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https://www.readbyqxmd.com/read/28916908/capsular-contracture-rate-after-breast-augmentation-with-periareolar-versus-other-two-inframammary-and-transaxillary-incisions-a-meta-analysis
#1
REVIEW
Shangshan Li, Lin Chen, Wenyue Liu, Dali Mu, Jie Luan
BACKGROUND: Capsular contracture has been the most common complication of cosmetic breast augmentation. The effect of incision pattern on capsular contracture is still unclear. This meta-analysis demonstrates current evidence with regard to the comparison of capsular contracture rate between periareolar and other two (transaxillary and inframammary) incisions. METHODS: PubMed, EMBASE, and Cochrane databases were searched up to January 2017. The results of selected studies were meta-analyzed to obtain a pooled odds ratio of the effect of periareolar versus other two incision patterns (transaxillary or inframammary incision) of breast augmentation on capsular contracture rates...
September 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28916881/a-3d-mammometric-comparison-of-implant-based-breast-reconstruction-with-and-without-acellular-dermal-matrix-adm
#2
Cynthia Tsay, Victor Zhu, Tracy Sturrock, Ajul Shah, Stephanie Kwei
This retrospective study utilizes 3D imaging and mammometrics to compare implant-based breast reconstruction with and without the use of ADM. Previous studies have suggested improved aesthetic outcomes with the use of ADM, but none have been able to quantify this difference. Images were obtained at early and late time points following the expander-implant exchange procedure. Measurements included the point of maximum projection, the superior, inferior, medial and lateral volumetric distribution, and the distance from the point of maximum projection to the inframammary fold along the breast meridian...
September 15, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28910822/a-new-molecular-based-lymph-node-staging-classification-determines-the-prognosis-of-breast-cancer-patients
#3
Tomo Osako, Takuji Iwase, Masaru Ushijima, Rika Yonekura, Shinji Ohno, Futoshi Akiyama
BACKGROUND: The one-step nucleic acid amplification (OSNA) assay is a novel molecular method that can detect metastasis in a whole lymph node based on cytokeratin 19 mRNA copy number. This cohort study aimed to establish an OSNA-based nodal staging (pN(mol)) classification for breast cancer. METHODS: The cohort consisted of 1039 breast cancer patients who underwent sentinel node (SN) biopsy using the OSNA assay. Cutoff value of the SN tumour burden stratifying distant disease-free survival (DDFS) was determined, and predictive factors for DDFS and breast cancer-specific survival (BCSS) were investigated...
September 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28898233/estimating-the-impact-of-a-cancer-diagnosis-on-life-expectancy-by-socio-economic-group-for-a-range-of-cancer-types-in-england
#4
Elisavet Syriopoulou, Hannah Bower, Therese M-L Andersson, Paul C Lambert, Mark J Rutherford
BACKGROUND: Differences in cancer survival exist across socio-economic groups for many cancer types. Standard metrics fail to show the overall impact for patients and the population. METHODS: The available data consist of a population of ∼2.5 million patients and include all patients recorded as being diagnosed with melanoma, prostate, bladder, breast, colon, rectum, lung, ovarian and stomach cancers in England between 1998 and 2013. We estimated the average loss in expectation of life per patient in years and the proportion of life lost for a range of cancer types, separately by deprivation group...
September 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28898231/albumin-bilirubin-uric-acid-and-cancer-risk-results-from-a-prospective-population-based-study
#5
Tilman Kühn, Disorn Sookthai, Mirja E Graf, Ruth Schübel, Heinz Freisling, Theron Johnson, Verena Katzke, Rudolf Kaaks
BACKGROUND: It has long been proposed that albumin, bilirubin and uric acid may inhibit cancer development due to their anti-oxidative properties. However, there is a lack of population-based studies on blood levels of these molecules and cancer risk. METHODS: Associations between pre-diagnostic serum albumin, bilirubin and uric acid and the risks of common cancers as well as cancer death in the EPIC-Heidelberg cohort were evaluated by multivariable Cox regression analyses...
