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https://www.readbyqxmd.com/read/27901039/early-factors-related-to-carbohydrate-and-fat-intake-at-8-and-12-months-results-from-the-eden-mother-child-cohort
#1
W L Yuan, S Nicklaus, S Lioret, C Lange, A Forhan, B Heude, M-A Charles, B de Lauzon-Guillain
BACKGROUND/OBJECTIVES: Few studies have examined the factors explaining the variability in fat and carbohydrate intake during infancy. We aimed to describe infants' fat and carbohydrate intake and analyse the associations with infant and maternal characteristics and feeding practices. SUBJECTS/METHODS: This study included 1275 infants aged 8 months from the French EDEN mother-child cohort. Carbohydrate intake, fat intake, added fat (vegetable oils and animal fats) and added sugar (honey, white sugar, brown sugar, jam and sweetened beverages) consumption were calculated at 8 and 12 months...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27875517/adjuvant-chemotherapy-and-her-2-directed-therapy-for-early-stage-breast-cancer-in-the-elderly
#2
J Sun, S Chia
There is a lack of sufficient evidence-based data defining the optimal adjuvant systemic therapies in older women. Recommendations are mainly based on retrospective studies, subgroup analyses within larger randomised trials and expert opinion. Treatment decisions should consider the functional fitness of the patient, co-morbidities, in addition to chronological age with the aim to balance risks and potential benefits from treatment(s). In this review, we discuss assessment tools to aid clinicians to select elderly patients who are 'fit' for chemotherapy, and review the literature on the use of chemotherapy and of the anti-HER 2 antibody trastuzumab in this population...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27875516/trastuzumab-associated-cardiac-events-in-the-persephone-trial
#3
Helena M Earl, Anne-Laure Vallier, Janet Dunn, Shrushma Loi, Emma Ogburn, Karen McAdam, Luke Hughes-Davies, Adrian Harnett, Jean Abraham, Andrew Wardley, David A Cameron, David Miles, Ioannis Gounaris, Chris Plummer, Louise Hiller
BACKGROUND: We report cardiac events in the Persephone trial which compares 6-12 months of adjuvant trastuzumab in women with confirmed HER2-positive, early-stage breast cancer. METHODS: Clinical cardiac events were defined as any of the following: symptoms and/or signs of congestive heart failure (CHF) and new or altered CHF medication. In addition, left ventricular ejection fraction (LVEF) was measured at baseline and then 3 monthly for 12 months. RESULTS: A total of 2500 patients, aged 22-82, were included: 1251 randomised to 12 months and 1249 to 6 months of trastuzumab treatment...
November 22, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27870643/yellow-fever-vaccine-17d-administered-to-healthy-women-aged-between-40-and-54-years-halves-breast-cancer-risk-an-observational-study
#4
Giuseppe Mastrangelo, Sofia Pavanello, Emanuela Fadda, Alessandra Buja, Ugo Fedeli
Transcripts of human endogenous retrovirus K are expressed in most breast cancers (BCs). Yellow fever vaccine 17D (YFV) expresses a protein with a closely homologous epitope. Cross-reactive immunity could hypothetically inhibit BC growth at least in women aged around 50 years at diagnosis, in whom the prognosis of BC was found to be better than that in women younger or older. A cohort of 12 804 women who received YFV in the Veneto Region, Italy, was divided into two subcohorts according to age at vaccination and followed up through the Veneto Tumor Registry...
