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cerebellar rehabilitation

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https://www.readbyqxmd.com/read/29021739/effect-of-error-augmentation-on-brain-activation-and-motor-learning-of-a-complex-locomotor-task
#1
Laura Marchal-Crespo, Lars Michels, Lukas Jaeger, Jorge López-Olóriz, Robert Riener
Up to date, the functional gains obtained after robot-aided gait rehabilitation training are limited. Error augmenting strategies have a great potential to enhance motor learning of simple motor tasks. However, little is known about the effect of these error modulating strategies on complex tasks, such as relearning to walk after a neurologic accident. Additionally, neuroimaging evaluation of brain regions involved in learning processes could provide valuable information on behavioral outcomes. We investigated the effect of robotic training strategies that augment errors-error amplification and random force disturbance-and training without perturbations on brain activation and motor learning of a complex locomotor task...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29019708/effects-of-long-term-exercise-and-low-level-inhibition-of-gabaergic-synapses-on-motor-control-and-the-expression-of-bdnf-in-the-motor-related-cortex
#2
Takahiro Inoue, Shuta Ninuma, Masataka Hayashi, Akane Okuda, Tadayoshi Asaka, Hiroshi Maejima
Objectives Brain-derived neurotrophic factor (BDNF) plays important roles in neuroplasticity in the brain. The objective of this study was to examine the effects of long-term exercise combined with low-level inhibition of GABAergic synapses on motor control and the expression of BDNF in the motor-related cortex. Methods ICR mice were divided into four groups based on the factors exercise and GABAA receptor inhibition. We administered the GABAA receptor antagonist bicuculline intraperitoneally (0.25 mg/kg)...
October 11, 2017: Neurological Research
https://www.readbyqxmd.com/read/28967438/identification-of-specific-gait-patterns-in-patients-with-cerebellar-ataxia-spastic-paraplegia-and-parkinson-s-disease-a-non-hierarchical-cluster-analysis
#3
Mariano Serrao, Giorgia Chini, Matteo Bergantino, Diego Sarnari, Carlo Casali, Carmela Conte, Alberto Ranavolo, Christian Marcotulli, Martina Rinaldi, Gianluca Coppola, Fabiano Bini, Francesco Pierelli, Franco Marinozzi
Patients with degenerative neurological diseases such as cerebellar ataxia, spastic paraplegia, and Parkinson's disease often display progressive gait function decline that inexorably impacts their autonomy and quality of life. Therefore, considering the related social and economic costs, one of the most important areas of intervention in neurorehabilitation should be the treatment of gait abnormalities. This study aims to determine whether an entire dataset of gait parameters recorded in patients with degenerative neurological diseases can be clustered into homogeneous groups distinct from each other and from healthy subjects...
September 26, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28967311/transpetrosal-approach-to-petro-clival-meningioma
#4
Turki Elarjani, Rakshith Shetty, Harminder Singh, Harley B da Silva, Laligam N Sekhar
A 38-year-old woman had a 3-week gradual onset of right-sided weakness in the upper and lower extremities. MRI showed a large left petro-clival meningioma encasing the basilar and left superior cerebellar artery and compressing the brainstem. A posterior transpetrosal approach, with a left temporal and retrosigmoid craniotomy and mastoidectomy, was performed. The tumor was removed in a gross-total resection with questionable remnants adherent to the brainstem. Intraoperative partial iatrogenic injury to the left oculomotor nerve was repaired with fibrin glue...
October 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28940047/epidemiology-of-cerebellar-diseases-and-therapeutic-approaches
#5
REVIEW
Michael S Salman
Diseases involving the cerebellum occur relatively commonly in children and adults around the globe. Many factors influence their epidemiology including geography, ethnicity, consanguinity, and the methodology used to ascertain patients. In addition, reliable epidemiological data rely heavily on accurate disease classification. Continuous advances in genetic research and neuroimaging modalities have resulted in improved understanding of cerebellar diseases and have led to several revisions in their classification...
