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https://www.readbyqxmd.com/read/27788511/the-bethesda-system-for-reporting-thyroid-cytopathology-ii
#1
Syed Z Ali, Edmund S Cibas
No abstract text is available yet for this article.
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27689252/clinical-sonographic-and-pathologic-characteristics-of-ras-positive-versus-braf-positive-thyroid-carcinoma
#2
Sujay Kakarmath, Howard T Heller, Caroline A Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta, Neal I Lindeman, Mary C Frates, Carol B Benson, Atul A Gawande, Nancy L Cho, Matthew Nehs, Francis D Moore, Ellen Marqusee, Mathew I Kim, P Reed Larsen, Norra Kwong, Trevor E Angell, Erik K Alexander
CONTEXT: Mutations in the BRAF and RAS oncogenes are responsible for most well-differentiated thyroid cancer. Yet, our clinical understanding of how BRAF-positive and RAS-positive thyroid cancers differ is incomplete. OBJECTIVE: We correlated clinical, radiographic, and pathologic findings from patients with thyroid cancer harboring a BRAF or RAS mutation. DESIGN: Prospective cohort study Setting: Academic, tertiary care hospital Patients: 101 consecutive patients with well-differentiated thyroid cancer Main Outcome Measure: We compared the clinical, sonographic, and pathologic characteristics of patients with BRAF-positive cancer to those with RAS-positive cancer...
September 30, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27501280/features-and-outcome-of-autonomous-thyroid-nodules-in-children-31-consecutive-patients-seen-at-a-single-center
#3
Samantha Ly, Mary C Frates, Carol B Benson, Hope E Peters, Frederick D Grant, Laura A Drubach, Stephan D Voss, Henry A Feldman, Jessica R Smith, Justine Barletta, Monica Hollowell, Edmund S Cibas, Francis D Moore, Biren Modi, Robert C Shamberger, Stephen A Huang
CONTEXT: Most thyroid nodules are benign and their accurate identification can avoid unnecessary procedures. In adult patients, documentation of nodule autonomy is accepted as reassurance of benign histology and as justification to forgo biopsy or thyroidectomy. In contrast, the negative predictive value of nodule autonomy in children is uncertain. Some recent publications recommend surgical resection as initial management, but few address the degree of TSH suppression or the specific scintigraphic criteria used to diagnose autonomy...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27457786/preoperative-cytologic-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-a-prospective-analysis
#4
Kyle C Strickland, Marina Vivero, Vickie Y Jo, Alarice C Lowe, Monica Hollowell, Xiaohua Qian, Tad J Wieczorek, Christopher A French, Lisa A Teot, Peter M Sadow, Erik K Alexander, Edmund S Cibas, Justine A Barletta, Jeffrey F Krane
BACKGROUND: The term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has been proposed to replace noninvasive follicular variant of papillary thyroid carcinoma (FVPTC) in recognition of the indolent behavior of this tumor. The ability to differentiate NIFTP from classical papillary thyroid carcinoma (cPTC) by fine-needle aspiration (FNA) would facilitate conservative management for NIFTP. The aim of this study was to determine if NIFTP can be distinguished prospectively from cPTC...
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27219469/noninvasive-follicular-variant-of-papillary-thyroid-carcinoma-and-the-afirma-gene-expression-classifier
#5
Kristine S Wong, Trevor E Angell, Kyle C Strickland, Erik K Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta
BACKGROUND: It is now recognized that noninvasive follicular variant of papillary thyroid carcinoma (NFVPTC) is a distinct subset of FVPTC with an exceedingly indolent clinical course. The Afirma gene-expression classifier (GEC) helps guide clinicians in the management of thyroid nodules with indeterminate fine-needle aspiration (FNA) results. Thyroid surgery is recommended for nodules with a suspicious Afirma result, whereas observation is deemed reasonable for most nodules with a benign result...
July 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26563459/bethesda-categorization-of-thyroid-nodule-cytology-and-prediction-of-thyroid-cancer-type-and-prognosis
#6
Xiaoyun Liu, Marco Medici, Norra Kwong, Trevor E Angell, Ellen Marqusee, Matthew I Kim, P Reed Larsen, Nancy L Cho, Matthew A Nehs, Daniel T Ruan, Atul Gawande, Francis Moore, Justine Barletta, Jeffrey F Krane, Edmund S Cibas, Tao Yang, Erik K Alexander
BACKGROUND: Since its inception, the Bethesda System for Reporting Thyroid Cytopathology (TBS) has been widely adopted. Each category conveys a risk of malignancy and recommended next steps, though it is unclear if each category also predicts the type and extent of malignancy. If so, this would greatly expand the utility of the TBS by providing prognostic information in addition to baseline cancer risk. METHODS: All patients prospectively enrolled into the authors' thyroid nodule database from 1995 to 2013 with histologically proven malignancy were analyzed...
