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https://www.readbyqxmd.com/read/29656208/akt-mtor-and-nf-%C3%AE%C2%BAb-pathway-activation-in-treponema-pallidum-stimulates-m1-macrophages
#1
Li-Rong Lin, Zheng-Xiang Gao, Yong Lin, Xiao-Zhen Zhu, Wei Liu, Dan Liu, Kun Gao, Man-Li Tong, Hui-Lin Zhang, Li-Li Liu, Yao Xiao, Jian-Jun Niu, Fan Liu, Tian-Ci Yang
The polarization of macrophages and the molecular mechanism involved during the early process of syphilis infection remain unknown. This study was conducted to explore the influence of Treponema pallidum (T. pallidum) treatment on macrophage polarization and the Akt-mTOR-NFκB signaling pathway mechanism involved in this process. M0 macrophages derived from the phorbol-12-myristate-13-acetate-induced human acute monocytic leukemia cell line THP-1 were cultured with T. pallidum. T. pallidum induced inflammatory cytokine (IL-1β and TNF-α) expression in a dose- and time-dependent manner...
April 12, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29655978/sitagliptin-prevents-isoproterenol-induced-myocardial-infarction-in-rats-by-modulating-nitric-oxide-synthase-enzymes
#2
Mohamed Abdellah Ibrahim, Ayman Geddawy, Soha Abdel-Wahab
Ischemic heart disease is a common cause of mortality worldwide. Sitagliptin is a new anti-diabetic drug acting as dipeptidyl peptidase-4 (DPP-4) inhibitor. The study investigated the ability of sitagliptin to prevent pathological changes of isoproterenol- (ISO-) induced myocardial injury in rats. The role of nitric oxide (NO) was also reported. Rats were assorted into six groups (n = 7) and treated for 12 days. Group 1: normal control, received normal saline. Group 2, sitagliptin control, received sitagliptin (10mg/kg, orally)...
April 12, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29655912/argemone-oil-an-edible-oil-adulterant-induces-systemic-immunosuppression-in-balb-c-mice-in-an-oral-28-days-repeated-dose-toxicity-study
#3
Payal Mandal, Prachi Tewari, Sachin Kumar, Sarika Yadav, Anjaneya Ayanur, Rajnish K Chaturvedi, Mukul Das, Anurag Tripathi
Consumption of edible oils contaminated with Argemone oil (AO) leads to a clinical condition called "Epidemic dropsy". Earlier studies have reported that metabolism and oxidative stress primarily contributes to AO toxicity, however, the involvement of immune system has not been assessed so far. Therefore, the present study was undertaken to systematically assess the effect of AO exposure on the function of immune system in Balb/c mice. The repeated exposure of AO for 28 days caused prominent regression of spleen and thymus; severe inflammatory changes in spleen depicted by the loss of distinct follicles, increased megakaryocyte infiltration, and enhanced expression levels of inflammatory markers (iNOS & COX-2)...
April 12, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29655681/anti-inflammatory-activity-of-khayandirobilide-a-from-khaya-senegalensis-via-nf-%C3%AE%C2%BAb-ap-1-and-p38-mapk-nrf2-ho-1-signaling-pathways-in-lipopolysaccharide-stimulated-raw-264-7-and-bv-2-cells
#4
Miao-Miao Zhou, Wen-Yan Zhang, Rui-Jun Li, Chao Guo, Shan-Shan Wei, Xiao-Meng Tian, Jun Luo, Ling-Yi Kong
BACKGROUND: Immunocytes-involved inflammation is considered to modulate the damage in various diseases. Herein, novel therapeutics suppressing over-activation of immunocytes could prove an effective strategy to prevent inflammation-related diseases. PURPOSE: The objective of this study is to evaluate the anti-inflammatory activity of Khayandirobilide A (KLA), a new andirobin-type limonoid with modified furan ring isolated from the Khaya senegalensis (Desr.) A. Juss...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655568/luteolin-attenuates-acute-lung-injury-in-experimental-mouse-model-of-sepsis
#5
Soya Rungsung, Thakur Uttam Singh, Dipankar Jyoti Rabha, Tarun Kumar, Madhu Cholenahalli Lingaraju, Subhashree Parida, Avishek Paul, Monalisa Sahoo, Dinesh Kumar
The present investigation was undertaken to assess the result of pretreatment of luteolin in sepsis-induced acute lung injury in mice and its mechanism of action. Luteolin was administered intraperitoneally one hour before caecal ligation and puncture (CLP) surgery in mice. Acute lung injury was assessed by estimation of different parameters like lung edema, protein content, cytokines level, oxidative stress, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule (ICAM)-1 expression and histopathology...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29653462/docosahexaenoic-acid-reversed-atherosclerotic-changes-in-human-endothelial-cells-induced-by-palmitic-acid-in-vitro
#6
Saeede Karbasforush, Alireza Nourazarian, Masoud Darabi, Reza Rahbarghazi, Fatemeh Khaki-Khatibi, Çıgır Biray Avci, Leila Salimi, Bakiye Goker Bagca, Tanaz Novin Bahador, Aysa Rezabakhsh, Majid Khaksar
Abnormal activity of atherosclerotic endothelial cells paving luminal surface of blood vessels has been described in many diseases. It has been reported that natural polyunsaturated fatty acids such as docosahexaenoic acid exert therapeutic effects in atherosclerotic condition. Human umbilical vein endothelial cells were treated with 1mM palmitic acid for 48 hours and exposed to 40μM docosahexaenoic acid for the next 24 hours. Real-time polymerase chain reaction analysis was used to measure the expression of PTX3, iNOS, and eNOS...
