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pontomedullary reticular formation

Kaoru Takakusaki, Ryosuke Chiba, Tsukasa Nozu, Toshikatsu Okumura
The lateral part of the mesopontine tegmentum contains functionally important structures involved in the control of posture and gait. Specifically, the mesencephalic locomotor region, which may consist of the cuneiform nucleus and pedunculopontine tegmental nucleus (PPN), occupies the interest with respect to the pathophysiology of posture-gait disorders. The purpose of this article is to review the mechanisms involved in the control of postural muscle tone and locomotion by the mesopontine tegmentum and the pontomedullary reticulospinal system...
July 2016: Journal of Neural Transmission
Wendy J Herbert, Kimerly Powell, John A Buford
The purposes of this pilot study were to create a model of focal cortical ischemia in Macaca fascicularis and to explore contributions of the reticulospinal system in recovery of reaching. Endothelin-1 was used to create a focal lesion in the shoulder/elbow representation of left primary motor cortex (M1) of two adult female macaques. Repetitive microstimulation was used to map upper limb motor outputs from right and left cortical motor areas and from the pontomedullary reticular formation (PMRF). In subject 1 with a small lesion and spontaneous recovery, reaching was mildly impaired...
November 2015: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Julie Quinet, Laurent Goffart
The fastigial oculomotor region is the output by which the medioposterior cerebellum influences the generation of saccades. Recent inactivation studies reported observations suggesting an involvement in their dynamics (velocity and duration). In this work, we tested this hypothesis in the head-restrained monkey with the electrical microstimulation technique. More specifically, we studied the influence of duration, frequency, and current on the saccades elicited by fastigial stimulation and starting from a central (straight ahead) position...
May 1, 2015: Journal of Neurophysiology
Thomas J Hirschauer, John A Buford
Neurons in the pontomedullary reticular formation (PMRF) give rise to the reticulospinal tract. The motor output of the PMRF was investigated using stimulus-triggered averaging of electromyography (EMG) and force recordings in two monkeys (M. fascicularis). EMG was recorded from 12 pairs of upper limb muscles, and forces were detected using two isometric force-sensitive handles. Of 150 stimulation sites, 105 (70.0%) produced significant force responses, and 139 (92.5%) produced significant EMG responses. Based on the average flexor EMG onset latency of 8...
April 1, 2015: Journal of Neurophysiology
M Strupp, O Kremmyda, C Adamczyk, N Böttcher, C Muth, C W Yip, T Bremova
An impairment of eye movements, or nystagmus, is seen in many diseases of the central nervous system, in particular those affecting the brainstem and cerebellum, as well as in those of the vestibular system. The key to diagnosis is a systematic clinical examination of the different types of eye movements, including: eye position, range of eye movements, smooth pursuit, saccades, gaze-holding function and optokinetic nystagmus, as well as testing for the different types of nystagmus (e.g., central fixation nystagmus or peripheral vestibular nystagmus)...
September 2014: Journal of Neurology
Kenneth S Dyson, Jean-Philippe Miron, Trevor Drew
We tested the hypothesis that the same spinal interneuronal pathways are activated by the reticulospinal system during locomotion and reaching. If such were the case, we expected that microstimulation within the pontomedullary reticular formation (PMRF) would evoke qualitatively similar responses in muscles active during both behaviors. To test this, we stimulated in 47 sites within the PMRF during both tasks. Stimulation during locomotion always produced a strongly phase-dependent, bilateral pattern of activity in which activity in muscles was generally facilitated or suppressed during one phase of activity (swing or stance) and was unaffected in the other...
November 15, 2014: Journal of Neurophysiology
Evan Kirsch, Gil Rivlis, Marc H Schieber
The joints of the hand provide 24 mechanical degrees of freedom. Yet 2-7 principal components (PCs) account for 80-95% of the variance in hand joint motion during tasks that vary from grasping to finger spelling. Such findings have led to the hypothesis that the brain may simplify operation of the hand by preferentially controlling PCs. We tested this hypothesis using data recorded from the primary motor cortex (M1) during individuated finger and wrist movements. Principal component analysis (PCA) of the simultaneous position of the five digits and the wrist showed relatively consistent kinematic synergies across recording sessions in two monkeys...
