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https://www.readbyqxmd.com/read/29470638/long-term-effects-of-low-dose-mouse-liver-irradiation-involve-ultrastructural-and-biochemical-changes-in-hepatocytes-that-depend-on-lipid-metabolism
#1
Malgorzata Lysek-Gladysinska, Anna Wieczorek, Anna Walaszczyk, Karol Jelonek, Artur Jozwik, Monika Pietrowska, Wolfgang Dörr, Dorota Gabrys, Piotr Widlak
The aim of the study was to investigate long-term effects of radiation on the (ultra)structure and function of the liver in mice. The experiments were conducted on wild-type C57BL/6J and apolipoprotein E knock-out (ApoE-/- ) male mice which received a single dose (2 or 8 Gy) of X-rays to the heart with simultaneous exposure of liver to low doses (no more than 30 and 120 mGy, respectively). Livers were collected for analysis 60 weeks after irradiation and used for morphological, ultrastructural, and biochemical studies...
February 22, 2018: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/29469589/preparation-of-vitamin-e-containing-high-density-lipoprotein-and-its-protective-efficacy-on-macrophages
#2
Manman Su, Dingding Wang, Weiqin Chang, Lixian Liu, Manhua Cui, Tianmin Xu
Atherosclerosis is a major cause for cardiovascular diseases. High-density lipoprotein (HDL) may reduce atherosclerosis through several different mechanisms. HDL is composed of lipids, cholesterol, cholesteryl esters, triglycerides, and phospholipids, mainly phosphatidylcholine plus specialized proteins called apolipoproteins (apos). In this study, we prepared vitamin E containing HDL (VE -HDL) that contains egg phosphatidylcholine, cholesterol, vitamin E, and two kinds of recombinant human apolipoproteins (rhapo)-rhapoA-I and rhapoE in vitro by the facilitation of cholate...
February 22, 2018: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29467953/meta-analysis-of-a-10-plex-urine-based-biomarker-assay-for-the-detection-of-bladder-cancer
#3
Norihiko Masuda, Osamu Ogawa, Meyeon Park, Alvin Y Liu, Steve Goodison, Yunfeng Dai, Landon Kozai, Hideki Furuya, Yair Lotan, Charles J Rosser, Takashi Kobayashi
A 10-plex urine-based bladder cancer (BCa) diagnostic signature has the potential to non-invasively predict the presence of BCa in at-risk patients, as reported in various case-control studies. The present meta-analysis was performed to re-evaluate and demonstrate the robustness and consistency of the diagnostic utility of the 10-plex urine-based diagnostic assay. We re-analyzed primary data collected in five previously published case-control studies on the 10-plex diagnostic assay. Studies reported the sensitivity and specificity of ten urinary protein biomarkers for the detection of BCa, including interleukin 8, matrix metalloproteinases 9 and 10, angiogenin, apolipoprotein E, syndecan 1, alpha-1 antitrypsin, plasminogen activator inhibitor-1, carbonic anhydrase 9, and vascular endothelial growth factor A...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29467356/endogenous-interleukin-1%C3%AE-is-implicated-in-intraplaque-hemorrhage-in-apolipoprotein-e-gene-null-mice
#4
Etsu Suzuki, Hiroyuki Imuta, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba, Arihiro Kiyosue, Hiroaki Nishimatsu
BACKGROUND: Intraplaque hemorrhage (IPH) has been implicated in plaque instability and rupture in atherosclerotic lesions, although the mechanisms by which IPH progresses remain largely unknown. In this study, apolipoprotein E-deficient mice with carotid artery ligation and cuff placement around the artery were used, and pro-inflammatory cytokines that are implicated in IPH were analyzed.Methods and Results:The expression of interleukin-1β (IL-1β) increased significantly following cuff placement compared with mice with carotid artery ligation alone...
February 22, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29467335/apolipoproteins-e-and-ciii-interact-to-regulate-hdl-metabolism-and-coronary-heart-disease-risk
#5
Allyson M Morton, Manja Koch, Carlos O Mendivil, Jeremy D Furtado, Anne Tjønneland, Kim Overvad, Liyun Wang, Majken K Jensen, Frank M Sacks
BACKGROUND: Subspecies of HDL contain apolipoprotein E (apoE) and/or apoCIII. Both proteins have properties that could affect HDL metabolism. The relation between HDL metabolism and risk of coronary heart disease (CHD) is not well understood. METHODS: Eighteen participants were given a bolus infusion of [D3]L-leucine to label endogenous proteins on HDL. HDL was separated into subspecies containing apoE and/or apoCIII and then into 4 sizes. Metabolic rates for apoA-I in HDL subspecies and sizes were determined by interactive modeling...