April 13, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29653184/estrogen-alleviates-neuropathic-pain-induced-after-spinal-cord-injury-by-inhibiting-microglia-and-astrocyte-activation
#7
Jee Youn Lee, Hae Young Choi, Bong Gun Ju, Tae Young Yune
Neuropathic pain after spinal cord injury (SCI) is developed in about 80% of SCI patients and there is no efficient therapeutic drug to alleviate SCI-induced neuropathic pain. Here we examined the effect of estrogen on SCI-induced neuropathic pain at below-level and its effect on neuroinflammation as underlying mechanisms. Neuropathic pain is developed at late phase after SCI and a single dose of 17β-estradiol (100, 300 μg/kg) were administered to rats with neuropathic pain after SCI through intravenous injection...
April 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29651892/the-intracerebral-hemorrhage-blood-transcriptome-in-humans-differs-from-the-ischemic-stroke-and-vascular-risk-factor-control-blood-transcriptomes
#8
Boryana Stamova, Bradley P Ander, Glen Jickling, Farah Hamade, Marc Durocher, Xinhua Zhan, Da Zhi Liu, Xiyuan Cheng, Heather Hull, Alan Yee, Kwan Ng, Natasha Shroff, Frank R Sharp
Understanding how the blood transcriptome of human intracerebral hemorrhage (ICH) differs from ischemic stroke (IS) and matched controls (CTRL) will improve understanding of immune and coagulation pathways in both disorders. This study examined RNA from 99 human whole-blood samples using GeneChip® HTA 2.0 arrays to assess differentially expressed transcripts of alternatively spliced genes between ICH, IS and CTRL. We used a mixed regression model with FDR-corrected p(Dx) < 0.2 and p < 0.005 and |FC| > 1...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29651204/ameliorative-effects-of-allium-sativum-extract-on-inos-gene-expression-and-no-production-in-liver-of-streptozotocin-nicotinamide-induced-diabetic-rats
#9
Nasrin Ziamajidi, Hamid Behrouj, Roghayeh Abbasalipourkabir, Fatemeh Lotfi
Diabetes mellitus (DM) is one of the most prevalent diseases in the world, which is strongly associated with liver dysfunction. Hyperglycemia, through an oxidative stress pathway, damages various tissues. Herbal medicine is a good candidate to ameliorate hyperglycemia and oxidative stress. In this study, the effects of aqueous Allium sativum (garlic) extract (AGE) on gene expression of inducible nitric oxide synthases (iNOS) and production of nitric oxide (NO) were evaluated in the liver tissue of diabetic rats...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29649568/honokiol-alleviates-the-degeneration-of-intervertebral-disc-via-suppressing-the-activation-of-txnip-nlrp3-inflammasome-signal-pathway
#10
Pan Tang, Jia-Ming Gu, Zi-Ang Xie, Yu Gu, Zhi-Wei Jie, Kang-Mao Huang, Ji-Ying Wang, Shun-Wu Fan, Xue-Sheng Jiang, Zhi-Jun Hu
Intervertebral disc degeneration (IVDD) is a multifactorial disease and responsible for many spine related disorders, causes disability in the workforce and heavy social costs all over the world. Honokiol, a low molecular weight natural product, could penetrate into and distribute in IVDs to achieve therapeutic effect in a rat tail model. Therefore, the present study was undertaken to examine the antiinflammatory, antioxidation and chondroprotective effect of honokiol using nucleus pulposus cells and investigate its mechanisms to provide a new basis for future clinical treatment of IVDD...
