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https://www.readbyqxmd.com/read/28812616/legacy-effects-of-developmental-stages-determine-the-functional-role-of-predators
#1
Volker H W Rudolf, B G Van Allen
Predators are instrumental in structuring natural communities and ecosystem processes. The strong effects of predators are often attributed to their high trophic position in the food web. However, most predators have to grow and move up the food chain before reaching their final trophic position, and during this developmental process their traits, interactions and abundances change. Here, we show that this process of 'moving up' the food chain during development strongly determines the ecological role of a predator...
January 13, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811773/transepithelial-corneal-crosslinking-in-treatment-of-progressive-keratoconus-12-months-clinical-results
#2
Bushra Akbar, Rana Intisar-Ul-Haq, Mazhar Ishaq, Sabahat Arzoo, Kashif Siddique
OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of transepithelial corneal collagen cross linking (TE-CXL) with modified riboflavin and accelerated UVA irradiance in thin corneas with pachymetry less than 400 microns at thinnest point, untreatable by epithelium off corneal collagen cross linking (CXL) in adult Pakistani population with progressive keratoconus. METHODS: This quasi experimental study included twenty six eyes of 26 patients with progressive keratoconus who underwent accelerated transepithelial CXL in Armed forced institute of ophthalmology with 12 months follow up...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28808888/has-time-come-for-the-use-of-direct-oral-anticoagulants-in-the-extended-prophylaxis-of-venous-thromboembolism-in-acutely-ill-medical-patients-yes
#3
Walter Ageno
Betrixaban is a direct factor Xa inhibitor with a renal excretion of only approximately 5-7%. On June 23rd 2017, it became the first direct oral anticoagulant to receive Food and Drug Administration approval for the prevention of venous thromboembolism in acutely ill medical patients, and the first anticoagulant agent to be approved for extended-duration thromboprophylaxis after hospital discharge in this setting. Approval followed the results of the APEX trial, a phase III clinical trial comparing betrixaban (80 mg) administered for 35-42 days with enoxaparin (40 mg) administered for 10 ± 4 days...
August 14, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28808640/light-emitting-diode-assessment-of-dentinal-defects-the-role-of-presumed-extraction-forces
#4
Marcelo Santos Coelho, Steven J Card, Peter Z Tawil
OBJECTIVES: The evaluation of iatrogenic dentinal defects in extracted teeth may be influenced by extraction forces and prolonged dry times. The purpose of this study was to compare the presence of dentinal defects in freshly extracted, periodontally compromised teeth with those in a group of teeth with uncontrolled extraction forces and storage time. MATERIALS AND METHODS: The experimental group consisted of eighteen roots obtained from teeth extracted due to periodontal reasons with class II or III mobility...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28808636/in-vivo-assessment-of-accuracy-of-propex-ii-root-zx-ii-and-radiographic-measurements-for-location-of-the-major-foramen
#5
Fernanda Garcia Tampelini, Marcelo Santos Coelho, Marcos de Azevêdo Rios, Carlos Eduardo Fontana, Daniel Guimarães Pedro Rocha, Sergio Luiz Pinheiro, Carlos Eduardo da Silveira Bueno
OBJECTIVES: The aim of this in vivo study was to assess the accuracy of 2 third-generation electronic apex locators (EALs), Propex II (Dentsply Maillefer) and Root ZX II (J. Morita), and radiographic technique for locating the major foramen (MF). MATERIALS AND METHODS: Thirty-two premolars with single canals that required extraction were included. Following anesthesia, access, and initial canal preparation with size 10 and 15 K-flex files and SX and S1 rotary ProTaper files, the canals were irrigated with 2...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28808472/successful-ultra-conservative-management-of-a-mandibular-premolar-with-dens-invaginatus
#6
Ramin Abazarpour, Masoud Parirokh, Aida Farhadi, Zahra Jalali, Nasir Kheirabadi
Dens invaginatus is one of the most common anomalies of tooth structure. It is caused by the invagination of the crown surface during odontogenesis that enters the pulp chamber of the affected tooth. Depending on the complexity of invagination, the tooth might present with pulp necrosis, open apex and a complicated root canal system. This case report presents an Oehlers' type 2 dens-invaginatus in a mandibular premolar with chronic apical abscess. In most cases, dens invaginatus is removed during treatment...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808469/endodontic-surgery-of-a-symptomatic-overfilled-mta-apical-plug-a-histological-and-clinical-case-report
#7
Saeed Asgary, Sara Fayazi
