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https://www.readbyqxmd.com/read/29346835/two-citrate-transporters-coordinately-regulate-citrate-secretion-from-rice-bean-root-tip-under-aluminum-stress
#1
Mei Ya Liu, He Qiang Lou, Wei Wei Chen, Miguel A Piñeros, Jia Meng Xu, Wei Fan, Leon V Kochian, Shao Jian Zheng, Jian Li Yang
Al-induced organic acid secretion from the root apex is an important Al resistance mechanism. However, it remains unclear how plants fine-tune root organic acid secretion which can contribute significantly to the loss of fixed carbon from the plant. Here, we demonstrate that Al-induced citrate secretion from the rice bean root apex is biphasic, consisting of an early phase with low secretion and a later phase of large citrate secretion. We isolated and characterized VuMATE2 as a possible second citrate transporter in rice bean functioning in tandem with VuMATE1, which we previously identified...
January 18, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29346116/4d-computed-tomography-scans-for-conformal-thoracic-treatment-planning-is-a-single-scan-sufficient-to-capture-thoracic-tumor-motion
#2
Yolanda D Tseng, Landon Wootton, Matthew Nyflot, Smith Apisarnthanarax, Ramesh Rengan, Charles Bloch, George Sandison, Sara St James
Four dimensional computed tomography (4DCT) scans are routinely used in radiation therapy to determine the internal treatment volume for targets that are moving (e.g. lung tumors). The use of these studies has allowed clinicians to create target volumes based upon the motion of the tumor during the imaging study. The purpose of this work is to determine if a target volume based on a single 4DCT scan at simulation is sufficient to capture thoracic motion. Phantom studies were performed to determine expected differences between volumes contoured on 4DCT scans and those on the evaluation CT scans (slow scans)...
January 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29343576/increased-epitope-complexity-correlated-with-antibody-affinity-maturation-and-a-novel-binding-mode-revealed-by-structures-of-rabbit-antibodies-against-the-third-variable-loop-v3-of-hiv-1-gp120
#3
Ruimin Pan, Yali Qin, Marisa Banasik, William Lees, Adrian J Shepherd, Michael W Cho, Xiang-Peng Kong
The V3 loop of HIV-1 gp120 is an immunodominant region targeted by neutralizing antibodies (nAbs). Despite limited breadth, better characterization of the structural details of the interactions between these nAbs and their target epitopes would enhance our understanding of the mechanism of neutralization and facilitate designing better immunogens to induce nAbs with greater breadth. Recently, we isolated two anti-V3 neutralizing monoclonal antibodies (mAbs), 10A3 and 10A37, from a rabbit immunized with gp120 of the M group consensus sequence...
January 17, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29341848/protection-of-root-apex-meristem-during-stress-responses
#4
Mohamed M Mira, Shuanglong Huang, Robert D Hill, Claudio Stasollaa
By regulating the levels of nitric oxide (NO) in a cell and tissue specific fashion, Phytoglobins (Pgbs), plant hemoglobin-like proteins, interfere with many NO-mediated pathways participating in developmental and stress-related responses. Recent evidence reveals that one of the functions of Pgbs is to protect the root apical meristem (RAM) from stress conditions by retaining the viability and function of the quiescent center (QC), required to maintain the stem cells in an undifferentiated state and ensure proper tissue patterning and root viability...
January 17, 2018: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/29341356/all-over-the-map-an-interobserver-agreement-study-of-tumor-location-based-on-the-pi-radsv2-sector-map
#5
Matthew D Greer, Joanna H Shih, Tristan Barrett, Sandra Bednarova, Ismail Kabakus, Yan Mee Law, Haytham Shebel, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
BACKGROUND: Prostate imaging reporting and data system version 2 (PI-RADSv2) recommends a sector map for reporting findings of prostate cancer mulitparametric MRI (mpMRI). Anecdotally, radiologists may demonstrate inconsistent reproducibility with this map. PURPOSE: To evaluate interobserver agreement in defining prostate tumor location on mpMRI using the PI-RADSv2 sector map. STUDY TYPE: Retrospective. POPULATION: Thirty consecutive patients who underwent mpMRI between October, 2013 and March, 2015 and who subsequently underwent prostatectomy with whole-mount processing...