April 9, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29649522/triptolide-up-regulates-metabotropic-glutamate-receptor-5-to-inhibit-microglia-activation-in-the-lipopolysaccharide-induced-model-of-parkinson-s-disease
#11
Yi-Ying Huang, Qian Zhang, Jian-Nan Zhang, Ya-Nan Zhang, Li Gu, Hui-Min Yang, Ning Xia, Xiao-Min Wang, Hong Zhang
Metabotropic glutamate receptor (mGlu)5 regulates microglia activation, which contributes to inflammation. However, the role of mGlu5 in neuroinflammation associated with Parkinson's disease (PD) remains unclear. Triptolide (T10) exerts potent immunosuppressive and anti-inflammatory effects and protects neurons by inhibiting microglia activation. In this study, we investigated the role of mGlu5 in the anti-inflammatory effect of T10 in a lipopolysaccharide (LPS)-induced PD model. In cultured BV2 cells and primary microglia, blocking mGlu5 activity or knocking down its expression abolished T10-inhibited release of proinflammatory cytokines induced by LPS...
April 9, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29645094/leishmania-amazonensis-downregulates-macrophage-inos-expression-via-histone-deacetylase-1-hdac1-a-novel-parasite-evasion-mechanism
#12
Teresa C Calegari-Silva, Áislan C Vivarini, Renata de M S Pereira, Karina L Dias-Teixeira, Carolina T Rath, Amanda S S Pacheco, Gabrielle B L Silva, Charlene A S Pinto, José V Dos Santos, Alessandra M Saliba, Carlos E P Corbett, Claudia M de Castro Gomes, Nicolas Fasel, Ulisses G Lopes
The induced expression of nitric oxide synthase (iNOS) controls the intracellular growth of Leishmania in infected macrophages. Histones deacetylases (HDACs) negatively regulate gene expression through the formation of complexes containing transcription factors such as NF-κB p50/50. Herein, we demonstrated the occupancy of p50/p50_HDAC1 to iNOS promoter associated with reduced levels of H3K9Ac. Remarkably, we found increased levels of HDAC1 in L. amazonensis-infected macrophages. HDAC1 upregulation was not found in L...
April 12, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29644482/metabolic-syndrome-and-the-decreased-levels-of-uric-acid-by-leflunomide-favor-redox-imbalance-in-patients-with-rheumatoid-arthritis
#13
Neide Tomimura Costa, Bruna Miglioranza Scavuzzi, Tatiana Mayumi Veiga Iriyoda, Marcell Alysson Batisti Lozovoy, Daniela Frizon Alfieri, Fabiano Aparecido de Medeiros, Marcelo Cândido de Sá, Pâmela Lonardoni Micheletti, Bruno Alexandre Sekiguchi, Edna Maria Vissoci Reiche, Michael Maes, Andréa Name Colado Simão, Isaias Dichi
Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP)...
April 11, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29643028/-chrysin-inhibits-lipopolysaccharide-induced-inflammatory-responses-of-macrophages-via-jak-stats-signaling-pathway
#14
Shi-Mei Qi, Qiang Li, Qi Jiang, Zhi-Lin Qi, Yao Zhang
OBJECTIVE: To investigate the mechanism of chrysin in regulating lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. METHODS: RAW264.7 cells were treated with different concentrations (0, 5, 10, 20, 40, 60, 80, 100, 150, and 200 µg/mL) of chrysin for 24 h, and the cell viability was measured using CCK-8. RAW264.7 cells were pre-treated with 10, 30, or 60 µg/mL chrysin for 2 h before stimulation with LPS for different times. The levels of TNF-α, IL-6 and MCP-1 were detected by ELISA, and Western blotting was used to detect the phosphorylation of JAK- 1, JAK-2, STAT-1 and STAT-3...
March 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29642726/donkey-milk-kefir-induces-apoptosis-and-suppresses-proliferation-of-ehrlich-ascites-carcinoma-by-decreasing-inos-in-mice
#15
Obb Esener, B M Balkan, E I Armutak, A Uvez, G Yildiz, M Hafizoglu, N Yilmazer, E Gurel-Gurevin
Donkey milk and donkey milk kefir exhibit antiproliferative, antimutagenic and antibacterial effects. We investigated the effects of donkey milk and donkey milk kefir on oxidative stress, apoptosis and proliferation in Ehrlich ascites carcinoma (EAC) in mice. Thirty-four adult male Swiss albino mice were divided into four groups as follows: group 1, administered 0.5 ml water; group 2, administered 0.5 ml water + EAC cells; group 3, administered 0.5 ml donkey milk + EAC cells; group 4, administered 0.5 ml donkey milk kefir + EAC cells...