November 18, 2016: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27861384/trends-of-triple-negative-breast-cancer-research-2007-2015-a-bibliometric-study
#5
Yiran Wang, Xiao Zhai, Chuan Liu, Ning Wang, Yajie Wang
BACKGROUND: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype. However, there have been limited data to evaluate the trend of TNBC research. This study aims to investigate the trend of TNBC research and compare the contribution of research from different regions, organizations, and authors. METHODS: TNBC-related publications from 2007 to 2015 were retrieved from the Web of Science database. Excel 2013 (Redmond, Washington, USA), GraphPad Prism 5 (GraphPad Prism Software Inc...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855106/the-ibra-2-immediate-breast-reconstruction-and-adjuvant-therapy-audit-study-protocol-for-a-prospective-national-multicentre-cohort-study-to-evaluate-the-impact-of-immediate-breast-reconstruction-on-the-delivery-of-adjuvant-therapy
#6
Rajiv Dave, Rachel O'Connell, Tim Rattay, Zoe Tolkien, Nicola Barnes, Joanna Skillman, Paula Williamson, Elizabeth Conroy, Matthew Gardiner, Adrian Harnett, Ciara O'Brien, Jane Blazeby, Shelley Potter, Chris Holcombe
INTRODUCTION: Immediate breast reconstruction (IBR) is routinely offered to improve quality of life for women with breast cancer requiring a mastectomy, but there are concerns that more complex surgery may delay the delivery of adjuvant oncological treatments and compromise long-term oncological outcomes. High-quality evidence, however, is lacking. iBRA-2 is a national prospective multicentre cohort study that aims to investigate the effect of IBR on the delivery of adjuvant therapy. METHODS AND ANALYSIS: Breast and plastic surgery centres in the UK performing mastectomy with or without (±) IBR will be invited to participate in the study through the trainee research collaborative network...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27832718/mind-body-interventions-for-vasomotor-symptoms-in-healthy-menopausal-women-and-breast-cancer-survivors-a-systematic-review
#7
Evgenia Stefanopoulou, Elizabeth Alice Grunfeld
Mind-body therapies are commonly recommended to treat vasomotor symptoms, such as hot flushes and night sweats (HFNS). The purpose of this systematic review was to evaluate the available evidence to date for the efficacy of different mind-body therapies to alleviate HFNS in healthy menopausal women and breast cancer survivors. Randomized controlled trials (RCTs) were identified using seven electronic search engines, direct searches of specific journals and backwards searches through reference lists of related publications...
November 11, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27818149/scientific-impact-of-presentations-from-the-euraps-and-the-aaps-meetings-a-10-year-review
#8
Hoda Khorasani, Mats Højbjerg Lassen, William Kuzon, Christian Bonde
INTRODUCTION: Presentation at scientific meetings is the usual first step to communicate new research findings. However, without subsequent, peer-reviewed publication, the wider propagation and the permanent documentation of important scholarly work may be lost. Our aim was to analyze and compare the publication status of the work presented at the European Association of Plastic Surgeons' (EURAPS) and at the American Association of Plastic Surgeons' (AAPS) annual meetings. MATERIALS AND METHODS: By using the abstract booklets from the annual meetings, all presentations given over a 10-year period (2000-2009) were analyzed...
October 17, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27814824/acr-appropriateness-criteria-%C3%A2-stage-i-breast-carcinoma
#9
Phan Tuong Huynh, Sergy V Lemeshko, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Jennifer A Harvey, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Constance D Lehman, Martha B Mainiero, David A Mankoff, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
Stage I breast carcinoma is classified when an invasive breast carcinoma is ≤2 cm in diameter (T1), with no regional (axillary) lymph node metastases (N0) and no distant metastases (M0). The most common sites for metastases from breast cancer are the skeleton, lung, liver, and brain. In general, women and health care professionals prefer intensive screening and surveillance after a diagnosis of breast cancer. Screening protocols include conventional imaging such as chest radiography, bone scan, ultrasound of the liver, and MRI of brain...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27814823/acr-appropriateness-criteria-stage-i-breast-cancer-initial-workup-and-surveillance-for-local-recurrence-and-distant-metastases-in-asymptomatic-women
#10
Linda Moy, Mary S Newell, Mary C Mahoney, Lisa Bailey, Lora D Barke, Selin Carkaci, Carl D'Orsi, Sharad Goyal, Bruce G Haffty, Jennifer A Harvey, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Martha B Mainiero, David A Mankoff, Samir B Patel, Monica M Yepes
