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https://www.readbyqxmd.com/read/29779032/kidney-disease-in-women-is-associated-with-disadvantaged-childhood-socioeconomic-position
#1
Mark Canney, Siobhan Leahy, Siobhan Scarlett, Rose Anne Kenny, Mark A Little, Conall M O'Seaghdha, Cathal McCrory
BACKGROUND: Socioeconomic position (SEP) is an important determinant of health and it is dynamic across the entire lifespan. We sought to investigate the relationship between life-course SEP and chronic kidney disease (CKD) using 3 conceptual models: critical period, pathway and accumulation. METHODS: Cross-sectional analysis of 4,996 participants from The Irish Longitudinal Study on Ageing, a nationally representative cohort of community-dwelling adults aged ≥50 years...
May 18, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29778516/facilitators-of-and-barriers-to-hpv-vaccination-among-sexual-and-gender-minority-patients-at-a-boston-community-health-center
#2
Kaan Z Apaydin, Holly B Fontenot, Derri Shtasel, Sannisha K Dale, Christina P C Borba, Christopher S Lathan, Lori Panther, Kenneth H Mayer, Alex S Keuroghlian
BACKGROUND: Young sexual minority individuals have lower human papillomavirus (HPV) vaccine completion rates than the general population, and little is known about how gender minority people perceive HPV vaccination. The aim of this study was to qualitatively identify patient-, provider-, and systems-level barriers and facilitators for HPV vaccination among sexual and gender minority (SGM) people. METHODS: Fifteen SGM-identified individuals, ages 23-26, were recruited at an urban community health center in Boston, MA, that specializes in care for SGM...
May 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29778461/average-ovarian-hormone-levels-rather-than-daily-values-and-their-fluctuations-are-related-to-facial-preferences-among-women
#3
Urszula M Marcinkowska, Gwenael Kaminski, Anthony C Little, Grazyna Jasienska
Hormones are of crucial importance for human behavior. Cyclical changes of ovarian hormones throughout women's menstrual cycle are suggested to underlie fluctuation in masculinity preference for both faces and bodies. In this study we tested this hypothesis based on daily measurements of estradiol and progesterone throughout menstrual cycle, and multiple measurements of women's preference towards masculinity of faces and bodies of men. We expected that due to a large variation among daily hormonal levels we would not observe a direct effect of daily hormone levels, but rather that average levels of ovarian hormones throughout the cycle (a reliable marker of a probability of conception) would better predict women's preferences...
May 17, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29778309/association-of-the-helicobacter-pylori-caga-vaca-and-icea-genotypes-with-chronic-follicular-gastritis-in-a-colombian-population-at-high-risk-for-gastric-cancer
#4
Y H Carlosama-Rosero, H Bolaños-Bravo, C H Sierra-Tórres, E A Rosero
INTRODUCTION AND OBJECTIVE: Follicular gastritis is associated with Helicobacter pylori infection, but little is known of its relation to bacterial genotypes. Our aim was to establish the relation between follicular gastritis and different H. pylori strains. MATERIALS AND METHODS: An analytic case-control study was conducted that included 36 patients with follicular gastritis (cases) and 83 with nonatrophic gastritis (controls). The sociodemographic information was obtained through a questionnaire...
May 16, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29778294/the-association-between-psychotic-experiences-and-health-related-quality-of-life-a-cross-national-analysis-based-on-world-mental-health-surveys
#5
Jordi Alonso, Sukanta Saha, Carmen C W Lim, Sergio Aguilar-Gaxiola, Ali Al-Hamzawi, Corina Benjet, Evelyn J Bromet, Louisa Degenhardt, Giovanni de Girolamo, Oluyomi Esan, Silvia Florescu, Oye Gureje, Josep M Haro, Chiyi Hu, Elie G Karam, Georges Karam, Viviane Kovess-Masfety, Jean-Pierre Lepine, Sing Lee, Zeina Mneimneh, Fernando Navarro-Mateu, Jose Posada-Villa, Nancy A Sampson, Kate M Scott, Juan Carlos Stagnaro, Margreet Ten Have, Maria Carmen Viana, Ronald C Kessler, John J McGrath
Psychotic experiences (PEs) are associated with a range of mental and physical disorders, and disability, but little is known about the association between PEs and aspects of health-related quality of life (HRQoL). We aimed to investigate the association between PEs and five HRQoL indicators with various adjustments. Using data from the WHO World Mental Health surveys (n = 33,370 adult respondents from 19 countries), we assessed for PEs and five HRQoL indicators (self-rated physical or mental health, perceived level of stigma (embarrassment and discrimination), and social network burden)...