2014: Frontiers in Neurology
Jorik Nonnekes, Alexander C H Geurts, Lars B Oude Nijhuis, Karin van Geel, Anke H Snijders, Bastiaan R Bloem, Vivian Weerdesteyn
Freezing of gait (FOG) is a disabling feature of Parkinson's disease. Emerging evidence suggests that dysfunction of the pedunculopontine nucleus (PPN) and pontomedullary reticular formation (pmRF) plays a role in the causation of FOG. These brainstem structures can be examined by the StartReact paradigm, which utilizes a startling stimulus to accelerate reaction times (StartReact). Here, we examined gait initiation in PD patients with and without FOG using this paradigm. Twenty-six patients with Parkinson's disease (12 freezers and 14 non-freezers) and 15 controls performed two tasks: rapid gait initiation in response to an imperative 'go' signal; and a control condition, involving a simple reaction-time task involving ankle dorsiflexion...
May 2014: Journal of Neurology
Mayu Takahashi, Yuriko Sugiuchi, Yoshikazu Shinoda
The caudal fastigial nucleus (FN) is known to be related to the control of eye movements and projects mainly to the contralateral reticular nuclei where excitatory and inhibitory burst neurons for saccades exist [the caudal portion of the nucleus reticularis pontis caudalis (NRPc), and the rostral portion of the nucleus reticularis gigantocellularis (NRG) respectively]. However, the exact reticular neurons targeted by caudal fastigioreticular cells remain unknown. We tried to determine the target reticular neurons of the caudal FN and superior colliculus (SC) by recording intracellular potentials from neurons in the NRPc and NRG of anesthetized cats...
February 2014: Journal of Neurophysiology
Demetris S Soteropoulos, Elizabeth R Williams, Stuart N Baker
Recent work has shown that the primate reticulospinal tract can influence spinal interneurons and motoneurons involved in control of the hand. However, demonstrating connectivity does not reveal whether reticular outputs are modulated during the control of different types of hand movement. Here, we investigated how single unit discharge in the pontomedullary reticular formation (PMRF) modulated during performance of a slow finger movement task in macaque monkeys. Two animals performed an index finger flexion–extension task to track a target presented on a computer screen; single units were recorded both from ipsilateral PMRF (115 cells) and contralateral primary motor cortex (M1, 210 cells)...
August 15, 2012: Journal of Physiology
K Takakusaki, K Obara, T Nozu, T Okumura
Pedunculopontine tegmental nucleus (PPN) contributes to the control muscle tone by modulating the activities of pontomedullary reticulospinal systems during wakefulness and rapid eye movement (REM) sleep. The PPN receives GABAergic projection from the substantia nigra pars reticulata (SNr), an output nucleus of the basal ganglia. Here we examined how GABAergic SNr-PPN projection controls the activity of the pontomedullary reticulospinal tract that constitutes muscle tone inhibitory system. Intracellular recording was made from 121 motoneurons in the lumbosacral segments in decerebrate cats (n=14)...
December 2011: Archives Italiennes de Biologie
Sang Seok Yeo, Min Cheol Chang, Yong Hyun Kwon, Young Jin Jung, Sung Ho Jang
The corticoreticular pathway (CRP) is involved in postural control and locomotor function. No study has been conducted for identification of the CRP in the human brain. In the current study, we attempted to identify the CRP in the human brain, using diffusion tensor tractography (DTT). We recruited 24 healthy volunteers for this study. Diffusion tensor images were scanned using 1.5-T. For reconstruction of the CRP, a seed region of interest (ROI) was placed on the reticular formation of the medulla. The first target ROI was placed on the midbrain tegmentum and the second target ROI was placed on the premotor cortex (Brodmann area 6)...
February 2, 2012: Neuroscience Letters
Heather N Lavezzi, Kenneth P Parsley, Daniel S Zahm
The mesopontine rostromedial tegmental nucleus (RMTg) is a GABAergic structure in the ventral midbrain and rostral pons that, when activated, inhibits dopaminergic neurons in the ventral tegmental area and substantia nigra compacta. Additional strong outputs from the RMTg to the pedunculopontine tegmental nucleus pars dissipata, dorsal raphe nucleus, and the pontomedullary gigantocellular reticular formation were identified by anterograde tracing. RMTg neurons projecting to the ventral tegmental area express the immediate early gene Fos upon psychostimulant administration...
July 2012: Brain Structure & Function
Laurens W J Bosman, Arthur R Houweling, Cullen B Owens, Nouk Tanke, Olesya T Shevchouk, Negah Rahmati, Wouter H T Teunissen, Chiheng Ju, Wei Gong, Sebastiaan K E Koekkoek, Chris I De Zeeuw
The rodent whisker system is widely used as a model system for investigating sensorimotor integration, neural mechanisms of complex cognitive tasks, neural development, and robotics. The whisker pathways to the barrel cortex have received considerable attention. However, many subcortical structures are paramount to the whisker system. They contribute to important processes, like filtering out salient features, integration with other senses, and adaptation of the whisker system to the general behavioral state of the animal...