September 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28894852/top-100-cited-classic-articles-in-breast-cancer-research
#6
Erdal Uysal
OBJECTIVE: This study aimed to analyze 100 most cited articles in breast cancer research. MATERIALS AND METHODS: The data in this study were obtained by a search conducted on the Web of Science (WOS). In brief, the term "breast cancer" was typed in the search box of WOS basic research including all the years and the data. The analysis was carried out by compiling the top 100 cited articles in the shortlist as sorted by the journals, categories of the studies, the countries, the centers, the authors and the publication date...
July 2017: Eur J Breast Health
https://www.readbyqxmd.com/read/28891436/radio-localization-of-non-palpable-breast-lesions-under-ultrasonographic-guidance-current-status-and-future-perspectives
#7
Giulia Anna Follacchio, Francesco Monteleone, Maria Letizia Meggiorini, Maria Paola Nusiner, Carlo De Felice, Giuseppe De Vincentis, Mauro Liberatore
BACKGROUND: Due to the spread of mammographic screening programs, a constant increase of clinically-occult breast cancer diagnosis has been registered. A correct approach to non-palpable breast lesions requires an accurate intra-operative localization in order to achieve a complete surgical resection. Aim of this paper is to describe the state of the art of the US-guided procedures such as Radio-guided Occult Lesion Localization (ROLL) and Radio-guided Seed Localization (RSL) in comparison to the most widely adopted Wire-Guided Localization (WGL)...
September 8, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/28881357/a-novel-inhibitory-anti-invasive-mab-isolated-using-phenotypic-screening-highlights-anxa6-as-a-functionally-relevant-target-protein-in-pancreatic-cancer
#8
Dermot O'Sullivan, Paul Dowling, Helena Joyce, Edel McAuley, Andrew McCann, Michael Henry, Brianan McGovern, Paul Barham, Fergal C Kelleher, Jean Murphy, Susan Kennedy, Niall Swan, Michael Moriarty, Martin Clynes, Annemarie Larkin
BACKGROUND: Discovery and validation of new antibody tractable targets is critical for the development of new antibody therapeutics to address unmet needs in oncology. METHODS: A highly invasive clonal variant of the MDA-MB-435S cell line was used to generate monoclonal antibodies (MAbs), which were screened for anti-invasive activity against aggressive cancer cells in vitro. The molecular target of selected inhibitory MAb 9E1 was identified using immunoprecipitation/liquid chromatography-tandem mass spectrometry...
September 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28876630/is-waiting-the-hardest-part-a-critical-study-of-the-experience-of-women-awaiting-breast-biopsy-results
#9
T Hodgkinson, C Govender, S Rayne
BACKGROUND: Most previous research efforts have focused on the psychological effects of receiving a cancer diagnosis rather than the period of waiting for definitive Results. Early detection of cancer is directly linked to successful treatment regimes, yet these procedures evoke significant anxiety in patients. The long wait for medical test Results in state health institutions, with one of the possible outcomes being a cancer diagnosis, means that the days of waiting can induce emotional distress before the diagnosis has even been given...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28859057/the-prevalence-of-unmet-needs-in-625-women-living-beyond-a-diagnosis-of-early-breast-cancer
#10
Marta Capelan, Nicolò Matteo Luca Battisti, Anne McLoughlin, Vivienne Maidens, Nikki Snuggs, Patrycja Slyk, Clare Peckitt, Alistair Ring
BACKGROUND: There are over half a million women with a previous breast cancer diagnosis living in the UK. It is important to establish their level of unmet physical and psychosocial needs, as many are not routinely seen for follow-up under current models of care. METHODS: We conducted a retrospective analysis of early breast cancer survivors entering an Open Access Follow-Up (OAFU) programme in 2015. Unmet needs were assessed using the Holistic Needs Assessment (HNA) or extracted directly from the electronic patient record (EPR), when the HNA had not been completed...
