keyword
MENU ▼
Read by QxMD icon Read
search

lung maturity preterm

keyword
https://www.readbyqxmd.com/read/29022513/discrepancies-in-animal-models-of-preterm-birth
#1
Clarence R Manuel, Charles R Ashby, Sandra E Reznik
BACKGROUND: Preterm birth (PTB) is a multifactorial syndrome occurring before the 37th week of full-term pregnancy [1]. Babies delivered preterm experience short-term and long-term complications affecting multiple organ systems, and serious maternal complications include hemorrhage and infection. Each year, an estimated 15 million babies are born preterm, and complications from prematurity are the leading cause of death among children up to 5 years of age [2]. With another increase in PTB rates over the last several years, the United States continues to have the highest incidence of any industrialized country [3]...
October 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28920101/potential-therapeutic-targets-in-nrf2-dependent-protection-against-neonatal-respiratory-distress-disease-predicted-by-cdna-microarray-analysis-and-bioinformatics-tools
#2
Hye-Youn Cho, Xuting Wang, Jianying Li, Douglas A Bell, Steven R Kleeberger
Hyperoxia exposure of newborn rodents has served as a model for bronchopulmonary dysplasia (BPD) phenotypes found in a sub-population of human premature infants. We previously demonstrated that Nrf2 modulates molecular events during saccular-to-alveolar lung maturation and also has a protective role in the pathogenesis of hyperoxia-induced acute lung injury, mortality, arrest of saccular-to-alveolar transition, and lung injury, using Nrf2-deficient and wild-type neonate mice. In this review, we describe how whole-genome transcriptome analyses can identify the means through which Nrf2 transcriptionally modulates organ injury and morphology, cellular growth/proliferation, vasculature development, and immune response during BPD-like pathogenesis...
December 2016: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/28883045/breath-to-breath-variability-of-exhaled-co2-as-a-marker-of-lung-dysmaturity-in-infancy
#3
Sotirios Fouzas, Ilias Theodorakopoulos, Edgar Wilfried Delgado-Eckert, Philipp Latzin, Urs Frey
The concept of diffusional screening implies that breath-to-breath variations in CO2 clearance, when related to the variability of breathing, may contain information on the quality and utilization of the available alveolar surface. We explored the validity of the above hypothesis in a cohort of young infants of comparable post-menstrual age but born at different stages of lung maturity, namely, in term-born infants (N = 128), preterm-born infants without chronic lung disease of infancy (CLDI) (N = 53) and preterm infants with moderate/severe CLDI (N = 87)...
September 7, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28856015/antenatal-corticosteroid-treatment-for-the-prevention-of-peri-intraventricular-haemorrhage-in-preterm-newborns-a-retrospective-cohort-study-using-transfontanelle-ultrasonography
#4
Bianca A Almeida, Livia T Rios, Edward Araujo Júnior, Luciano M Nardozza, Antonio F Moron, Marília G Martins
OBJECTIVE: The objective of this study was to assess the correlation between antenatal corticosteroids and peri-intraventricular haemorrhage (PIVH) using transfontanelle ultrasonography, as well as to evaluate the risk factors for its incidence. METHODS: We performed a retrospective cohort study using medical records of preterm newborns. The protocol for maternal corticoid administration for foetal lung maturation included dexamethasone 4 mg (intramuscular) 8/8 hours per 48 hours, with one cycle per week...
June 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28751157/end-of-life-decision-making-for-parents-of-extremely-preterm-infants
#5
Manya J Hendriks, Andrea Abraham
OBJECTIVE: To explore parental attitudes and values in the end-of-life decision-making process of extremely preterm infants (gestational age < 28 weeks). DESIGN: Hermeneutically oriented qualitative research design with in-depth interviews. SETTING: Level III NICU in Switzerland. PARTICIPANTS: Purposive sample of seven couples, five mothers, and one father (20 parents). METHODS: Qualitative content analysis was used to categorize and interpret themes from parents' narratives...
