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apolipoprotein

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https://www.readbyqxmd.com/read/29909179/apoe-%C3%AE%C2%B54-status-in-healthy-older-african-americans-is-associated-with-deficits-in-pattern-separation-and-hippocampal-hyperactivation
#1
Neha Sinha, Chelsie N Berg, Nicholas J Tustison, Ashlee Shaw, Diane Hill, Michael A Yassa, Mark A Gluck
African Americans are 1.4 times more likely than European Americans to carry the apolipoprotein E (APOE) ε4 allele, a risk factor for Alzheimer's disease (AD). However, little is known about the neural correlates of cognitive function in older African Americans and how they relate to genetic risk for AD. In particular, no past study on African Americans has examined the effect of APOE ε4 status on pattern separation-mnemonic discrimination performance and its corresponding neural computations in the hippocampus...
May 26, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29909178/the-effect-of-apoe-genotype-on-alzheimer-s-disease-risk-is-influenced-by-sex-and-docosahexaenoic-acid-status
#2
REVIEW
Matthew Pontifex, David Vauzour, Anne-Marie Minihane
An apolipoprotein E ε4 (APOE-ε4) genotype is the strongest common genetic determinant of Alzheimer's disease (AD). The pleiotropic nature of apolipoprotein E has made elucidation of the aetiological basis difficult to establish, which is further complicated by the fact that the penetrance of the APOE-ε4 allele is modulated by sex, age, and nutrition. A greater metabolic consequence of the APOE-ε4 allele is likely to contribute to the fact that two-thirds of AD patients are female. A higher tissue status of the marine n-3 fatty acid docosahexaenoic acid (DHA) is associated with a lower AD risk...
May 21, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29909101/lipoprotein-apheresis-acutely-reverses-coronary-microvascular-dysfunction-in-patients-with-severe-hypercholesterolemia
#3
Melinda D Wu, Federico Moccetti, Eran Brown, Brian P Davidson, Tamara Atkinson, J Todd Belcik, George Giraud, P Barton Duell, Sergio Fazio, Hagai Tavori, Sotirios Tsimikas, Jonathan R Lindner
OBJECTIVES: The study evaluated whether lipoprotein apheresis produces immediate changes in resting perfusion in subjects with severe hypercholesterolemia, and whether there is a difference in the response between peripheral and coronary microcirculations. BACKGROUND: Lipoprotein apheresis is used in patients with severe hypercholesterolemia to reduce plasma levels of low-density lipoprotein cholesterol. METHODS: Quantitative contrast-enhanced ultrasound perfusion imaging of the myocardium at rest and skeletal muscle at rest and during calibrated contractile exercise was performed before and immediately after lipoprotein apheresis in 8 subjects with severe hypercholesterolemia, 7 of whom had a diagnosis of familial hypercholesterolemia...
June 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29907817/serum-proteomic-profiling-to-identify-biomarkers-of-premature-carotid-atherosclerosis
#4
Santosh D Bhosale, Robert Moulder, Mikko S Venäläinen, Juhani S Koskinen, Niina Pitkänen, Markus T Juonala, Mika A P Kähönen, Terho J Lehtimäki, Jorma S A Viikari, Laura L Elo, David R Goodlett, Riitta Lahesmaa, Olli T Raitakari
To evaluate the presence of serum protein biomarkers associated with the early phases of formation of carotid atherosclerotic plaques, label-free quantitative proteomics analyses were made for serum samples collected as part of The Cardiovascular Risk in Young Finns Study. Samples from subjects who had an asymptomatic carotid artery plaque detected by ultrasound examination (N = 43, Age = 30-45 years) were compared with plaque free controls (N = 43) (matched for age, sex, body weight and systolic blood pressure)...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29906458/apolipoprotein-e-plays-crucial-roles-in-maintaining-bone-mass-by-promoting-osteoblast-differentiation-via-erk1-2-pathway-and-by-suppressing-osteoclast-differentiation-via-c-fos-nfatc1-and-nf-%C3%AE%C2%BAb-pathway
#5
Takaaki Noguchi, Kosuke Ebina, Makoto Hirao, Satoru Otsuru, Adam J Guess, Ryota Kawase, Tohru Ohama, Shizuya Yamashita, Yuki Etani, Gensuke Okamura, Hideki Yoshikawa
Apolipoprotein E (ApoE) plays crucial roles not only in lipid metabolism but also in bone metabolism. Specifically ApoE4, one of major ApoE isoforms, has been demonstrated to be associated with increased risk of developing osteoporosis compared to another major isoform ApoE3. However, the detailed mechanism of how the different ApoE isoforms affect bone metabolism remains unclear. Micro-CT analyses of distal femora demonstrated severely decreased bone mass in 48-week-old female homozygous ApoE-knockout (ApoE-KO) mice compared to age- and gender-matched wild type C57BL/6 J (WT) mice...
