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https://www.readbyqxmd.com/read/29679061/the-role-of-macrophage-migration-inhibitory-factor-in-the-function-of-intestinal-barrier
#1
Milica Vujicic, Tamara Saksida, Sanja Despotovic, Svetlana Sokovic Bajic, Ivana Lalić, Ivan Koprivica, Dragica Gajic, Natasa Golic, Maja Tolinacki, Ivana Stojanovic
Macrophage migration inhibitory factor (MIF) is a multifunctional protein that is involved in the development of gut-related inflammation. To investigate the role of MIF in the function of the intestinal barrier, we have explored intestinal permeability and gut-associated immune response in MIF-deficient (MIF-KO) mice. The absence of MIF provoked impairment of tight and adherens epithelial junctions in the colon through the disturbance of E-cadherin, zonula occludens-1, occludin and claudin-2 expression, which lead to the increase of intestinal barrier permeability...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678786/fetal-bovine-serum-induces-sustained-but-reversible-epithelial-mesenchymal-transition-in-the-beas-2b-cell-line
#2
S W Malm, E A Amouzougan, W T Klimecki
BEAS-2B is a non-malignant, immortalized human cell line that has been used extensively as a model of lung epithelium. Despite ATCC recommendations to culture BEAS-2B in defined, serum-free media, many publications describe culturing BEAS-2B in fetal bovine serum (FBS)-containing media. The objective of this study was to define the effects of FBS on BEAS-2B cells. FBS exposure resulted in increased nuclear levels of transcription factors responsible for regulating epithelial-mesenchymal transition (EMT), increased cell invasiveness and increased anchorage-independent growth...
April 17, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29676103/-protective-effect-and-mechanism-of-p-hydroxybenzaldehyde-on-blood-brain-barrier
#3
Yan-Ping Zhu, Xin Li, Yao Du, Lu Zhang, Li Ran, Ning-Na Zhou
The disruption of blood-brain barrier(BBB) induced by oxidative stress is an important pathological reaction which results in secondary brain injury during the cerebral ischemia-reperfusion. This study was designed to investigate the protective effect and mechanism of p-hydroxybenzaldehyde (p-HBA) from Gastrodia elata on BBB. The BBB is mainly consisted of vascular endothelial cells and astrocytes, so brain microvascular endothelial cell line (bEnd.3) and astrocytes (Ast) in mice were used in this study to establish BBB model...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675597/upregulated-epithelial-junction-expression-represents-a-novel-parameter-of-the-epithelial-radiation-response-to-fractionated-irradiation-in-oral-mucosa
#4
Sylvia Gruber, Nilsu Cini, Lisa-Marie Kowald, Julia Mayer, Andreas Rohorzka, Peter Kuess, Wolfgang Dörr
PURPOSE: During head and neck cancer treatment, the radiation response of the oral mucosa represents a frequent early side effect. Besides radiation-induced inhibition of proliferation, various other cellular responses occur. The radiation response of adherens and tight junction proteins was so far mostly investigated with large single-dose irradiation protocols, in vivo and in vitro. Therefore, the current study was initiated to investigate the impact of daily fractionated irradiation on the expression of adherens and tight junction proteins in vivo...
April 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29673682/dehydrated-hereditary-stomatocytosis-prenatal-management-of-ascites-and-pleural-effusions
#5
Claudine Le Vaillant, Anne-Sophie Riteau, Marion Eveillard, Claire Beneteau
No abstract text is available yet for this article.
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29673083/fine-particle-matter-disrupts-the-blood-testis-barrier-by-activating-tgf-%C3%AE-3-p38-mapk-pathway-and-decreasing-testosterone-secretion-in-rat
#6
Jianhui Liu, Lihua Ren, Jialiu Wei, Jin Zhang, Yupeng Zhu, Xiangyang Li, Li Jing, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Fine particle matter (PM) is correlated with male reproductive dysfunction in animals and humans, but the underlying mechanisms remain unknown. To investigate the toxic mechanism of PM, 32 male Sprague-Dawley (SD) rats were exposed to saline or PM2.5 with the doses of 1.8, 5.4, and 16.2 mg/kg.b.w. via intratracheal instillation, respectively, one time every 3 days, in total times for 30 days. Sperm concentration, hormone level, the expressions of BTB-associated protein and the mitogen-activated protein kinase (MAPK) pathway, tumor necrosis factor α and transforming growth factor β3 levels were detected...
April 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29673049/impact-of-ozone-on-claudins-and-tight-junctions-in-the-lungs
#7
Byeong-Gon Kim, Pureun-Haneul Lee, Sun-Hye Lee, Choon-Sik Park, An-Soo Jang
Claudins (CLDNs) are a major transmembrane protein component of tight junctions (TJs) in endothelia and epithelia. CLDNs are not only essential for sustaining the role of TJs in cell permeability but are also vital for cell signaling through protein-protein interactions. Ozone induces oxidative stress and lung inflammation in humans and experimental models, but the impact of ozone on claudins remains poorly understood. This study was to determine the expression of TJ proteins, such as claudin 3, 4, 5, and 14 following ozone exposure...