April 12, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29627876/naringin-attenuates-cerebral-ischemia-reperfusion-injury-through-inhibiting-peroxynitrite-mediated-mitophagy-activation
#16
Jinghan Feng, Xingmiao Chen, Shengwen Lu, Wenting Li, Dan Yang, Weiwei Su, Xijun Wang, Jiangang Shen
Excessive autophagy/mitophagy plays important roles during cerebral ischemia-reperfusion (I/R) injury. Peroxynitrite (ONOO- ), a representative reactive nitrogen species, mediates excessive mitophagy activation and exacerbates cerebral I/R injury. In the present study, we tested the hypothesis that naringin, a natural antioxidant, could inhibit ONOO- -mediated mitophagy activation and attenuate cerebral I/R injury. Firstly, we demonstrated that naringin possessed strong ONOO- scavenging capability and also inhibited the production of superoxide and nitric oxide in SH-SY5Y cells exposed to 10 h oxygen-glucose-deprivation plus 14 h of reoxygenation or ONOO- donor 3-morpholinosydnonimine conditions...
April 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29626798/synthesis-and-biological-evaluation-of-clovamide-analogues-as-potent-anti-neuroinflammatory-agents-in-vitro-and-in-vivo
#17
Xiao-Long Hu, Jun Lin, Xian-Yu Lv, Jia-Hao Feng, Xiao-Qi Zhang, Hao Wang, Wen-Cai Ye
A series of clovamide analogues, namely, 1a-13a and 1b-13b, was synthesized and evaluated for their anti-neuroinflammatory activities using BV-2 microglia cells. Among these compounds, six (1b, 4b-8b) showed NO inhibition with no or weak cytotoxicity (CC50  > 100 μM), especially 4b, and showed an IC50 value of 2.67 μM. Enzyme activity and docking assay revealed that the six compounds, especially 4b, target inducible NO synthase (iNOS) and exhibit potent inhibitory effects on iNOS with IC50 values ranging from 1...
April 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29626672/the-suppressive-effects-of-vochysia-divergens-aqueous-leaf-extract-and-its-5-methoxyflavone-on-murine-macrophages-and-lymphocytes
#18
Maria Fernanda Paresqui Corrêa, Thatiana Lopes Biá Ventura, Michelle Frazão Muzitano, Elaine Dos Anjos da Cruz, Maria Camilla Bergonzi, Anna Rita Bilia, Bartira Rossi-Bergmann, Sônia Soares Costa
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf infusion from the tree Vochysia divergens Pohl (Vochysiaceae), known as "cambará", is used in Brazilian popular medicine against respiratory infections and asthma. AIM OF THE STUDY: To evaluate the health-beneficial effects related to the ethnomedicinal uses of V. divergens (Vd), a biomonitored fractionation of an aqueous leaf extract was carried out. MATERIALS AND METHODS: Leaves were extracted by decoction with distilled water, and the extract fractionated by a combination of separation techniques including precipitation, organic partition and chromatography...
April 4, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29626669/the-effects-of-feeding-lactobacillus-pentosus-on-growth-immunity-and-disease-resistance-in-haliotis-discus-hannai-ino
#19
Gao Xiaolong, Zhang Mo, Li Xian, Han Yin, Wu Fucun, Liu Ying
To study the effects of probiotic-added food on the survival and growth of abalone (Haliotis discus hannai Ino), the expression levels of nonspecific immune genes and the anti-Vibrio parahaemolyticus infection were examined. During an 8-week culturing experiment in an indoor aquarium and a 2-week V. parahaemolyticus artificial infection experiment, the control group was fed with untreated food once a day, while the experimental groups (L1, L2 and L3) were fed with Lactobacillus pentosus added food. The concentration of probiotics in the experimental food was 103  cfu/g (L1), 105  cfu/g (L2) and 107  cfu/g (L3), respectively...
April 4, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29625194/titanium-dioxide-nanoparticle-stimulating-pro-inflammatory-responses-in-vitro-and-in-vivo-for-inhibited-cancer-metastasis
#20
Fenghui Zhao, Chengcheng Wang, Qiaolei Yang, Shuhong Han, Qinglian Hu, Zhengwei Fu
AIMS: The interaction of engineered nanoparticles (NPs) with the immune system and the possibility of inflammation induction are of particularly interest. Titanium dioxide nanoparticles (TiO2 NPs) are one of the most popular manufactured nanomaterials. In this study, we focused on the immune-modulatory effect of commercial P-25 TiO2 NPs in vivo and in vitro and their crucial role in cancer metastasis. MAIN METHODS: The female C57BL/6 mice were injected into abdominal cavity with PBS or P-25 TiO2 to investigate the immune-modulatory function of P-25...
April 3, 2018: Life Sciences
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