September 22, 2017: Cerebellum
https://www.readbyqxmd.com/read/28869475/effect-of-attention-training-in-mild-cognitive-impairment-patients-with-subcortical-vascular-changes-the-rehatt-study
#6
Leonardo Pantoni, Anna Poggesi, Stefano Diciotti, Raffaella Valenti, Stefano Orsolini, Eleonora Della Rocca, Domenico Inzitari, Mario Mascalchi, Emilia Salvadori
BACKGROUND AND OBJECTIVE: Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial. METHODS: Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28741720/alteplase-for-acute-ischemic-stroke-after-heparin-reversal-with-protamine-a-case-report-and-review
#7
Gabriel V Fontaine, Shawn M Smith
Few patients presenting with acute ischemic stroke (AIS) are eligible for alteplase, especially those receiving ongoing anticoagulation. We describe the first reported case of a patient receiving full-dose intravenous (IV) alteplase for AIS after heparin reversal with protamine. A 73-year-old man presented with AIS. He was treated with IV heparin, tirofiban, loading-dose prasugrel, and aspirin before percutaneous coronary intervention (PCI) for placement of a right coronary artery stent. One hour following PCI, he abruptly developed left hemiparesis and dysphagia...
July 25, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28664015/central-hypoventilation-syndrome-complicated-with-lateral-medullary-infarction-after-endovascular-treatment-of-the-vertebral-artery-dissecting-aneurysm-a-case-report
#8
Katsuhiro Tanaka, Hideki Kanamaru, Atsunori Morikawa, Kenji Kawaguchi
Lateral medullary infarction rarely leads to central hypoventilation syndrome (CHS). CHS is a life-threatening disorder characterized by hypoventilation during sleep. We report the first case of CHS as a complication of lateral medullary infarction after endovascular treatment. A 65-year-old man presented twice with severe headache. Computed tomography revealed subarachnoid hemorrhage and cerebral angiography showed a right vertebral dissecting aneurysm involving the posterior inferior cerebellar artery. After emergent endovascular patent artery occlusion, he developed Wallenberg syndrome and experienced apnea and a conscious disturbance episode due to CHS on postoperative days 6 and 16...
October 2016: NMC Case Rep J
https://www.readbyqxmd.com/read/28652948/streptococcus-mutans-a-potential-risk-factor-in-recurrent-hemorrhagic-stroke
#9
Tarek R Mansour, Yasaman Alam, Layth Dahbour, Ahmed Alnemari, Mouhammad Jumaa, Jason L Schroeder
Stroke is the fifth leading cause of death and is responsible for approximately nine percent of all deaths worldwide. Cases of Streptococcus mutans (S. mutans)-induced intracerebral hemorrhage as a result of bloodstream infections have seldom been reported. New reports show that bacteria with specific collagen binding proteins (CBPs), such as the Cnm type produced by S. mutans, may inhibit platelet aggregation and cause bleeding. In this article, we report on a 62-year-old man with a recent history of left frontal intracerebral hemorrhage (ICH) who presented to the emergency department after a fall due to suspected seizure while in rehabilitation...
May 19, 2017: Curēus
https://www.readbyqxmd.com/read/28627859/use-of-dynamic-movement-orthoses-to-improve-gait-stability-and-trunk-control-in-ataxic-patients
#10
Mariano Serrao, Carlo Casali, Alberto Ranavolo, Silvia Mari, Carmela Conte, Giorgia Chini, Luca Leonardi, Gianluca Coppola, Cherubino DI Lorenzo, Mahmoud Harfoush, Luca Padua, Francesco Pierelli
BACKGROUND: Patients with cerebellar ataxia show increased upper body movements, which have an impact on balance and walking. AIM: In this study, we investigated the effect of using dynamic movement orthoses (DMO), designed as elastic suits, on trunk motion and gait parameters. DESIGN: A longitudinal uncontrolled study. SETTING: Rehabilitative outpatient unit. POPULATION: Eleven patients (seven men, four women; mean age of 49...