June 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29905076/genetic-variation-in-9p21-and-the-plasma-proteome
#6
Sara Mahdavi, David J A Jenkins, Christoph H Borchers, Ahmed El-Sohemy
Single nucleotide polymorphisms (SNPs) in the non-coding region of 9p21 have been associated with cardiovascular disease (CVD), but the mechanisms by which these genetic variants contribute to the pathogenesis of CVD remain unknown since no annotated proteins are present in this region of DNA. The objective of the current study was to determine if 9p21 genotypes are associated with distinct plasma proteins in young adults. Subjects were 1,611 young adults aged 20-29 years from the Toronto Nutrigenomics and Health Study (1,098 females and 513 males)...
June 15, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29904807/determinants-of-achieved-ldl-cholesterol-and-non-hdl-cholesterol-in-the-management-of-dyslipidemias
#7
REVIEW
Chris J Packard
PURPOSE OF REVIEW: The advent of combination therapy to provide LDL lowering beyond that achieved with statins necessitates the development of greater understanding of how drugs work together, what changes occur in key lipoprotein fractions, and what residual risk remains. RECENT FINDINGS: Clinical trials of agents that, when added to statins, generate profound LDL lowering have been successful in reducing further the risk of cardiovascular disease. LDL cholesterol can be now decreased to unprecedented levels, so the focus of attention then shifts to other apolipoprotein B-containing, atherogenic lipoprotein classes such as lipoprotein(a) and remnants of the metabolism of triglyceride-rich particles...
June 14, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29903699/a-putative-role-of-apolipoprotein-l1-polymorphism-in-renal-parenchymal-scarring-following-febrile-urinary-tract-infection-in-nigerian-under-five-children-proposal-for-a-case-control-association-study
#8
Emmanuel Ademola Anigilaje
BACKGROUND: Although urinary tract infection (UTI) resolves with prompt treatment in a majority of children, some children, especially those aged less than 5 years, also develop renal parenchymal scarring (RPS). RPS causes high blood pressure that may lead to severe chronic kidney disease and end-stage renal disease (ESRD). Although the risk of UTI is higher in white children than in black children, it is unknown whether RPS is more common in white children than in black children as data are scarce in this regard...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29903237/-effects-of-medium-chain-fatty-acids-on-high-density-lipoprotein-in-rats-fed-with-high-fat-diet
#9
Yong Zhang, Xueyan Yang, Xinsheng Zhang, Qing Xu, Xiaoming Yu, Changyong Xue, Yinghua Liu
OBJECTIVE: To explore the effects of medium-chain fatty acid( MCFA) on high-density-lipoprotein( HDL) in serum, liver and small intestine in Sprague Dawley rats fed with high fat diet. METHODS: Thirty obese rats were divided into 3 groups randomly, and were fed high fat diet mixed with 2% octanoic acid, 2% decanoic acid, 2% oleic acid respectively for 8 weeks. The levels of blood HDL, apolipoprotein A1( ApoA1), apolipoprotein A2( ApoA2), triglyceride( TG), total cholesterol( TC), high-densitylipoprotein cholesterol( HDL-c), low-density lipoprotein cholesterol( HDL-c) in serum were measured at the fourth and eighth week...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29903170/-association-of-single-nucleotide-polymorphism-of-sirt1-and-apoc3-with-nonalcoholic-fatty-liver-disease
#10
Xiaochao Song, Chunli Song, Li Fan, Qinghua Ma, Jianliang Mao, Wenxin Xu, Xinli Li
OBJECTIVE: To explore the association of silent information regulator 1( SIRT1) rs12778366 and apolipoprotein C3( APOC3) rs2854116 gene polymorphisms with the susceptibility of nonalcoholic fatty liver disease( NAFLD). METHODS: One hundred and thirty two NAFLD patients and 252 healthy controls were enrolled in our present study according to the ultrasound diagnosis and physical examination. Venousblood samples were obtained in the morning after an overnight fast, and the samples were used to analyze the biochemical index, relating to hepatic enzymes, blood lipid and blood glucose metabolism...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902700/ticagrelor-a-p2y12-antagonist-attenuates-vascular-dysfunction-and-inhibits-atherogenesis-in-apolipoprotein-e-deficient-mice
#11
Byambasuren Ganbaatar, Daiju Fukuda, Hotimah Masdan Salim, Sachiko Nishimoto, Kimie Tanaka, Yasutomi Higashikuni, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Masataka Sata
BACKGROUND AND AIMS: Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein E-deficient (apoe-/- ) mice. METHODS: Eight-week-old male apoe-/- mice were fed a western-type diet (WTD) supplemented with 0...
