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cholelithiasis in dogs

Sungin Lee, Aeri Lee, Oh-Kyeong Kweon, Wan Hee Kim
The hormone leptin is produced by mature adipocytes and plays an important role in regulating food intake and energy metabolism through its interaction with the leptin receptor. In addition to roles in obesity and obesity-related diseases, leptin has been reported to affect the components and secretion of bile in leptin-deficient mice. Furthermore, gallbladder diseases such as cholelithiasis are known to be associated with serum leptin concentrations in humans. We hypothesized that the canine gallbladder is a source of leptin and that the leptin receptor may be localized in the gallbladder, where it plays a role in regulating the function of this organ...
September 19, 2016: Acta Histochemica
Julien Gautherot, Danièle Delautier, Marie-Anne Maubert, Tounsia Aït-Slimane, Gérard Bolbach, Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Delphine Firrincieli, Véronique Barbu, Nicolas Chignard, Chantal Housset, Michèle Maurice, Thomas Falguières
UNLABELLED: The ABCB4 transporter mediates phosphatidylcholine (PC) secretion at the canalicular membrane of hepatocytes and its genetic defects cause biliary diseases. Whereas ABCB4 shares high sequence identity with the multidrug transporter, ABCB1, its N-terminal domain is poorly conserved, leading us to hypothesize a functional specificity of this domain. A database of ABCB4 genotyping in a large series of patients was screened for variations altering residues of the N-terminal domain...
August 2014: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Maike Beisele, Zeli Shen, Nicola Parry, Melissa Mobley, Nancy S Taylor, Ellen Buckley, Mohammad Z Abedin, Floyd E Dewhirst, James G Fox
Prairie dogs (Cynomys ludovicianus) are used to study the aetiology and prevention of gallstones because of the similarities of prairie dog and human bile gallstone composition. Epidemiological and experimental studies have suggested a connection between infection with Helicobacter species and cholesterol cholelithiasis, cholecystis and gallbladder cancer. Ten of the 34 prairie dogs in this study had positive Helicobacter species identified by PCR using Helicobacter genus-specific primers. Ten of 34 prairie dogs had positive Campylobacter species identified in the intestine by PCR with Campylobacter genus-specific primers...
September 2011: Journal of Medical Microbiology
Katrina L Mealey, Jonathan D Minch, Stephen N White, Kevin R Snekvik, John S Mattoon
BACKGROUND: ABCB4 functions as a phosphatidylcholine translocater, flipping phosphatidylcholine across hepatocyte canalicular membranes into biliary canaliculi. In people, ABCB4 gene mutations are associated with several disease syndromes including intrahepatic cholestasis of pregnancy, progressive familial intrahepatic cholestasis (type 3), primary biliary cirrhosis, and cholelithiasis. Hepatobiliary disease, specifically gallbladder mucocele formation, has been recognized with increased frequency in dogs during the past decade...
2010: Comparative Hepatology
Angela C Brown, Steven P Wrenn, Nandita Suresh, William C Meyers, Mohammad Z Abedin
The incidence of gallstone disease is two to three times higher in women than in men, and female sex hormones, particularly estrogens, have been implicated as contributory factors. Cholesterol nucleation is the initial step in gallstone pathogenesis and proceeds from cholesterol-rich phospholipid vesicles. The aim of this study was to investigate if there is a difference in cholesterol nucleation rates in male and female bile and whether estrogen influences nucleation rates by interacting with cholesterol-rich regions known as "lipid rafts" that exist within the cholesterol-phospholipid vesicles of the bile...
December 2009: Journal of Membrane Biology
W B Hawkins, G H Whipple
A clearer understanding of the various abnormalities which may develop in relation to the experimental or clinical bile fistula will be of value to the laboratory worker as well as to the physician and surgeon. A better comprehension of these diseased conditions will make for a saner analysis of the great mass of experimental data relating to the various types of bile fistula. Too frequently in the literature the bile fistula material is used to debate a physiological state whereas in reality the animal is in a pathological condition...
September 30, 1935: Journal of Experimental Medicine
D R Drury
A day to day study has been made of the calcium content of the total liver bile of dogs intubated under sterile conditions. The concentration of this element in the bile is fairly constant under physiological conditions which do not involve wide fluctuations in the secretory output. It follows that the calcium yield for each 24 hour period in general varies directly with the amount of the bile. But when this amount becomes greatly lessened, as the result of fasting, the concentration of calcium becomes markedly increased, though not sufficiently so to compensate for the lessened volume...
November 30, 1924: Journal of Experimental Medicine
D R Drury, P D McMaster, P Rous
As previous papers from our laboratory have shown, there exists a well defined tendency for calcium carbonate to come out of solution in the normal liver bile of the dog, and for it to be deposited on certain nuclei not infrequent in the secretion under pathological circumstances. Gall stones that had arisen in this fashion were a frequent occurrence in the intubated animals we studied. The present paper is concerned with the reasons for the absence of such stones from dogs with an intact biliary tract. The solubility of calcium carbonate is known to be markedly affected by the reaction of the fluid in which it is contained...
