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https://www.readbyqxmd.com/read/29328875/environmental-determinants-of-breast-cancer
#1
Robert A Hiatt, Julia Green Brody
In the United States, breast cancer is the most common invasive malignancy and the second most common cause of death from cancer in women. Reproductive factors, estrogen, and progesterone have major causal roles, but concerns about other potential causes in the external environment continue to drive research inquiries and stimulate calls for action at the policy level. The environment is defined as anything that is not genetic and includes social, built, and chemical toxicant aspects. This review covers the scope of known and suspected environmental factors that have been associated with breast cancer and illustrates how epidemiology, toxicology, and mechanistic studies work together to create the full picture of environmental effects on this malignancy...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29302735/a-new-human-derived-acellular-dermal-matrix-for-breast-reconstruction-available-for-the-european-market-preliminary-results
#2
Secondo Folli, Annalisa Curcio, Davide Melandri, Elena Bondioli, Nicola Rocco, Giuseppe Catanuto, Fabio Falcini, Valeria Purpura, Matteo Mingozzi, Federico Buggi, Francesco Marongiu
INTRODUCTION: The introduction of acellular dermal matrices (ADMs) contributed to the growing diffusion of direct-to-implant breast reconstruction (DTI-BR) following mastectomy for breast cancer. According to specific legislations, European specialists could not benefit from the use of human-derived ADMs, even though most evidence in the literature are available for this kind of device, showed optimal outcomes in breast reconstruction. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of a new human cadaver-donor-derived ADM (named with the Italian acronym, MODA, for matrice omologa dermica acellulata) from the Italian National Transplant Center and National Health Institute...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302732/the-effects-of-platelet-rich-plasma-and-adipose-derived-stem-cells-on-neovascularization-and-fat-graft-survival
#3
Bing-Jun Xiong, Qiu-Wen Tan, Yu-Juan Chen, Yi Zhang, Di Zhang, Shen-Li Tang, Shu Zhang, Qing Lv
BACKGROUND: Adipose-derived stem cell (ADSCs)-assisted and platelet-rich plasma (PRP)-assisted lipofilling aim to enhance angiogenesis and cell proliferation and are promising techniques for lipofilling. This study aimed to compare the outcomes of ADSCs-assisted and PRP-assisted lipofilling. METHODS: Adipose tissue and human venous blood were obtained from women with early breast cancer. Human ADSCs were isolated and amplified in vitro. PRP was extracted through double centrifugation...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302731/quantifying-dynamic-deformity-after-dual-plane-breast-augmentation
#4
Marcelo Recondo Cheffe, Jorge Diego Valentini, Marcus Vinicius Martins Collares, Pedro Salomão Piccinini, Jefferson Luis Braga da Silva
BACKGROUND: Dynamic breast deformity (DBD) is characterized by visible distortion and deformity of the breast due to contraction of the pectoralis major muscle after submuscular breast augmentation; fortunately, in most cases, this is not a clinically significant complaint from patients. The purpose of this study is to present a simple method for objectively measuring DBD in patients submitted to dual plane breast augmentation (DPBA). METHODS: We studied 32 women, between 18 and 50 years old, who underwent primary DPBA with at least 1 year of follow-up...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302729/color-change-after-paramedical-pigmentation-of-the-nipple-areola-complex
#5
Shoichi Tomita, Katsuya Mori, Takeshi Miyawaki
BACKGROUND: Reconstruction of the nipple-areola complex is the final process in breast reconstruction. Local flaps and paramedical pigmentation is one of the major procedures for this. However, fading after paramedical pigmentation leads to a color difference between the selected pigment and its color in the skin. The aim of this study is to make a proposition in color choice of paramedical pigmentation for nipple-areola complex. METHODS: Our research focused on investigating the color changes over time after unilateral nipple-areola complex reconstruction using paramedical pigmentation in 25 patients to propose suitable color selections...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29302490/a-systematic-review-of-intraoperative-process-mapping-in-surgery
#6
REVIEW
Ru Dee Chung, David J Hunter-Smith, Robert T Spychal, Venkat V Ramakrishnan, Warren Matthew Rozen
Process mapping has been identified as a strategy to improve surgical efficiency but has been inconsistently applied in the literature and underutilised in surgical practice. In this journal, we recently described our utilisation of these approaches when applied to breast reconstruction. We showed that in surgery as complex as autologous breast reconstruction, process mapping can improve efficiency, and may improve surgical teaching, education and audit. The intraoperative period specifically is an area that can be applied not only to breast reconstruction, but to a much broader range of surgical procedures...