May 16, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29778231/clinical-germline-diagnostic-exome-sequencing-for-hereditary-cancer-findings-within-novel-candidate-genes-are-prevalent
#6
Zöe Powis, Carin R Espenschied, Holly LaDuca, Kelly D Hagman, Tripti Paudyal, Shuwei Li, Hiroto Inaba, Ann Mauer, Katherine L Nathanson, James Knost, Elizabeth C Chao, Sha Tang
Clinical diagnostic exome sequencing (DES) has been effective in diagnosing individuals with suspected genetic conditions; nevertheless little has been described regarding its clinical utility in individuals with a personal and family history of cancer. This study aimed to assess diagnostic yield and clinical characteristics of pediatric and adult patients undergoing germline DES for hereditary cancer. We retrospectively reviewed 2171 patients referred for DES; cases with a personal and/or family history of cancer were further studied...
August 2018: Cancer Genetics
https://www.readbyqxmd.com/read/29778204/presence-of-helicobacter-and-campylobacter-species-in-faecal-samples-from-zoo-mammals
#7
C De Witte, C Lemmens, B Flahou, P De Laender, T Bouts, F Vercammen, R Ducatelle, A Smet, F Haesebrouck
Helicobacter and Campylobacter species (spp.) colonize the gastrointestinal tract of various domesticated animals. Apart from their pathogenic significance in animals, several species are of zoonotic importance as well. For most non-domesticated animal spp., however, little is known on the presence and importance of these agents. Therefore, we investigated the presence of Helicobacter and Campylobacter spp. in marine and terrestrial zoo mammals. Faecal samples of various marine and terrestrial zoo mammals were collected from 6 different zoos in Belgium...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778200/the-nucleoside-analog-gs-441524-strongly-inhibits-feline-infectious-peritonitis-fip-virus-in-tissue-culture-and-experimental-cat-infection-studies
#8
B G Murphy, M Perron, E Murakami, K Bauer, Y Park, C Eckstrand, M Liepnieks, N C Pedersen
Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats. Recent studies of diseases caused by several RNA viruses in people and other species indicate that antiviral therapy may be effective against FIP in cats. The small molecule nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. We determined that GS-441524 was non-toxic in feline cells at concentrations as high as 100 uM and effectively inhibited FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal macrophages at concentrations as low as 1 uM...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778183/high-genetic-diversity-of-extended-spectrum-%C3%AE-lactamases-producing-escherichia-coli-in-feces-of-horses
#9
Syndia Sadikalay, Yann Reynaud, Stéphanie Guyomard-Rabenirina, Mélanie Falord, Célia Ducat, Laetitia Fabre, Simon Le Hello, Antoine Talarmin, Séverine Ferdinand
Extended-spectrum beta-lactamases (ESBLs), especially those of the CTX-M type, represent a major public health problem throughout the world. Although the carriage of ESBL-producing Enterobacteriaceae (EPE) in feces of horses is now well recognized, little is known about the diversity of EPE after treatment of horses with antibiotics. We undertook this study to assess and follow the diversity of EP Escherichia coli isolated from horses after antibiotic treatment for an infection. Fecal samples from two horses treated and two that were untreated were tested for the presence of EPE on different days...
June 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29778085/braf-and-mek-inhibitor-therapy-eliminates-nestin-expressing-melanoma-cells-in-human-tumors
#10
Deon B Doxie, Allison R Greenplate, Jocelyn S Gandelman, Kirsten E Diggins, Caroline E Roe, Kimberly B Dahlman, Jeffrey A Sosman, Mark C Kelley, Jonathan M Irish
Little is known about the in vivo impacts of targeted therapy on melanoma cell abundance and protein expression. Here, 21 antibodies were added to an established melanoma mass cytometry panel to measure 32 cellular features, distinguish malignant cells, and characterize dabrafenib and trametinib responses in BRAFV 600mut melanoma. Tumor cells were biopsied before neoadjuvant therapy and compared to cells surgically resected from the same site after 4 weeks of therapy. Approximately 50,000 cells per tumor were characterized by mass cytometry and computational tools t-SNE/viSNE, FlowSOM, and MEM...