February 22, 2018: JCI Insight
https://www.readbyqxmd.com/read/29466783/knockout-of-low-molecular-weight-fgf2-attenuates-atherosclerosis-by-reducing-macrophage-infiltration-and-oxidative-stress-in-mice
#6
Wenjing Liang, Qian Wang, Hui Ma, Wenjiang Yan, Jingjing Yang
BACKGROUND/AIMS: Fibroblast growth factor 2 (FGF2) plays a predominant role during angiogenesis in the adventitia and in atherosclerotic plaque. A dilemma exists, however, as to whether angiogenic stimulation by FGF2 for the prevention and treatment of atherogenesis is feasible. The aim of this study is to investigate the effect of the 18-kDa FGF-2 isoform on atherosclerosis progression in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice. METHODS: We established a model of atherosclerosis using ApoE and 18-kDa FGF-2 gene double knockout mice...
February 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29465426/advances-in-molecular-diagnosis-and-therapeutics-in-nephrotic-syndrome-and-focal-and-segmental-glomerulosclerosis
#7
Bedra Sharif, Moumita Barua
PURPOSE OF REVIEW: The widespread adoption of next-generation sequencing by research and clinical laboratories has begun to uncover the previously unknown genetic basis of many diseases. In nephrology, one of the best examples of this is seen in focal and segmental glomerulosclerosis (FSGS) and nephrotic syndrome. We review advances made in 2017 as a result of human and molecular genetic studies as it relates to FSGS and nephrotic syndrome. RECENT FINDINGS: There are more than 50 monogenic genes described in steroid-resistant nephrotic syndrome and FSGS, with seven reported in 2017...
February 19, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29465030/novel-host-restriction-factors-implicated-in-hiv-1-replication
#8
Dibya Ghimire, Madhu Rai, Ritu Gaur
Human immunodeficiency virus-1 (HIV-1) is known to interact with multiple host cellular proteins during its replication in the target cell. While many of these host cellular proteins facilitate viral replication, a number of them are reported to inhibit HIV-1 replication at various stages of its life cycle. These host cellular proteins, which are known as restriction factors, constitute an integral part of the host's first line of defence against the viral pathogen. Since the discovery of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G) as an HIV-1 restriction factor, several human proteins have been identified that exhibit anti-HIV-1 restriction...
February 19, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29464937/vascular-dysfunction-elicited-by-a-crosstalk-between-periaortic-adipose-tissue-and-the-vascular-wall-is-reversed-by-pioglitazone
#9
Isabel Quesada, Jimena Cejas, Rodrigo García, Beatriz Cannizzo, Analía Redondo, Claudia Castro
AIM: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signalling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of Metabolic Syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of Pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers...
February 21, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29463520/lipid-profile-and-effect-of-statin-treatment-in-pooled-phase-ii-and-phase-iii-baricitinib-studies
#10
Peter C Taylor, Joel M Kremer, Paul Emery, Steven H Zuckerman, Giacomo Ruotolo, Jinglin Zhong, Lei Chen, Sarah Witt, Chadi Saifan, Monika Kurzawa, James D Otvos, Margery A Connelly, William L Macias, Douglas E Schlichting, Terence P Rooney, Stephanie de Bono, Iain B McInnes
OBJECTIVES: Lipid profiles are altered by active disease in patients with rheumatoid arthritis (RA) and may be further modified by treatment with Janus kinase inhibitors and other disease-modifying antirheumatic drugs. METHODS: Lipid data were analysed from phase II and III studies of 4 mg (n=997) and 2 mg (n=479) oral baricitinib administered once daily in patients with moderate-to-severe active RA. Lipoprotein particle size and number and GlycA were evaluated with nuclear magnetic resonance in one phase III study...
