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breast journal

Nicholas M Pantelides, Jeyaram R Srinivasan
BACKGROUND: Implant rippling is a frequent complication following breast augmentation or implant-based reconstruction and results in significant patient dissatisfaction. Traditionally, the treatment has been to replace the implant, often placing it in a subpectoral pocket to reduce the risk of recurrence. Other techniques, such as increasing the implant size or tightening the capsule, can also be used. Recently, however, there has been much interest in alternative treatments, including fat grafting or insertion of an acellular dermal matrix...
March 15, 2018: Aesthetic Plastic Surgery
James H Pickar, Matthieu Boucher, Diana Morgenstern
OBJECTIVE: This review describes historical development of selective estrogen receptor modulators (SERMs) and their combination with estrogens, termed a tissue selective estrogen complex (TSEC), and considers the potential for future TSEC development. METHODS: This narrative review is based on literature identified on PubMed and the TSEC research and development experience of the authors. RESULTS: SERMs have estrogenic and antiestrogenic effects in various tissues; however, no single agent has achieved an optimal balance of agonist and antagonist effects for the treatment of menopausal symptoms...
March 12, 2018: Menopause: the Journal of the North American Menopause Society
Sukru Yazar, E Cigdem Karadag, Altug Altinkaya, Halil Kara, Cihan Uras
BACKGROUND: Breast reconstruction with a Becker-type expander is a common technique following mastectomy. However, inconsistency remains in the literature regarding risk factors for the survival of a Becker-type expander following immediate breast reconstruction. This study's purpose is to investigate possible risk factors for the Becker-type expander survival and to evaluate the complications related to expander removal following immediate breast reconstruction. METHODS: We performed a retrospective chart review of consecutive women who underwent a mastectomy followed by immediate breast reconstruction with a Becker-type expander from November 2010 to November 2016...
March 9, 2018: Aesthetic Plastic Surgery
Akihiko Ozaki, Morihito Takita, Tetsuya Tanimoto
Introduction Globally, laws and guidelines for managing conflict of interest are increasingly implemented to achieve transparency in financial ties between physicians and pharmaceutical and medical device industries, yet little information is available regarding the limitations of the current frameworks for disclosing these financial ties. Case In June 2017, the Capecitabine for Residual Cancer as Adjuvant Therapy (CREATE-X) trial was published in the New England Journal of Medicine. In this study, which suggested the post-surgery addition of capecitabine would improve survival of high-risk breast cancer patients, the cost of capecitabine for off-label use was illegally claimed to the Japanese public health insurance system, rather than being covered by the research budget...
March 8, 2018: Investigational New Drugs
Edward E Cornwell
On March 19-20, 2017; Howard University hosted a Festschrift inspired by Dr. Leffall's writings (Fig. 1). The celebrants highlighted the broad spectrum of Dr. Leffall's contributions in mentorship, leadership in American Surgery, breast cancer, endocrine cancer, pancreatic cancer, and familial polyposis coli. Perhaps most inspirational was the awe inspiring consistency the presenters demonstrated in describing the personal characteristics Dr. Leffall brings to his academic discourse: his encyclopedic knowledge and recall, his charm, eloquence, humility, and his total dedication to the patient, his students, and trainees...
December 12, 2017: American Journal of Surgery
Bok Ki Jung, In Sik Yun, Young Seok Kim, Tai Suk Roh
INTRODUCTION: Augmentation mammoplasty is one of the most popular aesthetic operations in the world. In Korea, one of the fillers used for breast augmentation is AQUAfilling® gel (Biomedica. spol, s,r,o, Czech Republic). AQUAfilling® gel is a hydrophilic gel composed of 98% sodium chloride solution (0.9%) and 2% cation copolyamide. METHODS: This is a case report describing a patient that suffered complications after AQUAfilling® gel injection for breast augmentation...
