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Herpes encephalitis

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https://www.readbyqxmd.com/read/28711084/herpes-zoster-in-psoriasis-patients-treated-with-tofacitinib
#1
Kevin L Winthrop, Mark Lebwohl, Arnon D Cohen, Jeffrey M Weinberg, Stephen K Tyring, Scott T Rottinghaus, Pankaj Gupta, Kaori Ito, Huaming Tan, Mandeep Kaur, Alexander Egeberg, Lotus Mallbris, Hernan Valdez
BACKGROUND: Tofacitinib is an oral Janus kinase (JAK) inhibitor. Immunomodulatory therapies can increase the risk for herpes zoster (HZ) in patients with psoriasis. OBJECTIVE: To evaluate the relationship between tofacitinib use and HZ risk. METHODS: We used phases 2 and 3 and long-term extension (LTE) data from the tofacitinib development program in psoriasis to calculate HZ incidence rates (IR; events per 100 patient-years); potential HZ risk factors were evaluated using Cox-proportional hazard models...
August 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28705180/etiology-and-prognosis-of-acute-viral-encephalitis-and-meningitis-in-chinese-children-a-multicentre-prospective-study
#2
Junhong Ai, Zhengde Xie, Gang Liu, Zongbo Chen, Yong Yang, Yuning Li, Jing Chen, Guo Zheng, Kunling Shen
BACKGROUND: In China, there were few studies about the pathogens of acute viral encephalitis and meningitis in children in recent years. The aims of this study were to characterize the etiology and prognosis of acute viral encephalitis and meningitis in Chinese children. METHODS: This was a multicentre prospective study. Two hundred and sixty one viral encephalitis patients and 285 viral meningitis patients were enrolled. The mean age of viral encephalitis and meningitis were 5...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28698721/is-herpes-simplex-virus-hsv-a-sign-of-encephalitis-in-iranian-newborns-prevalence-of-hsv-infection-in-pregnant-women-in-iran-a-systematic-review-and-meta-analysis
#3
REVIEW
Masoumeh Arabsalmani, Meysam Behzadifar, Hamid Reza Baradaranmd, Mansoureh Toghae, Gholam Beyranvand, Alireza Olyaeemanesh, Masoud Behzadifar
OBJECTIVE: Herpes Simplex virus (HSV) is one of the most common sexually transmitted diseases in the world. This study aimed to determine the prevalence of herpes simplex virus in pregnant women in Iran. MATERIALS & METHODS: A systematic literature review was conducted to study the HSV subtypes in Persian and English papers through several databases. We searched Pub Med, Scopus, Ovid, Science Direct and national databases as Magiran, Iranmedex and Science Information Database (SID) up to October 2015...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28697163/utility-of-lumbar-puncture-in-children-presenting-with-status-epilepticus
#4
Kenneth A Michelson, Todd W Lyons, Kara B Johnson, Lise E Nigrovic, Marvin B Harper, Amir A Kimia
OBJECTIVES: Because meningitis may trigger seizures, we sought to determine its frequency in children with first-time status epilepticus (SE). METHODS: We performed a retrospective cross-sectional study of children aged 1 month to 21 years who presented to a single pediatric emergency department between 1995 and 2012 with SE and who had a lumbar puncture (LP) performed as part of the diagnostic evaluation. We defined bacterial meningitis as a cerebrospinal fluid (CSF) culture positive for a bacterial pathogen or CSF pleocytosis (CSF white blood cells ≥10 cells/mm) with a blood culture positive for a bacterial pathogen...
July 11, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28693588/cxcl11-production-in-cerebrospinal-fluid-distinguishes-herpes-simplex-meningitis-from-herpes-simplex-encephalitis
#5
Liza Lind, Marie Studahl, Linn Persson Berg, Kristina Eriksson
BACKGROUND: The closely related herpes simplex viruses 1 and 2 can cause inflammations of the central nervous system (CNS), where type 1 most often manifest as encephalitis (HSE), and type 2 as meningitis (HSM). HSE is associated with severe neurological complications, while HSM is benign in adults. We proposed that studying the chemokine and cytokine production in cerebrospinal fluid (CSF) and serum could indicate why two closely related viruses exhibit different severity of their accompanied CNS inflammation...
