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cerebellar rehabilitation

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https://www.readbyqxmd.com/read/29907375/fndc5-expression-in-purkinje-neurons-of-adult-male-rats-with-acute-spinal-cord-injury-following-treatment-with-methylprednisolone
#1
Sajad Hassanzadeh, Seyed Behnamedin Jameie, Mehdi Mehdizadeh, Mansooreh Soleimani, Zeinab Namjoo, Maryam Soleimani
Spinal cord injury (SCI) is a serious and complex medical condition that can happen to anyone. At present, therapy mainly focuses on rehabilitation and pharmacological treatment, such as methylprednisolone (MP). Supra-spinal changes in certain structures, such as the cerebellum, that receive many afferents from the spinal cord might be one reason for unsuccessful therapeutic outcomes. Recently, the expression of FNDC5 was reported in cerebellar Purkinje cells as a possible neuroprotective agent. In the present study, we considered the expression of FNDC5 in Purkinje cells following SCI with and without MP administration in adult rats with SCI...
May 7, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29903447/neurophysiology-of-gait
#2
Mariano Serrao, Alberto Ranavolo, Carlo Casali
Beyond the classic clinical description, recent studies have quantitatively evaluated gait and balance dysfunction in cerebellar ataxias by means of modern motion analysis systems. These systems have the aim of clearly and quantitatively describing the differences, with respect to healthy subjects, in kinematic, kinetic, and surface electromyography variables, establishing the basis for a rehabilitation strategy and assessing its efficacy. The main findings which characterize the gait pattern of cerebellar patients are: increased step width, reduced ankle joint range of motion with increased coactivation of the antagonist muscles, and increased stride-to-stride variability...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29891072/drug-treatment
#3
Susan Perlman, Eugen Boltshauser
There are no approved disease-modifying therapies for any of the inherited cerebellar ataxias. Drug treatment in childhood ataxia is still very limited. Effective treatments are available for only a few rare metabolic hereditary disorders. Symptomatic management of associated tremor, spasticity, dystonia, or chorea can follow the medication recommendations in general usage. The foundation of management of cerebellar ataxia in adults or children remains rehabilitation.
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29891065/cerebellar-mutism-syndrome
#4
Coriene Catsman-Berrevoets, Zoltan Patay
Cerebellar mutism most commonly, but not exclusively, develops in children after surgery for midline cerebellar or intraventricular tumors in the posterior fossa, typically medulloblastoma. Cerebellar mutism syndrome (CMS) comprises a complex set of neurologic and neurocognitive signs and symptoms, the cardinal and central component of which is an initially profound but usually reversible speech disorder. As such, CMS is currently recognized as an extreme form of the so-called cerebellar cognitive affective syndrome (Schmahmann syndrome)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29797226/short-term-effects-of-cerebellar-tdcs-on-standing-balance-performance-in-patients-with-chronic-stroke-and-healthy-age-matched-elderly
#5
Sarah B Zandvliet, Carel G M Meskers, Gert Kwakkel, Erwin E H van Wegen
Transcranial direct current stimulation (tDCS) may serve as an adjunct approach in stroke rehabilitation. The cerebellum could be a target during standing balance training due to its role in motor adaptation. We tested whether cerebellar tDCS can lead to short-term effects on standing balance performance in patients with chronic stroke. Fifteen patients with a chronic stroke were stimulated with anodal stimulation on the contra-lesional cerebellar hemisphere, ipsi-lesional cerebellar hemisphere, or sham stimulation, for 20 min with 1...
May 24, 2018: Cerebellum
https://www.readbyqxmd.com/read/29718002/vertebral-artery-dissection-masquerading-as-concussion-in-an-adolescent
#6
Gogi Kumar, Bryan Ludwig, Vipul V Patel
OBJECTIVE: Educate providers about the clinical presentation and consequences of delaying diagnosis of traumatic vertebral artery dissection with thromboembolic ischemic strokes in the pediatric population. Vertebral artery dissection is often difficult to diagnose and can be a potentially devastating cause of ischemic stroke. METHODS: Review of the chart, peer review/discussion, and imaging interpretation. RESULTS: A 16-year-old boy was admitted with confusion after a head and neck trauma was sustained while wrestling...
