Mengdi Yang, Noah Hutchinson, Jianing Yin, Ming Guan, Zongqi Wang, Peiru Chen, Shaobo Yang, Justin D Crane, Ke Zhang, Jiahe Li
Lactic acid or lactate, a key byproduct of anaerobic glycolysis, plays pivotal roles in routine metabolism. An increase in lactic acid is observed in various pathological conditions such as cancer, diabetes, genetic mitochondrial disease, and aging. While several groups have proposed small molecule inhibitors to reduce circulating lactic acid, there are few clinically relevant ways to manage acute or chronic elevations in lactic acid in patients. In addition, recent evidence suggests that lactic acid exchanges between the gut, blood, and peripheral tissues, and professional marathon runners harbor specific gut microbial species that more efficiently metabolize lactic acid...
December 1, 2023: bioRxiv