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https://www.readbyqxmd.com/read/29445114/kinesin-1-regulates-cilia-length-through-an-interaction-with-the-bardet-biedl-syndrome-related-protein-ccdc28b
#1
Rossina Novas, Magdalena Cardenas-Rodriguez, Paola Lepanto, Matías Fabregat, Magela Rodao, María Inés Fariello, Mauricio Ramos, Camila Davison, Gabriela Casanova, Lucía Alfaya, Federico Lecumberry, Gualberto González-Sapienza, Florencia Irigoín, Jose L Badano
Bardet-Biedl syndrome (BBS) is a ciliopathy characterized by retinal degeneration, obesity, polydactyly, renal disease and mental retardation. CCDC28B is a BBS-associated protein that we have previously shown plays a role in cilia length regulation whereby its depletion results in shortened cilia both in cells and Danio rerio (zebrafish). At least part of that role is achieved by its interaction with the mTORC2 component SIN1, but the mechanistic details of this interaction and/or additional functions that CCDC28B might play in the context of cilia remain poorly understood...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29442558/progression-of-convulsive-and-nonconvulsive-seizures-during-epileptogenesis-after-pilocarpine-induced-status-epilepticus
#2
Zachariah Z Smith, Alexander M Benison, Florencia M Bercum, F Edward Dudek, Daniel S Barth
Although convulsive seizures occurring during pilocarpine-induced epileptogenesis have received considerable attention, nonconvulsive seizures have not been closely examined, even though they may reflect the earliest signs of epileptogenesis and potentially guide research on antiepileptogenic interventions. The definition of nonconvulsive seizures based on brain electrical activity alone has been controversial. Here, we define and quantify electrographic properties of convulsive and nonconvulsive seizures in the context of the acquired epileptogenesis that occurs after pilocarpine-induced status epilepticus (SE)...
February 14, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29441362/the-coupling-between-auditory-and-motor-cortices-is-rate-restricted-evidence-for-an-intrinsic-speech-motor-rhythm
#3
M Florencia Assaneo, David Poeppel
The relation between perception and action remains a fundamental question for neuroscience. In the context of speech, existing data suggest an interaction between auditory and speech-motor cortices, but the underlying mechanisms remain incompletely characterized. We fill a basic gap in our understanding of the sensorimotor processing of speech by examining the synchronization between auditory and speech-motor regions over different speech rates, a fundamental parameter delimiting successful perception. First, using magnetoencephalography, we measure synchronization between auditory and speech-motor regions while participants listen to syllables at various rates...
February 2018: Science Advances
https://www.readbyqxmd.com/read/29439273/effects-of-diet-on-telomere-length-systematic-review-and-meta-analysis
#4
Lisiane Marçal Pérez, Marina Azambuja Amaral, Eduardo Mundstock, Florencia M Barbé-Tuana, Fátima Teresinha Costa Rodrigues Guma, Marcus H Jones, Denise Cantarelli Machado, Edgar E Sarria, Maximiniano Marques E Marques, Luiza Tweedie Preto, Matias Epifanio, João Guilherme Meinem Garbin, Rita Mattiello
BACKGROUND: The goal of this systematic review and meta-analysis is to determine the effect of diet on telomere length. METHODS: We searched the following databases: MEDLINE, Embase, LILACS, CINAHL, ISI Web of Science, and Scopus, as well as the Cochrane Central Register of Controlled Trials and the National Institutes of Health, from inception to December 2016. Articles that assessed effects of diet on telomere length were included. RESULTS: A total of 2,128 studies were identified, 30 were read in full, and 7 were systematically reviewed...
February 13, 2018: Public Health Genomics
https://www.readbyqxmd.com/read/29432125/clinical-and-patient-centered-outcomes-in-obese-type-2-diabetes-patients-3-years-after-randomization-to-roux-en-y-gastric-bypass-surgery-versus-intensive-lifestyle-management-the-slimm-t2d-study
#5
Donald C Simonson, Florencia Halperin, Kathleen Foster, Ashley Vernon, Allison B Goldfine
OBJECTIVE: To compare the effect of Roux-en-Y gastric bypass (RYGB) surgery versus intensive medical diabetes and weight management (IMWM) on clinical and patient-reported outcomes in obese patients with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We prospectively randomized 38 obese patients with T2D (15 male and 23 female, with mean ± SD weight 104 ± 16 kg, BMI 36.3 ± 3.4 kg/m2, age 52 ± 6 years, and HbA1c 8.5 ± 1.3% [69 ± 14 mmol/mol]) to laparoscopic RYGB (n = 19) or IMWM (n = 19)...