February 27, 2018: Aesthetic Plastic Surgery
Zack Marshall, Fern Brunger, Vivian Welch, Shabnam Asghari, Chris Kaposy
BACKGROUND: This paper focuses on the collision of three factors: a growing emphasis on sharing research through open access publication, an increasing awareness of big data and its potential uses, and an engaged public interested in the privacy and confidentiality of their personal health information. One conceptual space where this collision is brought into sharp relief is with the open availability of patient medical photographs from peer-reviewed journal articles in the search results of online image databases such as Google Images...
February 26, 2018: Journal of Medical Internet Research
Sandra Faragó-Magrini, Cristina Aubá, Cristina Camargo, Carmen Laspra, Bernardo Hontanilla
BACKGROUND: Breast reconstruction after mastectomy is a part of breast cancer treatment. There is a lack of data regarding the impact of reconstruction over psychological traits and quality of life. The aim of this study is to evaluate personality changes in patients who underwent reconstructive surgery. METHODS: Thirty-seven women underwent breast reconstruction. These women took the Crown-Crisp Experiential Index before and after the different procedures. The questionnaire analyzes: (a) the satisfaction level with personal relationships before and after surgery, and the level of satisfaction with surgical results and (b) personality index...
February 22, 2018: Aesthetic Plastic Surgery
O Kambur, M A Kaunisto, B S Winsvold, T Wilsgaard, A Stubhaug, J A Zwart, E Kalso, C S Nielsen
P2X7 is a non-selective cation channel activated by extracellular ATP. P2X7 activation contributes to the pro-inflammatory response to injury or bacterial invasion and mediates apoptosis. Recently, P2X7 function has been linked to chronic inflammatory and neuropathic pain. P2X7 may contribute to pain modulation both by effects on peripheral tissue injury underlying clinical pain states, and through alterations in central nervous system processing, as suggested by animal models. To further test its role in pain sensitivity, we examined whether variation within the P2RX7 gene, which encodes the P2X7 receptor, was associated with experimentally induced pain in human patients...
February 20, 2018: Pain
Sung Ryul Lee, Seung Geun Lee, Geon Young Byun, Myoung Jin Kim, Bum Hwan Koo
BACKGROUND: Asymmetric bilateral gynecomastia (ABGM) is uncommon, and reports on its characteristics are rare. In the present study, we investigated the clinical characteristics and surgical treatment of ABGM. METHODS: We conducted a retrospective study of 1159 patients with gynecomastia who underwent subcutaneous mastectomy with liposuction at Damsoyu Hospital from January 2014 to February 2016. We then analyzed differences in the characteristics and operative results between two groups of patients: those with asymmetric and symmetric gynecomastia...
February 20, 2018: Aesthetic Plastic Surgery
Ján Remšík, Radek Fedr, Jiří Navrátil, Lucia Binó, Eva Slabáková, Pavel Fabian, Marek Svoboda, Karel Souček
BACKGROUND: The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. METHODS: We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial-mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal counterparts. Using multicolour flow cytometry, we then analysed the expression of 10 most robustly changed antigens and identified a 10-molecule surface signature, in pan-cytokeratin-positive/EpCAM-positive and -negative fractions of dissociated breast tumours...
February 20, 2018: British Journal of Cancer
Matan Sherf, Itay Wiser, Dov Klein, Lior Heller
BACKGROUND: Augmentation mammoplasty is one of the most common esthetic procedures worldwide. A wide range of motivations leads women to undergo this procedure, among them socioeconomic status and age group. The aim of this study was to identify the motivation spectrum for augmentation mammoplasty through different age groups. METHODS: We conducted a cross-sectional prospective survey given to Israeli women seeking augmentation mammoplasty consults in a hospital and private clinic settings, using a 17-item Motivation for Augmentation questionnaire...
February 19, 2018: Aesthetic Plastic Surgery
Daniel Fleming, Jason Stone, Patrick Tansley
BACKGROUND: First described in 1997, breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) was recognised by the World Health Organisation in 2016 as a specific disease. It typically presents as a late seroma-containing atypical, monoclonal T cells which are CD30+ and anaplastic lymphoma kinase negative. Until recently, it was thought that the disease was very rare. However, it is being diagnosed increasingly frequently with 56 cases confirmed in Australia by September 2017 and the estimated incidence revised from 1 in 300,000 to between 1 in 1000 and 1 in 10,000 patients with bilateral implants...
