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https://www.readbyqxmd.com/read/27933198/interferon-ifn-%C3%AE-is-a-potential-mediator-in-lupus-nephritis
#1
Agneta Zickert, Vilija Oke, Ioannis Parodis, Elisabet Svenungsson, Yvonne Sundström, Iva Gunnarsson
OBJECTIVES: Interferon (IFN)-α is thought to be central in the pathogenesis for lupus nephritis (LN) and recent studies also indicate a role for IFNλ. Little is known about these cytokines in the context of treatment response. We studied levels of IFNα and IFNλ in patients with LN in association with clinical and histological response (HR) to treatment. METHODS: Fifty-six patients with active LN were included. Renal biopsies were performed at baseline and after immunosuppressive therapy...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27933168/thermal-ecological-physiology-of-native-and-invasive-frog-species-do-invaders-perform-better
#2
Pablo A Cortes, Hans Puschel, Paz Acuña, José L Bartheld, Francisco Bozinovic
Biological invasions are recognized as an important biotic component of global change that threatens the composition, structure and functioning of ecosystems, resulting in loss of biodiversity and displacement of native species. Although ecological characteristics facilitating the establishment and spread of non-native species are widely recognized, little is known about organismal attributes underlying invasion success. In this study, we tested the effect of thermal acclimation on thermal tolerance and locomotor performance in the invasive Xenopus laevis and the Chilean native Calyptocephalella gayi...
2016: Conservation Physiology
https://www.readbyqxmd.com/read/27933109/functional-characterization-of-rare-foxp2-variants-in-neurodevelopmental-disorder
#3
Sara B Estruch, Sarah A Graham, Swathi M Chinnappa, Pelagia Deriziotis, Simon E Fisher
BACKGROUND: Heterozygous disruption of FOXP2 causes a rare form of speech and language impairment. Screens of the FOXP2 sequence in individuals with speech/language-related disorders have identified several rare protein-altering variants, but their phenotypic relevance is often unclear. FOXP2 encodes a transcription factor with a forkhead box DNA-binding domain, but little is known about the functions of protein regions outside this domain. METHODS: We performed detailed functional analyses of seven rare FOXP2 variants found in affected cases, including three which have not been previously characterized, testing intracellular localization, transcriptional regulation, dimerization, and interaction with other proteins...
2016: Journal of Neurodevelopmental Disorders
https://www.readbyqxmd.com/read/27932895/are-patients-and-doctors-accounts-of-the-first-specialist-consultation-for-chronic-back-pain-in-agreement
#4
Kathy B White, John Lee, Amanda C de C Williams
INTRODUCTION: The first consultation at a specialist pain clinic is potentially a pivotal event in a patient's pain history, affecting treatment adherence and engagement with longer term self-management. What doctors communicate to patients about their chronic pain and how patients interpret doctors' messages and explanations in pain consultations are under-investigated, particularly in specialist care. Yet, patients value personalized information about their pain problem. PATIENTS AND METHODS: Sixteen patients in their first specialist pain clinic consultation and the doctors they consulted were interviewed shortly after the consultation...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27932676/recovery-of-central-and-peripheral-neuromuscular-fatigue-after-exercise
#5
Timothy John Carroll, Janet L Taylor, Simon C Gandevia
Sustained physical exercise leads to a reduced capacity to produce voluntary force that typically outlasts the exercise bout. This "fatigue" can be due both to impaired muscle function, termed "peripheral fatigue", and a reduction in the capacity of the central nervous system to activate muscles, termed "central fatigue". In this mini-review we consider the factors that determine the recovery of voluntary force generating capacity after various types of exercise. After brief, high-intensity exercise there is typically a rapid restitution of force that is due to recovery of central fatigue (typically within 2min) and aspects of peripheral fatigue associated with excitation-contraction coupling and re-perfusion of muscles (typically within 3-5 min)...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932612/legionella-longbeachae-is-immunologically-silent-and-highly-virulent-in-vivo