February 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29463416/irradiation-of-rainbow-trout-at-early-life-stages-results-in-a-proteomic-legacy-in-adult-gills-part-a-proteomic-responses-in-the-irradiated-fish-and-in-non-irradiated-bystander-fish
#11
Richard W Smith, Richard D Moccia, Colin B Seymour, Carmel E Mothersill
Exposure to a single 0.5 Gy X-ray dose of eggs at 48 h after fertilisation (48 h egg), eyed eggs, yolk sac larvae (YSL) and first feeders induces a legacy effect in adult rainbow trout. This includes the transmission of a bystander effect to non-irradiated adult trout which had swam with the irradiated fish. The aim of this study was to investigate this legacy by analysing the gill proteome of these irradiated and bystander fish. Irradiation at all of the early life stages resulted in changes to proteins which play a key role in development but are also known to be anti-tumorigenic and anti-oxidant: upregulation of haemoglobin subunit beta (48 h egg), haemoglobin, serum albumin 1 precursor (eyed eggs), clathrin heavy chain 1 isoform X10 (eyed eggs and first feeders), and actin-related protein 2/3 complex subunit 4 (first feeders), downregulation of pyruvate dehydrogenase, histone 1 (48 h egg), triosephosphate isomerase (TPI), collagen alpha-1(1) chain like proteins (YSL), pyruvate kinase PKM-like protein (YSL and first feeders), ubiquitin-40S ribosomal proteins S27 and eukaryotic translation initiation factor 4 A isoform 1B (first feeders)...
February 17, 2018: Environmental Research
https://www.readbyqxmd.com/read/29463164/apolipoprotein-e-apoe-%C3%AE%C2%B54-genotype-is-associated-with-elevated-psychiatric-distress-in-veterans-with-a-history-of-mild-to-moderate-traumatic-brain-injury
#12
Victoria C Merritt, Alexandra L Clark, Scott F Sorg, Nicole D Evangelista, Madeleine Werhane, Mark W Bondi, Dawn M Schiehser, Lisa Delano-Wood
Since few studies have examined the relationship between the APOE gene and clinical outcomes following military-related traumatic brain injury (TBI), we aimed to determine whether the ε4 allele of the APOE gene influences neuropsychiatric symptoms in Veterans with a history of mild to moderate TBI. Participants included 133 Veterans (TBI=79, military controls [MC]=54) who underwent APOE genotyping and were divided into ε4+ (TBI=18, MC=15) and ε4- (TBI=61, MC=39) groups. All participants underwent evaluation of psychological distress using the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and PTSD Checklist-Military Version (PCL-M)...
February 20, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29462810/consumption-of-amaranth-induces-the-accumulation-of-the-antioxidant-protein-paraoxonase-arylesterase-1-and-modulates-dipeptidyl-peptidase-iv-activity-in-plasma-of-streptozotocin-induced-hyperglycemic-rats
#13
Aída J Velarde-Salcedo, Evelyn Regalado-Rentería, Rodrigo Velarde-Salcedo, Bertha I Juárez-Flores, Alberto Barrera-Pacheco, Elvira González de Mejía, Ana P Barba de la Rosa
BACKGROUND/AIM: Amaranth is a source of several bioactive compounds, among which peptides with inhibitory activity upon dipeptidyl peptidase IV (DPP-IV) have been reported. However, there is no information about the action of amaranth DPP-IV-inhibitory peptides using in vivo models. The aim of this work was to evaluate the effect of amaranth consumption on plasma and kidney DPP-IV activity as well the changes in plasma proteome profile of streptozotocin (STZ)-induced hyperglycemic rats...
February 20, 2018: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29462565/pycnogenol-r-protects-against-diet-induced-hepatic-steatosis-in-apolipoprotein-e-deficient-mice
#14
Difei Wang, Huiying Cong, Xiaoli Wang, Yanli Cao, Shoichiro Ikuyama, Bin Fan, Jianqiu Gu
Pycnogenol (PYC), a combination of active flavonoids derived from French maritime pine bark, is a natural antioxidant that has various pharmacological activities. Here, we investigated the beneficial effect of PYC on diet-induced hepatic steatosis. Apolipoprotein E (ApoE)-deficient male mice were administered PYC at oral doses of 30 or 100 mg•kg-1 •day-1 for two weeks in advance and were then fed a high cholesterol and fat diet (HCD) for eight weeks. Biochemical, immunohistochemical, and gene expression analyses were conducted to explore the effect of PYC on lipid metabolism in ApoE-deficient mice on a HCD...
February 20, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29459555/metabolic-and-immunological-assessment-of-small-for-gestational-age-children-during-one-year-treatment-with-growth-hormone-the-clinical-impact-of-apolipoproteins
#15
Kanako Kojima-Ishii, Naoko Toda, Kazuhiro Okubo, Vlad Tocan, Noriko Ohyama, Mika Makimura, Terumichi Matsuo, Masayuki Ochiai, Shouichi Ohga, Kenji Ihara
Children born small for gestational age (SGA) are at a higher risk for metabolic disorders later in life. In this study, we aimed to characterize young SGA children without catch-up growth and evaluate the effects of GH treatment on endocrinological, metabolic, and immunological parameters. Study design is a one-year single hospital-based study included prospective observation of SGA patients during 12 months of GH treatment. Clinical and laboratory profiles of SGA children at baseline were compared with controls born appropriate size for age...
