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https://www.readbyqxmd.com/read/29792038/downregulation-of-cancer-stemness-by-novel-diterpenoid-ovatodiolide-inhibits-hepatic-cancer-stem-cell-like-traits-by-repressing-wnt-formula-see-text-catenin-signaling
#1
Mingche Liu, Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Wei-Hwa Lee, Yen-Kuang Lin, Alexander T H Wu, Hsiao M, Yew-Min Tzeng, Chi-Tai Yeh, Jo-Ting Tsai
The hierarchical tumor propagation or cancer stem cells (CSCs) model of carcinogenesis postulates that like physiologic adult stem cell (ASC), the CSCs positioned at the apex of any tumor population form the crux of tumor evolution with a constitutive regenerative capacity and differentiation potential. The propagation and recurrence of the characteristically heterogeneous and therapy-resistant hepatocellular carcinoma (HCC), adds to accumulating evidence to support this CSCs model. Based on the multi-etiologic basis of HCC formation which among others, focuses on the disruption of the canonical Wnt signaling pathway, this study evaluated the role of cembrane-type phytochemical, Ovatodiolide, in the modulation of the Wnt/[Formula: see text]-catenin pathway, and its subsequent effect on liver CSCs' activities...
May 24, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29791686/extruded-upper-first-molar-intrusion-comparison-between-unilateral-and-bilateral-miniscrew-anchorage
#2
Mari Miura Sugii, Bruno de Castro Ferreira Barreto, Waldemir Francisco Vieira-Júnior, Katia Regina Izola Simone, Ataís Bacchi, Ricardo Armini Caldas
OBJECTIVE: The aim of his study was to evaluate the stress on tooth and alveolar bone caused by orthodontic intrusion forces in a supraerupted upper molar, by using a three-dimensional Finite Element Method (FEM). METHODS: A superior maxillary segment was modeled in the software SolidWorks 2010 (SolidWorks Corporation, Waltham, MA, USA) containing: cortical and cancellous bone, supraerupted first molar, periodontal tissue and orthodontic components. A finite element model has simulated intrusion forces of 4N onto a tooth, directed to different mini-screw locations...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791567/immunohistological-study-of-the-effect-of-vascular-endothelial-growth-factor-on-the-angiogenesis-of-mature-root-canals-in-rat-molars
#3
Cleber Keiti Nabeshima, José Edgar Valdivia, Hector Caballero-Flores, Victor Elias Arana-Chavez, Manoel Eduardo de Lima Machado
Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods Upper first molars of twelve 13-week old Wistar male rats were used. The root pulp of the mesiobuccal canal was removed and the root canal instrumented with K-files up to size #25. Periapical bleeding was induced into the root canal by introducing a #15 K-file beyond the apex...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29791378/design-of-an-adjustable-bipod-flexure-for-a-large-aperture-mirror-of-a-space-camera
#4
Bei Liu, Wei Wang, Yan-Jun Qu, Xu-Peng Li, Xiao Wang, Hui Zhao
An adjustable bipod flexure (ABF) technique for a large-aperture mirror of a space camera is presented. The proposed flexure mount can decrease the surface distortions caused by the machining error and the assembly error of the mirror assembly (MA) in a horizontal optical testing layout. Through the analysis of the compliance matrix of conventional bipod flexure, the positional relationship between the rotation center and the apex of the flexure is investigated. Then, the principle of the adjustable flexure, known as the trapezoidal switching principle, is proposed based on the analysis result...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791285/cardiac-structure-injury-after-radiotherapy-for-breast-cancer-cross-sectional-study-with-individual-patient-data
#5
Carolyn Taylor, Paul McGale, Dorthe Brønnum, Candace Correa, David Cutter, Frances K Duane, Bruna Gigante, Maj-Britt Jensen, Ebbe Lorenzen, Kazem Rahimi, Zhe Wang, Sarah C Darby, Per Hall, Marianne Ewertz
Purpose Incidental cardiac irradiation can cause cardiac injury, but little is known about the effect of radiation on specific cardiac segments. Methods For 456 women who received breast cancer radiotherapy between 1958 and 2001 and then later experienced a major coronary event, information was obtained on the radiotherapy regimen they received and on the location of their cardiac injury. For 414 women, all with documented location of left ventricular (LV) injury, doses to five LV segments were estimated. For 133 women, all with documented location of coronary artery disease with ≥ 70% stenosis, doses to six coronary artery segments were estimated...