April 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29671892/frequent-loss-of-claudin-4-expression-in-dedifferentiated-and-undifferentiated-endometrial-carcinomas
#8
Basile Tessier-Cloutier, Robert A Soslow, Colin J R Stewart, Martin Köbel, Cheng-Han Lee
INTRO: Dedifferentiated/undifferentiated endometrial carcinomas (DDEC/UEC) are aggressive endometrial cancers with frequent genomic inactivation of core components of switch/sucrose non-fermentable (SWI/SNF) complex proteins. Claudin-4, an epithelial intercellular tight junction protein was recently found to be expressed in SWI/SNF-deficient undifferentiated carcinomas but not SWI/SNF-deficient sarcomas. The aim of this study is to examine claudin-4 expression in UEC/DDEC and other high-grade uterine carcinomas...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29670818/fingolimod-promotes-blood-nerve-barrier-properties-in-vitro
#9
Hideaki Nishihara, Toshihiko Maeda, Yasuteru Sano, Maho Ueno, Nana Okamoto, Yukio Takeshita, Fumitaka Shimizu, Michiaki Koga, Takashi Kanda
Objective: The main effect of fingolimod is thought to be functional antagonism of lymphocytic S1P1 receptors and the prevention of lymphocyte egress from lymphoid tissues, thereby reducing lymphocyte infiltration into the nervous system. However, a growing number of reports suggest that fingolimod also has a direct effect on several cell types in the nervous system. Although we previously reported that fingolimod enhances blood-brain barrier (BBB) functions, there have been no investigations regarding the blood-nerve barrier (BNB)...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29670469/dietary-n-3-pufa-may-attenuate-experimental-colitis
#10
Cloé Charpentier, Ronald Chan, Emmeline Salameh, Khaly Mbodji, Aito Ueno, Moïse Coëffier, Charlène Guérin, Subrata Ghosh, Guillaume Savoye, Rachel Marion-Letellier
Background: Inflammatory bowel diseases (IBD) occurred in genetically predisposed people exposed to environmental triggers. Diet has long been suspected to contribute to the development of IBD. Supplementation with n-3 polyunsaturated fatty acids (PUFA) protects against intestinal inflammation in rodent models while clinical trials showed no benefits. We hypothesized that intervention timing is crucial and dietary fatty acid pattern may influence intestinal environment to modify inflammation genesis...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29668497/surgical-treatment-of-venous-malformations-of-the-knee-treatment-outcomes-for-35-patients
#11
Claude Laurian, Claudine Masonni, Michel Wassef, Emmanuel Houdart, Francesca Toni, Veronique Marteau, Nikos Paraskevas, Stephanie Lenck, Annouk Bisdorff
BACKGROUND: The place of open surgery in venous malformations (VMs) of knee joint is still discussed. The aim of this study was to evaluate the benefits of surgery in terms of pain, function, and quality of life. DESIGN: This was a retrospective observational study. METHODS: Thirty-five consecutive young patients undergoing surgery for VMs of the knee between 2011 and 2014 were included. Data collection was performed using a prospective database by reviewing patient records...
April 17, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29666801/current-therapeutic-landscape-for-advanced-gastroesophageal-cancers
#12
REVIEW
Anthony Lopez, Kazuto Harada, Dilsa Mizrak Kaya, Jaffer A Ajani
Treatment of advanced gastroesophageal cancers remains challenging for clinicians, patients, and caregivers alike. Despite considerable research, the therapeutic armamentarium is restricted and hardly personalized. In the first-line setting, trastuzumab with a fluoropyrimidine and platinum agent is the standard-of-care in patients with HER2-positive tumor. For the others, a platinum-based doublet (preferably with oxaliplatin) is recommended. Three-drug cytotoxic regimens should be reserved for exceptional cases where patients have good performance status...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29664376/rickettsia-asembonensis-characterization-by-multilocus-sequence-typing-of-complete-genes-peru
#13
Steev Loyola, Carmen Flores-Mendoza, Armando Torre, Claudine Kocher, Melanie Melendrez, Alison Luce-Fedrow, Alice N Maina, Allen L Richards, Mariana Leguia
While studying rickettsial infections in Peru, we detected Rickettsia asembonensis in fleas from domestic animals. We characterized 5 complete genomic regions (17kDa, gltA, ompA, ompB, and sca4) and conducted multilocus sequence typing and phylogenetic analyses. The molecular isolate from Peru is distinct from the original R. asembonensis strain from Kenya.
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29661855/the-heptad-repeat-domain-1-of-mitofusin-has-membrane-destabilization-function-in-mitochondrial-fusion
#14
Frédéric Daste, Cécile Sauvanet, Andrej Bavdek, James Baye, Fabienne Pierre, Rémi Le Borgne, Claudine David, Manuel Rojo, Patrick Fuchs, David Tareste
Mitochondria are double-membrane-bound organelles that constantly change shape through membrane fusion and fission. Outer mitochondrial membrane fusion is controlled by Mitofusin, whose molecular architecture consists of an N-terminal GTPase domain, a first heptad repeat domain (HR1), two transmembrane domains, and a second heptad repeat domain (HR2). The mode of action of Mitofusin and the specific roles played by each of these functional domains in mitochondrial fusion are not fully understood. Here, using a combination of in situ and in vitro fusion assays, we show that HR1 induces membrane fusion and possesses a conserved amphipathic helix that folds upon interaction with the lipid bilayer surface...