July 24, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28735176/reduced-short-term-variation-following-antenatal-administration-of-betamethasone-is-reduced-fetal-size-a-predisposing-factor
#6
Tullio Ghi, Andrea Dall'Asta, Gabriele Saccone, Federica Bellussi, Tiziana Frusca, Pasquale Martinelli, Gianluigi Pilu, Nicola Rizzo
OBJECTIVE: To assess the association between fetal size and the incidence of reduced short-term variability (STV) following bethametasone administration for fetal lung maturity. STUDY DESIGN: This was a retrospective, multicenter, cohort study conducted in two Tertiary University Units. Only uncomplicated singleton pregnancies admitted for threatened preterm labor between 26 and 34 weeks and submitted to betamethasone for fetal lung maturity were included. Delivery occurring within 72h from betamethasone administration represented criteria for exclusion...
July 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28693356/contemporary-practice-patterns-in-the-use-of-amniocentesis-for-fetal-lung-maturity
#7
Kevin C Visconti, Emily DeFranco, Beena D Kamath-Rayne
PURPOSE: Fetal lung maturity (FLM) testing has been performed to help direct delivery timing in complex obstetrical conditions. We explored current practice patterns of FLM testing attempting to identify factors affecting its use. MATERIALS AND METHODS: We distributed a 31-question survey to obstetricians and perinatologists that examined practice characteristics potentially affecting FLM usage. Logistic regression measured associations between these factors and test utilization...
July 25, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28690548/optimization-of-variable-ventilation-for-physiology-immune-response-and-surfactant-enhancement-in-preterm-lambs
#8
Erzsébet Bartolák-Suki, Peter B Noble, Samer Bou Jawde, Jane J Pillow, Béla Suki
Preterm infants often require mechanical ventilation due to lung immaturity including reduced or abnormal surfactant. Since cyclic stretch with cycle-by-cycle variability is known to augment surfactant release by epithelial cells, we hypothesized that such in vivo mechanotransduction improves surfactant maturation and hence lung physiology in preterm subjects. We thus tested whether breath-by-breath variability in tidal volume (VT) in variable ventilation (VV) can be tuned for optimal performance in a preterm lamb model...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28665932/surfactant-phospholipid-composition-of-gastric-aspirate-samples-differs-between-male-and-female-very-preterm-infants
#9
Foula Sozo, Noreen Ishak, Risha Bhatia, Peter G Davis, Richard Harding
BACKGROUND: Among preterm infants, males have a greater incidence of respiratory distress and death than females born at the same gestational age, likely due to sex-related differences in lung maturation. Our aim was to determine whether surfactant phospholipid composition differs between male and female preterm infants. METHODS: Gastric aspirate samples from male and female infants born between 25 and 30 weeks of gestation at The Royal Women's Hospital, Melbourne, Australia, were collected within 1 h after birth...
June 30, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28627012/effect-of-betamethasone-on-fetal-pulmonary-and-umbilical-artery-doppler-velocimetry-and-relationship-with-respiratory-distress-syndrome-development
#10
Emre Sinan Güngör, Gülşah İlhan, Hüseyin Gültekin, Ali Galip Zebitay, Serdar Cömert, Fatma Ferda Verit
OBJECTIVES: Respiratory distress syndrome (RDS) is a major cause of neonatal morbidity and mortality. It is primarily a disease of premature neonates. The aim of this study was to evaluate the impact of maternal betamethasone administration on the fetal pulmonary arteries (PAs) and umbilical arteries (UAs) and the correlation between RDS development and PA Doppler results. METHODS: Forty singleton pregnancies between 24 and 34 gestational weeks with a diagnosis of preterm birth were included prospectively...