December 2017: Gland Surgery
https://www.readbyqxmd.com/read/29298171/expression-of-%C3%AE-v-tubulin-in-secretory-cells-of-the-fallopian-tube-epithelium-marks-cellular-atypia
#7
Deepti Mathew, Yanhua Wang, Anne Van Arsdale, Susan Band Horwitz, Hayley McDaid
OBJECTIVES: Class V Beta tubulin isotype (βV-tubulin) was recently found to have tissue-specific expression patterns in epithelial tissues with secretory function and aberrant expression in tumors. The aims of this pilot study were (a) to examine expression of βV-tubulin in the fallopian tube epithelium (FTE) of patients who underwent salpingectomy, (b) to characterize FTE atypia in high-risk patients with BRCA mutations, and (c) to determine expression of βV-tubulin in serous ovarian neoplasms...
January 3, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29276849/male-breast-cancer-a-nation-wide-population-based-comparison-with-female-breast-cancer
#8
Marianne D Lautrup, Signe S Thorup, Vibeke Jensen, Susanne Bokmand, Karen Haugaard, Inger Hoejris, Anne-Marie B Jylling, Hjoerdis Joernsgaard, Giedrius Lelkaitis, Mette H Oldenburg, Gro M Qvamme, Katrine Soee, Peer Christiansen
OBJECTIVE: Describe prognostic parameters of Danish male breast cancer patients (MBCP) diagnosed from 1980-2009. Determine all-cause mortality compared to the general male population and analyze survival/mortality compared with Danish female breast cancer patients (FBCP) in the same period. MATERIAL AND METHODS: The MBCP cohort was defined from three national registers. Data was extracted from medical journals. Data for FBCP is from the DBCG database. Overall survival (OS) was quantified by Kaplan-Meier estimates...
December 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29275156/aripiprazole-use-during-pregnancy-peripartum-and-lactation-a-systematic-literature-search-and-review-to-inform-clinical-practice
#9
REVIEW
A Cuomo, A Goracci, A Fagiolini
BACKGROUND: Aripiprazole is used relatively frequently in women with bipolar disorder or schizophrenia in childbearing years, owing to its efficacy and relatively favorable side effect profile. As is the case for other psychotropic medications, for ethical reasons, no prospective randomized placebo controlled trial to assess aripiprazole safety during pregnancy has ever been conducted. However, animal data are available and the amount of exposure and outcome data for human fetuses and infants has recently increased, providing published prospective safety data in relatively large numbers of pregnant women treated with aripiprazole...
December 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29273932/treatment-of-gigantomastia-using-a-medial-lateral-bipedicle-reduction-mammoplasty-the-role-of-doppler-assisted-preoperative-perforator-identification
#10
Nader Gomaa Elmelegy, Mohamed Saad Sadaka, Ahmed M Hegazy, Doaa E Abdeldaim
The purpose of this study is to introduce a breast reduction technique designed to reduce the incidence of postoperative nipple-areola complex ischemia and necrosis following reduction mammoplasty, while at the same time allowing all the other goals of breast reduction to be realized. This is achieved through preoperative detection of perforating vessels supplying the nipple-areola complex using a hand-held Doppler. The horizontally based parenchymal pedicle is designed to include these perforators whether originating from the internal mammary artery, lateral thoracic artery or both...