February 6, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29429812/bordetella-pertussis-bp-disease-before-2003-2011-and-after-2013-2016-maternal-immunization-strategy-in-a-pediatric-hospital
#6
Angela Gentile, María Del Valle Juarez, María Florencia Lucion, Ana Clara Martínez, Viviana Romanin, Soledad Areso, Alicia Mistchenko
INTRODUCTION: Whooping cough continues to be a major cause of morbidity and mortality in infants younger than 1 year. In 2012, Argentina introduced Tdap in pregnancy to prevent infant mortality. The aim of this study is to describe the impact of maternal immunization on the hospitalization and mortality rates of confirmed Bordetella pertussis (Bp) cases by comparing pre- and post-Tdap vaccine recommendation periods. MATERIAL AND METHODS: All PCR-confirmed Bp cases from "R...
February 8, 2018: Vaccine
https://www.readbyqxmd.com/read/29428956/prognosis-of-ocular-myasthenia-gravis-in-an-argentinian-population
#7
Florencia Aguirre, Andres M Villa
BACKGROUND: We investigated the prognosis of patients with myasthenia gravis (MG) initially presenting with only ocular symptoms in an Argentinian population. SUMMARY: We performed a retrospective analysis of 61 patients with MG with pure ocular involvement at onset. Generalized MG (gMG) developed in 73.7% of patients, while the rest only exhibited ocular symptoms throughout the course of the disease (ocular MG [oMG]). The AChR antibody (AChR-ab) was found in 81...
February 9, 2018: European Neurology
https://www.readbyqxmd.com/read/29426737/-demodex-genus-colonizing-parasites-of-healthy-people-or-mites-associated-with-ocular-pathology
#8
Florencia Mongi, Laura Laconte, Rodolfo D Casero
Demodex folliculorum and Demodex brevis are mites that are responsible for human demodicosis affecting skin and frequently linked to ocular diseasess. The aim of this work was to determine the association between Demodex sp. and eyelid and eyelash diseases and to establish the predisposing factors for acquiring this parasitic disease. Eyelashes from symptomatic and asymptomatic patients (n=72) between 9 and 82 years old were analyzed, where 53% were positive for Demodex sp., of which 66% manifested ocular symptoms and pathologies, blepharitis and dry eye being prevalent...
February 6, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29425321/splicing-regulation-by-long-noncoding-rnas
#9
Natali Romero-Barrios, Maria Florencia Legascue, Moussa Benhamed, Federico Ariel, Martin Crespi
Massive high-throughput sequencing techniques allowed the identification of thousands of noncoding RNAs (ncRNAs) and a plethora of different mRNA processing events occurring in higher organisms. Long ncRNAs can act directly as long transcripts or can be processed into active small si/miRNAs. They can modulate mRNA cleavage, translational repression or the epigenetic landscape of their target genes. Recently, certain long ncRNAs have been shown to play a crucial role in the regulation of alternative splicing in response to several stimuli or during disease...
February 7, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29422624/deep-sea-hydrothermal-vents-as-natural-egg-case-incubators-at-the-galapagos-rift
#10
Pelayo Salinas-de-León, Brennan Phillips, David Ebert, Mahmood Shivji, Florencia Cerutti-Pereyra, Cassandra Ruck, Charles R Fisher, Leigh Marsh
The discovery of deep-sea hydrothermal vents in 1977 challenged our views of ecosystem functioning and yet, the research conducted at these extreme and logistically challenging environments still continues to reveal unique biological processes. Here, we report for the first time, a unique behavior where the deep-sea skate, Bathyraja spinosissima, appears to be actively using the elevated temperature of a hydrothermal vent environment to naturally "incubate" developing egg-cases. We hypothesize that this behavior is directly targeted to accelerate embryo development time given that deep-sea skates have some of the longest egg incubation times reported for the animal kingdom...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29415056/novel-role-of-the-lps-core-glycosyltransferase-waph-for-cold-adaptation-in-the-antarctic-bacterium-pseudomonas-extremaustralis
#11
Florencia C Benforte, Maria A Colonnella, Martiniano M Ricardi, Esmeralda C Solar Venero, Leonardo Lizarraga, Nancy I López, Paula M Tribelli
Psychrotroph microorganisms have developed cellular mechanisms to cope with cold stress. Cell envelopes are key components for bacterial survival. Outer membrane is a constituent of Gram negative bacterial envelopes, consisting of several components, such as lipopolysaccharides (LPS). In this work we investigated the relevance of envelope characteristics for cold adaptation in the Antarctic bacterium Pseudomonas extremaustralis by analyzing a mini Tn5 wapH mutant strain, encoding a core LPS glycosyltransferase...
