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https://www.readbyqxmd.com/read/28454078/new-complexes-of-cu-ii-with-dipicolinate-and-pyridyl-based-ligands-an-experimental-and-dft-approach
#1
Florencia Luzardo, Natalia Álvarez, Carlos Kremer, Andrea S S de Camargo, Jorge S Gancheff
The three novel mononuclear copper(II) complexes with dipicolinate and pyridyl-based ligands [Cu(dipic)(L)(OH2)] (L=4-picoline, vinylpyridine, 4-styrylpyridine; dipic(2-)=dipicolinate) were afforded and structurally characterized. X-ray diffraction studies accounted for slight distorted square-pyramidal structures in which the dianion dipic(2-) acts as a tridentate ligand in a mer-fashion, the N-donor species occupy an in-plane position, and a water molecule was detected apically coordinated. To assess the effect of the nature of the pyridyl-substituent (para position) on electronic properties, other complexes were also synthesized: [Cu(dipic)(py)(OH2)], [{Cu(dipic)(OH2)}2(μ-pyz)] and [{Cu(dipic)(OH2)}(μ-pypy){Cu(dipic)}] (py=pyridine, pyz=pyrazine, pypy=(E)-1,2-bis(pyridine-4-yl)ethane)...
April 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28446053/immunotherapy-for-the-treatment-of-breast-cancer
#2
Mariela A Moreno Ayala, Maria Florencia Gottardo, Antonela S Asad, Camila Zuccato, Alejandro Nicola, Adriana Seilicovich, Marianela Candolfi
Introduction Breast cancer is the most common cancer as well as the highest cause of death by cancer in women worldwide. Although routine treatment improves the outcome of early stage breast cancer patients, there is no effective therapy for the disseminated disease. Immunotherapy has emerged as a powerful therapeutic strategy for the treatment of many cancers. Although traditionally conceived as a non-immunogenic tumor, breast cancer is now considered a potential target for immunotherapy. Areas covered In this review, the authors discuss different immunotherapeutic strategies that are currently being tested for the treatment of breast cancer: These strategies include: (i) the blockade of immunological checkpoints, (ii) antitumor vaccines, (iii) adoptive T-cell transfer therapy, and (iv) adoptive immunotherapy with monoclonal antibodies...
April 27, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28442719/chlamydia-trachomatis-neither-exerts-deleterious-effects-on-spermatozoa-nor-impairs-male-fertility
#3
Jenniffer Puerta Suarez, Leonardo R Sanchez, Florencia C Salazar, Hector A Saka, Rosa Molina, Andrea Tissera, Virginia E Rivero, Walter D Cardona Maya, Ruben D Motrich
Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection. However, whether Chlamydia trachomatis has a negative impact on sperm quality and male fertility is still controversial. Herein, we report the effects on sperm quality of the in vitro exposure of spermatozoa to Chlamydia trachomatis, and also the effects of male genital infection on male fertility using an animal model. Human and mouse sperm were obtained from healthy donors and cauda epididimys from C57BL/6 mice, respectively...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28441444/contexts-of-occurrence-of-child-malnutrition-in-the-district-of-villaguay-entre-r%C3%A3-os-argentina-a-multivariate-analysis
#4
María Laura Bergel Sanchís, María Florencia Cesani, Evelia Edith Oyhenart
The analysis of nutritional status is anthropologically important to address the complex interaction of biological, social, political, economic and cultural factors. To deepen the knowledge about contexts of occurrence of child malnutrition, we analyzed nutritional status in relation to socio-environmental conditions of residence in children between three and six years from Villaguay, Entre Ríos, Argentina. We performed a cross-sectional study of 1,435 school children of both sexes. Body weight and height were measured and prevalence of low height/age (LH/A), low weight/age (LW/A), low BMI/age (LBMI/A), overweight (Ow) and obesity (Ob) was calculated using World Health Organization reference charts...