December 22, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29259059/protocol-for-the-brecar-study-a-prospective-cohort-follow-up-on-the-impact-of-breast-reconstruction-timing-on-health-related-quality-of-life-in-women-with-breast-cancer
#11
Maria Herrera de la Muela, Enrique García López, Laura Frías Aldeguer, Paloma Gómez-Campelo
INTRODUCTION: The completion of postmastectomy breast reconstruction (BR) in women with breast cancer can last from months to years, and to our knowledge, there is a lack of studies that analyse how the different types and times of reconstruction impact on the patient's quality of life and psychosocial adjustment.The primary aim of the BREast Cancer Reconstruction (BRECAR Study) is twofold. First, to describe health-related quality of life (HRQoL), overall satisfaction with surgery and psychological impact (body image, self-esteem, depression and anxiety) on women who will have undergone a mastectomy with planned BR, considering the varied timing of BR procedures (immediate BR (iBR), delayed BR (dBR) and two-stage BR (2sBR))...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29246224/optimizing-clinical-and-organizational-practice-in-cancer-survivor-transitions-between-specialized-oncology-and-primary-care-teams-a-realist-evaluation-of-multiple-case-studies
#12
Dominique Tremblay, Catherine Prady, Karine Bilodeau, Nassera Touati, Maud-Christine Chouinard, Martin Fortin, Isabelle Gaboury, Jean Rodrigue, Marie-France L'Italien
BACKGROUND: Cancer is now viewed as a chronic disease, presenting challenges to follow-up and survivorship care. Models to shift from haphazard, suboptimal and fragmented episodes of care to an integrated cancer care continuum must be developed, tested and implemented. Numerous studies demonstrate improved care when follow-up is assured by both oncology and primary care providers rather than either group alone. However, there is little data on the roles assumed by specialized oncology teams and primary care providers and the extent to which they work together...
December 16, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29235566/long-term-survival-outcomes-of-triple-receptor-negative-breast-cancer-survivors-who-are-disease-free-at-5-years-and-relationship-with-low-hormone-receptor-positivity
#13
S M Reddy, C H Barcenas, A K Sinha, L Hsu, S L Moulder, D Tripathy, G N Hortobagyi, V Valero
BACKGROUND: We counsel our triple-negative breast cancer (TNBC) patients that the risk of recurrence is highest in the first 5 years after diagnosis. However, there are limited data with extended follow-up on the frequency, characteristics, and predictors of late events. METHODS: We queried the MD Anderson Breast Cancer Management System database to identify patients with stage I-III TNBC who were disease free at 5 years from diagnosis. The Kaplan-Meier method was used to estimate yearly recurrence-free interval (RFI), recurrence-free survival (RFS), and distant relapse-free survival (DRFS), as defined by the STEEP criteria...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29221997/what-do-patients-want-to-know-questions-and-concerns-regarding-mammography-expressed-through-social-media
#14
Abbas M Charlie, Yiming Gao, Samantha L Heller
PURPOSE: The purpose of this project is to identify questions and concerns patients have regarding breast cancer screening mammography to establish priorities in patient education and health care communication. METHODS: A content analysis of posted questions (June 2010 to February 2017) containing the keywords mammogram and mammography was conducted on the social media question and answer website Quora (Quora Inc, Mountainview, California). Question topic, responses, and number of views were recorded...
December 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29218474/superomedial-pedicle-vertical-scar-breast-reduction-objective-and-subjective-assessment-of-breast-symmetry-and-aesthetics
#15
Ofir Ron, Amir Inbal, Ehud Arad, Arik Zaretski, David Leshem, Ravit Yanko, Eyal Gur, Yoav Barnea
BACKGROUND: The superomedial vertical scar breast reduction (SVBR) described by Hall-Findlay is gaining popularity among surgeons worldwide. The aim of this study was to evaluate its long-term aesthetic outcome, the extent of quality of life improvement and the factors that influence patient satisfaction and reviewers' evaluation of aesthetic/surgical outcome. METHODS: In this historical prospective study, we included women who underwent SVBR at least one year prior to enrollment and responded to a quality of life questionnaire...