January 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29340898/epidemiological-aspects-of-healthcare-associated-infections-and-microbial-genomics
#6
C Mirande, I Bizine, A Giannetti, N Picot, A van Belkum
Hospital-acquired infections (HAIs) are a cause of continuously increasing morbidity and mortality. Most of these infections are caused by a limited set of bacterial species, which share the capability to efficiently spread from patient to patient and to easily acquire antibiotic resistance determinants. This renders correct and rapid species identification and antibiotic susceptibility testing (AST) important and underscores the relevance of bacterial epidemiological typing. The latter is needed for the sensitive detection and exact tracing of nosocomial spread of these potentially multidrug-resistant microorganisms (MDRO)...
January 17, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29340134/does-mycorrhizal-status-alter-herbivore-induced-changes-in-whole-plant-resource-partitioning
#7
Colin M Orians, Sara Gomez, Timothy Korpita
Both mycorrhizae and herbivore damage cause rapid changes in source-sink dynamics within a plant. Mycorrhizae create long-term sinks for carbon within the roots while damage by leaf-chewing herbivores causes temporary whole-plant shifts in carbon and nitrogen allocation. Thus, induced responses to herbivory might depend on the presence or absence of mycorrhizae. We examined the effects of mycorrhizal presence on induced resource partitioning in tomato (Solanum lycopersicon) in response to cues from a specialist herbivore Manduca sexta...
February 2018: AoB Plants
https://www.readbyqxmd.com/read/29339023/calculated-shape-dependence-of-electromagnetic-field-in-tip-enhanced-raman-scattering-by-using-a-monopole-antenna-model
#8
Yasutaka Kitahama, Tamitake Itoh, Toshiaki Suzuki
To evaluate the shape of an Ag tip with regard to tip-enhanced Raman scattering (TERS) signal, the enhanced electromagnetic (EM) field and scattering spectrum, arising from surface plasmon resonance at the apex of the tip, were calculated using a finite-difference time domain (FDTD) method. In the calculated forward scattering spectra from the smooth Ag tip, the band appeared within the visible region, similar to the experimental results and calculation for a corrugated Ag cone. In the FDTD calculation of TERS, the Ag tip acting as a monopole antenna was adopted by insertion of a perfect electric conductor between the root of the tip and a top boundary surface of the calculation space...
January 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29338293/betrixaban-a-new-oral-factor-xa-inhibitor-for-extended-venous-thromboembolism-prophylaxis-in-high-risk-hospitalized-patients
#9
Scott G Garland, Christina E DeRemer, Steven M Smith, John G Gums
OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of the factor Xa (FXa) inhibitor betrixaban for extended-duration prophylaxis of acute medically ill patients with venous thromboembolism (VTE) risk factors. DATA SOURCES: A MEDLINE/PubMed (January 1990 to October 2017) search was conducted using the following keywords: betrixaban, PRT054021, FXa inhibitor, novel oral anticoagulant, NOAC, direct oral anticoagulant, DOAC, and target specific oral anticoagulant, TSOAC...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29338272/morphologic-assessment-of-mandibular-anterior-teeth-root-canal-using-cbct
#10
Sina Haghanifar, Ehsan Moudi, Ali Bijani, Mohammad Kazemi Ghanbarabadi
OBJECTIVE: The aim of this study was to evaluate the number and morphological characteristics of the roots and root canals in mandibular anterior teeth, using cone beam computed tomography. METHODS AND MATERIALS: In this cross-sectional study, 1053 anterior mandibular teeth from 200 CBCT scans were evaluated. The teeth were completely developed and should have had no fillings in the root or crown. The teeth were investigated in terms of the number of roots and root canals, the location of the apical foramen, the distance of the apical foramen to the anatomical apex, root length, crown length, dilacerations and the type of canals according to Vertucci's classification...