2017: PloS One
https://www.readbyqxmd.com/read/28432455/dual-activation-of-toll-like-receptors-7-and-9-impairs-the-efficacy-of-antitumor-vaccines-in-murine-models-of-metastatic-breast-cancer
#5
Mariela A Moreno Ayala, María Florencia Gottardo, María Soledad Gori, Alejandro Javier Nicola Candia, Carla Caruso, Andrea De Laurentiis, Mercedes Imsen, Slobodanka Klein, Elisa Bal de Kier Joffé, Gabriela Salamone, Maria G Castro, Adriana Seilicovich, Marianela Candolfi
PURPOSE: Since combination of Toll-like receptor (TLR) ligands could boost antitumor immunity, we evaluated the efficacy of dendritic cell (DC) vaccines upon dual activation of TLR9 and TLR7 in breast cancer models. METHODS: DCs were generated from mouse bone marrow or peripheral blood from healthy human donors and stimulated with CpG1826 (mouse TLR9 agonist), CpG2006 or IMT504 (human TLR9 agonists) and R848 (TLR7 agonist). Efficacy of antitumor vaccines was evaluated in BALB/c mice bearing metastatic mammary adenocarcinomas...
April 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28423416/beauveria-bassiana-ascomycota-hypocreales-introduced-as-an-endophyte-in-corn-plants-and-its-effects-on-consumption-reproductive-capacity-and-food-preference-of-dichroplus-maculipennis-orthoptera-acrididae-melanoplinae
#6
Sebastian A Pelizza, Yanina Mariottini, Leticia M Russo, M Florencia Vianna, Ana C Scorsetti, Carlos E Lange
In this study, the effects of strain Beauveria bassiana (LPSC 1067) as an endophyte in corn plants on consumption, fecundity, and food preference of Dichroplus maculipennis were examined. We observed that the daily consumption by grasshoppers fed with control plants was almost twice that of those that were fed treated plants. Significant differences in fecundity of grasshoppers that were fed with treated plants compared with those that only fed on control plants were also observed. The number of eggs laid per female fed with control plants was 27...
January 1, 2017: Journal of Insect Science
https://www.readbyqxmd.com/read/28419596/effects-of-culture-conditions-on-the-size-morphology-and-wet-density-of-spores-of-bacillus-cereus-569-and-bacillus-megaterium-qm-b1551
#7
Ke Xu Zhou, Florencia Wisnivesky, D Ian Wilson, Graham Christie
The influence of variable culture conditions on the size and wet density of spores of Bacillus cereus and Bacillus megaterium were examined in this work. Culture temperature and initial pH was shown to have a significant impact on the size of both species, with increasingly alkaline culture media and elevated culture temperatures resulting in spores that were, on average, up to 25% reduced in volume. Increasing concentrations of inorganic salts in sporulation media exerted differing effects on each species; whereas a five-fold increase in the concentration of all salts resulted in only minor differences to the dimensions of B...
April 17, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28415397/surface-modified-bioresorbable-electrospun-scaffolds-for-improving-hemocompatibility-of-vascular-grafts
#8
Pablo C Caracciolo, María Isabel Rial-Hermida, Florencia Montini-Ballarin, Gustavo A Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
The replacement of small-diameter vessels is one of the main challenges in tissue engineering. Moreover, the surface modification of small-diameter vascular grafts (SDVG) is a key factor in the success of the therapy due to their increased thrombogenicity and infection susceptibility caused by the lack of a functional endothelium. In this work, electrospun scaffolds were prepared from blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) with a composition designed to perform as SDVG inner layer...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28410997/international-incidence-of-childhood-cancer-2001-10-a-population-based-registry-study
#9
Eva Steliarova-Foucher, Murielle Colombet, Lynn A G Ries, Florencia Moreno, Anastasia Dolya, Freddie Bray, Peter Hesseling, Hee Young Shin, Charles A Stiller
BACKGROUND: Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. METHODS: This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001-10...
