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https://www.readbyqxmd.com/read/29138205/long-term-prognosis-of-young-breast-cancer-patients-%C3%A2-40-years-who-did-not-receive-adjuvant-systemic-treatment-protocol-for-the-paradigm-initiative-cohort-study
#1
Gwen Mhe Dackus, Natalie D Ter Hoeve, Mark Opdam, Willem Vreuls, Zsuzsanna Varga, Esther Koop, Stefan M Willems, Carolien Hm Van Deurzen, Emilie J Groen, Alicia Cordoba, Jos Bart, Antien L Mooyaart, Jan G van den Tweel, Vicky Zolota, Jelle Wesseling, Anna Sapino, Ewa Chmielik, Ales Ryska, Frederic Amant, Annegien Broeks, Ron Kerkhoven, Nikolas Stathonikos, Mitko Veta, Adri Voogd, Katarzyna Jozwiak, Michael Hauptmann, Marlous Hoogstraat, Marjanka K Schmidt, Gabe Sonke, Elsken van der Wall, Sabine Siesling, Paul J van Diest, Sabine C Linn
INTRODUCTION: Currently used tools for breast cancer prognostication and prediction may not adequately reflect a young patient's prognosis or likely treatment benefit because they were not adequately validated in young patients. Since breast cancers diagnosed at a young age are considered prognostically unfavourable, many treatment guidelines recommend adjuvant systemic treatment for all young patients. Patients cured by locoregional treatment alone are, therefore, overtreated. Lack of prognosticators for young breast cancer patients represents an unmet medical need and has led to the initiation of the PAtients with bReAst cancer DIaGnosed preMenopausally (PARADIGM) initiative...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29136407/phospholipase-d-inhibitors-reduce-human-prostate-cancer-cell-proliferation-and-colony-formation
#2
Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney and thyroid carcinomas but its role in prostate cancer (PCa), the major cancer of men in the western world, is unclear. METHODS: PLD1 protein expression in cultured PNT2C2, PNT1A, P4E6, LNCaP, PC3, PC3M, VCaP, 22RV1 cell lines and patient-derived PCa cells was analysed by western blotting...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29136405/survival-outcomes-for-australian-women-receiving-trastuzumab-for-her2-positive-metastatic-breast-cancer-following-neo-adjuvant-trastuzumab-a-national-population-based-observational-study-2006-2014
#3
Benjamin Daniels, Belinda E Kiely, Nehmat Houssami, Sarah J Lord, Timothy Dobbins, Christine Y Lu, Robyn L Ward, Sallie-Anne Pearson
BACKGROUND: Patients treated with (neo)adjuvant trastuzumab who relapse and receive trastuzumab for metastatic breast cancer (MBC) are a growing population with little outcome data given their exclusion from most clinical trials. We aim to estimate survival outcomes for this trastuzumab 'pre-treated' population. METHODS: Population-based study of Australian women receiving trastuzumab for HER2-positive MBC between 2006 and 2014, who also received (neo)adjuvant trastuzumab...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29135571/validation-of-cancer-cases-using-primary-care-cancer-registry-and-hospitalization-data-in-the-uk
#4
Andrea V Margulis, Joan Fortuny, James A Kaye, Brian Calingaert, Maria Reynolds, Estel Plana, Lisa J McQuay, Willem Jan Atsma, Billy Franks, Stefan de Vogel, Susana Perez-Gutthann, Alejandro Arana
BACKGROUND: In the United Kingdom, hospital or cancer registry data can be linked to electronic medical records for a subset of general practices and years. METHODS: We used Clinical Practice Research Datalink data (2004-2012) from patients treated for overactive bladder. We electronically identified provisional cases of 10 common cancers in General Practitioner Online Database data and validated them by medical profile review. In practices with linkage to Hospital Episodes Statistics and National Cancer Data Repository (2004-2010), we validated provisional cancer cases against these data sources...
November 9, 2017: Epidemiology
https://www.readbyqxmd.com/read/29135534/the-multiple-faces-of-programmed-cell-death-ligand-1-expression-in-malignant-and-nonmalignant-cells
#5
Edwin R Parra, Pamela Villalobos, Jaime Rodriguez-Canales
Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy. PD-L1 is not a specific tumor marker and its expression is also observed in various nonmalignant cells, such as macrophages and lymphocytes, causing confusion in immunohistochemistry analysis when these inflammatory cells are overlapping with tumors cells...
November 13, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29127950/sirna-mediated-silencing-of-nin1-rpn12-binding-protein-1-homolog-inhibits-proliferation-and-growth-of-breast-cancer-cells
#6
Wei-Yi Huang, Dong-Hui Chen, Li Ning, Li-Wei Wang
Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells...
