and a refractory, persistent form in which headaches continue unabated for years...
June 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27011641/patients-with-tension-type-headaches-feel-stigmatized
#17
Sanjay Prakash
The author, a sufferer of tension-type headache (TTH), believes that the word "tension" in "tension-type headache" carries a social stigma and that patients do not accept a diagnosis of TTH readily. TTH is the most common primary headache disorder. The disability of TTH as a burden of society is greater than that of migraine. Absenteeism because of TTH is higher than that due to migraine. However, patients with TTH do not go for consultation. Even the prevalence of new daily persistent headache (NDPH) is 12 times higher at the headache clinic than that of chronic TTH (CTTH)...
January 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/26981128/spontaneous-intracranial-hypotension-treated-with-a-targeted-ct-guided-epidural-blood-patch
#18
Inês Correia, Inês Brás Marques, Rogério Ferreira, Miguel Cordeiro, Lívia Sousa
Spontaneous intracranial hypotension (SIH) is an important cause of new daily persistent headache. It is thought to be due to spontaneous spinal cerebrospinal fluid (CSF) leaks, which probably have a multifactorial etiology. The classic manifestation of SIH is an orthostatic headache, but other neurological symptoms may be present. An epidural blood patch is thought to be the most effective treatment, but a blind infusion may be ineffective. We describe the case of a young man who developed an acute severe headache, with pain worsening when assuming an upright posture and relief gained with recumbency...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/26927912/resolution-of-new-daily-persistent-headache-after-osteopathic-manipulative-treatment
#19
Joshua Alexander
New daily persistent headache is a refractory headache with an elusive cause and treatment. Limited available data suggest that abnormalities in the musculoskeletal system may increase vulnerability to this type of headache. Osteopathic manipulative treatment has been used successfully to manage primary headache disorders. In this case report, a patient with new daily persistent headache and severe somatic dysfunction had resolution of her pain after osteopathic manipulative treatment. This case suggests that osteopathic manipulative treatment may be useful in patients with this typically treatment-resistant disorder...
March 2016: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/26926707/a-survey-of-headache-medicine-physicians-on-the-likeability-of-headaches-and-their-personal-headache-history
#20
Randolph W Evans, Kamalika Ghosh
BACKGROUND: Two prior studies have shown an increased prevalence of migraine among physicians who are headache medicine specialists (HMS). There have been no studies of the prevalence of other headache disorders among HMS. A prior survey showed that neurologists like to treat some headaches more than others but there has not been a similar survey of HMS. OBJECTIVES: The aim of the survey was to learn more about the prevalence of headaches among HMS and which headache disorders they like to treat...
March 2016: Headache
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