April 11, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28403692/severe-hypokalemia-due-to-a-possible-drug-drug-interaction-between-vinblastine-and-antiretrovirals-in-a-hiv-infected-patient-with-hodgkin-s-lymphoma
#10
Ezequiel Cordova, Laura Morganti, Andrea Odzak, Florencia Arcondo, Mariana Silva, Marcelo Zylberman, Claudia Rodriguez
A 60-year-old HIV-1 infected woman on antiretroviral therapy (emtricitabine/tenofovir, and ritonavir-boosted atazanavir) developed Hodgkin's lymphoma. The patient initiated ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) chemotherapy and presented with neutropenia and severe hypokalemia. Hypokalemia was considered as part of a proximal tubular renal dysfunction, and other causes of hypokalemia were excluded. Due to suspicion of drug--drug interactions between antiretrovirals and vinblastine, ritonavir-boosted atazanavir was switched to dolutegravir and the patient continued emtricitabine/tenofovir...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28401640/bacterial-and-plant-natriuretic-peptides-improve-plant-defense-responses-against-pathogens
#11
Florencia A Ficarra, Carolina Grandellis, Betiana S Garavaglia, Natalia Gottig, Jorgelina Ottado
Plant natriuretic peptides (PNPs) are implicated in the regulation of ions and water homeostasis, and their participation in the plant immune response has been also proposed. Xanthomonas citri subsp. citri contains a gene encoding a PNP-like protein (XacPNP) that has no homologues in other bacteria. XacPNP mimics its Arabidopsis thaliana homolog AtPNP-A by modifying host responses to create favorable conditions for pathogen survival. However, the ability of XacPNP to induce plant defense responses was never investigated...
April 12, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/28392212/n-acetylcysteine-improves-the-quality-of-red-blood-cells-stored-for-transfusion
#12
Florencia Amen, Andrea Machin, Cristina Touriño, Ismael Rodríguez, Ana Denicola, Leonor Thomson
Storage inflicts a series of changes on red blood cells (RBC) that compromise the cell survival and functionality; largely these alterations (storage lesions) are due to oxidative modifications. The possibility of improving the quality of packed RBC stored for transfusion including N-acetylcysteine (NAC) in the preservation solution was explored. Relatively high concentrations of NAC (20-25 mM) were necessary to prevent the progressive leakage of hemoglobin, while lower concentrations (≥2.5 mM) were enough to prevent the loss of reduced glutathione during the first 21 days of storage...
May 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28385237/prosopis-alba-exudate-gum-as-novel-excipient-for-fish-oil-encapsulation-in-polyelectrolyte-bead-system
#13
Franco Emanuel Vasile, María Alicia Judis, María Florencia Mazzobre
In this work, a bottom-up approach based on the study of polyelectrolyte interactions was performed in order to evaluate the effect of Prosopis alba exudate gum as novel excipient for fish oil encapsulation in composed calcium-alginate-chitosan beads. Emulsion and beads properties such as oil distribution, encapsulation efficiency, yield, microstructure and thermo-oxidative protection were evaluated. Alginate and gum exert a synergistic effect on emulsion stability properties, which conducted to better oil distribution in the beads and higher encapsulation efficiencies (98%) and yield (89%)...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28378125/humanin-inhibits-apoptosis-in-pituitary-tumor-cells-through-several-signaling-pathways-including-nf-%C3%AE%C2%BAb-activation
#14
María Florencia Gottardo, Mariela Moreno Ayala, Jimena Ferraris, Sandra Zárate, Daniel Pisera, Marianela Candolfi, Gabriela Jaita, Adriana Seilicovich
Humanin (HN) and Rattin (HNr), its homologous in the rat, are peptides with cytoprotective action in several cell types such as neurons, lymphocytes and testicular germ cells. Previously, we have shown that HNr is expressed in pituitary cells and that HN inhibited the apoptotic effect of TNF-α in both normal and tumor pituitary cells. The aim of the present study was to identify signaling pathways that mediate the antiapoptotic effect of HN in anterior pituitary cells from ovariectomized rats and in GH3 cells, a somatolactotrope cell line...