May 19, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29777191/eradication-of-hepatitis-c-virus-is-associated-with-the-attenuation-of-steatosis-as-evaluated-using-a-controlled-attenuation-parameter
#11
Kohei Shimizu, Yoko Soroida, Masaya Sato, Hiromi Hikita, Tamaki Kobayashi, Momoe Endo, Mamiko Sato, Hiroaki Gotoh, Tomomi Iwai, Ryosuke Tateishi, Kazuhiko Koike, Yutaka Yatomi, Hitoshi Ikeda
Chronic hepatitis C virus (HCV) infection was shown to cause hepatic steatosis or suppression of serum lipid levels. However, little is known about the changes in hepatic steatosis following HCV eradication. We aimed to evaluate this issue using the controlled attenuation parameter (CAP), which was recently shown to provide a standardized non-invasive measure of hepatic steatosis. We enrolled 70 patients with chronic HCV infections and steatosis (CAP of over 248 dB/m) who had achieved a sustained viral response at 12 weeks after discontinuation of antiviral treatment using direct-acting antivirals (DAA)...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29777000/nmt1-and-nmt3-n-methyltransferase-activity-is-critical-to-lipid-homeostasis-morphogenesis-and-reproduction
#12
Weihua Chen, Hooman Salari, Matthew C Taylor, Ricarda Jost, Oliver Berkowitz, Russell Barrow, Deyun Qiu, Remi Branco, Josette Masle
Phosphatidylcholine (PC) is a major membrane phospholipid and a precursor for most signalling molecules. Understanding its synthesis is important for improving plant growth, nutritional value and resistance to stress. PC synthesis is complex, involving several interconnected pathways, one of which proceeds from serine-derived phosphoethanolamine (PEA) to form phosphocholine (PCho) through three sequential phospho-base methylations catalysed by phosphoethanolamine N-methyltransferases (PEAMTs). The contribution of this pathway to the production of PC and plant growth has been a matter of some debate...
May 18, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29776876/-efficacy-of-botulinum-toxin-a-injections-in-the-urethral-sphincter-in-patients-with-difficulties-to-perform-self-intermittent-catherization
#13
T Honore, F Le Breton, N Turmel, B Bignani, C Chesnel, A Charlanes, G Amarenco
PURPOSE: To evaluate safety and efficacy of botulinum toxin A injections in the urethral striated sphincter in patients with difficulties to perform self-intermittent catherization. METHODS: In this prospective study, 12 patients suffering from upper motor neuron diseases (8 multiple sclerosis, 2 myelitis, 1 brain injury, 1 multi system atrophy) and with difficulties to perform self-intermittent catherization, defined by a ICDQ score>1 (Intermittent Catheterization Difficulty Questionnaire) have had injections of 100U BOTOX® under EMG guidance in the urethral striated sphincter, for a total of 15 injections...
May 15, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29776653/accuracy-of-phase-contrast-velocity-mapping-proximal-and-distal-to-stent-artifact-during-cardiac-magnetic-resonance-imaging
#14
Catherine M Avitabile, Matthew A Harris, Ravi S Doddasomayajula, Steven G Chopski, Matthew J Gillespie, Yoav Dori, Andrew C Glatz, Mark A Fogel, Kevin K Whitehead
Little data are available on the accuracy of phase-contrast magnetic resonance imaging (PC-MRI) velocity mapping in the vicinity of intravascular metal stents other than nitinol stents. Therefore, we sought to determine this accuracy using in vitro experiments. An in vitro flow phantom was used with 3 stent types: (1) 316L stainless steel, (2) nitinol self-expanding, and (3) platinum-iridium. Steady and pulsatile flow was delivered with a magnetic resonance imaging-compatible pump (CardioFlow 5000, Shelley Medical, London, Ontario, Canada)...