June 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28610460/vitamin-d-levels-in-newborns-and-association-with-neonatal-hypocalcemia
#11
Büşra Yılmaz, Canan Aygün, Erhan Çetinoğlu
OBJECTIVE: Vitamin D has many important functions in our body. Especially in intrauterine and early infancy periods, Vitamin D plays a major role in bone development, growth, and the maturation of tissues such as lung and brain. Fetus is dependent on the mother in terms of Vitamin D and maternal Vitamin D deficiency results in a Vitamin D deficient newborn. The purpose of this study was to determine the levels of Vitamin D in newborns and to investigate the association between Vitamin D status of the baby and neonatal hypocalcemia...
June 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28583603/influence-of-prenatal-maternal-corticosteroid-therapy-on-clinical-and-metabolic-features-and-pulmonary-function-of-preterm-newborn-puppies
#12
F M Regazzi, L C G Silva, C F Lúcio, G A L Veiga, D S R Angrimani, D Kishi, M M M Barbosa, C I Vannucchi
Although the effects of antenatal corticosteroid therapy in clinical improvement and pulmonary maturation in preterm have been described, little is known on premature newborn puppies. This study aimed to evaluate the effect of maternal administration of a single dose of prenatal betamethasone on lung function of preterm newborn puppies in the first hours of life, especially from the clinical point of view and acid-base balance. A prospective study was conducted involving 21 puppies allocated into three experimental groups: Term Group (63 days post-ovulation), Preterm-Treated Group (57 days post-ovulation and maternal administration of a single dose of 0...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28538237/update-on-postnatal-steroids
#13
Henry L Halliday
Antenatal steroid treatment to enhance fetal lung maturity and surfactant treatment to prevent or treat respiratory distress syndrome have been major advances in perinatal medicine in the past 40 years contributing to improved outcomes for preterm infants. Use of postnatal steroids to prevent or treat chronic lung disease in preterm infants has been less successful and associated with adverse neurodevelopmental outcomes. Although early (in the first week of life) postnatal steroid treatment facilitates earlier extubation and reduces the risk of chronic lung disease, it is associated with adverse effects, such as hyperglycemia, hypertension, gastrointestinal bleeding and perforation, hypertrophic cardiomyopathy, growth failure, and cerebral palsy, and cannot be recommended...
2017: Neonatology
https://www.readbyqxmd.com/read/28537511/vitamin-a-supplementation-for-the-prevention-of-bronchopulmonary-dysplasia-in-preterm-infants-an-update
#14
Emily Schwartz, Rena Zelig, Anna Parker, Stephani Johnson
Bronchopulmonary dysplasia (BPD) is a common complication of premature birth and is associated with significant morbidity. Vitamin A supplementation has been suggested as a potential preventative measure against BPD due to its role in lung maturation and because preterm infants are particularly predisposed to vitamin A deficiency. The aim of this review was to determine whether vitamin A supplementation reduces BPD risk among preterm infants. PubMed, CINAHL, and Web of Science databases were searched with the keywords "bronchopulmonary dysplasia," "vitamin A," and "preterm infants" and with the time frame of 2006-2016, and 4 studies were selected for review per the inclusion criteria...
June 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28531215/association-of-cord-blood-chemokines-and-other-biomarkers-with-neonatal-complications-following-intrauterine-inflammation
#15
Yoshikazu Otsubo, Kunio Hashimoto, Taro Kanbe, Muneichiro Sumi, Hiroyuki Moriuchi
BACKGROUND: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. AIM: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. PATIENTS AND METHODS: We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28486361/universal-cervical-length-screening-and-antenatal-corticosteroid-timing
#16
Nicole Sahasrabudhe, Catherine Igel, Ghislaine C Echevarria, Peʼer Dar, Diana Wolfe, Peter S Bernstein, Robert Angert, Ashlesha Dayal, Patience Gallagher, Mara Rosner
OBJECTIVE: To evaluate the relationship between universal transvaginal screening for short cervical length in the second trimester and the timing of antenatal corticosteroids. METHODS: We performed a retrospective cohort study of patients with nonanomalous singleton gestations and spontaneous preterm birth between 24 and 34 weeks of gestation after the initiation of a universal transvaginal cervical length screening program between October 2012 and August 2015. Our primary outcome was antenatal corticosteroid administration to a delivery interval of fewer than 7 days...