April 16, 2018: EMBO Reports
https://www.readbyqxmd.com/read/29661352/effects-of-alpinetin-on-intestinal-barrier-function-inflammation-and-oxidative-stress-in-dextran-sulfate-sodium-induced-ulcerative-colitis-mice
#15
Yue Tan, Changqing Zheng
BACKGROUND: Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata that has demonstrated anti-inflammatory, antibacterial and anti-tumor activities. However, alpinetin has not been widely studied in amelioration of inflammatory bowel disease. The study aimed to investigate the role of alpinetin on intestinal epithelial tight junctions, oxidative stress and Nrf2/HO-1 signaling pathway in dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. METHODS: A total of 40 mice were divided into 5 groups (n = 8/group): control group, DSS group (received 3% DSS), and low, medium and high-dose treatment groups (3% DSS + alpinetin 25, 50 and 100mg/kg)...
April 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29659957/dietary-fermentable-fibers-attenuate-chronic-kidney-disease-in-mice-by-protecting-the-intestinal-barrier
#16
Tran Van Hung, Takuya Suzuki
Background: Chronic kidney disease (CKD) is a worldwide health problem. Although the pathogenesis of CKD is still unclear, recent studies suggest that systemic inflammation caused by a dysregulated microflora and an impaired intestinal barrier is involved in CKD development. Objective: We investigated the effects of the fermentable dietary fibers (DFs), unmodified guar gum (GG), and partially hydrolyzed GG (PHGG) (i.e., substances with distinct viscosity characteristics) on CKD development, with a particular focus on colonic tight junction (TJ) barriers in mice...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29659773/gut-barrier-dysfunction-a-primary-defect-in-twins-with-crohn-s-disease-predominantly-caused-by-genetic-predisposition
#17
Åsa V Keita, Mårten Carl Lindqvist, Åke Öst, Carlos D L Magana, Ida Schoultz, Jonas Halfvarson
Background and aims: The aetiology of Crohn's disease is poorly understood. By investigating twin pairs discordant for Crohn's disease we aimed to assess if the dysregulated barrier represents a cause or a consequence of inflammation and to evaluate the impact of genetic predisposition on barrier function. Methods: Ileal biopsies from 15 twin pairs discordant for Crohn's disease (monozygotic n=9, dizygotic n=6) and 10 external controls were mounted in Ussing chambers to assess paracellular permeability to51Chromium (Cr)-EDTA and trancellular passage to non-pathogenic E...
April 12, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29655947/co-occurrence-of-medical-conditions-exposing-patterns-through-probabilistic-topic-modeling-of-snomed-codes
#18
Moumita Bhattacharya, Claudine Jurkovitz, Hagit Shatkay
Patients associated with multiple co-occurring health conditions often face aggravated complications and less favorable outcomes. Co-occurring conditions are especially prevalent among individuals suffering from kidney disease, an increasingly widespread condition affecting 13% of the general population in the US. This study aims to identify and characterize patterns of co-occurring medical conditions in patients employing a probabilistic framework. Specifically, we apply topic modeling in a non-traditional way to find associations across SNOMED-CT codes assigned and recorded in the EHRs of >13,000 patients diagnosed with kidney disease...
April 12, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29655840/capillary-electrophoresis-for-aluminum-ion-speciation-optimized-separation-conditions-for-complex-polycation-mixtures
#19
Nesrine Ouadah, Claudine Moire, Fabien Brothier, Jean-François Kuntz, Olivier Deschaume, Carmen Bartic, Hervé Cottet
Aluminum chlorohydrates (ACH) are used in numerous applications and commercial products on a global scale including water treatment, catalysis or antiperspirants. They are complex mixtures of water soluble aluminum polycations of different degrees of polymerization, that are difficult to separate and quantify due to their susceptibility to depolymerize in solution when placed out of equilibrium, which is inherent to any separation process. We recently achieved the first capillary electrophoresis separation and characterization of ACH oligomers using 4-morpholineethanesulfonic acid (MES) as background electrolyte counter-ion...
March 29, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29652939/seeing-for-speaking-semantic-and-lexical-information-provided-by-briefly-presented-naturalistic-action-scenes
#20
Pienie Zwitserlood, Jens Bölte, Reinhild Hofmann, Claudine C Meier, Christian Dobel
At the interface between scene perception and speech production, we investigated how rapidly action scenes can activate semantic and lexical information. Experiment 1 examined how complex action-scene primes, presented for 150 ms, 100 ms, or 50 ms and subsequently masked, influenced the speed with which immediately following action-picture targets are named. Prime and target actions were either identical, showed the same action with different actors and environments, or were unrelated. Relative to unrelated primes, identical and same-action primes facilitated naming the target action, even when presented for 50 ms...
2018: PloS One
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