2011: Frontiers in Integrative Neuroscience
Anne-Sophie Rolland, Carine Karachi, Marie-Paule Muriel, Etienne C Hirsch, Chantal François
The locomotor area has recently emerged as a target for deep brain stimulation to lessen gait disturbances in advanced parkinsonian patients. An important step in choosing this target is to define anatomical limits of its 2 components, the pedunculopontine nucleus and the cuneiform nucleus, their connections with the basal ganglia, and their output descending pathway. Based on the hypothesis that pedunculopontine nucleus controls locomotion whereas cuneiform nucleus controls axial posture, we analyzed whether both nuclei receive inputs from the internal pallidum and substantia nigra using anterograde and retrograde tract tracing in monkeys...
August 1, 2011: Movement Disorders: Official Journal of the Movement Disorder Society
Elizabeth R Williams, Demetris S Soteropoulos, Stuart N Baker
Tremor imposes an important limit to the accuracy of fine movements in healthy individuals and can be a disabling feature of neurological disease. Voluntary slow finger movements are not smooth but are characterized by large discontinuities (i.e., steps) in the tremor frequency range (approximately 10 Hz). Previous studies have shown that these discontinuities are coherent with activity in the primary motor cortex (M1), but that other brain areas are probably also involved. We investigated the contribution of three important subcortical areas in two macaque monkeys trained to perform slow finger movements...
June 15, 2010: Proceedings of the National Academy of Sciences of the United States of America
Wendy J Herbert, Adam G Davidson, John A Buford
The pontomedullary reticular formation (PMRF) of the monkey produces motor outputs to both upper limbs. EMG effects evoked from stimulus-triggered averaging (StimulusTA) were compared with effects from stimulus trains to determine whether both stimulation methods produced comparable results. Flexor and extensor muscles of scapulothoracic, shoulder, elbow, and wrist joints were studied bilaterally in two male M. fascicularis monkeys trained to perform a bilateral reaching task. The frequency of facilitation versus suppression responses evoked in the muscles was compared between methods...
June 2010: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
C D Rice, S A Weber, A L Waggoner, M E Jessell, B J Yates
During breathing, the diaphragm and abdominal muscles contract out of phase. However, during other behaviors (including vomiting, postural adjustments, and locomotion) simultaneous contractions are required of the diaphragm and other muscle groups including abdominal muscles. Recent studies in cats using transneuronal tracing techniques showed that in addition to neurons in the respiratory groups, cells in the inferior and lateral vestibular nuclei (VN) and medial pontomedullary reticular formation (MRF) influence diaphragm activity...
May 2010: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Lorenzo Guerrasio, Julie Quinet, Ulrich Büttner, Laurent Goffart
When primates maintain their gaze directed toward a visual target (visual fixation), their eyes display a combination of miniature fast and slow movements. An involvement of the cerebellum in visual fixation is indicated by the severe gaze instabilities observed in patients suffering from cerebellar lesions. Recent studies in non-human primates have identified a cerebellar structure, the fastigial oculomotor region (FOR), as a major cerebellar output nucleus with projections toward oculomotor regions in the brain stem...
April 2010: Journal of Neurophysiology
Toshiko Tsumori, Yi Qin, Shigefumi Yokota, Jian-Guo Niu, Yukihiko Yasui
The retrorubral field (RRF) contains numerous dopaminergic neurons and projects to the parvicellular reticular formation (RFp) of the medullary and pontomedullary brainstem, where many premotor neurons project to the orofacial motor nuclei. To know how the amygdala affects the RRF-RFp pathway in the rat, we first examined the synaptic organization between the central amygdaloid nucleus (CeA) fibers and the RFp-projecting RRF neurons by using combined anterograde and retrograde tracing techniques. After ipsilateral injections of biotinylated dextran amine (BDA) into the CeA and Fluoro-gold (FG) into the RFp, the prominent overlapping distribution of BDA-labeled axon terminals and FG-labeled neurons was found in the lateral part of the RRF ipsilateral to the injection sites, where the BDA-labeled axon terminals made symmetrical synapses with somata and dendrites of the FG-labeled neurons...
January 8, 2010: Brain Research
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