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https://www.readbyqxmd.com/read/29353224/coronary-microvascular-dysfunction-may-be-related-to-igf-1-in-acromegalic-patients-and-can-be-restored-by-therapy
#1
Sara Tellatin, Pietro Maffei, Elena Osto, Francesca Dassie, Giulia Famoso, Roberta Montisci, Chiara Martini, Francesco Fallo, Martina Perazzolo Marra, Roberto Mioni, Sabino Iliceto, Roberto Vettor, Francesco Tona
BACKGROUND AND AIMS: Acromegaly increases the risk of cardiovascular mortality. Data on the cardiovascular risk in asymptomatic acromegaly are limited. In particular, data on coronary microvascular abnormalities are lacking. We assessed coronary flow reserve (CFR) as a marker of coronary microvascular function in asymptomatic acromegaly. METHODS: We studied 40 acromegalic patients (23 male, age 52 ± 11 years) without clinical evidence of cardiovascular disease, and 40 control subjects matched for age and sex...
December 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353190/characterization-of-acrylamide-induced-oxidative-stress-and-cardiovascular-toxicity-in-zebrafish-embryos
#2
Mengmeng Huang, Jingjing Jiao, Jun Wang, Zhidan Xia, Yu Zhang
Acrylamide (AA) is a high production volume chemical in industrial applications and widely found in baked or fried carbohydrate-rich foods. In this study, we unravelled that AA induced developmental toxicity associated with oxidative stress status and disordered lipid distribution in heart region of developing zebrafish. Treatment with AA caused a deficient cardiovascular system with significant heart malformation and dysfunction. We also found that AA could reduce the number of cardiomyocytes through the reduced capacity of cardiomyocyte proliferation rather than cell apoptosis...
January 8, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29351855/the-relationship-of-circulating-fibroblast-growth-factor-21-levels-with-incident-atrial-fibrillation-the-multi-ethnic-study-of-atherosclerosis
#3
Tsz Him Hui, Robyn L McClelland, Matthew A Allison, Carlos J Rodriguez, Richard A Kronmal, Susan R Heckbert, Erin D Michos, Philip J Barter, Kerry-Anne Rye, Kwok Leung Ong
BACKGROUND AND AIMS: Elevated circulating levels of fibroblast growth factor 21 (FGF21) are associated with multiple cardiovascular disease (CVD) risk factors and incident events. Previous small cross-sectional studies, mainly in Chinese populations, have suggested FGF21 may play a role in the development of atrial fibrillation (AF). We therefore investigated the relationship of FGF21 levels with incident AF in participants free of clinically apparent CVD at baseline in a large, multi-ethnic cohort...
December 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29351480/mechanistically-different-effects-of-fat-and-sugar-on-insulin-resistance-hypertension-and-gut-microbiota-in-rats
#4
Sara Ramos-Romero, Mercè Hereu, Lidia Atienza, Josefina Casas, Olga Jáuregui, Susana Amézqueta, Gabriel Dasilva, Isabel Medina, Maria Rosa Nogués, Marta Romeu, Josep Lluís Torres
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to type-2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The roles of dietary fat and fructose in the development of IR, IGT and hypertension are controversial. We tested the long-term effects of an excess of fat or sucrose (fructose/glucose) on healthy male Wistar Kyoto (WKY) rats. Fat affects IR and IGT earlier than fructose through low-grade systemic inflammation evidenced by liver inflammatory infiltration, increased levels of plasma interleukin-6, prostaglandin E2 and reduced levels of protective short-chain fatty acids without triggering hypertension...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29349100/vitamin-d-deficiency-associated-with-markers-of-cardiovascular-disease-in-children-with-obesity
#5
Marisa Censani, Hoda T Hammad, Paul J Christos, Tiffany Schumaker
Adult studies have reported associations of low 25-hydroxyvitamin D (25OHD) with dyslipidemia and cardiovascular disease; however, there are scarce pediatric data regarding relationships between vitamin D status and specific lipid markers affecting cardiovascular risk. In this cross-sectional study of children evaluated at university-based pediatric endocrinology clinics, 178 patients meeting criteria for overweight or obesity had 25OHD levels assessed over a 2-year period; 60 of 178 had non-HDL (high-density lipoprotein) cholesterol and fasting lipid parameters performed...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29345597/pediatric-markers-of-adult-cardiovascular-disease
#6
Micah Olson, Melissa Chambers, Gabe Shaibi
Cardiovascular disease (CVD) is the leading cause of mortality in the United States . Atherosclerotic CV events do not occur until adulthood, except in the context of rare genetic disorders such as homozygous familial hypercholesterolemia. However, the atherogenic process that leads to CVD begins in childhood and progresses throughout the lifespan . The degree of atherosclerosis early in life is associated with established risk factors for CVD (e.g. family history, obesity, dyslipidemia), indicating that the development and progression of atherosclerosis in childhood is driven by genetic as well as environmental factors...