May 23, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29790246/a-review-of-predation-as-a-limiting-factor-for-bird-populations-in-mesopredator-rich-landscapes-a-case-study-of-the-uk
#6
Staffan Roos, Jennifer Smart, David W Gibbons, Jeremy D Wilson
The impact of increasing vertebrate predator numbers on bird populations is widely debated among the general public, game managers and conservationists across Europe. However, there are few systematic reviews of whether predation limits the population sizes of European bird species. Views on the impacts of predation are particularly polarised in the UK, probably because the UK has a globally exceptional culture of intensive, high-yield gamebird management where predator removal is the norm. In addition, most apex predators have been exterminated or much depleted in numbers, contributing to a widely held perception that the UK has high numbers of mesopredators...
May 22, 2018: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/29789815/challenging-case-robot-assisted-laparoscopic-prostatectomy-after-prior-suprapubic-open-prostatectomy
#7
Shirin Razdan, Sanjay Razdan
Introduction: Given the ubiquity of robot-assisted laparoscopic prostatectomy (RALP) for treatment of localized prostate cancer, more surgeons are encountering challenging cases, either secondary to difficult anatomy, prior abdominal surgery, or prior radiation therapy. Our case is of RALP in a patient after prior suprapubic prostatectomy. Case Presentation: A 61-year-old otherwise healthy Hispanic gentleman presented for consultation after being found to have Gleason 4 + 4 = 8 prostate cancer on transrectal ultrasound-guided biopsy by an outside provider in July 2017...
2018: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29788925/de-novo-transcriptome-assembly-of-the-eight-major-organs-of-sacha-inchi-plukenetia-volubilis-and-the-identification-of-genes-involved-in-%C3%AE-linolenic-acid-metabolism
#8
Xiao-Di Hu, Bang-Zhen Pan, Qiantang Fu, Longjian Niu, Mao-Sheng Chen, Zeng-Fu Xu
BACKGROUND: Sacha Inchi (Plukenetia volubilis L.), which belongs to the Euphorbiaceae, has been considered a new potential oil crop because of its high content of polyunsaturated fatty acids in its seed oil. The seed oil especially contains high amounts of α-linolenic acid (ALA), which is useful for the prevention of various diseases. However, little is known about the genetic information and genome sequence of Sacha Inchi, which has largely hindered functional genomics and molecular breeding studies...
May 22, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29785185/morphometric-analysis-of-the-mental-foramen-using-cone-beam-computed-tomography
#9
Rudyard Dos Santos Oliveira, Maria Rodrigues Coutinho, Francine Kühl Panzarella
This study evaluated the effects of age and sex on the location and size of the mental foramen (MF). A total of 104 cone-beam computed tomography (CBCT) scans from patients' aged 18-80 years were selected. Images were evaluated using the following parameters: position and size of the MF, and Distances A (distance from the upper limit of the MF to the apex of the first lower premolar), B (distance from the upper cortical border of the MF to the alveolar crest), and C (distance from the border of the MF to the base of the mandible)...
2018: International Journal of Dentistry
https://www.readbyqxmd.com/read/29784768/b-alleviates-al-toxicity-by-promoting-alkalization-in-root-transition-zone-via-polar-auxin-transport
#10
Xuewen Li, Ya Lin Li, Jingwen Mai, Lin Tao, Mei Qu, Jia You Liu, Ren Fang Shen, Gui Lian Xu, Ying Ming Feng, Hong Dong Xiao, Li Shu Wu, Lei Shi, Shao Xue Guo, Jian Liang, Yiyong Zhu, Yongming He, Frantisek Baluska, Sergey Shabala, Min Yu
Boron (B) supply alleviates aluminum (Al) toxicity in higher plants. The underlying mechanisms behind this phenomenon remain elusive. Here we demonstrate that B promotes, while Al inhibits, surface pH gradients, leading to alkalization in the root transition zone and acidification in the elongation zone, as shown by using a bromocresol green pH indicator. B supply significantly decreased Al accumulation in the transition zone (~ 1.0-2.5 mm from the apex) of lateral pea (Pisum sativum) roots, thus alleviated Al-induced inhibition of root elongation...