#6
Liliana M Massis, Mariana A Assis-Marques, Fernanda V S Castanheira, Yasmin J Capobianco, Andiamira C Balestra, Pedro Escoll, Rebecca E Wood, Graziele Z Manin, Vani M A Correa, José C Alves-Filho, Fernando Q Cunha, Carmen Buchrieser, Marcos C Borges, Hayley J Newton, Dario S Zamboni
BACKGROUND: Legionella longbeachae (Llo) and Legionella pneumophila (Lpn) are the most common pneumonia-causing agents of the genus. Although both species can be lethal to humans and are highly prevalent, little is known about the molecular pathogenesis of Llo infections. In murine models of infection, Lpn infection is self-limited whereas Llo infection is lethal. DESIGN/METHODS: We used mouse macrophages, human macrophages, human epithelial cells and mouse infections in vivo to evaluate multiple parameters of the infection...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27932501/molecular-mechanism-s-involved-in-differential-expression-of-vitamin-c-transporters-along-the-intestinal-tract
#7
Veedamali S Subramanian, Padmanabhan Srinivasan, Alexis J Wildman, Jonathan S Marchant, Hamid M Said
Mammalian cells utilize two transporters for the uptake of ascorbic acid (AA), the sodium-dependent vitamin C transporter-1 & -2 (SVCT-1 and SVCT-2). In the intestine, these transporters are involved in the absorption of AA and are expressed at the apical and basolateral membrane domains of the polarized epithelia, respectively. Little is known about the differential expression of these two transporters along the anterior-posterior axis of the intestinal tract and the molecular mechanism(s) that dictate this pattern of expression...
December 8, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27932487/mortality-risk-among-workers-with-exposure-to-dioxins
#8
J J Collins, K M Bodner, L L Aylward, T J Bender, S Anteau, M Wilken, C M Bodnar
BACKGROUND: In several studies, dioxin exposure has been associated with increased risk from several causes of death. AIMS: To compare the mortality experience of workers exposed to dioxins during trichlorophenol (TCP) and pentachlorophenol (PCP) production to that of the general population and to examine mortality risk by estimated exposure levels. METHODS: A retrospective cohort study which followed up workers' vital status from 1940 to 2011, with serum surveys to support estimation of historical dioxin exposure levels...
December 7, 2016: Occupational Medicine
https://www.readbyqxmd.com/read/27932254/investigating-possible-biological-targets-of-bj-crp-the-first-cysteine-rich-secretory-protein-crisp-isolated-from-bothrops-jararaca-snake-venom
#9
Marina E Lodovicho, Tássia R Costa, Carolina P Bernardes, Danilo L Menaldo, Karina F Zoccal, Sante E Carone, José C Rosa, Manuela B Pucca, Felipe A Cerni, Eliane C Arantes, Jan Tytgat, Lúcia H Faccioli, Luciana S Pereira-Crott, Suely V Sampaio
Cysteine-rich secretory proteins (CRISPs) are commonly described as part of the protein content of snake venoms, nevertheless, so far, little is known about their biological targets and functions. Our study describes the isolation and characterization of Bj-CRP, the first CRISP isolated from Bothrops jararaca snake venom, also aiming at the identification of possible targets for its actions. Bj-CRP was purified using three chromatographic steps (Sephacryl S-200, Source 15Q and C18) and showed to be an acidic protein of 24...
December 5, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27932223/relationship-between-psychophysical-measures-of-retinal-ganglion-cell-density%C3%A2-and-in%C3%A2-vivo-measures-of-cone-density%C3%A2-in-glaucoma
#10
Juliane Matlach, Pádraig J Mulholland, Marketa Cilkova, Reena Chopra, Nilpa Shah, Tony Redmond, Steven C Dakin, David F Garway-Heath, Roger S Anderson
PURPOSE: Considerable between-individual variation in retinal ganglion cell (RGC) density exists in healthy individuals, making identification of change from normal to glaucoma difficult. In ascertaining local cone-to-RGC density ratios in healthy individuals, we wished to investigate the usefulness of objective cone density estimates as a surrogate of baseline RGC density in glaucoma patients, and thus a more efficient way of identifying early changes. DESIGN: Exploratory cohort study...