February 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26465395/the-influence-of-patient-age-on-thyroid-nodule-formation-multinodularity-and-thyroid-cancer-risk
#7
Norra Kwong, Marco Medici, Trevor E Angell, Xiaoyun Liu, Ellen Marqusee, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta, Matthew I Kim, P Reed Larsen, Erik K Alexander
INTRODUCTION: Although advancing age is known to influence the formation of thyroid nodules, the precise relationship remains unclear. Furthermore, it is uncertain whether age influences the risk that any thyroid nodule may prove cancerous. AIM: The aim was to determine the impact of patient age on nodule formation, multinodularity, and risk of thyroid malignancy. METHOD: We conducted a prospective cohort analysis of consecutive adults (ages 20-95 y) who presented for evaluation of nodular disease from 1995 to 2011...
December 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26353010/afirma-benign-thyroid-nodules-show-similar-growth-to-cytologically-benign-nodules-during-follow-up
#8
Trevor E Angell, Mary C Frates, Marco Medici, Xiaoyun Liu, Norra Kwong, Edmund S Cibas, Matthew I Kim, Ellen Marqusee
CONTEXT: The Afirma gene expression classifier (GEC) is a molecular diagnostic test that has a high negative predictive value for ruling out malignancy in thyroid nodules with indeterminate cytology. Many patients with a cytologically indeterminate and GEC benign (Cyto-I/GEC-B) nodule undergo monitoring instead of diagnostic surgery, but few data describe their follow-up. OBJECTIVE: The objective of the study was to determine the sonographic changes and clinical outcomes for patients with Cyto-I/GEC-B nodules compared with patients with cytologically benign (Cyto-B) nodules...
November 2015: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26253102/the-variable-phenotype-and-low-risk-nature-of-ras-positive-thyroid-nodules
#9
Marco Medici, Norra Kwong, Trevor E Angell, Ellen Marqusee, Matthew I Kim, Mary C Frates, Carol B Benson, Edmund S Cibas, Justine A Barletta, Jeffrey F Krane, Daniel T Ruan, Nancy L Cho, Atul A Gawande, Francis D Moore, Erik K Alexander
BACKGROUND: Oncogenic mutations are common in thyroid cancers. While the frequently detected RAS-oncogene mutations have been studied for diagnostic use in cytologically indeterminate thyroid nodules, no investigation has studied such mutations in an unselected population of thyroid nodules. No long-term study of RAS-positive thyroid nodules has been performed. METHODS: We performed a prospective, blinded cohort study in 362 consecutive patients presenting with clinically relevant (>1 cm) thyroid nodules...
August 7, 2015: BMC Medicine
https://www.readbyqxmd.com/read/26137287/comparison-of-two-different-standards-of-care-in-detecting-malignant-thyroid-nodules-using-thyroid-fine-needle-aspiration
#10
Xiaoyun Liu, Lijun Zhu, Zhixiao Wang, Dai Cui, Huanhuan Chen, Ling Wei, Yunsong Wu, Rong Rong, Yan Wu, Qing Yao, Zhihong Zhang, Edmund S Cibas, Erik K Alexander, Tao Yang
The aim of the present study was to verify the optimal method to obtain enough fine-needle aspiration (FNA) materials for detecting thyroid malignancy. A prospective study was performed by comparing two different regional standards of care. In one group a traditional FNA method mainly used in Asian countries, including China, was performed in which a single pass of a 22-G needle was applied with or without aspiration. In the other group, the method mainly used in Western countries was performed in which three passes of a 25-G needle with non-aspiration were undertaken for thyroid nodules...
May 2015: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/26114752/the-impact-of-noninvasive-follicular-variant-of-papillary-thyroid-carcinoma-on-rates-of-malignancy-for-fine-needle-aspiration-diagnostic-categories
#11
Kyle C Strickland, Brooke E Howitt, Ellen Marqusee, Erik K Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta
BACKGROUND: Increased recognition of the indolent nature of noninvasive follicular variant of papillary thyroid carcinoma (NFVPTC) along with greater insight into the molecular alterations of these tumors has prompted endocrine pathologists to question whether these tumors warrant a diagnosis of carcinoma. However, a change in terminology would affect the rates of malignancy of fine-needle aspiration (FNA) diagnostic categories. Therefore, the aim of this study was to determine the percentage decrease in associated risk of malignancy for each FNA diagnostic category if NFVPTCs were no longer termed carcinomas...