November 2017: Acta Medica Academica
https://www.readbyqxmd.com/read/29336881/influence-of-contracted-endodontic-access-on-root-canal-geometry-an-in%C3%A2-vitro-study
#11
Mario Alovisi, Damiano Pasqualini, Edoardo Musso, Elena Bobbio, Carlotta Giuliano, Davide Mancino, Nicola Scotti, Elio Berutti
INTRODUCTION: Contracted endodontic cavities (CECs) have developed from the concept of minimally invasive dentistry and provide an alternative to traditional endodontic cavities (TECs). They have been designed in an effort to preserve the mechanical stability of teeth. The contracted cavity design preserves more of the dentin but may influence the geometric shaping parameters. The aim of this micro-computed tomographic study was to evaluate the influence of contracted endodontic cavities on the preservation of the original root canal anatomy after shaping with nickel-titanium rotary instruments...
January 12, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29335888/root-lengthening-with-apical-closure-in-two-maxillary-immature-permanent-central-incisors-after-placement-of-mineral-trioxide-aggregate-mta-as-an-apical-plug
#12
F Masmoudi, I Bourmeche, A Sebai, Z Baccouche, F Maatouk
BACKGROUND: Necrosis of permanent immature teeth is a common reason for consultation in paediatric dentistry. Apexification is a therapeutic procedure aiming to create an apical calcified barrier in open apex teeth. CASE REPORT: Two cases are presented in which apexification were completed on immature permanent traumatised incisors using a mineral trioxide aggregate (MTA) plug. FOLLOW-UP: At 2 and 5 years showed apical closure and radicular elongation beyond the MTA plug...
January 15, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29334470/heterologous-expression-of-rhizobial-celc2-cellulase-impairs-symbiotic-signaling-and-nodulation-in-medicago-truncatula
#13
Marta Robledo, Esther Menéndez, Jose Ignacio Jimenez-Zurdo, Raúl Rivas, Encarna Velazquez, Eustoquio Martinez-Molina, Giles Oldroyd, Pedro F Mateos
The infection of legume plants by rhizobia is tightly regulated to ensure accurate bacterial penetration, infection and development of functionally efficient nitrogen-fixing root nodules. Rhizobial Nod Factors (NF) have key roles in the elicitation of nodulation signalling. Infection of white clover roots also involves the tightly regulated specific breakdown of the non-crystalline apex of cell walls in growing root hairs, which is mediated by Rhizobium leguminosarum bv. trifolii cellulase CelC2. Here, we have analyzed the impact of this endoglucanase on symbiotic signalling in the model legume Medicago truncatula...
January 15, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29333593/control-of-anterior-segment-using-an-antero-posterior-lingual-sliding-retraction-system-a-preliminary-cone-beam-ct-study
#14
Min Hwang, Hyo-Won Ahn, Soon-Yong Kwon, Jeong-Ho Choi, Seong-Hun Kim, Gerald Nelson
BACKGROUND: This study was performed to evaluate the treatment effects of the antero-posterior lingual retractor (APLR), focusing on the 3-dimensional (3D) tooth movement of the maxillary anterior teeth and their alveolar bone levels. METHODS: En masse retraction was performed using either the C-lingual retractor (CLR, C-group, n = 9) or the antero-posterior lingual retractor (APLR, AP-group, n = 8). We evaluated 3D movement of the maxillary anterior teeth and alveolar bone levels, root length of the central incisors, long axes of the maxillary canines, and occlusal plane changes from CBCT images...
January 15, 2018: Progress in Orthodontics
https://www.readbyqxmd.com/read/29330841/delayed-replantation-of-an-avulsed-immature-permanent-incisor-and-apexification-using-a-novel-fast-setting-calcium-silicate-cement-containing-fluoride-a-3-year-follow-up-case-report
#15
A Vafaei, B Ranjkesh, L Erfanparast, H Løvschall
BACKGROUND: Traumatic tooth avulsion requires an urgent intervention to replant the tooth. Prolonged post-injury dry extra-oral conditions worsen the prognosis and increase the risk of root resorption. Fluoride has the potential to delay replacement resorption. Calcium silicate cements (CSC) are used to seal the root canal system and to stimulate periapical regeneration in immature open apex teeth (apexification). This report suggests the application of a novel fast-setting CSC with fluoride for apexification in an attempt to hinder root resorption...