February 29, 1924: Journal of Experimental Medicine
P Rous, D R Drury, P D McMaster
A day-to-day study has been made of the sediment in the sterile liver bile of intubated dogs. There exists a marked tendency for calcium carbonate to be deposited therefrom. After hepatic or duct injury a great deal of organic débris of various sorts may be present in the bile, but it never causes deposition out of the fluid save when it accumulates in quantity on the tube wall. Particles of the material of which "bile thrombi" are composed may be found in the bile when the liver has been appropriately damaged, but these fail to act as centers of stone formation...
January 1, 1924: Journal of Experimental Medicine
P Rous, P D McMaster, D R Drury
Gall stones frequently form in dogs intubated for the collection of bile under sterile conditions, in the absence of stasis and of gall bladder influence. The stones consist almost entirely of two substances-calcium carbonate and calcium bilirubinate-and they are remarkably uniform in character, as would follow from the limiting conditions of their development. They are not the result of bile loss, for similar ones may be recovered from the wall of glass tubes interpolated in ducts with intestinal connection undisturbed...
January 1, 1924: Journal of Experimental Medicine
P Rous, P D McMaster
The gall bladder and ducts exert opposite influences upon the bile. The ducts fail to concentrate and thicken it with mucus as the bladder does, but dilute it slightly with a thin secretion of their own that is colorless and devoid of cholates even when the organism is heavily jaundiced. The fluid may readily be collected into a rubber bag connected with an isolated duct segment. It continues to be formed against a considerable pressure, and, in the dog, is slightly alkaline to litmus, clear, almost watery, practically devoid of cholesterol, and of low specific gravity to judge from the one specimen tested...
June 30, 1921: Journal of Experimental Medicine
Sharon A Center
Most disorders of the biliary system are associated with increased activity of parenchymal transaminases (alanine aminotransferase, aspartate aminotransferase) and cholestatic enzymes (alkaline phosphatase and gamma glutamyl transferase) with or without hyperbilirubinemia or jaundice. While parenchymal liver disease is most common in the dog, inflammatory disorders involving the small- and medium-sized bile ducts and zone 1 (periportal) hepatocytes predominate in the cat. Historically, the incidence of disorders restricted to the gallbladder is low in both species; however, with routine diagnostic use of abdominal ultrasonography, the incidence of gallbladder mucoceles and cholelithiasis has increased...
May 2009: Veterinary Clinics of North America. Small Animal Practice
Ale L Aguirre, Sharon A Center, John F Randolph, Amy E Yeager, Alicia M Keegan, H Jay Harvey, Hollis N Erb
OBJECTIVE: To determine risk, clinical features, and treatment responses for gallbladder disorders in Shetland Sheepdogs. DESIGN: Retrospective case-control study. ANIMALS: 38 Shetland Sheepdogs with gallbladder disease. PROCEDURES: Medical records were reviewed for signalment, history, physical findings, laboratory results, imaging features, coexistent illnesses, histologic findings, treatments, and survival rates. RESULTS: Mature dogs with gastrointestinal signs were predisposed (odds ratio, 7...
July 1, 2007: Journal of the American Veterinary Medical Association
Renata Ward
A 10-year-old, neutered male, keeshond was presented for vomiting, lethargy, icterus, and anorexia. Obstructive cholelithiasis was diagnosed based on analysis of a serum biochemical profile, abdominal radiographs, and ultrasonography. Choleliths were removed from the gall bladder and common bile duct via a cholecystotomy.
November 2006: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
Philipp D Mayhew, Robert W Richardson, Stephen J Mehler, David E Holt, Chick W Weisse
OBJECTIVE: To determine clinicopathologic features, surgical management, complications, and long-term outcome associated with diseases of the extrahepatic portion of the biliary tract treated via choledochal stent placement in dogs. DESIGN: Retrospective case series. ANIMALS: 13 dogs. PROCEDURE: Data were obtained from medical records, and follow-up information was obtained via reexamination or telephone interview with owners or referring veterinarians...
April 15, 2006: Journal of the American Veterinary Medical Association
Stephen J Mehler, Philipp D Mayhew, Kenneth J Drobatz, David E Holt
OBJECTIVE: To report clinical findings and define clinical variables associated with outcome in dogs undergoing extrahepatic biliary surgery. STUDY DESIGN: Retrospective study. ANIMALS: Sixty dogs that had extrahepatic biliary tract surgery. RESULTS: Primary diagnoses included necrotizing cholecystitis (36 dogs, 60%), pancreatitis (12 dogs, 20%), neoplasia (5 dogs, 8%), trauma (4 dogs, 7%), and gallbladder rupture from cholelithiasis without necrotizing cholecystitis (3 dogs, 5%)...
November 2004: Veterinary Surgery: VS
No abstract text is available yet for this article.
November 17, 1964: Langenbecks Archiv Für Klinische Chirurgie ... Vereinigt mit Deutsche Zeitschrift Für Chirurgie
No abstract text is available yet for this article.
August 1964: American Journal of Surgery
No abstract text is available yet for this article.
July 1964: Archives of Surgery
No abstract text is available yet for this article.
March 1964: Archives des Maladies de L'appareil Digestif et des Maladies de la Nutrition
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