2018: PloS One
https://www.readbyqxmd.com/read/29412931/impact-of-prosopis-alba-exudate-gum-on-sorption-properties-and-physical-stability-of-fish-oil-alginate-beads-prepared-by-ionic-gelation
#12
Franco Emanuel Vasile, María Alicia Judis, María Florencia Mazzobre
This study was conducted to evaluate the effect of Prosopis alba exudate gum (G) as encapsulating matrix component on water-solid interactions, physical state, oxidative damage and appearance properties of alginate-chitosan encapsulates containing fish oil. With this purpose, water sorption isotherms were obtained at 25 °C. G increased the hygroscopicity of encapsulates, showing a higher monolayer water content (7.87 ± 0.47% db.) than control (1.07 ± 0.04% db.). G introduction reduced the plasticizing effect of water, increasing the aw range (aw < 0...
June 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29409032/critical-role-of-phosphodiesterase-2a-in-mouse-congenital-heart-defects
#13
Maria Rita Assenza, Federica Barbagallo, Florencia Barrios, Marisa Cornacchione, Federica Campolo, Elisabetta Vivarelli, Daniele Gianfrilli, Luigi Auletta, Andrea Soricelli, Andrea M Isidori, Andrea Lenzi, Manuela Pellegrini, Fabio Naro
Aims: Phosphodiesterase 2A, a cAMP-hydrolysing enzyme, is essential for mouse development, however the cause of Pde2A knockout embryonic lethality is unknown. To understand if Pde2A plays a role in cardiac development, hearts of Pde2A deficient embryos were analysed at different stage of development. Methods and Results: At the stage of four chambers, Pde2A deficient hearts were enlarged compared to the hearts of Pde2A heterozygous and wild-type. Pde2A knockout embryos revealed cardiac defects such as absence of atrial trabeculation, interventricular septum defects, hypertrabeculation and thinning of the myocardial wall and in rare cases they had overriding aorta and valves defects...
February 2, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29398651/bacteroides-fragilis-toxin-coordinates-a-pro-carcinogenic-inflammatory-cascade-via-targeting-of-colonic-epithelial-cells
#14
Liam Chung, Erik Thiele Orberg, Abby L Geis, June L Chan, Kai Fu, Christina E DeStefano Shields, Christine M Dejea, Payam Fathi, Jie Chen, Benjamin B Finard, Ada J Tam, Florencia M McAllister, Hongni Fan, Xinqun Wu, Sudipto Ganguly, Andriana Lebid, Paul Metz, Sara W Van Meerbeke, David L Huso, Elizabeth C Wick, Drew M Pardoll, Fengyi Wan, Shaoguang Wu, Cynthia L Sears, Franck Housseau
Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using ApcMin mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis (ETBF) as a model of microbe-induced colon tumorigenesis, we show that the Bacteroides fragilis toxin (BFT) triggers a pro-carcinogenic, multi-step inflammatory cascade requiring IL-17R, NF-κB, and Stat3 signaling in colonic epithelial cells (CECs). Although necessary, Stat3 activation in CECs is not sufficient to trigger ETBF colon tumorigenesis...