April 4, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28375197/axial-involvement-according-to-asas-criteria-in-an-observational-psoriatic-arthritis-cohort
#15
Pedro David Carvalho, Florencia Savy, Carmen Moragues, Xavier Juanola, Jesus Rodriguez-Moreno
The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Our study included consecutive patients who had a visit in a tertiary Rheumatology centre...
October 20, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28360912/exosomes-isolated-from-ascites-of-t-cell-lymphoma-bearing-mice-expressing-surface-cd24-and-hsp-90-induce-a-tumor-specific-immune-response
#16
Florencia Menay, Leticia Herschlik, Julieta De Toro, Federico Cocozza, Rodrigo Tsacalian, María José Gravisaco, María Paula Di Sciullo, Alejandrina Vendrell, Claudia I Waldner, Claudia Mongini
Extracellular vesicles (EVs), including endosome-derived nanovesicles (exosomes), are involved in cell-cell communication. Through transfer of their molecular contents, extracellular nanovesicles can alter the function of recipient cells. Due to these characteristics, EVs have shown potential as a new alternative for cancer immunotherapy. Tumor exosomes isolated from malignant ascites can activate dendritic cells, thereby priming the immune system to recognize and kill cancer cells. However, a suppressive role on tumor immune response has also been reported, suggesting that the neoplastic stage of carcinogenesis and the microenvironment where tumor cells grow may influence the amount of EVs released by the cell...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28352472/erratum-to-options-in-human-papillomavirus-hpv-detection-for-cervical-cancer-screening-comparison-between-full-genotyping-and-a-rapid-qualitative-hpv-dna-assay-in-ghana
#17
Dorcas Obiri-Yeboah, Yaw Adu-Sarkodie, Florencia Djigma, Kafui Akakpo, Ebenezer Aniakwa-Bonsu, Daniel Amoako-Sakyi, Jacques Simpore, Philippe Mayaud
[This corrects the article DOI: 10.1186/s40661-017-0041-1.].
2017: Gynecologic Oncology Research and Practice
https://www.readbyqxmd.com/read/28351714/evaluation-of-environmental-and-nutritional-factors-and-sua-gene-on-in%C3%A2-vitro-biofilm-formation-of-streptococcus-uberis-isolates
#18
Melina Vanesa Moliva, Florencia Cerioli, Elina Beatriz Reinoso
The pathogenesis of Streptococcus uberis is attributed to a combination of extracellular factors and properties such as adherence and biofilm formation. The aim of this work was to evaluate the influence of different factors, additives and bovine milk compounds on S. uberis biofilm formation, as the presence of the sua gene by PCR. Additionally, extracellular DNA and the effect of DNaseI were evaluated in the biofilms yielded. Optimal biofilm development was observed when the pH was adjusted to 7.0 and 37 °C...
March 27, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28343859/-azospirillum-brasilense-az39-labeled-with-gfp-in-arabidopsis-thaliana-roots
#19
Silvana M Díaz Herrera, Florencia J Rossello, María P Benavides, María D Groppa, Myriam S Zawoznik
No abstract text is available yet for this article.
March 23, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28340187/biofilm-adherence-and-hydrophobicity-as-virulence-factors-in-malassezia-furfur
#20
Letizia Angiolella, Claudia Leone, Florencia Rojas, Javier Mussin, María de Los Angeles Sosa, Gustavo Giusiano
Malassezia species are natural inhabitants of the healthy skin. However, under certain conditions, they may cause or exacerbate several skin diseases. The ability of this fungus to colonize or infect is determined by complex interactions between the fungal cell and its virulence factors. This study aims to evaluate "in vitro" the hydrophobicity levels, the adherence on a plastic surface and the biofilm formation of 16 clinical isolates of Malassezia furfur. Cellular surface hydrophobicity (CSH) levels were determined by two-phase system...
March 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
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