October 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29124379/use-of-the-breast-q%C3%A2-survey-in-the-prospective-evaluation-of-reduction-mammaplasty-outcomes
#7
Isaias Vieira Cabral, Edgard da Silva Garcia, Rebecca Neponucena Sobrinho, Natália Lana Larcher Pinto, Yara Juliano, Joel Veiga-Filho, Lydia Masako Ferreira, Daniela Francescato Veiga
INTRODUCTION: BREAST-Q™ is a patient-reported outcomes survey instrument with a specific module that evaluates breast reduction surgery. It allows assessment of patient's satisfaction with received treatment and evaluates the impact of surgery on different aspects of the patient's quality of life. This article aims to assess the satisfaction and quality of life of patients who underwent reduction mammaplasty. MATERIALS AND METHODS: Women aged between 18 and 60 years, with a body mass index ranging from 19 to 30 kg/m(2), who were already scheduled for reduction mammaplasty, were included in the study...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29124375/reductive-augmentation-of-the-breast
#8
Paul E Chasan
AIM: Although breast reduction surgery plays an invaluable role in the correction of macromastia, it almost always results in a breast lacking in upper pole fullness and/or roundness. We present a technique of breast reduction combined with augmentation termed "reductive augmentation" to solve this problem. The technique is also extremely useful for correcting breast asymmetry, as well as revising significant pseudoptosis in the patient who has previously undergone breast augmentation with or without mastopexy...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29124374/complications-and-treatment-strategy-after-breast-augmentation-by-polyacrylamide-hydrogel-injection-summary-of-10-year-clinical-experience
#9
Rui Jin, Xusong Luo, Xiaoke Wang, Jie Ma, Fei Liu, Qun Yang, Jun Yang, Xi Wang
From 1997 to 2006, polyacrylamide hydrogel (PAAG) was approved for use in China as a permanent filler for breast augmentation, and it is estimated that 200,000 women have undergone PAAG injection since then. After injection, complications such as pain, mass, hematoma, asymmetry, migration, infection, and even cancer continue to emerge. Because of the potential toxicity and unstable nature of the material and the nonstandardized injection layers, complications after PAAG injection breast augmentation are often complex and difficult to treat...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29124373/-the-chignon-mastopexy-a-double-glandular-suspended-flaps-for-an-auto-augmentation-effect
#10
Bouraoui Kotti
BACKGROUND: Many mastopexy techniques have been described in the literature focusing on the new nipple areolar complex position and the breast deflation treatment, but only few of them detailed the glandular volume redistribution to avoid the use of implants. We describe a mastopexy procedure that brings the maximum of the volume to the central part of the breast. We compare the procedure to a "chignon" hair style way to vulgarize the technique and simplify its comprehension. METHODS: Breast volume is reshaped by the use of a vertical mastopexy and two deepithelized glandular flaps sutured for the first one to the pectoralis major fascia and for the second one to the contralateral flap...
November 9, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29111858/women-s-health-endocrine-update
#11
Ekta Kapoor, Stephanie Faubion, Stephanie Hines, Cynthia A Stuenkel
The clinical update serves as a brief review of recently published, high-impact, and potentially practice changing journal articles summarized for our readers. Topics include menopause, sexual dysfunction, breast health, contraception, osteoporosis, and cardiovascular disease. In this clinical update, we selected four recent high-impact publications related to endocrine issues in women. We have chosen to highlight research on subclinical hypothyroidism during pregnancy and adverse pregnancy outcomes, including cognitive outcomes in offspring; the progression of metabolic syndrome severity during the menopausal transition; and the association of diabetes and metformin use with cancer risk and mortality...
November 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29104286/leptin-regulation-of-the-p53-hif1%C3%AE-pkm2-aromatase-axis-in-breast-adipose-stromal-cells-a-novel-mechanism-for-the-obesity-breast-cancer-link
#12
H Zahid, K Subbaramaiah, N M Iyengar, X K Zhou, I-C Chen, P Bhardwaj, A Gucalp, M Morrow, C A Hudis, A J Dannenberg, K A Brown
BACKGROUND/OBJECTIVES: Obesity (body mass index (BMI) ⩾30) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elevated in breast tissue of obese women. Recently, the regulation of aromatase by the p53-HIF1α/PKM2 axis was characterized in adipose stromal cells (ASCs) of women with Li-Fraumeni Syndrome, a hereditary cancer syndrome that predisposes to estrogen-dependent breast cancer...