May 21, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29784623/regional-myocardial-strain-measurements-from-4dct-in-patients-with-normal-lv-function
#11
Elliot R McVeigh, Amir Pourmorteza, Michael Guttman, Veit Sandfort, Francisco Contijoch, Suhas Budhiraja, Zhennong Chen, David A Bluemke, Marcus Y Chen
BACKGROUND: CT SQUEEZ is a new automated technique to evaluate regional endocardial strain by tracking features on the endocardium from 4D cine CT data. The objective of this study was to measure the range of endocardial regional strain (RSCT ) values obtained with CT SQUEEZ in the normal human left ventricle (LV) from standard clinical 4D coronary CTA exams. METHODS: RSCT was measured over the heart cycle in 25 humans with normal LV function using cine CT from three vendors...
May 9, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29782225/a-comparison-of-reproductive-and-energetic-states-in-a-marine-apex-predator-the-tiger-shark-galeocerdo-cuvier
#12
Neil Hammerschlag, Rachel A Skubel, James Sulikowski, Duncan J Irschick, Austin J Gallagher
To fuel the high energetic demands of reproduction, vertebrates employ different tactics of resource use. Large sharks exhibit long gestation periods and have relatively few well-developed young, which likely incurs high energetic costs. However, information on the relationship between the reproductive and energetic states for most shark species is lacking. In the present study, we used a noninvasive approach to assess relationships among reproductive stage, plasma triglyceride levels, body condition, and circulating reproductive hormones in free-ranging female tiger sharks (Galeocerdo cuvier)...
July 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29780829/the-effect-of-c-arm-mobility-and-field-of-vision-on-radiation-exposure-in-the-treatment-of-proximal-femoral-fractures-a-randomized-clinical-trial
#13
Mahmut Kalem, Kerem Başarır, Hakan Kocaoğlu, Ercan Şahin, Hakan Kınık
Objectives: To examine the effect of fluoroscopy devices with different sizes of image intensifier and C-arm maneuverability on operating time, fluoroscopy time, radiation dose and reduction, and fixation quality at intertrochanteric femoral fractures. Design: Single-center, randomized, prospective study. Setting: Academic Level I trauma hospital. Patients and Intervention: 34 patients treated with cephalomedullary nailing for a stable, intertrochanteric proximal femur fracture (OTA A1)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780559/spatially-resolved-acyl-transfer-on-surface-by-organo-catalytic-scanning-probe-nanolithography-o-cspl
#14
Julien Botton, Katharina Gratzer, Cyril François, Vincent Mesquita, Lionel Patrone, Teodor S Balaban, Sylvain Clair, Jean-Luc Parrain, Olivier Chuzel
Groundbreaking research done in the area of nanolithography makes it a versatile tool to produce nanopatterns for a broad range of chemical surface functionalization or physical modifications. We report for the first time an organocatalytic scanning probe nanolithography (o-cSPL) approach. Covalent binding of an organocatalyst on the apex of an atomic force microscope (AFM) tip gives way to a system that allows the formation of locally defined acylated-alcohol patterns on self-assembled monolayers (SAMs). With resolutions comparable to those of other cSPL methods, this first example of o-cSPL holds promise for future applications of bottom-up nanolithography set-ups employing this novel technique...
May 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29780176/sex-size-and-isotopes-cryptic-trophic-ecology-of-an-apex-predator-the-white-shark-carcharodon-carcharias
#15
G C A French, S Rizzuto, M Stürup, R Inger, S Barker, J H van Wyk, A V Towner, W O H Hughes
Demographic differences in resource use are key components of population and species ecology across the animal kingdom. White sharks ( Carcharodon carcharias ) are migratory, apex predators, which have undergone significant population declines across their range. Understanding their ecology is key to ensuring that management strategies are effective. Here, we carry out the first stable isotope analyses of free-swimming white sharks in South Africa. Biopsies were collected in Gansbaai (34.5805°S, 19.3518°E) between February and July 2015...