May 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29656311/consensus-paper-neurophysiological-assessments-of-ataxias-in-daily-practice
#7
REVIEW
W Ilg, M Branscheidt, A Butala, P Celnik, L de Paola, F B Horak, L Schöls, H A G Teive, A P Vogel, D S Zee, D Timmann
The purpose of this consensus paper is to review electrophysiological abnormalities and to provide a guideline of neurophysiological assessments in cerebellar ataxias. All authors agree that standard electrophysiological methods should be systematically applied in all cases of ataxia to reveal accompanying peripheral neuropathy, the involvement of the dorsal columns, pyramidal tracts and the brainstem. Electroencephalography should also be considered, although findings are frequently non-specific. Electrophysiology helps define the neuronal systems affected by the disease in an individual patient and to understand the phenotypes of the different types of ataxia on a more general level...
April 14, 2018: Cerebellum
https://www.readbyqxmd.com/read/29649992/protocol-for-promoting-recovery-optimization-of-walking-activity-in-stroke-prowalks-a-randomized-controlled-trial
#8
Henry Wright, Tamara Wright, Ryan T Pohlig, Scott E Kasner, Jonathan Raser-Schramm, Darcy Reisman
BACKGROUND: Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothesize that the combination of a fast walking intervention that improves walking capacity, with a step activity monitoring program that facilitates translation of gains from the clinic to the "real-world", would generate greater improvements in real world walking activity than with either intervention alone...
April 12, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29623858/cognitive-rehabilitation-of-cerebellar-deficits
#9
Hiroshi Mitoma, Peter Marien, Kim van Dun, Frank Van Overwalle, Mario Manto
During the past 3 decades numerous neurophysiological, neuroimaging, experimental and clinical studies have evidenced a crucial role for the cerebellum in cognitive, affective and behavioral functions. As a result of the acknowledged modulatory role of the cerebellum upon remote structures such as the cerebral cortex, cerebellar injury may give rise to a constellation of behavioral, affective and cognitive symptoms (Schmahmann's Syndrome). In sharp contrast to the wide range of therapeutic interventions to treat cognitive and affective disorders following cerebral cortical lesions and despite the consequences of Schmahmann's syndrome upon daily life activities, the literature is surprisingly only scantly documented with studies investigating the impact of cognitive therapies on cerebellar induced cognitive and affective disorders...
April 3, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29601222/effects-of-dance-based-movement-therapy-on-balance-gait-and-psychological-functions-in-severe-cerebellar-ataxia-a-case-study
#10
Yong-Gwan Song, Young-Uk Ryu, Seung-Jin Im, Ye-Seung Lee, Jin-Hoon Park
PURPOSE: Individuals in the later stages of cerebellar ataxia usually experience serious balance and immobility problems. Currently, there is a lack of adequate rehabilitative programs for individuals with severe cerebellar ataxia that can help improve ataxia-related motor impairment. The purpose of the present study was to explore the potential physiotherapeutic benefits of partnered dance on balance, motor functions, and psychological well-being in an individual demonstrating severe cerebellar ataxia symptoms...
March 30, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29588240/superficial-temporal-artery-superior-cerebellar-artery-bypass-with-anterior-petrosectomy
#11
Masaaki Hokari, Katsuyuki Asaoka, Daisuke Shimbo, Kazuki Uchida, Koji Itamoto
BACKGROUND: Superficial temporal artery (STA) to superior cerebellar artery (SCA) bypass is associated with a relatively high risk of surgical complications, such as hematoma and/or edema caused by temporal lobe retraction. Therefore, the right side is typically used to avoid retraction of the left temporal lobe. In this report, we present a case of left STA-SCA bypass with anterior petrosectomy to avoid retraction of dominant-side temporal lobe and describe the surgical technique in detail...