December 5, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27932218/bisphenol-a-bpa-in-the-serum-of-pet-dogs-following-short-term-consumption-of-canned-dog-food-and-potential-health-consequences-of-exposure-to-bpa
#11
Zoe L Koestel, Robert C Backus, Kaoru Tsuruta, William G Spollen, Sarah A Johnson, Angela B Javurek, Mark R Ellersieck, Charles E Wiedmeyer, Kurunthachalam Kannan, Jingchuan Xue, Nathan J Bivens, Scott A Givan, Cheryl S Rosenfeld
Bisphenol A (BPA) is a widely present endocrine disruptor chemical found in many household items. Moreover, this chemical can bioaccumulate in various terrestrial and aquatic sources; thereby ensuring continual exposure of animals and humans. For most species, including humans, diet is considered the primary route of exposure. However, there has been little investigation whether commercial-brands of dog foods contain BPA and potential health ramifications of BPA-dietary exposure in dogs. We sought to determine BPA content within dog food, whether short-term consumption of these diets increases serum concentrations of BPA, and potential health consequences, as assessed by potential hematological, serum chemistry, cortisol, DNA methylation, and gut microbiome changes, in dogs associated with short-term dietary exposure to BPA...
December 5, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27932177/cardiac-tamponade-due-to-suprahepatic-surgical-exploration-in-liver-retransplantation-a-case-report
#12
M S Chae, Y K Jeon, D G Kim, G H Na, Y S Yi, C S Park
BACKGROUND: Cardiac tamponade is an emergency condition that requires early recognition and prompt pericardial decompression. Little has been reported on cardiac tamponade in liver retransplantation (reLT), but most cases are fatal. We managed a case of reLT complicated by accidental cardiac tamponade. CASE REPORT: A 59-year-old man underwent an emergency reLT because of liver cirrhosis with recurrent hepatitis B. During the dissection, suprahepatic exploration was attempted, but this resulted in severe hemorrhage because of the many tissue adhesions...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27932105/b-cell-activating-factor-levels-are-associated-with-antibody-mediated-histological-damage-in-kidney-transplantation
#13
C Sango, D Merino, D San Segundo, E Rodrigo, M Lopez-Hoyos, A Benito, M Ángeles Ramos, J Gómez-Román, M Arias
INTRODUCTION: Along with death engraftment, in recent years, antibody-mediated damage has been identified as the leading cause of loss of kidney transplants. Despite the recognition of the role of the B-lymphocyte subpopulation in the development of both tolerance and rejection, little is known about the trigger mechanisms and effectors of this humoral response. BACKGROUND: We analyzed the relationship between B lymphocyte subpopulations and levels of B-cell-activating factor (BAFF) with the histological findings in biopsies of renal transplantation...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931777/effects-of-maternal-separation-on-nicotine-induced-conditioned-place-preference-and-subsequent-learning-and-memory-in-adolescent-female-rats
#14
Fatemeh Delavari, Nouzar Nakhaee, Khadijeh Esmaeilpour, Saeid Esmaeili Mahani, Vahid Sheibani
Adverse early life experiences can potentially increase risk for drug abuse later in life. However, little research has been conducted studying the effects of maternal separation (MS), an experimental model for early life stress, on the rewarding effects of nicotine. Cognitive function may be affected by MS. So, we also investigated whether nicotine administration affect spatial learning and memory in MS adolescent female rats. Rat pups were subjected to daily MS for 15min (MS15) or 180min (MS180) during the first 2 weeks of life or reared under normal animal facility rearing (AFR) conditions...
December 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27931749/-hereditary-epidermolysis-bullosa-french-national-guidelines-pnds-for-diagnosis-and-treatment
#15
C Chiaverini, E Bourrat, J Mazereeuw-Hautier, S Hadj-Rabia, C Bodemer, J-P Lacour
Hereditary epidermolysis bullosa (EB) is a heterogeneous group of rare genetic diseases characterized by fragile skin and/or mucous membrane, and it may be either local or generalized. It is caused by mutations in genes encoding different proteins involved mainly in the structure and function of the dermal-epidermal junction. Nineteen genes have so far been identified. They are classified by level of skin cleavage (from top to bottom) into four groups: EB simplex, junctional EB, dystrophic EB and Kindler syndrome...