Women newly diagnosed with stage 1 breast cancer have an early-stage disease that can be effectively treated. Evidence provides little justification for performing imaging to exclude metastasis in asymptomatic women with stage I breast cancer. No differences have been found in survival or quality of life in women regardless of whether they underwent initial workup for metastatic disease. These women generally prefer intensive follow-up to detect an early recurrence. However, survival rates do not differ between women who obtain intensive screening and surveillance, with imaging and laboratory studies, and women who undergo testing only as a result of development of symptoms or findings on clinical examinations...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27814822/acr-appropriateness-criteria-palpable-breast-masses
#11
Jennifer A Harvey, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Mary K Hayes, Peter M Jokich, Su-Ju Lee, Constance D Lehman, Martha B Mainiero, David A Mankoff, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
A palpable breast mass is one of the most common presenting features of breast carcinoma. However, the clinical features are frequently nonspecific. Imaging performed before biopsy is helpful in characterizing the nature of the mass. For women with clinically detected breast masses, the vast majority will require evaluation with ultrasound. Diagnostic mammography is the initial imaging modality of choice for women aged ≥ 40 years; ultrasound is typically necessary unless a definitively benign mass is identified as the etiology of the clinical finding...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27814813/acr-appropriateness-criteria-breast-cancer-screening
#12
Martha B Mainiero, Ana Lourenco, Mary C Mahoney, Mary S Newell, Lisa Bailey, Lora D Barke, Carl D'Orsi, Jennifer A Harvey, Mary K Hayes, Phan Tuong Huynh, Peter M Jokich, Su-Ju Lee, Constance D Lehman, David A Mankoff, Joshua A Nepute, Samir B Patel, Handel E Reynolds, M Linda Sutherland, Bruce G Haffty
Mammography is the recommended method for breast cancer screening of women in the general population. However, mammography alone does not perform as well as mammography plus supplemental screening in high-risk women. Therefore, supplemental screening with MRI or ultrasound is recommended in selected high-risk populations. Screening breast MRI is recommended in women at high risk for breast cancer on the basis of family history or genetic predisposition. Ultrasound is an option for those high-risk women who cannot undergo MRI...
November 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/27805927/management-of-gynecomastia-in-patients-with-different-body-types-considerations-on-312-consecutive-treated-cases
#13
Alessandro Innocenti, Dario Melita, Francesco Mori, Francesco Ciancio, Marco Innocenti
BACKGROUND: Gynecomastia is a common finding in male subjects which incidence varies widely in the world population. In adolescents, it is frequently temporary but, if it becomes persistent, it generates considerable embarrassment, inducing the patients to seek surgical consultation. Even in patients with good body contour, gynecomastia creates even greater distress considering the special attention given by these subjects to their physical appearance. The authors present their experience in the treatment of gynecomastia comparing different body types of patients with the aim to investigate dissimilar expectations, needs and surgical outcomes thus optimizing the management of the pathological condition, achieving high levels of agreement and reducing unsatisfied patients arising from cosmetic surgery...
November 1, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27802453/determining-cancer-survivors-preferences-to-inform-new-models-of-follow-up-care
#14
Peter Murchie, Patricia F Norwood, Marta Pietrucin-Materek, Terry Porteous, Philip C Hannaford, Mandy Ryan
BACKGROUND: Specialist-led cancer follow-up is becoming increasingly expensive and is failing to meet many survivors' needs. Alternative models informed by survivors' preferences are urgently needed. It is unknown if follow-up preferences differ by cancer type. We conducted the first study to assess British cancer survivors' follow-up preferences, and the first anywhere to compare the preferences of survivors from different cancers. METHODS: A discrete choice experiment questionnaire was mailed to 1201 adults in Northeast Scotland surviving melanoma, breast, prostate or colorectal cancer...
November 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27802449/the-prognostic-performance-of-adjuvant-online-and-nottingham-prognostic-index-in-young-breast-cancer-patients
#15
Matteo Lambertini, Ana Catarina Pinto, Lieveke Ameye, Lynn Jongen, Lucia Del Mastro, Fabio Puglisi, Francesca Poggio, Marta Bonotto, Giuseppe Floris, Kathleen Van Asten, Hans Wildiers, Patrick Neven, Evandro de Azambuja, Marianne Paesmans, Hatem A Azim
BACKGROUND: Limited data are available on the prognostic performance of Adjuvant! Online (AOL) and Nottingham Prognostic Index (NPI) in young breast cancer patients. METHODS: This multicentre hospital-based retrospective cohort study included young (⩽40 years) and older (55-60 years) breast cancer patients treated from January 2000 to December 2004 at four large Belgian and Italian institutions. Predicted 10-year overall survival (OS) and disease-free survival (DFS) using AOL and 10-year OS using NPI were calculated for every patient...