January 16, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29344026/evaluation-of-the-predictive-value-of-the-serum-calcium-magnesium-ratio-for-all-cause-and-cardiovascular-mortality-in-incident-dialysis-patients
#7
Hiroyuki Sato, Youichi Takeuchi, Ken Matsuda, Ayako Saito, Saeko Kagaya, Hirotaka Fukami, Yoshie Ojima, Tasuku Nagasawa
Background/Aim: Cardiovascular disease is the most serious cause of death in patients on hemodialysis. Low serum magnesium (Mg) and high serum calcium (Ca) levels have been associated with poor outcome and cardiovascular mortality in patients on maintenance and initiation dialysis. As a more accurate marker is warranted, we evaluated the efficacy of a novel serum Ca-Mg marker of all-cause and cardiovascular mortality that indicates vessel calcification. Methods: We recruited 378 consecutive patients with end-stage renal disease who started dialysis between January 2009 and December 2015 at the Japanese Red Cross Ishinomaki Hospital...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29343953/impact-of-acute-exacerbations-on-platelet-reactivity-in-chronic-obstructive-pulmonary-disease-patients
#8
Mariana Muñoz-Esquerre, José Luis Ferreiro, Daniel Huertas, Ana Lucrecia Marcano, Marta López-Sánchez, Gerard Roura, Joan Antoni Gómez-Hospital, Jordi Dorca, Angel Cequier, Salud Santos
Background: A higher risk of atherothrombotic cardiovascular events, which are platelet-driven processes, has been described during acute exacerbations of chronic obstructive pulmonary disease (AECOPD). However, the relevance of platelet reactivity during AECOPD and whether this is affected by antiplatelet agents are not fully elucidated to date. This study aimed to evaluate whether platelet reactivity is augmented during an exacerbation in COPD patients with and without antiplatelet therapy and its association with systemic inflammatory parameters...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29343929/yoga-offers-cardiovascular-protection-in-early-postmenopausal-women
#9
Sinha M Praveena, Gandhi Asha, Mondal Sunita, Jain Anju, Biswas Ratna
Context: Postmenopause, an estrogen deficient state comes with increased incidence of cardiovascular diseases (CVDs). Yoga has been described as having a beneficial effect on heart rate variability (HRV), a marker for cardiac autonomic activity which can assess cardiovascular risk, in various populations. Aim: the aim of the study was to study the effect of 3-month long Yoga practice on HRV in early postmenopausal women. Settings and Design: A prospective longitudinal study of 67 women within 5 years of menopause between 45 and 60 years of age attending menopause clinic of Department of Gynaecology, Sucheta Kriplani Hospital fulfilling inclusion and exclusion criteria and consenting were enrolled for the study...
January 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29343179/b-type-natriuretic-peptide-for-prediction-of-incident-clinically-significant-abdominal-aortic-aneurysm-a-population-based-prospective-study
#10
Stefan Acosta, Anders Gottsäter, Gunnar Engström, Olle Melander, Moncef Zarrouk, Peter M Nilsson, J Gustav Smith
Pathogenesis of abdominal aortic aneurysm (AAA) is unclear. The aim of this study was to evaluate inflammatory and hemodynamic plasma biomarkers as predictors for AAA in the prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer Study ( n=5551; 1991-94). C-reactive protein, cystatin C, copeptin, N-terminal pro-B-type natriuretic peptide (N-BNP), midregional pro-atrial natriuretic peptide (MR-proANP) and conventional risk factors at baseline were measured in patients with incident AAA during follow-up and compared to individuals without a diagnosis of AAA...