July 10, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28680648/treating-refractory-post-herpetic-anti-n-methyl-d-aspartate-receptor-encephalitis-with-rituximab
#6
Christine Strippel, Constanze Mönig, Kristin S Golombeck, Andre Dik, Kathrin Bönte, Stjepana Kovac, Andreas Schulte-Mecklenbeck, Heinz Wiendl, Sven G Meuth, Andreas Johnen, Catharina C Gross, Nico Melzer
Herpes simplex virus-1 has been identified as the trigger factor in certain cases of NMDA-receptor autoimmune encephalitis. We report on a 67-year-old female patient, who was severely affected by post-herpetic NMDA-receptor autoimmune encephalitis. Her symptoms did not improve under methylprednisolone pulse therapy and plasma exchange under acyclovir prophylaxis. She received protein A immunoadsorption and a long-term immunosuppression with rituximab. Under treatment, activated T-cells as well as B- and plasma cells decreased in peripheral blood and cerebrospinal fluid, and anti-NMDA-R IgG titers in serum and cerebrospinal fluid declined with near complete cessation of intrathecal autoantibody synthesis...
July 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28680463/diagnosis-and-treatment-of-herpes-simplex-1-virus-infection-in-pregnancy
#7
REVIEW
Rachel Lee, Manju Nair
A nulliparous woman presented at 21 weeks' gestation with a 72-h history of a rash on her left arm. Initially isolated to the forearm, it had quickly spread, becoming multiple itchy fluid-filled blisters. Blood tests showed mild neutrophilia and raised CRP. Skin swabs demonstrated the presence of herpes simplex virus type 1 (HSV1) DNA. There was no history of previous HSV1 exposure. There is scant literature on uncomplicated cutaneous HSV1 since the majority is oral/genital. The incidence of transmission varies and is dependent on site of infection and immunological status...
June 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/28664352/erratum-to-acyclovir-resistance-in-herpes-simplex-virus-type-i-encephalitis-a-case-report
#8
M Bergmann, R Beer, M Kofler, R Helbok, B Pfausler, E Schmutzhard
No abstract text is available yet for this article.
June 29, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#9
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28637937/herpes-simplex-encephalitis-presenting-as-stroke-like-symptoms-with-atypical-mri-findings-and-lacking-cerebrospinal-fluid-pleocytosis
#10
Shintaro Tsuboguchi, Takahiro Wakasugi, Yoshitaka Umeda, Maiko Umeda, Mutsuo Oyake, Nobuya Fujita
A 73-year-old woman presented with sudden onset of right hemiparesis and was diagnosed as having cerebral infarction on the basis of diffusion-weighted brain MRI, which demonstrated lesions in the left parietal cortex. On the 3rd day, the patient developed right upper limb myoclonus, aphasia, and disturbance of consciousness with high fever. On the 6th day, she was transferred to our hospital with suspected viral encephalitis, and treatment with acyclovir was started. By the 6th day, the lesions detected by MRI had expanded to the gyrus cinguli, insula and thalamus, but not to the temporal lobe...
June 21, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28637763/analysis-of-hsv-reactivation-in-explant-reveals-a-method-dependent-difference-in-measured-timing-of-reactivation
#11
Jessica R Doll, Nancy M Sawtell
Herpes simplex virus (HSV) infection is widespread in the human population. Following orofacial infection, HSV establishes latency in innervating sensory neurons, primarily located in the trigeminal ganglia. A central feature of HSV pathogenesis is the ability to periodically reactivate in those neurons and transport back to the body surface. Both transmission and disease; such as keratitis, encephalitis, and neurodegeneration, have been linked to reactivation. Despite invaluable insights obtained from model systems, interactions between viral and host functions that regulate reactivation are still incompletely understood...
June 21, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28636287/the-spectrum-of-aseptic-central-nervous-system-infections-in-southern-germany-demographic-clinical-and-laboratory-findings
#12
M Kaminski, V Grummel, D Hoffmann, A Berthele, B Hemmer
BACKGROUND AND PURPOSE: Aseptic infections of the central nervous system (CNS) are frequently observed in Germany. However, no study has systematically addressed the spectrum of aseptic CNS infections in Germany. METHODS: Data on 191 adult patients diagnosed from January 2007 to December 2014 with aseptic meningitis or encephalitis/meningoencephalitis at our hospital were collected by chart review and analyzed for demographic, clinical and laboratory findings. Patients were stratified according to the causative virus and findings were compared between groups...
June 21, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28633400/herpes-zoster-encephalitis-a-rare-complication-in-a-nonagenarian
#13
Henry A Tapia, Tania Tello, Miguel Galvez, Luis F Varela
No abstract text is available yet for this article.
