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Neurogenic bladder

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https://www.readbyqxmd.com/read/29473309/efficacy-of-mirabegron-for-overactive-bladder-with-human-t-cell-lymphotropic-virus-1-associated-myelopathy
#1
Tomohiro Matsuo, Yasuyoshi Miyata, Tatsufumi Nakamura, Katsuya Satoh, Hideki Sakai
OBJECTIVE: Mirabegron is widely considered as an effective and safe drug for patients with overactive bladder (OAB). However, there is no evidence regarding the efficacy of mirabegron in human T cell lymphotropic virus-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients with OAB symptoms. The aim of the present study was to clarify the efficacy of mirabegron in HAM/TSP patients with OAB symptoms. METHODS: The present study evaluated the efficacy of mirabegron treatment (50 mg, once daily) in nineteen HAM/TSP patients with OAB symptoms by assessing subjective symptoms using the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) before and 12 weeks after administration...
February 22, 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29470276/anatomical-feasibility-of-extradural-transferring-s2-and-s3-ventral-roots-to-s1-ventral-root-for-restoring-neurogenic-bladder-in-spinal-cord-injury
#2
Kaixiang Yang, Hongtao Chen, Jian Tang, Dawei Ge, Sheng Zhang, Tao Sui, Xiaojian Cao
STUDY DESIGN: Anatomic study in 6 formalin-fixed cadavers. OBJECTIVE: To determine the anatomical feasibility of transferring the S2 and S3 ventral roots (VRs) to S1 VR as a method for restoring bladder dysfunction in spinal cord injury. SUMMARY OF BACKGROUND DATA: A large quantity of researches of neuroanastomosis methods have been used for treating the bladder dysfunction in spinal cord injury (SCI). However, some limitations retard the development of those studies...
February 21, 2018: Spine
https://www.readbyqxmd.com/read/29465789/a-real-world-experience-with-augmentation-enterocystoplasty-high-patient-satisfaction-with-high-complication-rates
#3
Shu-Yu Wu, Hann-Chorng Kuo
AIMS: To investigate the real treatment outcomes after augmentation enterocystoplasty (AE) of patients with refractory neurogenic lower urinary tract dysfunction. METHODS: Retrospective follow-up in a single center. The videourodynamic data, renal function, incontinence grade, voiding pattern and management, clinical outcome, and complications were evaluated. RESULTS: Seventy-nine patients (62 men and 17 women) were included. The mean age at operation was 39...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29465304/a-mapp-network-study-overexpression-of-tumor-necrosis-factor-%C3%AE-in-mouse-urothelium-mimics-interstitial-cystitis
#4
Wenbin Yang, Timothy J Searl, Ryan E Yaggie, Anthony J Schaeffer, David J Klumpp
Interstitial cystitis/ bladder pain syndrome (IC/BPS) is a chronic bladder condition associated with pain and voiding dysfunction that is often regarded as a neurogenic cystitis. Patient symptoms are correlated with the presence of urothelial lesions. We previously characterized a murine neurogenic cystitis model that recapitulates mast cell accumulation and urothelial lesions, and these events were dependent upon TNF. To further explore the role of TNF in bladder inflammation and function, we generated a transgenic mouse model with chronic TNF overexpression in urothelium under the control of the uroplakin II (UPII) promoter...