December 5, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27930657/the-effects-of-auricular-electro-acupuncture-on-ameliorating-the-dysfunction-of-interstitial-cells-of-cajal-networks-and-nnosmrna-expression-in-antrum-of-stz-induced-diabetic-rats
#16
Huan Chen, Weijian Zhu, Jing Lu, Jinqing Fan, Luning Sun, Xiaoke Feng, Hao Liu, Zhaohui Zhang, Yongqing Wang
BACKGROUD: Interstitial cells of Cajal (ICCs) and nNOS play a crucial role in diabetic gastrointestinal dysmotility(DGD). Our previous study found that electro-acupuncture(EA) on ear point 'stomach' could repair the gastric dysrhythmias in rats induced by rectal distention(RD) after meal. However, little were known about the possible effect of auricular electro-acupuncture (AEA) on diabetic rats. Thus, we designed this study to investigate the effect of AEA on streptozotocin(STZ)-induced diabetic rats...
2016: PloS One
https://www.readbyqxmd.com/read/27930526/models-predicting-the-risks-of-six-life-threatening-morbidities-and-bile-leakage-in-14-970-hepatectomy-patients-registered-in-the-national-clinical-database-of-japan
#17
Hideki Yokoo, Hiroaki Miyata, Hiroyuki Konno, Akinobu Taketomi, Tatsuhiko Kakisaka, Norimichi Hirahara, Go Wakabayashi, Mitsukazu Gotoh, Masaki Mori
To construct a robust morbidity risk-prediction model based on a Japanese nationwide web-based database of patients who underwent liver surgery.Although liver resection has become safer, patient mortality and morbidity still occur. This study investigated postoperative morbidity risks in patients who underwent hepatectomy in Japan at institutions registered in the National Clinical Database.This analysis involved 14,970 patients who underwent hepatectomy of more than 1 section, except for left lateral sectionectomy, during 2011 and 2012 at 1192 hospitals in Japan...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929457/advanced-animal-model-of-colorectal-metastasis-in-liver-imaging-techniques-and-properties-of-metastatic-clones
#18
Go Oshima, Melinda E Stack, Sean C Wightman, Darren Bryan, Elizabeth Poli, Lai Xue, Kinga B Skowron, Abhineet Uppal, Sean P Pitroda, Xiaona Huang, Mitchell C Posner, Samuel Hellman, Ralph R Weichselbaum, Nikolai N Khodarev
Patients with a limited number of hepatic metastases and slow rates of progression can be successfully treated with local treatment approaches(1,2). However, little is known about the heterogeneity of liver metastases, and animal models capable of evaluating the development of individual metastatic colonies are needed. Here, we present an advanced model of hepatic metastases that provides the ability to quantitatively visualize the development of individual tumor clones in the liver and estimate their growth kinetics and colonization efficiency...
November 30, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929331/information-processing-in-illness-representation-implications-from-an-associative-learning-framework
#19
Rob Lowe, Paul Norman
OBJECTIVE: The common-sense model (Leventhal, Meyer, & Nerenz, 1980) outlines how illness representations are important for understanding adjustment to health threats. However, psychological processes giving rise to these representations are little understood. To address this, an associative-learning framework was used to model low-level process mechanics of illness representation and coping-related decision making. METHOD: Associative learning was modeled within a connectionist network simulation...
December 8, 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27929312/decision-making-style-and-response-to-parental-involvement-in-brief-interventions-for-adolescent-substance-use
#20
Timothy F Piehler, Ken C Winters
Adolescent decision making has been previously identified as risk factor for substance abuse as well as a proximal intervention target. The study sought to extend this research by evaluating the role of decision-making style in response to parent involvement in brief substance abuse interventions. Adolescents (aged 12 to 18 years; n = 259) identified in a school setting as abusing alcohol and marijuana were randomly assigned to complete 1 of 2 brief interventions (BIs), either a 2-session adolescent-only program (BI-A) or the 2-session adolescent program with an additional parent session (BI-AP)...
December 8, 2016: Journal of Family Psychology: JFP
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