February 20, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29459426/inhibition-of-mir-155-attenuates-abdominal-aortic-aneurysm-in-mice-by-regulating-macrophage-mediated-inflammation
#16
Zhidong Zhang, Kai Liang, Gangqiang Zou, Xiaosan Chen, Shuaitao Shi, Guoquan Wang, Kewei Zhang, Kun Li, Shuiting Zhai
The aim of this study was to identify abdominal aortic aneurysms (AAA)-associated miR-155 contributing to AAA pathology by regulating macrophage-mediated inflammation. Angiotensin II (AngII)-infused apolipoprotein E-deficient (ApoE-/-) mice and THP-1 cells model of miR-155 over-expression and deficiency were used in the experiments. The expression of miR-155 was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Cytokines were evaluated using enzyme-linked immunoabsorbent assay (ELISA)...
February 19, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29459295/the-link-between-insulin-resistance-parameters-and-serum-uric-acid-is-mediated-by-adiposity
#17
Mohsen Mazidi, Niki Katsiki, Dimitri P Mikhailidis, Maciej Banach
BACKGROUND AND AIMS: Conflicting results suggest a link between serum uric acid (SUA), inflammation and glucose/insulin homeostasis; however, the role of adiposity in this relationship is not clear. Therefore, we evaluated the role of different adiposity factors, including central body mass index (BMI), peripheral waist circumference (WC), and visceral adiposity [visceral adipose tissue (apVAT)], on the association between SUA, inflammation and glucose/insulin homeostasis among US adults...
December 26, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29459264/induction-of-microrna-10a-using-retinoic-acid-receptor-%C3%AE-and-retinoid-x-receptor-%C3%AE-agonists-inhibits-atherosclerotic-lesion-formation
#18
Ding-Yu Lee, Tung-Lin Yang, Yi-Hsuan Huang, Chih-I Lee, Li-Jing Chen, Yu-Tsung Shih, Shu-Yi Wei, Wei-Li Wang, Chih-Cheng Wu, Jeng-Jiann Chiu
BACKGROUND AND AIMS: MicroRNA (miR)-10a is a shear-regulated miR with the lowest expression in vascular endothelial cells (ECs) in athero-susceptible regions with oscillatory shear stress (OS). The aim of this study is to elucidate the relationship between EC miR-10a and atherosclerosis and develop a hemodynamics-based strategy for atherosclerosis treatment. METHODS: A combination of in vitro flow system and in vivo experimental animals was used to examine the functional roles of EC miR-10a and its clinical applications in atherosclerosis...
February 8, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29459263/hyperlipidemia-induces-typical-atherosclerosis-development-in-ldlr-and-apoe-deficient-rats
#19
Yongliang Zhao, Yiqing Yang, Roumei Xing, Xueqin Cui, Yufang Xiao, Ling Xie, Panpan You, Tongtong Wang, Li Zeng, Wenhui Peng, Dali Li, Huaqing Chen, Mingyao Liu
BACKGROUND AND AIMS: Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in rats. To this end, Ldlr and Apoe KO rats were generated and the potential to develop novel atherosclerosis models was evaluated. METHODS: We established Apoe/Ldlr single and double KO (DKO) rats via the CRISPR/Cas9 system in the same background...
February 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29458426/disease-related-determinants-are-associated-with-mortality-in-dementia-due-to-alzheimer-s-disease
#20
Hanneke F M Rhodius-Meester, Hilkka Liedes, Ted Koene, Afina W Lemstra, Charlotte E Teunissen, Frederik Barkhof, Philip Scheltens, Mark van Gils, Jyrki Lötjönen, Wiesje M van der Flier
BACKGROUND: Survival after dementia diagnosis varies considerably. Previous studies were focused mainly on factors related to demographics and comorbidity rather than on Alzheimer's disease (AD)-related determinants. We set out to answer the question whether markers with proven diagnostic value also have prognostic value. We aimed to identify disease-related determinants associated with mortality in patients with AD. METHODS: We included 616 patients (50% female; age 67 ± 8 years; mean Mini Mental State Examination score 22 ± 3) with dementia due to AD from the Amsterdam Dementia Cohort...
February 20, 2018: Alzheimer's Research & Therapy
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