February 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29464756/impact-on-quality-of-life-and-sexual-satisfaction-of-continent-cystostomy-with-enterocystoplasty-in-an-adult-neurologic-population
#5
Ornella Lam Van Ba, Laurent Soustelle, Laurent Wagner, Nicolas Siegler, Michel Boukaram, Kamel Ben Naoum, Stéphane Droupy, Armand Chevrot, Pierre Costa
AIMS: To evaluate long-term general and urinary quality of life (QOL) and sexual satisfaction in adult neurologic patients undergoing continent cystostomy surgery associated with a bladder enlargement to treat neurogenic lower urinary tract dysfunction. METHODS: Monocentre, retrospective series of adult neurologic patients who underwent continent cystostomy with bladder enlargement and followed-up in the long-term. We assessed during follow-up, urinary and renal function and patients filled QOL questionnaires on general QOL, sexuality and urinary (short form Qualiveen) disability...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29458282/cost-effectiveness-of-hydrophilic-coated-intermittent-catheters-compared-with-uncoated-catheters-in-canada-a-public-payer-perspective
#6
Blayne Welk, Wanrudee Isaranuwatchai, Andrei Krassioukov, Louise Husted Torp, Dean Elterman
STUDY DESIGN: A Markov model was used to analyze cost-effectiveness over a lifetime horizon. OBJECTIVE: To investigate the cost-effectiveness of hydrophilic-coated intermittent catheters (HCICs) compared with uncoated catheters (UCs) among individuals with neurogenic bladder dysfunction (NB) due to spinal cord injury (SCI). SETTING: A Canadian public payer perspective based on data from Ontario; including a scenario analysis from the societal perspective...
February 20, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29458265/clean-intermittent-catheterization-rates-after-initial-and-subsequent-treatments-with-onabotulinumtoxina-for-non-neurogenic-overactive-bladder-in-real-world-clinical-settings
#7
Michael Kennelly, Lonny Green, Nancy Alvandi, Salim Wehbe, John Joseph Smith, Scott MacDiarmid, Jeffrey Mangel, Marc Schwartz, Tamer Aboushwareb, Brian Murray
OBJECTIVE: Previous randomized controlled trials have reported a 6.1-6.9% incidence of clean intermittent catheterization (CIC) following treatment with onabotulinumtoxinA in non-neurogenic overactive bladder (OAB) patients who were inadequately managed by ≥1 anticholinergic. A multi-center retrospective chart review assessed the real-world rate of voiding dysfunction requiring catheterization. METHODS: Patients received onabotulinumtoxinA 100U (approved dose) administered by experienced injectors between January 2013 and June 2015...
February 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#8
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29449969/stigma-and-self-management-an-interpretative-phenomenological-analysis-of-the-impact-of-chronic-recurrent-urinary-tract-infections-after-spinal-cord-injury
#9
Jasmine Heath Hearn, Sen Selvarajah, Paul Kennedy, Julian Taylor
Study Design: Qualitative, phenomenological design. Objectives: Neurogenic bladder dysfunction and urinary tract infection (UTI) are common secondary consequences to neurological damage to the spinal cord. This study sought to establish the impact of chronic, recurrent UTIs on people with spinal cord injury (SCI). Setting: Community sample, United Kingdom. Methods: Twelve participants with SCI, aged between 28 and 68 years, who had experienced at least three recurrent UTI events within the previous 12 months were recruited...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29441610/a-cross-sectional-single-institution-study-of-quality-of-life-in-adult-patients-with-spina-bifida
#10
Caitlin T Coco, Bhalaajee Meenakshi-Sundaram, Ahmed Eldefrawy, Millard L Henry, Tanya Watts, Christopher E Aston, Jennifer Lewis, Dominic C Frimberger, Gennady Slobodov
OBJECTIVE: To describe and compare differences in perception of independence, urinary continence, and quality of life in an adult spina bifida (SB) population. METHODS: We collected data on adult neurogenic bladder patients which included demographics, relevant procedures, and quality of life (QoL) questionnaires. QoL and functional outcomes were assessed using spinal cord independence measure (SCIM) and SF-8 health questionnaire. International consultation of incontinence questionnaire (ICIQ) was used to assess incontinence...
February 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29436607/decreased-hyperpolarization-activated-cyclic-nucleotide-gated-channels-are-involved-in-bladder-dysfunction-associated-with-spinal-cord-injury
#11
Qian Liu, Chao Wu, Shengquan Huang, Qingjian Wu, Tao Zhou, Xiaobing Liu, Xin Liu, Xiaoyan Hu, Longkun Li
Spinal cord injury (SCI) leads to bereft voluntary control of bladder, but the possible role of spontaneous excited system in bladder of SCI patients is poorly understood. Hyper-polarization-activated cyclic nucleotide-gated (HCN) channels are deemed to regulate the spontaneous contraction of bladder, our study explored the functional role of HCN channels in SCI induced neurogenic bladder. Sixty female Sprague-Dawley rats were randomized into control, sham and SCI groups. Rat models subjected to SCI at S2 levels were successfully established and were assessed using hematoxylin and eosin staining and cystometry...