August 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28859055/separase-is-a-marker-for-prognosis-and-mitotic-activity-in-breast-cancer
#11
Natalia Gurvits, Eliisa Löyttyniemi, Marjukka Nykänen, Teijo Kuopio, Pauliina Kronqvist, Kati Talvinen
BACKGROUND: Cancer cell proliferation is a critical feature in classifying and predicting the outcome of breast carcinoma. Separase has a central role in cell cycle progression in unleashing sister-chromatids at anaphase onset. Abnormally functioning separase is known to lead to chromosomal instability. METHODS: The study comprises 349 breast carcinoma patients treated in Central Hospital of Central Finland. The prognostic value, role as a proliferation marker and regulatory interactions of separase are evaluated by immunohistochemical and double- and triple-immunofluorescence (IF) detections based on complete clinical data and >22-year follow-up of the patient material...
August 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28857777/barbed-ribbon-device-for-progressive-tension-closure-reduces-seroma-after-breast-reconstruction
#12
Devan Griner, Caleb M Steffen, Kristopher M Day, Mark A Brzezienski
PURPOSE: Implant-based breast reconstruction is fraught with complications related to seroma formation. Soft tissue stabilization with progressive tension closure (PTC) has been shown to decrease seroma formation after various procedures but is less suitable for mastectomy flap stabilization. We evaluate the incidence of seroma in breast reconstruction using bioabsorbable barbed ribbon devices (BRDs) as a novel approach to PTC. METHODS: We performed a retrospective review of all patients whose mastectomy flaps were stabilized with BRDs...
August 29, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28856383/side-effects-of-radiotherapy-in-breast-cancer-patients-the-internet-as-an-information-source
#13
S Janssen, L Käsmann, F B Fahlbusch, D Rades, D Vordermark
AIM: Breast cancer is the most common cancer type among women necessitating adjuvant radiotherapy. As the Internet has become a major source of information for cancer patients, this study aimed to evaluate the quality of websites giving information on side effects of radiotherapy for breast cancer patients. METHODS: A patients' search for the English terms "breast cancer - radiotherapy - side effects" and the corresponding German terms "Brustkrebs - Strahlentherapie - Nebenwirkungen" was carried out twice (5 months apart) using the search engine Google...
August 30, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28842781/closed-suction-drains-after-subcutaneous-mastectomy-for-gynecomastia-do-they-reduce-complications
#14
Jerry W Chao, Janani A Raveendran, Connor Maly, Gary Rogers, Michael Boyajian, Albert K Oh
BACKGROUND: In cases of refractory gynecomastia, surgical excision of excess glandular breast tissue is often warranted. Closed-suction drain placement is commonplace; however, the effect of drains on preventing complications after male breast surgery has not been fully elucidated in the literature. OBJECTIVE: To investigate the effect of drains on reducing seroma and hematoma after subcutaneous mastectomy for gynecomastia. METHODS: Retrospective chart review of patients undergoing subcutaneous mastectomy for gynecomastia over a 10-year period...
August 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28842766/desmoid-tumor-and-silicone-breast-implant-surgery-is-there-really-a-connection-a-literature-review
#15
REVIEW
R Tzur, E Silberstein, Y Krieger, Y Shoham, Y Rafaeli, A Bogdanov-Berezovsky
BACKGROUND: Desmoid tumors are borderline tumors of the connective tissue, arising in the musculo-aponeurotic stromal elements. A desmoid tumor (DT) has an infiltrative and locally aggressive growth pattern and usually does not metastasize; however, it has a high recurrence and complication rate. DT located in the breast (BDT) represents a rare extra-abdominal form. Recently, the presence of breast silicone implants was suggested by several researchers as a risk factor for developing BDT...