February 14, 2018: Aesthetic Plastic Surgery
V Tanaydin, J Beugels, A Andriessen, J H Sawor, R R W J van der Hulst
BACKGROUND: Negative pressure wound therapy (NPWT) for postsurgical incision treatment has demonstrated benefits. A prospective randomized study was developed including 32 patients who underwent bilateral breast reduction mammoplasty. Patients served as their own control and received NPWT to one breast and fixation strips to the other breast. METHODS: The primary outcome was the number of wound healing complications within 21 days when comparing NPWT treatment with fixation strips...
February 13, 2018: Aesthetic Plastic Surgery
Mark S Chambers, Hope S Rugo, Jennifer K Litton, Timothy F Meiller
BACKGROUND: Patients with metastatic breast cancer may develop oral morbidities that result from therapeutic interventions. Mammalian target of rapamycin (mTOR) inhibitor-associated stomatitis (mIAS) is a common adverse event (AE), secondary to mTOR inhibitor therapy, that can have a negative impact on treatment adherence, quality of life, and health care costs. A multidisciplinary team approach is important to minimize mIAS and to maximize treatment benefits to patients with breast cancer...
February 10, 2018: Journal of the American Dental Association
James R Bradford, Angela Cox, Philip Bernard, Nicola J Camp
[This corrects the article DOI: 10.1371/journal.pone.0163238.].
2018: PloS One
Manoosh Zendehdel, Babak Niakan, Abbasali Keshtkar, Elahe Rafiei, Fatemeh Salamat
Breast cancer is a multifactorial disease. Benign breast disease (BBD) is one of the most important risk factors for breast cancer. The etiology of BBD is unknown. It is divided into nonproliferative and proliferative diseases. The selection of studies will be based on titles, abstract screening, inclusion and exclusion criteria, and quality assessment. Previous studies have shown that all types of BBD increase the risk of breast cancer, but the risk degree is different for each one. Accurate risk estimation of breast cancer in each category can be very important for proper clinical management...
January 2018: Iranian Journal of Medical Sciences
Hyun Jeong Kim, Shin Young Kim, Sun Huh
Metaplastic carcinoma is a rare subtype of breast cancer that comprises histologically diverse malignancies. Metaplastic carcinoma tends to have an aggressive clinical presentation, high metastatic potential, and more chances of local recurrence, as compared with intraductal carcinoma. Although many clinical and pathologic finding have been reported, to our knowledge, there are few reports of imaging findings for this type of tumor.In this study, we reviewed data of 5 patients with histopathologically proven metaplastic breast carcinoma...
February 1, 2018: Ultrasound Quarterly
Masami Arai, Shiro Yokoyama, Chie Watanabe, Reiko Yoshida, Mizuho Kita, Megumi Okawa, Akihiro Sakurai, Masayuki Sekine, Junko Yotsumoto, Hiroyuki Nomura, Yoshinori Akama, Mayuko Inuzuka, Tadashi Nomizu, Takayuki Enomoto, Seigo Nakamura
Correction to: Journal of Human Genetics advance online publication, 08 November 2017;
January 31, 2018: Journal of Human Genetics
Karen Legler, Ricarda Rosprim, Tosca Karius, Kathrin Eylmann, Maila Rossberg, Ralph M Wirtz, Volkmar Müller, Isabell Witzel, Barbara Schmalfeldt, Karin Milde-Langosch, Leticia Oliveira-Ferrer
BACKGROUND: Alterations in protein glycosylation have been related to malignant transformation and tumour progression. We recently showed that low mRNA levels of Golgi alpha-mannosidase MAN1A1 correlate with poor prognosis in breast cancer patients. METHODS: We analysed the role of MAN1A1 on a protein level using western blot analysis (n=105) and studied the impact of MAN1A1-related glycosylation on the prognostic relevance of adhesion molecules involved in breast cancer using microarray data (n=194)...
January 30, 2018: British Journal of Cancer
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