This case report presents the successful surgical treatment of a symptomatic open apex upper central incisor with a failed overfilled mineral trioxide aggregate (MTA) apical plug. Unintentional overextension of the MTA had occurred two years before the initial visit. An apical lesion adjacent to the excess MTA was radiographically detectable. Endodontic surgery was performed using calcium-enriched mixture (CEM) cement as a root-end filling material. Curettage of the apical lesion showed a mass of unset MTA particles; histopathological examination revealed fragments of MTA and granulation tissues...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808458/effect-of-propylene-glycol-on-the-sealing-ability-of-mineral-trioxide-aggregate-and-calcium-enriched-mixture-cement-apical-barriers
#8
Alireza Adl, Fereshte Sobhnamayan, Nooshin Sadat Shojaee, Fateme Tahmasebi Azad, Mohsen Bahmani
INTRODUCTION: Propylene glycol (PG) improves the handling, physical, and chemical properties of mineral trioxide aggregate (MTA). This study aimed to evaluate the effect of PG on the sealing ability of MTA and calcium-enriched mixture (CEM) apical barriers. METHODS AND MATERIALS: A total of 70 extracted human maxillary single-rooted teeth were prepared using ProTaper rotary system. The apical 3 mm of the root tips were resected and the root canals were enlarged with Peeso reamers up to #4, to create open apex teeth...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28807998/immunogenicity-and-structures-of-a-rationally-designed-prefusion-mers-cov-spike-antigen
#9
Jesper Pallesen, Nianshuang Wang, Kizzmekia S Corbett, Daniel Wrapp, Robert N Kirchdoerfer, Hannah L Turner, Christopher A Cottrell, Michelle M Becker, Lingshu Wang, Wei Shi, Wing-Pui Kong, Erica L Andres, Arminja N Kettenbach, Mark R Denison, James D Chappell, Barney S Graham, Andrew B Ward, Jason S McLellan
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage C betacoronavirus that since its emergence in 2012 has caused outbreaks in human populations with case-fatality rates of ∼36%. As in other coronaviruses, the spike (S) glycoprotein of MERS-CoV mediates receptor recognition and membrane fusion and is the primary target of the humoral immune response during infection. Here we use structure-based design to develop a generalizable strategy for retaining coronavirus S proteins in the antigenically optimal prefusion conformation and demonstrate that our engineered immunogen is able to elicit high neutralizing antibody titers against MERS-CoV...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807015/genomic-upregulation-of-cardiac-cav1-2%C3%AE-and-ncx1-by-estrogen-in-women
#10
Rita Papp, Glenna C L Bett, Agnieszka Lis, Randall L Rasmusson, István Baczkó, András Varró, Guy Salama
BACKGROUND: Women have a higher risk of lethal arrhythmias than men in long QT syndrome type 2 (LQTS2), but the mechanisms remain uncertain due to the limited availability of healthy control human tissue. We have previously reported that in female rabbits, estrogen increases arrhythmia risk in drug-induced LQTS2 by upregulating L-type Ca(2+) (ICa,L) and sodium-calcium exchange (INCX) currents at the base of the epicardium by a genomic mechanism. This study investigates if the effects of estrogen on rabbit ICa,L and INCX apply to human hearts...
August 14, 2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28806543/200%C3%A2-kev-cold-field-emission-source-using-carbon-cone-nanotip-application-to-scanning-transmission-electron-microscopy
#11
Shuichi Mamishin, Yudai Kubo, Robin Cours, Marc Monthioux, Florent Houdellier
We report the use of a pyrolytic carbon cone nanotip as field emission cathode inside a modern 200 kV dedicated scanning transmission electron microscope. We show an unprecedented improvement in the probe current stability while maintaining all the fundamental properties of a cold field emission source such as a small angular current density together with a high brightness. We have also studied the influence of the low extraction voltage, as enabled by the nanosized apex of the cones, on the electron optics properties of the source that prevent the formation of a virtual beam cross-over of the gun...
August 9, 2017: Ultramicroscopy
https://www.readbyqxmd.com/read/28806174/left-ventricular-apex-venting-in-high-risk-redo-sternotomy-with-severe-aortic-insufficiency-a-case-report
#12
Brett J Wakefield, Alexander J Leone, Shiva Sale
Redo cardiac surgery in patients with severe aortic insufficiency can present unique challenges to the anesthesiologist. We report a case highlighting the challenge and importance of interdisciplinary planning between cardiothoracic surgeons and anesthesiologists prior to high-risk surgery. Failure to place an endoaortic balloon and percutaneous coronary sinus catheter due to anatomical abnormalities prompted the adoption of an alternate technique involving apical ventricular venting to assist sternal reentry...
August 10, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28805486/cop1-integrates-light-signals-to-rop2-for-cell-cycle-activation
#13
Wenguo Cai, Xiaojuan Li, Yanlin Liu, Yaowei Wang, Yue Zhou, Tongda Xu, Yan Xiong
The exquisite regulation of cell division at the shoot apex according to the external environmental cues enables plants to adapt the ever-changing environment. We have recently shown that light direct signaling and carbohydrate (sugar) energy signaling are both essential for the activation of cell division at the shoot apex. Light is converted to auxin signal to activate small GTPase 2 (ROP2). Subsequently, the activated ROP2 directly interacts with Target of Rapamycin (TOR) protein kinase, a pivotal regulator of cell division, to promotes its kinase activity...