September 2015: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/25926393/molecular-analysis-of-residual-thinprep-material-from-thyroid-fnas-increases-diagnostic-sensitivity
#12
Jeffrey F Krane, Edmund S Cibas, Erik K Alexander, Ralf Paschke, Markus Eszlinger
BACKGROUND: Molecular testing for genetic alterations associated with malignancy is a potential triage approach for thyroid fine-needle aspiration (FNA) samples with indeterminate cytology. Because liquid-based FNA material allows for efficient RNA extraction, the authors analyzed residual material for common point mutations and rearrangements. METHODS: Thyroid FNAs were classified according to The Bethesda System for Reporting Thyroid Cytopathology after routine ThinPrep slide preparation...
June 2015: Cancer Cytopathology
https://www.readbyqxmd.com/read/25369542/fine-needle-aspiration-biopsy-of-secondary-neoplasms-of-the-thyroid-gland-a-multi-institutional-study-of-62-cases
#13
MULTICENTER STUDY
Marc Pusztaszeri, He Wang, Edmund S Cibas, Celeste N Powers, Massimo Bongiovanni, Syed Ali, Kamal K Khurana, Paul J Michaels, William C Faquin
BACKGROUND: Secondary neoplasms of the thyroid gland (SNTGs) are uncommon, and it is important to recognize them in thyroid fine-needle aspiration biopsy (FNAB). METHODS: The authors report a cohort of 62 SNTGs from 7 institutions in the United States and Europe. Patients were identified retrospectively by searching through medical records of the respective institutions. All initial diagnoses were rendered by FNAB. RESULTS: SNTGs represented 0...
January 2015: Cancer Cytopathology
https://www.readbyqxmd.com/read/24891128/fnab-of-benign-thyroid-nodules-with-papillary-hyperplasia-a-cytological-and-histological-evaluation
#14
Marc P Pusztaszeri, Jeffrey F Krane, Edmund S Cibas, Gilbert Daniels, William C Faquin
BACKGROUND: Benign thyroid nodules with papillary hyperplasia (BTN-PH) are sometimes misinterpreted cytologically as papillary thyroid carcinoma (PTC). We evaluated a fine-needle aspiration biopsy (FNAB) series of BTN-PH to identify the causes of diagnostic error and to better define its cytologic criteria. METHODS: A total of 48 FNAB cases of histologically confirmed BTN-PHs from 44 patients were identified from our archives. The available cytological and histological slides were reviewed and scored for 10 cytomorphological features...
September 2014: Cancer Cytopathology
https://www.readbyqxmd.com/read/24345455/how-are-childhood-thyroid-nodules-discovered-opportunities-for-improving-early-detection
#15
Anjuli Gupta, Samantha Ly, Luciana A Castroneves, Mary C Frates, Carol B Benson, Henry A Feldman, Ari J Wassner, Jessica R Smith, Ellen Marqusee, Erik K Alexander, Justine Barletta, Funmilayo Muyide, Peter M Doubilet, Hope E Peters, Susan Webb, Biren P Modi, Harriet J Paltiel, Yolanda Martins, Kelly Burmeister, Harry Kozakewich, Monica Hollowell, Edmund S Cibas, Francis D Moore, Robert C Shamberger, P Reed Larsen, Stephen A Huang
In a retrospective analysis of childhood thyroid nodules, 18% were radiographic incidentalomas and 41% were discovered by a clinician's palpation; 40% were discovered by patients' families. The latter group had the largest nodules and highest rates of thyroid cancer metastasis, suggesting opportunities for earlier detection through annual well-child visits.
March 2014: Journal of Pediatrics
https://www.readbyqxmd.com/read/24276452/determination-of-the-optimal-time-interval-for-repeat-evaluation-after-a-benign-thyroid-nodule-aspiration
#16
Eric Nou, Norra Kwong, Lukas K Alexander, Edmund S Cibas, Ellen Marqusee, Erik K Alexander
INTRODUCTION: The optimal timing for repeat evaluation of a cytologically benign thyroid nodule greater than 1 cm is uncertain. Arguably, the most important determinant is the disease-specific mortality resulting from an undetected thyroid cancer. Presently there exist no data that evaluate this important end point. METHODS: We studied the long-term status of all patients evaluated in our thyroid nodule clinic between 1995 and 2003 with initially benign fine-needle aspiration (FNA) cytology...