January 12, 2018: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29327942/efficient-selective-screening-for-heart-failure-in-elderly-men-and-women-from-the-community-a-diagnostic-individual-participant-data-meta-analysis
#16
Rogier F Kievit, Aisha Gohar, Arno W Hoes, Michiel L Bots, Evelien Es van Riet, Yvonne van Mourik, Loes Cm Bertens, Leandra Jm Boonman-de Winter, Hester M den Ruijter, Frans H Rutten
Background Prevalence of undetected heart failure in older individuals is high in the community, with patients being at increased risk of morbidity and mortality due to the chronic and progressive nature of this complex syndrome. An essential, yet currently unavailable, strategy to pre-select candidates eligible for echocardiography to confirm or exclude heart failure would identify patients earlier, enable targeted interventions and prevent disease progression. The aim of this study was therefore to develop and validate such a model that can be implemented clinically...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29327863/endoscopic-endonasal-transpterygoid-approach-to-petrous-pathologies-technique-limitations-and-alternative-approaches
#17
Gautam U Mehta, Shaan M Raza
The endoscopic endonasal transpterygoid approach is a versatile technique, providing direct access to the petrous apex through an anterior surgical corridor. In this review we detail the transpterygoid approach to the petrous apex and highlight its relative indications. Although this approach is a useful strategy for many lesions of the petrous apex, disease extension into lateral, superior, or posterior compartments may limit extent of resection afforded by an anterior approach alone. Based on these considerations, a disease compartment-specific strategy is discussed...
January 10, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29326494/experience-of-an-academic-institute-in-importing-a-novel-preclinical-drug-into-india
#18
M Praveen Kumar, Bikash Medhi
The article throws light on the process of importing a novel preclinical drug into India based on the real-life experience from one of our studies. A novel drug "X" acting through a new mechanism of action was hypothesized by us to function as a neuroprotectant. It was decided to import this novel drug from a university located in Brazil. An official collaboration pact was exchanged between both the sides. In accordance with the Indian Drug and Cosmetics Act 1940, unauthorized import of drug into India is not permitted...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29325963/surgical-anatomy-of-the-eustachian-tube-for-endoscopic-transnasal-skull-base-surgery-a-cadaveric-and-radiological-study
#19
Noritaka Komune, Satoshi Matsuo, Koichi Miki, Yojiro Akagi, Ryota Kurogi, Koji Iihara, Takashi Nakagawa
OBJECTIVE: The endoscopic endonasal approach to the anatomically complex lateral skull base presents technical challenges. The use of the Eustachian tube as a landmark to identify the petrous internal carotid artery has recently been reported, and this study aims to define the anatomical relationship between the Eustachian tube and its surrounding structures using cadaveric dissection and radiologic analysis. METHODS: To clarify the relationship of the Eustachian tube with its surrounding structures, we performed endoscopic and microscopic dissection of four adult cadaveric heads, and analyzed computed topography scans from 20 patients...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29325588/milk-flow-data-collected-routinely-in-an-automatic-milking-system-an-alternative-to-milking-time-testing-in-the-management-of-teat-end-condition
#20
Håvard Nørstebø, Amira Rachah, Gunnar Dalen, Odd Rønningen, Anne Cathrine Whist, Olav Reksen
BACKGROUND: Having a poor teat-end condition is associated with increased mastitis risk, hence avoiding milking machine settings that have a negative effect on teat-end condition is important for successful dairy production. Milking-time testing (MTT) can be used in the evaluation of vacuum conditions during milking, but the method is less suited for herds using automatic milking systems (AMS) and relationships with teat end condition is poorly described. This study aimed to increase knowledge on interpretation of MTT in AMS and to assess whether milk-flow data obtained routinely by an AMS can be useful for the management of teat-end health...
January 11, 2018: Acta Veterinaria Scandinavica
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