November 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27801737/digital-image-analysis-of-her2-immunostained-gastric-and-gastroesophageal-junction-adenocarcinomas
#16
Sofie L Nielsen, Søren Nielsen, Mogens Vyberg
Manual assessment of human epidermal growth factor receptor 2 (HER2) protein expression by immunohistochemistry (IHC) in gastric and gastroesophageal junction (GGEJ) adenocarcinomas is prone to interobserver variability and hampered by tumor heterogeneity and different scoring criteria. Equivocal cases are frequent, requiring additional in situ hybridization analysis. This study aimed to evaluate the accuracy of digital image analysis for the assessment of HER2 protein expression. In total, 110 GGEJ adenocarcinomas were included in tissue microarrays with 3 tissue cores per case...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27798424/considering-the-optimal-timing-of-breast-reconstruction-with-abdominal-flaps-with-adjuvant-irradiation-in-370-consecutive-pedicled-transverse-rectus-abdominis-myocutaneous-flap-and-free-deep-inferior-epigastric-perforator-flap-performed-in-a-chinese-oncology
#17
Shanshan He, Jian Yin, Geoffrey L Robb, Jingyan Sun, Xuehui Zhang, Haixin Li, Jing Liu, Chunyong Han
PURPOSE: There is an ongoing debate on the optimal sequence of radiation and breast reconstruction. The purpose of this article was to (a) assess the impact of radiation on autologous breast reconstruction and (b) analyze the best timing for autologous breast reconstruction in the setting of radiation in a Chinese population. METHODS: A retrospective review of patients undergoing breast reconstruction with autologous lower abdominal flaps between 2001 and 2014 in the Tianjin Medical University and Cancer Hospital was performed...
October 28, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27782920/successful-integrative-medicine-assessment-and-treatment-of-chronic-pain-associated-with-breast-surgery-a-report-of-3-cases
#18
Myung Kyu Chung, Patrick J LaRiccia
Presented is the first reported case series of chronic neck and back pain associated with breast scars from breast surgery and successfully treated with an integrative medicine assessment and treatment approach, which included the assessment technique of autonomic response testing and the scar therapy technique of neural therapy. Implications for nursing practice are discussed.
January 2017: Holistic Nursing Practice
https://www.readbyqxmd.com/read/27782108/whole-exome-sequencing-of-finnish-hereditary-breast-cancer-families
#19
Kirsi Määttä, Tommi Rantapero, Anna Lindström, Matti Nykter, Minna Kankuri-Tammilehto, Satu-Leena Laasanen, Johanna Schleutker
A remarkable proportion of factors causing genetic predisposition to breast cancer (BC) are unknown in non-BRCA1/2 families. Exome sequencing was performed for 13 high-risk Finnish hereditary breast and/or ovarian cancer (HBOC) families to detect variants contributing to BC susceptibility. After filtering, 18 candidate variants in DNA damage response (DDR) pathway genes were screened in 129 female HBOC patients, up to 989 female controls, and 31 breast tumours by Sanger sequencing/TaqMan assays. In addition, two variants were further studied in 49 male BC patients and 909 male controls...
October 26, 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27780193/short-term-breast-cancer-survival-in-relation-to-ethnicity-stage-grade-and-receptor-status-national-cohort-study-in-england
#20
Henrik Møller, Katherine Henson, Margreet Lüchtenborg, John Broggio, Jackie Charman, Victoria H Coupland, Elizabeth Davies, Ruth H Jack, Richard Sullivan, Peter Vedsted, Kieran Horgan, Neil Pearce, Arnie Purushotham
BACKGROUND: In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items. METHODS: We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI)...
November 22, 2016: British Journal of Cancer
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