August 14, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28805295/multi-parametric-magnetic-resonance-imaging-mpmri-identifies-significant-apical-prostate-cancers
#14
Alexander P Kenigsberg, Tsutomu Tamada, Andrew B Rosenkrantz, Elton Llukani, Fang-Ming Deng, Jonathan Melamed, Ming Zhou, Herbert Lepor
OBJECTIVE: To determine if multiparametric MRI (mpMRI) identifies significant apical disease, thereby informing decisions regarding preservation of the membranous urethra. MATERIALS AND METHODS: Men undergoing radical prostatectomy between January 2012 and June 2016 who underwent a 12-core transrectal-ultrasound guided systematic biopsy, preoperative 3-T MRI, and sectioning of the prostate specimen with tumor foci mapping were extracted from a single surgeon's prospective longitudinal outcomes database...
August 14, 2017: BJU International
https://www.readbyqxmd.com/read/28803805/three-dimensional-evaluation-of-molar-buccolingual-inclinations-after-orthodontic-treatment-using-edgewise-mechanics
#15
Branson Billings, Lana Helms, Katherine Kula, Achint Utreja, George Eckert, Ahmed Ghoneima
OBJECTIVES: The purpose of this study was to measure changes in buccolingual inclination and in thickness of maxillary and mandibular buccal and lingual bone of maxillary and mandibular molars following orthodontic treatment using edgewise mechanics. MATERIALS AND METHODS: Cone-beam computed tomography scans of 48 patients taken before and after completion of comprehensive orthodontic treatment were collected for this retrospective study. Buccolingual molar inclinations were reported as angular measurements using the long axis of the teeth and inferior border of the nasal floor and inferior border of the mandible, respectively...
August 10, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28801201/effectiveness-of-controlled-telescoping-system-for-lateral-hip-pain-caused-by-sliding-of-blade-following-intramedullary-nailing-of-trochanteric-fracture
#16
Suk Kyu Choo, Hyoung-Keun Oh, Hyeong Tak Ko, Dong-Uk Min, Youngwoo Kim
INTRODUCTION: The purpose of this study was to demonstrate the effectiveness of controlled telescoping system for lateral hip pain caused by sliding of the blade following intramedullary nailing of trochanteric fractures. MATERIALS AND METHODS: A retrospective cohort study was performed to compare the controlled telescoping system (Compression Hip Nail; CHN) with the conventional sliding system (Proximal Femoral Nail Antirotation; PFNA) for trochanteric fractures...
July 25, 2017: Injury
https://www.readbyqxmd.com/read/28800388/rapid-access-to-nanographenes-and-fused-heteroaromatics-by-palladium-catalyzed-annulative-%C3%AF-extension-reaction-of-unfunctionalized-aromatics-with-diiodobiaryls
#17
Wataru Matsuoka, Hideto Ito, Kenichiro Itami
Efficient and rapid access to nanographenes and π-extended fused heteroaromatics is important in materials science. Here we report a Pd-catalyzed efficient one-step annulative π-extension (APEX) reaction of PAHs and heteroaromatics, producing various π-extended aromatics. In the presence of a cationic Pd complex, triflic acid, silver pivalate, and diiodobiaryls, diverse unfunctionalized PAHs and heteroaromatics were directly transformed into larger PAHs, nanographenes, and π-extended fused heteroaromatics in a single step...
August 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28799958/learning-curve-of-small-incision-lenticule-extraction-challenges-and-complications
#18
Jeewan S Titiyal, Manpreet Kaur, Anubha Rathi, Ruchita Falera, Manthan Chaniyara, Namrata Sharma
PURPOSE: To describe the intraoperative complications observed during the initial learning curve of small incision lenticule extraction (SMILE) and their management. METHODS: Prospective evaluation of 100 consecutive eyes (50 patients) undergoing SMILE was performed at an apex tertiary care ophthalmic center. Patients older than 18 years with a stable refractive error ranging from -1.0 to -10.0 D myopia and up to 3.0 D astigmatism were included. Any intraoperative complications and their management were noted...
August 9, 2017: Cornea
https://www.readbyqxmd.com/read/28799878/letter-to-the-editor-microsurgery-for-basilar-apex-aneurysms-in-the-modern-era
#19
Ryan P Morton, Louis J Kim, Laligam N Sekhar
No abstract text is available yet for this article.
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28798854/microfluidic-measurement-for-blood-flow-and-platelet-adhesion-around-a-stenotic-channel-effects-of-tile-size-on-the-detection-of-platelet-adhesion-in-a-correlation-map
#20
Sung Yong Jung, Eunseop Yeom
Platelet aggregation affects the surrounding blood flow and usually occurs where a blood vessel is narrowed as a result of atherosclerosis. The relationship between blood flow and platelet aggregation is not yet fully understood. This study proposes a microfluidic method to measure the velocity and platelet aggregation simultaneously by combining the micro-particle image velocimetry technique and a correlation mapping method. The blood flow and platelet adhesion procedure in a stenotic micro-channel with 90% severity were observed for a relatively long period of 4 min...
March 2017: Biomicrofluidics
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