January 1, 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29343081/atorvastatin-reduces-plasma-inflammatory-and-oxidant-biomarkers-in-patients-with-risk-of-atherosclerotic-cardiovascular-disease
#11
Fadia Mayyas, Duha Baydoun, Rasheed Ibdah, Khalid Ibrahim
BACKGROUND: Oxidative stress and inflammation are associated with endothelial injury and coronary artery disease. Inflammatory factors that promote oxidative damage include endothelin-1 (ET-1), myeloperoxidase (MPO), and C-reactive protein (CRP). Current guidelines recommend the use of statins in patients with risk of atherosclerotic cardiovascular disease (ASCVD). AIM: To assess the impact of atorvastatin on plasma inflammatory and oxidant biomarkers in patients with moderate to very high risk of ASCVD...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29339689/atherogenic-index-of-plasma-as-a-cardiovascular-risk-marker-in-manic-depressive-and-euthymic-stages-of-bipolar-disorder
#12
Tevfik Kalelioğlu, Pelin Ünalan, Burcu Kök, Şule Sözen, Özge Yüksel, Mustafa Akkuş, Refik Cihnioğlu, Nesrin Karamustafalıoğlu
OBJECTIVE: Individuals with bipolar disorder (BD) frequently suffer from cardiovascular disease (CVD), and it is a leading cause of mortality. Clinicians use routine laboratory tests, including a lipid profile, to predict cardiovascular risk. In addition, a particular lipid ratio, the atherogenic index of plasma (AIP), is a sensitive, new parameter that can be used to assess highrisk groups. To our knowledge, this is the first study evaluating cardiovascular risk via AIP in different stages of BD...
January 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29338747/oxidative-stress-predicts-cognitive-decline-with-aging-in-healthy-adults-an-observational-study
#13
Ihab Hajjar, Salim S Hayek, Felicia C Goldstein, Greg Martin, Dean P Jones, Arshed Quyyumi
BACKGROUND: Redox signaling, which can be assessed by circulating aminothiols, reflects oxidative stress (OS) status and has been linked to clinical cardiovascular disease and its risk factors. These, in turn, are related to executive function decline. OS may precede the pro-inflammatory state seen in vascular disease. The objective of this study is to investigate the association between aminothiol markers of OS and inflammation in cognitive decline, especially in the executive cognitive domain which is highly susceptible to cardiovascular risk factors and is an important predictor of cognitive disability...
January 16, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29337679/the-effects-of-physical-activity-on-chronic-subclinical-systemic-inflammation
#14
Alba Maria Dalbello Tir, Marina Labor, Davor Plavec
Chronic subclinical systemic inflammation (CSSI) is a pathogenic event and a common risk factor for many noncommunicable diseases like atherosclerosis, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, cancer, and obstructive lung disease. On the other hand, regular physical activity has been found to reduce this risk. Many studies of different design were conducted to assess the association between inflammatory mediators as markers of CSSI and regular physical activity. The aim of this review was to present the current level of evidence and understanding of potential mechanisms by which physical activity reduces inflammatory mediators involved in CSSI and the types of physical activity required for the expected effect...
December 20, 2017: Arhiv za Higijenu Rada i Toksikologiju
https://www.readbyqxmd.com/read/29336935/update-on-the-laboratory-investigation-of-dyslipidemias
#15
REVIEW
I Ramasamy
The role of the clinical laboratory is evolving to provide more information to clinicians to assess cardiovascular disease (CVD) risk and target therapy more effectively. Current routine methods to measure LDL-cholesterol (LDL-C), the Friedewald calculation, ultracentrifugation, electrophoresis and homogeneous direct methods have established limitations. Studies suggest that LDL and HDL size or particle concentration are alternative methods to predict future CVD risk. At this time there is no consensus role for lipoprotein particle or subclasses in CVD risk assessment...
January 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29336616/study-of-the-osteoprotegerin-receptor-activator-of-nuclear-factor-kb-ligand-system-association-with-inflammation-and-atherosclerosis-in-systemic-sclerosis
#16
Rania M Gamal, Walid M Gamal, Abeer M Ghandour, Hanan Sayed M Abozaid, Mona Embarek Mohamed, Yasser Emad, Ahmed Abdel Galeel
OBJECTIVE: we aimed to study systemic sclerosis patients in order to assess osteoprotegerin/Receptor activator of nuclear factor-kB ligand (OPG/RANKL) system and find the relation of these biomarkers with the clinical features of the disease, the carotid intima thickness, markers of inflammation, lipid profile, and other laboratory characteristics. METHODS: both the level of (RANKL), (OPG) in sera of participants, in 30 (SSc) patients and the atherosclerotic changes affecting the common carotid artery were measured and, were compared to 30 healthy controls matched for age and sex...