June 19, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28588791/synchronous-adie-s-syndrome-and-type-1-antineuronal-nuclear-antibody-anti-hu-related-paraneoplastic-neurological-syndromes-as-predictors-of-complete-response-in-limited-stage-small-cell-lung-cancer-a-case-report
#11
Katherina Bernadette Sreter, Blazenka Barisic, Marija Barisic Kutija, Suzana Kukulj, Miroslav Samarzija
Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal-specific Hu proteins that are abnormally expressed in small-cell lung cancer (SCLC). We herein present the unique case of a 55-year-old obese woman, previous heavy smoker, who, during treatment with standard cisplatin-etoposide chemotherapy for limited-stage SCLC, developed simultaneous AS and worsening symptoms consistent with PSN CA that led to significant neurological disability and severe axonal electrophysiological pattern on nerve conduction studies...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28562425/rotational-and-collic-vestibular-evoked-myogenic-potential-testing-in-normal-developing-children-and-children-with-combined-attention-deficit-hyperactivity-disorder
#12
Younes Lotfi, Nima Rezazadeh, Abdollah Moossavi, Hojjat Allah Haghgoo, Reza Rostami, Enayatollah Bakhshi, Faride Badfar, Sedigheh Farokhi Moghadam, Vahid Sadeghi-Firoozabadi, Yousef Khodabandelou
OBJECTIVES: Vestibular dysfunction in childhood can have a major effect on a child's developmental process. Balance function has been reported to be poorer in children with attention deficit and hyperactivity disorder (ADHD) than in their typically developing peers. Due to contradictory available evidence and the paucity of research on vestibular function specifically in children with combined ADHD (cADHD), we designed this aged-matched study to assess vestibular function in children with cADHD...
May 26, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28469001/cerebellar-patients-do-not-benefit-from-cerebellar-or-m1-transcranial-direct-current-stimulation-during-force-field-reaching-adaptation
#13
Thomas Hulst, Liane John, Michael Küper, Jos N van der Geest, Sophia L Göricke, Opher Donchin, Dagmar Timmann
Several studies have identified transcranial direct current stimulation (tDCS) as a potential tool in the rehabilitation of cerebellar disease. Here, we tested whether tDCS could alleviate motor impairments of subjects with cerebellar degeneration. Three groups took part in this study: 20 individuals with cerebellar degeneration, 20 age-matched controls, and 30 young controls. A standard reaching task with force-field perturbations was used to compare motor adaptation among groups and to measure the effect of stimulation of the cerebellum or primary motor cortex (M1)...
August 1, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28422031/the-importance-of-labyrinthine-examination-in-the-prognosis-and-therapy-for-balance-in-spinocerebellar-ataxia
#14
João Henrique Faryniuk, Bianca Simone Zeigelboim, Hélio Afonso Ghizoni Teive, Vinicius Ribas Fo, Paulo Breno Noronha Liberalesso, Jair Mendes Marques
INTRODUCTION: Spinocerebellar ataxias (SCAs) are a heterogeneous group of neurodegenerative diseases that are characterized by the presence of progressive cerebellar ataxia. OBJECTIVE: Identify vestibular disorders and demonstrate the importance of labyrinthine examination in the prognosis and therapy for balance in patients with SCAs. MATERIALS AND METHODS: The study had a retrospective cross-sectional design and evaluated 57 patients, mean age of 41...
April 19, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28372326/does-functional-connectivity-provide-a-marker-for-cognitive-rehabilitation-effects-in-alzheimer-s-disease-an-interventional-study
#15
Sina Ochmann, Martin Dyrba, Michel J Grothe, Elisabeth Kasper, Steffi Webel, Karlheinz Hauenstein, Stefan J Teipel
BACKGROUND: Cognitive rehabilitation (CR) is a cognitive intervention for patients with Alzheimer's disease (AD) that aims to maintain everyday competences. The analysis of functional connectivity (FC) in resting-state functional MRI has been used to investigate the effects of cognitive interventions. OBJECTIVES: We evaluated the effect of CR on the default mode network FC in a group of patients with mild AD, compared to an active control group. METHODS: We performed a three-month interventional study including 16 patients with a diagnosis of AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28290743/brain-anatomy-of-symptom-stratification-in-schizophrenia-a-voxel-based-morphometry-study
#16
Giuseppe Delvecchio, Alessandra Lorandi, Cinzia Perlini, Marco Barillari, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Although some Magnetic Resonance Imaging (MRI) studies have investigated the relationship between clinical severity and neuroanatomical alterations in patients with schizophrenia (SCZ), the biological signature associated with illness severity in schizophrenia is still uncertain. Therefore, this study aims to investigate structural brain abnormalities in SCZ, with particular regards to the identification of potential deficits associated with the severity of illness. METHODS: In total, 1...