June 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28426693/influence-of-prenatal-hypoxia-and-postnatal-hyperoxia-on-morphologic-lung-maturation-in-mice
#17
Andreas Schmiedl, Torge Roolfs, Erol Tutdibi, Ludwig Gortner, Dominik Monz
BACKGROUND: Oxygen supply as a lifesaving intervention is frequently used to treat preterm infants suffering additionally from possible prenatal or perinatal pathogen features. The impact of oxygen and/or physical lung injury may influence the morphological lung development, leading to a chronic postnatal lung disease called bronchopulmonary dysplasia (BPD). At present different experimental BPD models are used. However, there are no systematic comparative studies regarding different influences of oxygen on morphological lung maturation...
2017: PloS One
https://www.readbyqxmd.com/read/28388600/influence-of-antenatal-glucocorticoid-on-preterm-lamb-diaphragm
#18
Tanzila Mahzabin, J Jane Pillow, Gavin J Pinniger, Anthony J Bakker, Peter B Noble, Robert B White, Kanakeswary Karisnan, Yong Song
BackgroundPregnant women at a high risk of preterm delivery receive glucocorticoids to accelerate fetal lung maturation and surfactant synthesis. However, the effect of antenatal steroids on the developing diaphragm remains unclear. We hypothesized that maternal betamethasone impairs the fetal diaphragm, and the magnitude of the detrimental effect increases with longer duration of exposure. We aimed to determine how different durations of fetal exposure to maternal betamethasone treatment influence the fetal diaphragm at the functional and molecular levels...
September 2017: Pediatric Research
https://www.readbyqxmd.com/read/28342715/prediction-of-neonatal-respiratory-morbidity-by-quantitative-ultrasound-lung-texture-analysis-a-multicenter-study
#19
MULTICENTER STUDY
Montse Palacio, Elisenda Bonet-Carne, Teresa Cobo, Alvaro Perez-Moreno, Joan Sabrià, Jute Richter, Marian Kacerovsky, Bo Jacobsson, Raúl A García-Posada, Fernando Bugatto, Ramon Santisteve, Àngels Vives, Mauro Parra-Cordero, Edgar Hernandez-Andrade, José Luis Bartha, Pilar Carretero-Lucena, Kai Lit Tan, Rogelio Cruz-Martínez, Minke Burke, Suseela Vavilala, Igor Iruretagoyena, Juan Luis Delgado, Mauro Schenone, Josep Vilanova, Francesc Botet, George S H Yeo, Jon Hyett, Jan Deprest, Roberto Romero, Eduard Gratacos
BACKGROUND: Prediction of neonatal respiratory morbidity may be useful to plan delivery in complicated pregnancies. The limited predictive performance of the current diagnostic tests together with the risks of an invasive procedure restricts the use of fetal lung maturity assessment. OBJECTIVE: The objective of the study was to evaluate the performance of quantitative ultrasound texture analysis of the fetal lung (quantusFLM) to predict neonatal respiratory morbidity in preterm and early-term (<39...
August 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28342395/longitudinal-progression-of-fetal-short-term-variation-and-average-acceleration-and-deceleration-capacity-after-antenatal-maternal-betamethasone-application
#20
Joy Weyrich, Anna Setter, Alexander Müller, Georg Schmidt, Christine E Brambs, Javier U Ortiz, Silvia M Lobmaier
OBJECTIVE: To analyze the effect of maternal betamethasone given for fetal lung maturation on fetal short-term variation (STV) and average acceleration and deceleration capacity (AAC/ADC). Both of these factors are calculated by phase-rectified signal averaging (PRSA) and represent new parameters to assess the fetal autonomic nervous system. STUDY DESIGN: A longitudinal prospective study including 26 pregnant women at risk for preterm delivery was performed. Two injections of 12mg betamethasone were administered intramuscularly at a 24h interval for lung maturation...
May 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
keyword
keyword
96543
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"