June 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29556411/the-combined-effect-of-cranial-nerve-non-invasive-neuromodulation-with-high-intensity-physiotherapy-on-gait-and-balance-in-a-patient-with-cerebellar-degeneration-a-case-report
#12
Andisheh Bastani, L Eduardo Cofré Lizama, Maryam Zoghi, Grant Blashki, Stephen Davis, Andrew H Kaye, Fary Khan, Mary P Galea
Background: Cranial-nerve non-invasive neuromodulation (CN-NINM) using the portable neuromodulation stimulator (PoNS™) device has been proposed as a novel adjuvant intervention to improve efficacy of gait and balance. This device modulates input and output signals during motor tasks which prompts neuroplastic changes. In this study, we investigated the efficacy of physiotherapy using the PoNS™ in a case with cerebellar degeneration. Case presentation: The PoNS™ was used during a high-intensity physiotherapy programme delivered over 2 weeks (2 × 1...
2018: Cerebellum & Ataxias
https://www.readbyqxmd.com/read/29540894/evidence-of-cognitive-flexibility-deficits-and-impaired-emotion-regulation-in-childhood-survivors-of-acute-lymphoblastic-leukaemia-findings-from-task-switching-study
#13
Amara Gul, Sadia Zafar
The objective of the current study was to compare cognitive flexibility and emotion regulation between childhood survivors of Acute Lymphoblastic Leukaemia (ALL) and healthy control subjects. Twenty-five childhood survivors of ALL treated with intrathecal chemotherapy between 2013 to 2016 from Shaukat Khanum Memorial Cancer Hospital, Children Hospital and Jinnah Hospital Lahore and twenty-five healthy demographically matched children (control group) participated in the study. Participants performed task switching experiment as a measure of cognitive flexibility and emotion regulation questionnaire for children and adolescents...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29500687/the-use-of-goal-attainment-scaling-gas-in-the-rehabilitation-of-ataxic-patients
#14
Ender Ayvat, Özge Onursal Kılınç, Fatma Ayvat, Gülşah Sütçü, Muhammed Kılınç, Songül Aksoy, Sibel Aksu Yıldırım
The aim of this study was to formulate an exercise program according to GAS, an approach that reflects the patients' point of view and expectations and investigate the effects of this program in ataxia rehabilitation. This study was designed as an assessor-blinded, single-group trial, and 24 patients with cerebellar ataxia were included. Treatment goals, postural control, disease severity, and daily living activities were assessed pre- and post-treatment using the Goal Attainment Scaling (GAS), the Sensory Organization Test (SOT), the International Cooperative Ataxia Rating Scale (ICARS), and the Barthel Index (BI), respectively...
May 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29468104/cerebellar-stroke-occupational-therapy-and-physical-therapy-management-from-intensive-care-unit-to-outpatient-a-case-report
#15
Christopher M Wilson, Christina L Mitchell, Katherine M Hebert
Cerebellar stroke increases the risk of extensive physical disability and long-term institutionalization. The purpose of this case report is to describe the 14-month longitudinal rehabilitation management and outcomes from the intensive care unit, inpatient rehabilitation unit and outpatient care of a patient after cerebellar stroke. A goal of this case report is to provide rehabilitation clinicians with a long-term perspective and understanding of the course of recovery for a patient after cerebellar cerebrovascular accident or related injury...
December 14, 2017: Curēus
https://www.readbyqxmd.com/read/29465035/-insufficient-ct-scan-in-visualizing-an-intracerebral-parenchymal-damage-in-a-six-month-old-boy
#16
Louise Kollander Jakobsen, Jacob Madsen, Maria Terase F Simonsen, Søren Kjærgaard
A six-month-old boy fell over, and a crochet hook penetrated his skin underneath his left eye. The hook was removed, and an emergency physician found a Glasgow Coma Scale score of 6-7. A CT scan showed no cerebral or ophthalmic injury. However, the patient was persistently apathic with head- and gaze direction towards the left and a facial nerve palsy. An MRI showed a linear intracerebral lesion stretching through pons into the cerebellar vermis. The patient had neuropaediatric rehabilitation and recovered fully within months...