April 20, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29775686/the-comparative-efficacy-of-antiseptics-against-candida-auris-biofilms
#15
Ryan Kean, Emily McKloud, Eleanor M Townsend, Leighann Sherry, Christopher Delaney, Brian L Jones, Craig Williams, Gordon Ramage
Candida auris has emerged as a significant clinical entity due to its ability to cause outbreaks within the healthcare setting. A key feature of its nosocomial lifestyle is its ability to transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates was screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared to planktonic cells...
May 15, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29775173/healthcare-barriers-and-supports-for-american-indian-women-with-cancer
#16
Jessica L Liddell, Catherine E Burnette, Soonhee Roh, Yeon-Shim Lee
Although American Indian (AI) women continue to experience cancer at higher rates and have not seen the same decline in cancer prevalence as the general U.S. population, little research examines how interactions with health care providers may influence and exacerbate these health disparities. The purpose of the study was to understand the experiences of AI women who receive cancer treatment, which is integral for eradication of AI cancer disparities among women. A qualitative descriptive methodology was used with a sample of 43 AI women with breast, cervical, colon, and other types of cancer from the Northern Plains region of South Dakota...
May 18, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29775072/exploring-the-patients-experiences-of-living-with-a-subcutaneous-implantable-cardioverter-defibrillator
#17
Jacqueline Forman, Jennifer Baumbusch, Heather Jackson, Jen Lindenberg, Alyssa Shook, Jamil Bashir
BACKGROUND: The implantable cardioverter defibrillator provides effective treatment for the prevention of sudden cardiac arrest but significant risks associated with transvenous implantation persist. The subcutaneous implantable cardioverter defibrillator has proven to be an alternative and innovative treatment option for select patients to mitigate these risks. Obtaining the patients' perspectives can provide clinicians with essential information to guide implant selection, procedural decision-making, and support patient management...
May 1, 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29774972/temperature-response-of-permafrost-soil-carbon-is-attenuated-by-mineral-protection
#18
Norman Gentsch, Birgit Wild, Robert Mikutta, Petr Čapek, Katka Diáková, Marion Schrumpf, Stephanie Turner, Cynthia Minnich, Frank Schaarschmidt, Olga Shibistova, Jörg Schnecker, Tim Urich, Antje Gittel, Hana Šantrůčková, Jiři Bárta, Nikolay Lashchinskiy, Roland Fuß, Andreas Richter, Georg Guggenberger
Climate change in Arctic ecosystems fosters permafrost thaw and makes massive amounts of ancient soil organic carbon (OC) available to microbial breakdown. However, fractions of the organic matter (OM) may be protected from rapid decomposition by their association with minerals. Little is known about the effects of mineral-organic associations (MOA) on the microbial accessibility of OM in permafrost soils and it is not clear which factors control its temperature sensitivity. In order to investigate if and how permafrost soil OC turnover is affected by mineral controls, the heavy fraction (HF) representing mostly MOA was obtained by density fractionation from 27 permafrost soil profiles of the Siberian Arctic...
May 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29774232/multiple-origins-of-green-blood-in-new-guinea-lizards
#19
Zachary B Rodriguez, Susan L Perkins, Christopher C Austin
Several species of lizards from the megadiverse island of New Guinea have evolved green blood. An unusually high concentration of the green bile pigment biliverdin in the circulatory system of these lizards makes the blood, muscles, bones, tongue, and mucosal tissues bright green in color, eclipsing the crimson color from their red blood cells. This is a remarkable physiological feature because bile pigments are toxic physiological waste products of red blood cell catabolism and, when chronically elevated, cause jaundice in humans and all other vertebrates...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29774043/integration-of-the-pokeweed-mirna-and-mrna-transcriptomes-reveals-targeting-of-jasmonic-acid-responsive-genes
#20
Kira C M Neller, Alexander Klenov, Juan C Guzman, Katalin A Hudak
The American pokeweed plant, Phytolacca americana , displays broad-spectrum resistance to plant viruses and is a heavy metal hyperaccumulator. However, little is known about the regulation of biotic and abiotic stress responses in this non-model plant. To investigate the control of miRNAs in gene expression, we sequenced the small RNA transcriptome of pokeweed treated with jasmonic acid (JA), a hormone that mediates pathogen defense and stress tolerance. We predicted 145 miRNAs responsive to JA, most of which were unique to pokeweed...
2018: Frontiers in Plant Science
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