May 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29901187/a-novel-scoring-system-for-gastric-cancer-risk-assessment-based-on-the-expression-of-three-clip4-dna-methylation-associated-genes
#12
Chenggong Hu, Yongfang Zhou, Chang Liu, Yan Kang
Gastric cancer (GC) is the fifth most common cancer and the third leading cause of cancer-associated mortality worldwide. In the current study, comprehensive bioinformatic analyses were performed to develop a novel scoring system for GC risk assessment based on CAP-Gly domain containing linker protein family member 4 (CLIP4) DNA methylation status. Two GC datasets with methylation sequencing information and mRNA expression profiling were downloaded from the The Cancer Genome Atlas and Gene Expression Omnibus databases...
June 6, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29900637/human-apolipoprotein-e-as-a-reservoir-of-cryptic-bioactive-peptides-the-case-of-apoe-133-167
#13
Anna Zanfardino, Andrea Bosso, Giovanni Gallo, Valeria Pistorio, Michela Di Napoli, Rosa Gaglione, Eliana Dell'Olmo, Mario Varcamonti, Eugenio Notomista, Angela Arciello, Elio Pizzo
Bioactive peptides derived from the receptor-binding region of human apolipoprotein E have previously been reported. All these peptides, encompassing fragments of this region or designed on the basis of short repeated cationic sequences identified in the same region, show toxic activities against a broad spectrum of bacteria and interesting immunomodulatory effects. However, the ability of these molecules to exert antibiofilm properties has not been described so far. In the present work, we report the characterization of a novel peptide, corresponding to residues 133 to 167 of human apolipoprotein E, here named ApoE (133-167)...
June 14, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29899427/treating-the-intestine-with-oral-apoa-i-mimetic-tg6f-reduces-tumor-burden-in-mouse-models-of-metastatic-lung-cancer
#14
Arnab Chattopadhyay, Xinying Yang, Pallavi Mukherjee, Dawoud Sulaiman, Hannah R Fogelman, Victor Grijalva, Steven Dubinett, Tonya C Wasler, Manash K Paul, Ramin Salehi-Rad, Julia J Mack, M Luisa Iruela-Arispe, Mohamad Navab, Alan M Fogelman, Srinivasa T Reddy
Having demonstrated that apolipoprotein A-I (apoA-I) mimetic peptides ameliorate cancer in mouse models, we sought to determine the mechanism for the anti-tumorigenic function of these peptides. CT-26 cells (colon cancer cells that implant and grow into tumors in the lungs) were injected into wild-type BALB/c mice. The day after injection, mice were either continued on chow or switched to chow containing 0.06% of a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F). After four weeks, the number of lung tumors was significantly lower in Tg6F-fed mice...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29898042/prevalence-of-metabolic-syndrome-and-framingham-risk-score-in-apparently-healthy-vegetarian-and-omnivorous-men
#15
Julio Cesar Acosta Navarro, Luiza Antoniazzi, Adriana Midori Oki, Maria Carlos Bonfim, Valeria Hong, Luiz Aparecido Bortolotto, Pedro Acosta-Cardenas, Valeria Sandrim, Marcio Hiroshi Miname, Raul Dias Dos Santos Filho
BACKGROUND: Recent studies have shown a lower prevalence of metabolic syndrome (MSyn) in vegetarians (VEG) despite the inconclusive evidence from others. OBJECTIVE: To verify the association between diet and other lifestyle characteristics and the prevalence of MSyn, cardiovascular risk factors (CRF), and Framingham Risk Score (FRS) in apparently healthy VEG and omnivorous (OMN) men. METHODS: In this cross-sectional study, 88 apparently healthy men ≥ 35 years, 44 VEG and 44 OMN, were assessed for anthropometric data, blood pressure, blood lipids, glucose, C-reactive protein (CRP) and FRS...