February 13, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29427331/the-role-of-the-mucosa-in-modulation-of-evoked-responses-in-the-spinal-cord-injured-rat-bladder
#12
Claire Doyle, Vivian Cristofaro, Bryan S Sack, Fabliha Mahmood, Maryrose P Sullivan, Rosalyn M Adam
AIMS: Mounting evidence indicates that a variety of factors released from the urothelium or suburothelium can modulate smooth muscle activity. Although the relationship between the mucosa and smooth muscle has been investigated, little is known about the pathophysiologic changes in detrusor-mucosa interactions in neurogenic bladders. The goal of the study was to determine the impact of the mucosa on evoked responses in spinal cord injured (SCI) bladders. METHODS: Urinary bladders were obtained from 6wk SCI rats or age-matched uninjured controls...
February 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29416289/multiple-bladder-diverticula-treated-with-robotic-approach-assisted-with-cystoscopy
#13
Diego Antonio Preciado-Estrella, Pascual Cortés-Raygoza, Jorge Gustavo Morales-Montor, Carlos Pacheco-Gahbler
A bladder diverticulum (BD) is a herniation of the bladder urothelium through the muscular bladder wall. As a result, BD presents as a thin walled bag, urine filled connected to bladder lumen through a neck or ostium. The clinical problem with bladder diverticula is their poorly empty during micturition which results in multiple lower urinary tract symptoms as well as recurrent urinary tract infections. Bladder diverticula can be grossly classified in two groups as follows: congenital or acquired with different age presentation and etiological factors in each one...
January 2018: Urology Annals
https://www.readbyqxmd.com/read/29412074/macroplastique-and-botox-are-superior-to-macroplastique-alone-in-the-management-of-neurogenic-vesicoureteric-reflux-in-spinal-cord-injury-population-with-presumed-healthy-bladders
#14
Vasileios I Sakalis, Rachel Oliver, Peter J Guy, Melissa C Davies
CONTEXT/OBJECTIVE: Vesico-ureteric reflux(VUR) is a known complication of neuropathic bladder in spinal cord injury(SCI) population. Bulking agents such as Macroplastique are new minimally-invasive treatment option for VUR with good results. The aim of this study is to assess the efficacy of Macroplastique alone or in combination with Botox(BTX-A), in managing VUR in SCI population with presumed healthy bladders and correlate the pre-and post-injection urodynamic findings with the outcome...
February 7, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29398585/does-intraoperative-success-predict-outcome-in-the-treatment-of-urethral-sphincter-insufficiency-with-bulking-agent
#15
Niklas Pakkasjärvi, Seppo Taskinen
INTRODUCTION: Sphincter insufficiency is mostly associated with neurogenic and some structural abnormalities in the pediatric population. As a mini-invasive treatment, urethral bulking agents have been used to treat this problem. OBJECTIVE: The aim was to evaluate if technical success, defined as intraoperative increase in abdominal leak point pressure (ALPP), predicts the outcome of the treatment of sphincter insufficiency with urethral bulking agent. STUDY DESIGN: We reviewed all children treated first time with dextranomer/hyaluronic acid (Dx/HA) copolymer (Deflux) for urethral sphincter insufficiency and who intraoperatively had ALPPs measured during 2004-2014...