2018: Marine Biology
https://www.readbyqxmd.com/read/29779908/fixation-of-lung-apex-in-spontaneous-pneumothorax-is-safe-and-efficient-in-decrease-recurrences
#16
Wendy Yang, Pei-Yeh Chang, Ai-Hua Yeh, Yung-Ching Ming, Jeng Chang Chen, Jin-Yao Lai
BACKGROUND: Video-assisted thoracoscopic bullectomy with pleurodesis is widely used to treat spontaneous pneumothorax. However, 1%-3% of patients experience postoperative complications that may require reoperation, such as bleeding or prolonged air leaks, and 3%-7% of patients require a repeat thoracoscopic bullectomy due to recurrence. Therefore, a modified procedure with improved outcomes is required. METHODS: Between January 1, 2011 and December 31, 2015, 196 patients with spontaneous pneumothorax underwent thoracoscopic bullectomy and pleurodesis with or without fixation of the lung apex to the chest wall...
May 3, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29779186/mastoid-foramen-mastoid-emissary-vein-and-clinical-implications-in-neurosurgery
#17
Martin Hampl, David Kachlik, Katerina Kikalova, Roxane Riemer, Matej Halaj, Vlastimil Novak, Premysl Stejskal, Miroslav Vaverka, Lumir Hrabalek, David Krahulik, Ondrej Nanka
BACKGROUND: Mastoid emissary vein is especially important from the neurosurgical point of view, because it is located in variable number in the area of the occipitomastoid suture and it can become a source of significant bleeding in surgical approaches through the mastoid process, especially in retrosigmoid craniotomy, which is used for approaches to pathologies localized in the cerebellopontine angle. Ideal imaging method for diagnosis of these neglected structures when planning a surgical approach is high-resolution computed tomography...
May 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29778469/communications-of-staphylococcus-aureus-and-non-aureus-staphylococcus-species-from-bovine-intramammary-infections-and-teat-apex-colonization
#18
Yasser S Mahmmod, Ilka Christine Klaas, Line Svennesen, Karl Pedersen, Hanne Ingmer
The role of non-aureus staphylococci (NAS) in the risk of acquisition of intramammary infections with Staphylococcus aureus is vague and still under debate. The objectives of this study were to (1) investigate the distribution patterns of NAS species from milk and teat skin in dairy herds with automatic milking systems, and (2) examine if the isolated NAS influences the expression of S. aureus virulence factors controlled by the accessory gene regulator (agr) quorum sensing system. In 8 herds, 14 to 20 cows with elevated somatic cell count were randomly selected for teat skin swabbing and aseptic quarter foremilk samples from right hind and left front quarters...
May 16, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29778454/influence-of-the-beam-profile-crosslinking-setting-on-changes-in-corneal-topography-and-tomography-in-progressive-keratoconus-preliminary-results
#19
Robert Herber, Kathleen S Kunert, Věra Veliká, Eberhard Spoerl, Lutz E Pillunat, Frederik Raiskup
PURPOSE: To evaluate the effect of accelerated corneal crosslinking (CXL) with a "higher peripheral intensity" profile setting compared with a standard "top hat" profile setting performed using different CXL systems. SETTING: Department of Ophthalmology, University Hospital Carl Gustav Carus, Dresden, Germany. DESIGN: Retrospective case series. METHODS: Eyes from patients with progressive keratoconus were included...
May 16, 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29777400/ontogeny-of-anastomosed-laticifers-in-the-stem-apex-of-hancornia-speciosa-apocynaceae-a-topographic-approach
#20
Mayara Pereira Gonçalves, Maria Olívia Mercadante-Simões, Leonardo Monteiro Ribeiro
Latex is a complex plant secretion with both ecological and economic importance. There is little information currently available on the cytological aspects of the ontogenesis of anastomosed laticifers, the ducts originating through the lysis of adjacent cell walls. Hancornia speciosa is a tree typical of the Cerrado (neotropical savanna) biome. Its latex has medicinal value and is also used to produce rubber. The ontogenesis of its laticifers and the process of latex synthesis are described here. Structural, cytochemical, and ultrastructural analyses of the stem apex and phytochemical analyses of the latex were performed...
May 18, 2018: Protoplasma
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