December 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29216920/body-mass-index-had-different-effects-on-premenopausal-and-postmenopausal-breast-cancer-risks-a-dose-response-meta-analysis-with-3-318-796-subjects-from-31-cohort-studies
#16
Yanzi Chen, Li Liu, Quan Zhou, Mustapha Umar Imam, Jialin Cai, Yaxuan Wang, Minjie Qi, Panpan Sun, Zhiguang Ping, Xiaoli Fu
BACKGROUND: There is sufficient evidence supporting a relationship between increased body mass index (BMI) and an increased risk for breast cancer among postmenopausal women. However, most studies have found a decreased risk for premenopausal breast cancer. This study was conducted to find out the different effects of BMI on the risk of breast cancer among premenopausal and postmenopausal women, and explore the potential factors that influence the associations. METHODS: A dose-response meta-analysis with 3,318,796 participants from 31 articles was conducted...
December 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29209939/disaggregating-the-mortality-reductions-due-to-cancer-screening-model-based-estimates-from-population-based-data
#17
James Anthony Hanley, Sisse Helle Njor
The mortality impact in cancer screening trials and population programs is usually expressed as a single hazard ratio or percentage reduction. This measure ignores the number/spacing of rounds of screening, and the location in follow-up time of the averted deaths vis-a-vis the first and last screens. If screening works as intended, hazard ratios are a strong function of the two Lexis time-dimensions. We show how the number and timing of the rounds of screening can be included in a model that specifies what each round of screening accomplishes...
December 5, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29195057/novel-radiotherapy-techniques-for-breast-cancer
#18
Julie A Bradley, Nancy P Mendenhall
During the early decades of radiation therapy for breast cancer, local control of disease was documented consistently but, enigmatically, an anticipated impact on breast cancer survival was not observed, leading to confusion in our understanding of the natural history of breast cancer and radiation effects. Now, almost 90 years after its first use in breast cancer, technology developments in diagnostic imaging and radiation therapy have elucidated parts of this enigma. The data now available demonstrate a significant impact of radiation therapy on survival as well as disease control and treatment-related mortality, opening a doorway to understanding the powerful impact of radiation therapy on both breast cancer and critical organs...
December 1, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/29182609/variation-in-fast-track-referrals-for-suspected-cancer-by-patient-characteristic-and-cancer-diagnosis-evidence-from-670%C3%A2-000-patients-with-cancers-of-35-different-sites
#19
Y Zhou, S C Mendonca, G A Abel, W Hamilton, F M Walter, S Johnson, J Shelton, L Elliss-Brookes, S McPhail, G Lyratzopoulos
BACKGROUND: In England, 'fast-track' (also known as 'two-week wait') general practitioner referrals for suspected cancer in symptomatic patients are used to shorten diagnostic intervals and are supported by clinical guidelines. However, the use of the fast-track pathway may vary for different patient groups. METHODS: We examined data from 669 220 patients with 35 cancers diagnosed in 2006-2010 following either fast-track or 'routine' primary-to-secondary care referrals using 'Routes to Diagnosis' data...
November 28, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29175074/staphylococcus-aureus-and-staphylococcus-epidermidis-infections-on-implants
#20
REVIEW
Weslley F Oliveira, Priscila M S Silva, Rayane C S Silva, Germana M M Silva, Giovanna Machado, Luana C B B Coelho, Maria T S Correia
BACKGROUND: Infections are one of the main reasons for removal of implants from patients, and usually need difficult and expensive treatments. Staphylococcus aureus and Staphylococcus epidermidis are the most frequent pathogens. AIM: To review the epidemiology and pathogenesis of implant-related infections. METHODS: Relevant studies were identified by electronic searching of the following databases: PubMed, ScienceDirect, Academic Google and CAPES Journal Portal...
November 21, 2017: Journal of Hospital Infection
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