January 31, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29392753/value-of-urodynamic-findings-in-predicting-upper-urinary-tract-damage-in-neuro-urological-patients-a-systematic-review
#16
REVIEW
Stefania Musco, Barbara Padilla-Fernández, Giulio Del Popolo, Matteo Bonifazi, Bertil F M Blok, Jan Groen, Lisette 't Hoen, Jürgen Pannek, Jerome Bonzon, Thomas M Kessler, Marc P Schneider, Tobias Gross, Gilles Karsenty, Véronique Phé, Rizwan Hamid, Hazel Ecclestone, David Castro-Diaz
AIM: The main goals of neurogenic lower urinary tract dysfunction (NLUTD) management are preventing upper urinary tract damage (UUTD), improving continence, and quality of life. Here, we aimed to systematically assess all available evidence on urodynamics predicting UUTD in patients with NLUTD. METHODS: A systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement was performed in March 2017. Only neuro-urological patients assessed by urodynamics were included...
February 2, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29388934/-the-application-of-the-physical-factors-for-the-medical-rehabilitation-of-the-children-presenting-with-neurogenic-dysfunction-of-the-bladder
#17
I V Pogonchenkova, M A Khan, N B Korchazhkina, E V Novikova, I A Bokova, N A Lyan
This article describes the modern technologies for the medical rehabilitation of the children presenting with neurogenic dysfunction of the bladder aimed at improving the act of urination at all levels of innervation. The most frequent variant of neurogenic dysfunction of the bladder in the children is the hyper-reflexive one; it is this variant in which the most pronounced disorders of urodynamics due to intravesical hypertension and detrusor hypoxia are observed. The urodynamic disorders are known to contribute to the formation of the characteristic clinical picture associated with the hyper-reflexive urinary bladder dysfunction in the children characterized by the mandatory urination syndrome, pollakiuria, imperative urges, and mandatory urinary incontinence in the combination with enuresis...
December 28, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29388933/-the-application-of-the-modern-phototherapeutic-technologies-for-the-medical-rehabilitation-of-the-children
#18
M A Khan, А I Chubarova, I V Pogonchenkova, M A Rassulova, E Y Sergeenko, E L Vakhova, N A Lyan, N A Mikitchenko
This literature review is focused on the application of polychromatic and monochromatic polarized light for the treatment of various diseases of the childhood including those in the newborns and the premature babies. The analysis of the data of scientific research gives evidence of the beneficial effect of polychromatic polarized light on the clinical course of various skin diseases in the newborn children. Moreover, the improved immunological and reparative processes were revealed after the surgical interventions for congenital heart defects in the newborns...
December 28, 2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29387559/inadvertent-placement-of-a-urinary-catheter-into-the-ureter-a-report-of-3-cases-and-review-of-the-literature
#19
Rui Luo, Song Liang Lee, Foo Cheong Ng, Li-Tsa Koh
We describe three cases of inadvertent placement of the urinary catheter into the ureter. An 85-year-old gentleman on long-term indwelling catheter (IDC) for neurogenic bladder presented with fever and right flank pain. CT of abdomen and pelvis demonstrated the tip of the IDC to be located within the right vesicoureteric junction with acute right hydronephrosis and acute pyelonephritis. A 74-year-old woman, on long-term IDC for neurogenic bladder was found to have hydronephrosis on ultrasound imaging. Contrast-enhanced CT intravenous pyelography done subsequently showed the IDC was in the right distal ureter...
October 2017: Asian Journal of Urology
https://www.readbyqxmd.com/read/29382457/gentamicin-bladder-instillations-decrease-symptomatic-urinary-tract-infections-in-neurogenic-bladder-patients-on-intermittent-catheterization
#20
Lindsey Cox, Chang He, Jack Bevins, J Quentin Clemens, John T Stoffel, Anne P Cameron
INTRODUCTION: This study aimed to determine if gentamicin bladder instillations reduce the rate of symptomatic urinary tract infection (UTI) in neurogenic bladder (NGB) patients on intermittent self-catheterization (ISC) who have recurrent UTIs. Secondary aims were to examine the effects of intravesical gentamicin on the organism resistance patterns. METHODS: We retrospectively reviewed our prospective NGB database. Inclusion criteria were NGB patients performing ISC exclusively for bladder drainage with clinical data available for six months before and six months after initiating prophylactic intravesical gentamicin instillations...
September 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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