August 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28842752/sexuality-among-women-treated-for-breast-cancer-a-survey-of-three-surgical-procedures
#16
Ana Olivia Cortés-Flores, Adriana Vargas-Meza, Gilberto Morgan-Villela, Jorge Jiménez-Tornero, Carlos José Zuloaga-Fernández Del Valle, Manuel Solano-Genesta, Roberto Carlos Miranda-Ackerman, Iztel Vázquez-Reyna, Luis Alberto García-González, Guillermo Alonso Cervantes-Cardona, Gabino Cervantes-Guevara, Clotilde Fuentes-Orozco, Alejandro González-Ojeda
BACKGROUND: The quality of life of Mexican patients with breast cancer has been studied, but female sexual function has only been explored superficially. The Female Sexual Function Index (FSFI) questionnaire has been validated as a tool to measure sexual function among women with cancer. However, no study in Mexico has been published. PURPOSE: To evaluate and compare female sexuality of breast cancer survivors treated with three surgical procedures. MATERIALS AND METHODS: This is a cross-sectional questionnaire survey applied in patients without active disease and free of any oncologic treatment who underwent conservative mastectomy, and mastectomy with and without reconstruction...
August 25, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28840288/comparison-of-sensory-changes-following-superomedial-and-inferior-pedicle-breast-reduction
#17
Ümran Muslu, Dilek Şenen Demirez, Asım Uslu, Mehmet Ali Korkmaz, Meral Bilgilisoy Filiz
BACKGROUND: More attention is focused on sensory outcomes following breast reduction operations. We conducted this prospective, non-randomized study to compare two commonly used breast reduction techniques, superomedial pedicle and inferior pedicle, regarding sensation of the nipple-areolar complex. METHODS: We prospectively assigned 60 patients with macromastia into the superomedial pedicle group (SMP group, n = 30) or the inferior pedicle (IP group, n = 30) group...
August 24, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28829761/rho-gtpase-activating-protein-18-a-biomarker-associated-with-good-prognosis-in-invasive-breast-cancer
#18
Mohammed A Aleskandarany, Sultan Sonbul, Rachel Surridge, Abhik Mukherjee, Carlos Caldas, Maria Diez-Rodriguez, Ibraheem Ashankyty, Khalil I Albrahim, Ahmed M Elmouna, Ritu Aneja, Stewart G Martin, Ian O Ellis, Andrew R Green, Emad A Rakha
BACKGROUND: The prognostic value of lymphovascular invasion (LVI) in breast cancer (BC) has been demonstrated in several independent studies. However, identification of driver molecules for LVI remains a challenging task. Large-scale transcriptomic profiling of histologically validated LVI can potentially identify genes that regulate LVI. METHODS: Integrative bio-informatics analyses of the METABRIC study were performed utilising a subset of strictly defined LVI using histological and immunohistochemical (IHC) criteria...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28817836/sitting-physical-activity-and-serum-oestrogen-metabolism-in-postmenopausal-women-the-women-s-health-initiative-observational-study
#19
Hannah Oh, Hannah Arem, Charles E Matthews, Nicolas Wentzensen, Kerryn W Reding, Louise A Brinton, Garnet L Anderson, Sally B Coburn, Jane A Cauley, Chu Chen, Deborah Goodman, Ruth M Pfeiffer, Roni T Falk, Xia Xu, Britton Trabert
BACKGROUND: Prolonged sitting and lower levels of physical activity have been associated with increased levels of parent oestrogens (oestrone and oestradiol), the key hormones in female cancers, in postmenopausal women. However, it is unknown whether sitting and physical activity are associated with circulating oestrogen metabolite levels. METHODS: Among 1804 postmenopausal women enrolled in the Women's Health Initiative Observational Study, 15 serum oestrogens/oestrogen metabolites were quantified using liquid chromatography-tandem mass spectrometry...
August 17, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28815201/benign-papilloma-of-the-breast
#20
Moshe Sadofsky
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.
January 2017: Acad Pathol
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