February 12, 2018: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/29449518/-the-efficacy-of-percutaneous-transluminal-angioplasty-and-stenting-for-traumatic-vertebral-artery-dissection-due-to-cervical-vertebral-fracture
#17
Misato Kawaguchi, Kouhei Nii, Kimiya Sakamoto, Kanae Kawahara, Ritsurou Inoue, Fumihiro Hiraoka, Yusuke Morinaga, Takafumi Mitsutake, Hayatsura Hanada, Masanori Tsutsumi
A 73-year-old man was admitted at another hospital after a traffic accident. The diagnosis was cervical vertebral fracture. Despite conservative treatment, 5 days later he manifested dysarthria due to cerebellar infarction and was transferred to our hospital. Imaging studies revealed right vertebral arterial dissection at the level of the axial fracture. We performed percutaneous transluminal angioplasty with stenting to address his subacute vertebral artery dissection prior to treating the cervical vertebral fracture using external fixation...
February 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29440566/comprehensive-systematic-review-summary-treatment-of-cerebellar-motor-dysfunction-and-ataxia-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#18
Theresa A Zesiewicz, George Wilmot, Sheng-Han Kuo, Susan Perlman, Patricia E Greenstein, Sarah H Ying, Tetsuo Ashizawa, S H Subramony, Jeremy D Schmahmann, K P Figueroa, Hidehiro Mizusawa, Ludger Schöls, Jessica D Shaw, Richard M Dubinsky, Melissa J Armstrong, Gary S Gronseth, Kelly L Sullivan
OBJECTIVE: To systematically review evidence regarding ataxia treatment. METHODS: A comprehensive systematic review was performed according to American Academy of Neurology methodology. CONCLUSIONS: For patients with episodic ataxia type 2, 4-aminopyridine 15 mg/d probably reduces ataxia attack frequency over 3 months (1 Class I study). For patients with ataxia of mixed etiology, riluzole probably improves ataxia signs at 8 weeks (1 Class I study)...
March 6, 2018: Neurology
https://www.readbyqxmd.com/read/29425940/rehabilitation-course-and-specification-of-dysmetria-of-a-patient-with-ataxia-dysmetria-and-hemiparesis-after-a-stroke-in-the-corona-radiata-a-case-presentation
#19
Monir Mohar, Kosandra Hartman, Bronwyn Long, Peter Lee, Adrian Didita, Eric L Altschuler
We present a case of a patient with ataxia, dysmetria, and hemiparesis after a stroke in the corona radiata. The patient had an excellent clinical course with near resolution of symptoms in 2 and a half weeks and returned and back to work full duty and full time a couple of weeks later. We use a video of several neurologic tests to demonstrate and characterize the dysmetria. Interestingly, a key characteristic of the dysmetria appears to be different from that seen in patients with dysmetria arising from a cerebellar, thalamic, or pontine lesion...
February 6, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29400912/classic-block-design-pseudo-resting-state-fmri-changes-after-a-neurorehabilitation-program-in-patients-with-multiple-sclerosis
#20
Deborah Pareto, Jaume Sastre-Garriga, Juli Alonso, Ingrid Galán, Maria Jesus Arévalo, Marta Renom, Xavier Montalban, Àlex Rovira
BACKGROUND AND PURPOSE: The goal of this study was to assess changes in the resting-state networks (RSNs) of patients with multiple sclerosis (MS) after a cognitive rehabilitation program (CRP), by retrospectively analyzing functional magnetic resonance imaging (fMRI) studies using the classical block design. METHODS: Fifteen patients with MS (2 primary progressive, 3 relapsing-remitting, 10 secondary progressive) were scanned before and after the CRP on a 1.5T MRI scanner...
February 5, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
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