June 14, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28627955/herpes-simplex-encephalitis-with-thalamic-brainstem-and-cerebellar-involvement
#14
Meenal Garg, Shilpa Kulkarni, Anaita Udwadia Hegde
Herpes simplex virus encephalitis is a common and treatable cause of acute encephalitis in all age groups. Certain radiological features such as temporal parenchymal involvement facilitate the diagnosis. The use of herpes simplex virus polymerase chain reaction has expanded the clinical and imaging spectrum. We report the case of a young patient who presented with a movement disorder and predominant involvement of thalami, brainstem and cerebellum on magnetic resonance imaging, and was diagnosed with herpes simplex virus encephalitis...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28615901/varicella-zoster-virus-infection-of-the-central-nervous-system-10-year-experience-from-a-tertiary-hospital-in-south-india
#15
Ronald Albert Benton Carey, Vignesh Kumar Chandiraseharan, Anitha Jasper, Tunny Sebastian, Chrusolitha Gujjarlamudi, Sowmya Sathyendra, Anand Zachariah, Asha Mary Abraham, Thambu David Sudarsanam
INTRODUCTION: Varicella zoster virus is an exclusively human neurotrophic virus. The primary infection with the virus causes varicella. The virus remains latent in nervous tissue and upon secondary activation causes a variety of syndromes involving the central nervous system (CNS) including meningoencephalitis and cerebellitis. MATERIALS AND METHODS: In this study, we looked at the epidemiology, clinical and laboratory features, and outcomes of patients who were admitted with varicella zoster of the CNS from 2005 to 2014...
April 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28587310/viral-encephalitis-of-unknown-cause-current-perspective-and-recent-advances
#16
REVIEW
Peter G E Kennedy, Phenix-Lan Quan, W Ian Lipkin
Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most frequent known cause of fatal sporadic encephalitis in humans, an increasingly wide range of viruses and other microbial pathogens are implicated. Up to 60% of cases of presumed viral encephalitis remain unexplained due to the failure of conventional laboratory techniques to detect an infectious agent. High-throughput DNA sequencing technologies have the potential to detect any microbial nucleic acid present in a biological specimen without any prior knowledge of the target sequence...
June 6, 2017: Viruses
https://www.readbyqxmd.com/read/28580682/decoding-the-association-between-herpes-simplex-virus-and-antibody-mediated-encephalitis
#17
Mark A Ellul, Michael J Griffiths
No abstract text is available yet for this article.
June 5, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28579869/management-of-viral-central-nervous-system-infections-a-primer-for-clinicians
#18
REVIEW
P Brandon Bookstaver, Phillip L Mohorn, Ansal Shah, Lauren D Tesh, April M Quidley, Ravish Kothari, Christopher M Bland, Sharon Weissman
Viruses are a common cause of central nervous system (CNS) infections with many host, agent, and environmental factors influencing the expression of viral diseases. Viruses can be responsible for CNS disease through a variety of mechanisms including direct infection and replication within the CNS resulting in encephalitis, infection limited to the meninges, or immune-related processes such as acute disseminated encephalomyelitis. Common pathogens including herpes simplex virus, varicella zoster, and enterovirus are responsible for the greatest number of cases in immunocompetent hosts...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28566084/-multicenter-investigation-of-bufavirus-in-the-etiology-of-viral-central-nervous-system-infections-of-adults-and-children
#19
Aylin Altay Koçak, Murat Öcal, Meltem Polat, Saliha Kanık Yüksek, Anıl Aktaş Tapısız, Hasan Tezer, Aykut Özkul, Koray Ergünay, Gülendam Bozdayı, Kamruddin Ahmed
Bufavirus (BuV) is a newly-identified parvovirus in the family of Parvoviridae. Metagenomic analysis of fecal samples from children in Burkina Faso with acute diarrhea showed a highly divergent parvovirus, which was named bufavirus (BuV). The global distribution, epidemiology and genetic characteristics of BuVs infections are obscure. It was first discovered as an agent causing gastroenteritis but the association of BuV infections with various clinical presentations mostly remain to be explored. The aims of this study were to investigate probable impact of BuV in central nervous system infections in a region where it was previously reported to cause human infections and to detect enteroviruses (EV) which are reported as a cause of central nervous system infections in our country...
April 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28566076/-evaluation-of-viral-etiology-in-central-nervous-system-infections-from-a-university-hospital-point-of-view-in-izmir-based-on-seven-years-data
#20
Ayşın Zeytinoğlu, Selda Erensoy, Rüçhan Sertöz, İmre Altuğlu, Candan Çiçek, Münevver Kayın, Hadiye Şirin, Şafak Taner
The serious diseases of the central nervous system (CNS); encephalitis and meningitis, have high mortality and morbidity rate especially not diagnosed and treated in time. Nucleic acid testing (NAT) is the tool of choice for viral diagnosis in CNS infections. In this study, viral etiological agents found in cerebrospinal fluid (CSF) samples sent to our university hospital virology laboratory for laboratory diagnosis of CNS infections were retrospectively evaluated and results were compared with other reports from our country...
April 2017: Mikrobiyoloji Bülteni
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