January 16, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29335288/prognostic-value-of-high-sensitivity-troponin-t-in-chronic-heart-failure-an-individual-patient-data-meta-analysis
#17
REVIEW
Alberto Aimo, James L Januzzi, Giuseppe Vergaro, Andrea Ripoli, Roberto Latini, Serge Masson, Michela Magnoli, Inder S Anand, Jay N Cohn, Luigi Tavazzi, Gianni Tognoni, Jørgen Gravning, Thor Ueland, Ståle H Nymo, Hans-Peter Brunner-La Rocca, Antoni Bayes-Genis, Josep Lupón, Rudolf A de Boer, Akiomi Yoshihisa, Yasuchika Takeishi, Michael Egstrup, Ida Gustafsson, Hanna K Gaggin, Kai M Eggers, Kurt Huber, Ioannis Tentzeris, Wai H W Tang, Justin Grodin, Claudio Passino, Michele Emdin
BACKGROUND: Most patients with chronic heart failure have detectable troponin concentrations when evaluated by high-sensitivity assays. The prognostic relevance of this finding has not been clearly established so far. We aimed to assess high-sensitivity troponin assay for risk stratification in chronic heart failure through a meta-analysis approach. METHODS: Medline, EMBASE, Cochrane Library, and Scopus were searched in April 2017 by 2 independent authors. The terms were "troponin" AND "heart failure" OR "cardiac failure" OR "cardiac dysfunction" OR "cardiac insufficiency" OR "left ventricular dysfunction...
January 16, 2018: Circulation
https://www.readbyqxmd.com/read/29335013/fit-for-function-study-protocol-for-a-randomized-controlled-trial
#18
Julie Richardson, Ada Tang, Gordon Guyatt, Lehana Thabane, Feng Xie, Demetrios Sahlas, Robert Hart, Rebecca Fleck, Genevieve Hladysh, Louise Macrae
BACKGROUND: The current state of evidence suggests that community-based exercise programs are beneficial in improving impairment, function, and health status, and are greatly needed for persons with stroke. However, limitations of these studies include risk of bias, feasibility, and cost issues. METHODS/DESIGN: This single-blinded, randomized controlled trial (RCT) of 216 participants with stroke will compare the effectiveness of a 12-week YMCA community-based wellness program (FIT for FUNCTION) specifically designed for community-dwelling persons with stroke to persons who receive a standard YMCA membership...
January 15, 2018: Trials
https://www.readbyqxmd.com/read/29334345/arm-crank-ergometry-improves-cardiovascular-disease-risk-factors-and-community-mobility-independent-of-body-composition-in-high-motor-complete-spinal-cord-injury
#19
James J Bresnahan, Gary J Farkas, Jody L Clasey, James W Yates, David R Gater
OBJECTIVE: Evaluate the effect of aerobic exercise using arm crank ergometry (ACE) in high motor complete (ISNCSCI A/B) spinal cord injury (SCI) as primarily related to cardiovascular disease (CVD) risk factors and functional mobility and secondarily to body composition and metabolic profiles. DESIGN: Longitudinal interventional study at an academic medical center. METHODS: Ten previously untrained participants (M8/F2, Age 36.7 y ± 10.1, BMI 24...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29333503/the-effect-of-a-vegan-versus-aha-diet-in-coronary-artery-disease-evade-cad-trial-study-design-and-rationale
#20
Binita Shah, Lisa Ganguzza, James Slater, Jonathan D Newman, Nicole Allen, Edward Fisher, John Larigakis, Francisco Ujueta, Eugenia Gianos, Yu Guo, Kathleen Woolf
Background: Multiple studies demonstrate the benefit of a vegan diet on cardiovascular risk factors when compared to no intervention or usual dietary patterns. The aim of this study is to evaluate the effect of a vegan diet versus the American Heart Association (AHA)-recommended diet on inflammatory and glucometabolic profiles in patients with angiographically defined coronary artery disease (CAD). Study Design: This study is a randomized, open label, blinded end-point trial of 100 patients with CAD as defined by ≥50% diameter stenosis in a coronary artery ≥2 mm in diameter on invasive angiography...
December 2017: Contemporary Clinical Trials Communications
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