February 1, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29397672/depression-and-mania-induce-pro-inflammatory-activation-of-macrophages-following-application-of-serum-from-individuals-with-bipolar-disorder
#15
Pamela Ferrari, Mariana Migliorini Parisi, Rafael Colombo, Matheus Becker, Gabriel Fries, Bruna Maria Ascoli, Luiza Paul Géa, Márcia Kauer-Sant Anna, Flávio Kapczinski, Fábio Klamt, Fátima T C R Guma, Adriane Ribeiro Rosa, Florencia M Barbé-Tuana
Objective: Evidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood. This study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of cultured macrophages. Methods: Eighteen subjects with BD and five healthy individuals were included in this study. The human monocyte cell line U-937 was activated with phorbol 12-myristate 13-acetate (PMA) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 hours...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29369082/compliance-with-the-2009-royal-college-of-obstetricians-and-gynaecologists-guidelines-for-venous-thromboembolic-disease-prophylaxis-in-pregnancy-and-postpartum-period-in-uruguay
#16
Sofía Grille, Gerardo Vitureira, Rosario Morán, Lucía Retamosa, Valeria Alonso, Luis M Gómez, Federico Quartara, Florencia Feldman, Valentina López, Paola Turcatti, Viviana Castro, Leonardo Sosa, Cecilia Guillermo, Lilián Díaz, Mariana Stevenazzi
: Venous thromboembolism remains as one of the leading causes of maternal death. Prevention of venous thromboembolism in the obstetric population is challenging as recommendations for prophylaxis have low grade of evidence. Risk factors and prophylaxis guidelines have been highlighted by Royal College of Obstetricians and Gynaecologists. In 2014, we developed a written alert following this guidelines to guide thromboprophylaxis. The aim of this study is to assess recommendations compliance. This study was conducted at University-Hospital in Uruguay from January 2014 to December 2016...
January 23, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29367397/simpler-grammar-larger-vocabulary-how-population-size-affects-language
#17
Florencia Reali, Nick Chater, Morten H Christiansen
Languages with many speakers tend to be structurally simple while small communities sometimes develop languages with great structural complexity. Paradoxically, the opposite pattern appears to be observed for non-structural properties of language such as vocabulary size. These apparently opposite patterns pose a challenge for theories of language change and evolution. We use computational simulations to show that this inverse pattern can depend on a single factor: ease of diffusion through the population. A population of interacting agents was arranged on a network, passing linguistic conventions to one another along network links...
January 31, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29361774/the-ifng-rs1861494-single-nucleotide-polymorphism-is-associated-with-protection-against-tuberculosis-disease-in-argentina
#18
Agustín Rolandelli, Joaquín M Pellegrini, Nicolás O Amiano, María C Santilli, María P Morelli, Florencia A Castello, Nancy L Tateosian, Alberto Levi, Nicolás Casco, Domingo J Palmero, Verónica E García
Interferon gamma (IFNG) plays a key role during Mycobacterium tuberculosis (Mtb) infection, and several polymorphisms located in its gene are associated with risk of tuberculosis in diverse populations. Nevertheless, the genetic resistance/susceptibility to tuberculosis in Argentina is unknown. The IFNG rs1861494 polymorphism (G→A) was reported to alter the binding of transcription factors to this region, influencing IFNG production. Using a case-control study, we found an association between the AA and AG genotypes and tuberculosis resistance (AA vs...
January 22, 2018: Genes
https://www.readbyqxmd.com/read/29360077/-struma-ovarii-associated-with-graves-disease
#19
Valeria Pastorino Casas, M Florencia Borghi Torzillo, Daniel Schere, Rubén J Lutfi, Eduardo N Faure
Hyperthyroidism is defined as an excessive production of thyroid hormones by eutopic or ectopic mature thyroid tissue. The overall prevalence of hyperthyroidism is 1.2% and the most common cause is Graves' disease. Struma ovarii represents 1% of all ovarian tumors and is an uncommon cause of ectopic hyperthyroidism. It is benign in >90% of the cases; usually asymptomatic, and only 8% are presented with thyrotoxicosis, being rare its association with Graves' disease. We report the case of a patient with this association...
2018: Medicina
https://www.readbyqxmd.com/read/29352443/baculovirus-based-gene-silencing-of-humanin-for-the-treatment-of-pituitary-tumors
#20
María Florencia Gottardo, Matías L Pidre, Camila Zuccato, Antonela S Asad, Mercedes Imsen, Gabriela Jaita, Marianela Candolfi, Víctor Romanowski, Adriana Seilicovich
Pituitary tumors are the most common primary intracranial neoplasms. Humanin (HN) and Rattin (HNr), a rat homolog of HN, are short peptides with a cytoprotective action. In the present study, we aimed to evaluate whether endogenous HNr plays an antiapoptotic role in pituitary tumor cells. Thus, we used RNA interference based on short-hairpin RNA (shRNA) targeted to HNr (shHNr). A plasmid including the coding sequences for shHNr and dTomato fluorescent reporter gene was developed (pUC-shHNr). Transfection of somatolactotrope GH3 cells with pUC-shHNr increased apoptosis, suggesting that endogenous HNr plays a cytoprotective role in pituitary tumor cells...
January 19, 2018: Apoptosis: An International Journal on Programmed Cell Death
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