November 6, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29101985/acr-appropriateness-criteria-%C3%A2-monitoring-response-to-neoadjuvant-systemic-therapy-for%C3%A2-breast-cancer
#13
Priscilla J Slanetz, Linda Moy, Paul Baron, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Su-Ju Lee, Alana A Lewin, Ana P Lourenco, Bethany Niell, Ashley R Stuckey, Sunita Trikha, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Patients with locally advanced invasive breast cancers are often treated with neoadjuvant chemotherapy prior to definitive surgical intervention. The primary aims of this approach are to: 1) reduce tumor burden thereby permitting breast conservation rather than mastectomy; 2) promptly treat possible metastatic disease, whether or not it is detectable on preoperative staging; and 3) potentially tailor future chemotherapeutic decisions by monitoring in-vivo tumor response. Accurate radiological assessment permits optimal management and planning in this population...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101984/acr-appropriateness-criteria-%C3%A2-imaging-of-deep-inferior-epigastric-arteries-for-surgical-planning-breast-reconstruction-surgery
#14
Isabel B Oliva, Kevin Day, Karin E Dill, Michael Hanley, Osmanuddin Ahmed, Shelby J Bennett, Benoit Desjardins, Kenneth L Gage, Michael Ginsburg, Adam H Hamawy, Michael L Steigner, Richard Strax, Nupur Verma, Frank J Rybicki
Breast cancer is the most common malignancy in women in the United States. Breast reconstruction surgery is a commonly used therapy for patients with breast cancer. The technique for the deep inferior epigastric perforator flap uses a preserved rectus muscle, which decreases donor site morbidity. Accurate identification and measurement of the perforator branches of the deep inferior epigastric artery is pivotal during pre-operative planning so that the surgeon can prioritize the best vessel to use and ultimately improve clinical outcome...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101979/acr-appropriateness-criteria-%C3%A2-breast-cancer-screening
#15
Martha B Mainiero, Linda Moy, Paul Baron, Aarati D Didwania, Roberta M diFlorio, Edward D Green, Samantha L Heller, Anna I Holbrook, Su-Ju Lee, Alana A Lewin, Ana P Lourenco, Kara J Nance, Bethany L Niell, Priscilla J Slanetz, Ashley R Stuckey, Nina S Vincoff, Susan P Weinstein, Monica M Yepes, Mary S Newell
Breast cancer screening recommendations are based on risk factors. For average-risk women, screening mammography and/or digital breast tomosynthesis is recommended beginning at age 40. Ultrasound (US) may be useful as an adjunct to mammography for incremental cancer detection in women with dense breasts, but the balance between increased cancer detection and the increased risk of a false-positive examination should be considered in the decision. For intermediate-risk women, US or MRI may be indicated as an adjunct to mammography depending upon specific risk factors...
November 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29101436/anaplastic-large-cell-lymphoma-associated-with-breast-implants-a-case-report-of-a-transgender-female
#16
Matej Patzelt, Lucie Zarubova, Pavel Klener, Josef Barta, Kamila Benkova, Adrianna Brandejsova, Marek Trneny, Robert Gürlich, Andrej Sukop
Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare peripheral T cell lymphoma. BIA-ALCL is a disease of the fibrous capsule surrounding the implant and occurs in patients after both breast reconstruction and augmentation. More than 300 cases have been reported so far, including two in a transgender patient. Here we describe BIA-ALCL presented with a mass in a transgender patient and the first case of BIA-ALCL in the Czech Republic. In 2007, a 33-year-old transgender male to female underwent bilateral breast augmentation as a part of his transformation to female...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29101435/polyurethane-foam-wound-dressing-technique-for-areola-skin-graft-stabilization-and-nipple-protection-after-nipple-areola-reconstruction
#17
Toshihiko Satake, Mayu Muto, Yu Nagashima, Shoko Haga, Yuki Homma, Reiko Nakasone, Marina Kadokura, Seiko Kou, Hiroshi Fujimoto, Jiro Maegawa
We describe a new wound management technique using a soft dressing material to stabilize the areola skin graft and protect the nipple after nipple-areola reconstruction at the final stage of breast reconstruction. We introduced a center-fenestrated multilayered hydrocellular polyurethane foam dressing material that provides adequate pressure and retains a moist environment for a smooth skin graft "take." Moreover, the reconstructed nipple can be monitored at any time through the fenestrated window for adequate blood circulation...
November 3, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29095272/treatment-of-triple-negative-breast-cancer-with-chinese-herbal-medicine-a-prospective-cohort-study-protocol
#18
MULTICENTER STUDY
Hui Meng, Nan Peng, Mingwei Yu, Xu Sun, Yunfei Ma, Guowang Yang, Xiaomin Wang
INTRODUCTION: Triple-negative breast cancer (TNBC) is featured with the biological properties of strong aggressive behaviors, rapid disease progression, high risk of recurrence and metastasis, and low disease free survival. Patients with this tumor are insensitive to the endocrine therapy and target treatment for HER-2; therefore, chemotherapy is often used as routine treatment in clinical. Because of the fact that a considerable number of patients seek for Chinese herbal medicine (CHM) treatment after operation and chemotherapy and (or) radiotherapy, it is thus need to evaluate the correlation between Chinese herbal medicine treatment and prognosis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29093057/first-person-libi-anandi
#19
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Libi Anandi is the first author on 'DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage', published in Journal of Cell Science. Libi is a PhD student in the laboratory of Mayurika Lahiri at Indian Institute of Science Education and Research, Pune, India, investigating the early events of cellular transformation...
November 1, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29075821/mastopexy-on-reconstructed-breast-following-massive-weight-loss-an-innovative-technique-using-dermo-capsular-flaps
#20
A Cogliandro, M Barone, G Cassotta, R Salzillo, P Persichetti
BACKGROUND: We have developed a dermo-capsular flap mastopexy technique for patients who have experienced massive weight loss after breast reconstruction. The aim of this technique is to lift the inframammary fold, adequately cover the implant, and remove excess skin, elevating the breast and obtaining symmetry with the contralateral breast. METHODS: Between January 2014 and February 2017, we performed this technique on 20 women who were candidates for second-stage breast reconstruction following nipple-sparing mastectomy...
October 26, 2017: Aesthetic Plastic Surgery
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