February 2014: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24026318/a-prospective-assessment-defining-the-limitations-of-thyroid-nodule-pathologic-evaluation
#17
MULTICENTER STUDY
Edmund S Cibas, Zubair W Baloch, Giovanni Fellegara, Virginia A LiVolsi, Stephen S Raab, Juan Rosai, James Diggans, Lyssa Friedman, Giulia C Kennedy, Richard T Kloos, Richard B Lanman, Susan J Mandel, Nicole Sindy, David L Steward, Martha A Zeiger, Bryan R Haugen, Erik K Alexander
BACKGROUND: Clinical management of thyroid neoplasms is based on light microscopic diagnosis, but its accuracy and precision are poorly defined. OBJECTIVE: To assess inter- and intraobserver variability of preoperative cytopathologic and postoperative histopathologic thyroid diagnoses. DESIGN: Samples were collected in a prospective, multicenter trial validating a gene expression classifier between June 2009 and December 2010. SETTING: 14 academic and 35 community clinical sites...
September 3, 2013: Annals of Internal Medicine
https://www.readbyqxmd.com/read/23860349/fine-needle-aspiration-of-primary-langerhans-cell-histiocytosis-of-the-thyroid-gland-a-potential-mimic-of-papillary-thyroid-carcinoma
#18
Marc P Pusztaszeri, Kenan J Sauder, Edmund S Cibas, William C Faquin
The clinical presentation of Langerhans cell histiocytosis (LCH) as a primary solitary nodule in the thyroid gland is rare. As a result, there are few reports of its cytologic features in thyroid aspirates where it can pose a diagnostic pitfall. CASE AND CONCLUSION: To foster familiarity with its cytomorphology, we report the fine-needle aspiration biopsy (FNAB) findings of 3 specimens from 2 patients with LCH presenting as a solitary thyroid nodule. All aspirates contained numerous dispersed cells with prominent nuclear grooves, and the background showed a mixed pattern of chronic inflammation including scattered eosinophils...
2013: Acta Cytologica
https://www.readbyqxmd.com/read/23737541/a-standardized-assessment-of-thyroid-nodules-in-children-confirms-higher-cancer-prevalence-than-in-adults
#19
COMPARATIVE STUDY
Anjuli Gupta, Samantha Ly, Luciana A Castroneves, Mary C Frates, Carol B Benson, Henry A Feldman, Ari J Wassner, Jessica R Smith, Ellen Marqusee, Erik K Alexander, Justine Barletta, Peter M Doubilet, Hope E Peters, Susan Webb, Biren P Modi, Harriet J Paltiel, Harry Kozakewich, Edmund S Cibas, Francis D Moore, Robert C Shamberger, P Reed Larsen, Stephen A Huang
CONTEXT: Thyroid cancer is the most common endocrine malignancy, but due to its rare occurrence in the pediatric population, the cancer risk of childhood thyroid nodules is incompletely defined, and optimal management of children with suspected nodules is debated. OBJECTIVE: The aim was to study the presenting features and cancer risk of sporadic childhood thyroid nodules using a standardized clinical assessment and management plan. DESIGN AND SETTING: Boston Children's Hospital and Brigham and Women's Hospital collaborated to create a multidisciplinary pediatric thyroid nodule clinic and implement a standardized assessment plan...
August 2013: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23275525/thyroid-nodule-size-and-prediction-of-cancer
#20
Sophia C Kamran, Ellen Marqusee, Mathew I Kim, Mary C Frates, Julie Ritner, Hope Peters, Carol B Benson, Peter M Doubilet, Edmund S Cibas, Justine Barletta, Nancy Cho, Atul Gawande, Daniel Ruan, Francis D Moore, Karla Pou, P Reed Larsen, Erik K Alexander
CONTEXT: Thyroid nodule size is routinely measured, although its impact on thyroid cancer risk is unclear. OBJECTIVE: Our objective was to evaluate the association of nodule size upon cancer risk. DESIGN, SETTING, AND PATIENTS: We conducted a retrospective cohort analysis at an academic hospital with 4955 consecutive patients evaluated between 1995 and 2009. INTERVENTION: Ultrasound and ultrasound-guided fine-needle aspiration of nodules >1 cm was done...
February 2013: Journal of Clinical Endocrinology and Metabolism
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