May 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29896743/-relationship-between-gstm1-and-gstt1-gene-polymorphisms-and-plasma-lipid-and-apolipoprotein-levels-in-chinese-normalipidemic-and-endogenous-hypertriglyceridemic-subjects
#16
Yue Zhu, Linbo Guan, Ping Fan, Rui Liu, Xing Wei, Yu Liu, Huai Bai
OBJECTIVE: To investigate effects of GSTM1 and GSTT1 gene polymorphisms on serum lipid and apopoprotein levels in healthy normolipidemic and endogenous hypertriglyceridemic subjects. METHODS: Two hundred and thirty-seven healthy normolipidemic and 102 endogenous hypertriglyceridemic subjects from a population of Chinese Han nationality in Chengdu area were studied using the multiplex polymerase chain reaction (PCR). Serum lipids were measured by enzymatic kits and apolipoproteins AⅠ, AⅡ, B100, CⅡ, CⅢ and E were measured by the RID kits...
June 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29896424/association-of-apoe-genetic-polymorphism-and-type-2-diabetes-with-cognition-in-non-demented-aging-chinese-adults-a-community-based-cross-sectional-study
#17
Jie Zhen, Tong Lin, Xiaochen Huang, Huiqiang Zhang, Shengqi Dong, Yifan Wu, Linlin Song, Rong Xiao, Linhong Yuan
Apolipoprotein E (ApoE) gene polymorphism has been implicated in predisposition to diabetes and dementia in old population, but the results from the different studies were inconclusive. A cross-sectional study was carried out to explore the relationship among ApoE gene polymorphism, diabetes and cognition in non-demented aging Chinese adults. A total number of 1000 community dwellers aged 55 years and above were randomly recruited. Demographic information of the participants was collected using well designed self-administered questionnaires...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896071/molecular-assessment-of-some-cardiovascular-genetic-risk-factors-among-iraqi-patients-with-ischemic-heart-diseases
#18
Wisam Jasim Mohammed, Bassam Musa Sadik Al-Musawi, Christian Oberkanins, Helene Pühringer
Objective: The underlying molecular basis of ischemic heart diseases (IHDs) has not yet been studied among Iraqi people. This study determined the frequency and types of some cardiovascular genetic risk factors among Iraqi patients with IHDs. Methods: This is a cross-sectional study recruiting 56 patients with acute IHD during a 2-month period excluding patients >50 years and patients with documented hyperlipidemia. Their ages ranged between 18 and 50 years; males were 54 and females were only 2...
May 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29892926/the-relationship-between-genetic-polymorphisms-in-apolipoprotein-e-apoe-gene-and-osteonecrosis-of-the-femoral-head-induced-by-steroid-in-chinese-han-population
#19
Lin Yuan, Wei Li, Xianquan Wang, Guang Yang, Haiyang Yu, Shui Sun
Previous studies suggested that apolipoprotein E (ApoE) genetic polymorphisms (SNPs) may result in abnormal lipid metabolism. Therefore, genetic polymorphisms in ApoE may be associated with the occurrence of osteonecrosis of the femoral head (ONFH). A case control study was designed to include 580 patients with steroid-induced ONFH and 560 age- and sex-matched non steroid-induced ONFH control subjects to analyze the association between ApoE polymorphisms and susceptibility of steroid-induced ONFH. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was utilized to differentiate two genotypes SNPs (rs7412 C/T and rs429358 T/C) in ApoE gene...
February 2018: Genes & Genomics
https://www.readbyqxmd.com/read/29892819/thyroid-hormones-and-derivatives-endogenous-thyroid-hormones-and-their-targets
#20
Josef Köhrle
More than a century after the discovery of L-Thyroxine, the main thyroid hormone secreted solely by the thyroid gland, several metabolites of this iodinated, tyrosine-derived ancestral hormone have been identified. These are utilized as hormones during development, differentiation, metamorphosis, and regulation of most biochemical reactions in vertebrates and their precursor species. Among those metabolites are the thyromimetically active 3,3',5-Triiodo-L-thyronine (T3) and 3,5-Diiodo-L-thronine, reverse-T3 (3,3',5'-Triiodo-L-thyronine) with still unclear function, the recently re-discovered thyronamines (e...
2018: Methods in Molecular Biology
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