March 14, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28274722/effects-of-vestibular-rehabilitation-combined-with-transcranial-cerebellar-direct-current-stimulation-in-patients-with-chronic-dizziness-an-exploratory-study
#17
Satoko Koganemaru, Fumiyuki Goto, Miki Arai, Keitaro Toshikuni, Makoto Hosoya, Takeshi Wakabayashi, Nobuko Yamamoto, Shujiro Minami, Satoshi Ikeda, Katsunori Ikoma, Tatsuya Mima
BACKGROUND: Vestibular rehabilitation is useful to alleviate chronic dizziness in patients with vestibular dysfunction. It aims to induce neuronal plasticity in the central nervous system (especially in the cerebellum) to promote vestibular compensation. Transcranial cerebellar direct current stimulation (tcDCS) reportedly enhances cerebellar function. OBJECTIVE/HYPOTHESIS: We investigated whether vestibular rehabilitation partially combined with tcDCS is superior to the use of rehabilitation alone for the alleviation of dizziness...
May 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28264544/efficacy-of-bont-a-and-swallowing-treatment-for-oropharyngeal-dysphagia-recovery-in-a-patient-with-lateral-medullary-syndrome-a-case-study
#18
Irene Battel, Isabella Koch, Federica Biddau, Carla Carollo, Francesco Piccione, Francesca Meneghello, Merico Antonio, Katie Palmer, Rosario Marchese Ragona
BACKGROUND: Wallenberg's syndrome (WS) is known as posterior inferior cerebellar artery syndrome. Dysphagia has been reported from 51% to 94% of the patients, ranging from mild to severe. CASE PRESENTATION: We reported a case of a patient (Male; 52yrs) with WS. MRI showed an intense hypodense area in the dorsolateral part of the ponto-medullary junction. The clinical signs were severe dysphagia, fed by PEG (FOIS 1; PAS 7), sialorrhea, trismus and ataxia. CLINICAL REHABILITATION IMPACT: Dysphagia was treated by botulinum toxin tipe A (BoNT-A), which was injected into the parotid and submandibular salivary glands, temporalis and masseter muscles, cricopharyngeal muscle associated with specific swallowing exercise and food trails...
March 6, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28228797/femoral-neck-s-fracture-in-fahr-s-syndrome-case-report
#19
Marcello Sallì, Antonio D'Arienzo, Mariella Bonanno, Salvatore Morello, Antonino Sanfilippo, Giulia Letizia Mauro, Michele D'Arienzo
Fahr's syndrome, also known as "Bilateral Striopallidodentate Calcinosis" (BSPDC) primitive, is a rare neurological disease characterized by the presence of idiopathic, bilateral, symmetrical and abnormal deposition of calcium in areas of the brain that control movements including the basal ganglia, dentate nuclei of the cerebellum, nuclei of thalamus and semi-oval center. We describe a case of a 76-year-old male patient underwent reduction and fixation of a subtrochanteric fracture with intramedullary nail...
September 2016: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/28166646/the-meanings-of-physiotherapy-and-exercise-for-people-living-with-progressive-cerebellar-ataxia-an-interpretative-phenomenological-analysis
#20
Elizabeth Cassidy, Sandra Naylor, Frances Reynolds
PURPOSE: To understand the meanings of exercise and physiotherapy for people living with a progressive cerebellar ataxia. METHOD: An interpretative phenomenological analysis was undertaken with 12 participants (4 women, 8 men) recruited via their membership of a national support group. Semistructured interviews were audiorecorded and transcribed. Data were analyzed using interpretivist methods. RESULTS: Two main themes were constructed. Firstly, participants highly valued building collaborative and supportive long-term therapeutic relationships with expert physiotherapists and were not necessarily looking to improve ataxia-related impairments...
February 6, 2017: Disability and Rehabilitation
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