keyword
https://read.qxmd.com/read/38545184/association-of-non-hdl-c-apob-ratio-with-long-term-mortality-in-the-general-population-a-cohort-study
#1
JOURNAL ARTICLE
Kerui Zhang, Chenchen Wei, Yaqing Shao, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Yuan Li, Zhongshan Gou
BACKGROUND: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable indicator for assessing the risk of cardiovascular disease. However, the ability of non-HDL-C/apoB ratio to predict the risk of long-term mortality among the general population remains uncertain. The aim of this study is to explore the association of non-HDL-C/apoB ratio with long-term all-cause and cardiovascular mortality in adults of the United States...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38535329/effect-of-adding-apolipoprotein-b-testing-on-the-prevalence-of-dyslipidemia-and-risk-of-cardiovascular-disease-in-the-korean-adult-population
#2
JOURNAL ARTICLE
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Traditional lipid parameters-including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and non-HDL-C (calculated as TC minus HDL-C)-have long been used as indicators of cardiovascular disease (CVD) risk. The laboratory records of 9604 Korean adults who underwent traditional lipid panel tests (TC, TG, and HDL), as well as ApoB testing, were analyzed to evaluate the prevalence of dyslipidemia and high CVD risk (utilizing the NCEP ATP III criteria for traditional lipid panels and various ApoB test cutoffs recommended by international guidelines (145 mg/dL, 130 mg/dL, and 100 mg/dL))...
March 18, 2024: Metabolites
https://read.qxmd.com/read/38532495/sex-and-statin-related-genetic-associations-at-the-pcsk9-gene-locus-results-of-genome-wide-association-meta-analysis
#3
JOURNAL ARTICLE
Janne Pott, Azin Kheirkhah, Jesper R Gadin, Marcus E Kleber, Graciela E Delgado, Holger Kirsten, Lukas Forer, Stefanie M Hauck, Ralph Burkhardt, Hubert Scharnagl, Markus Loeffler, Winfried März, Joachim Thiery, Christian Gieger, Annette Peters, Angela Silveira, Ferdinand Van't Hooft, Florian Kronenberg, Markus Scholz
BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key player of lipid metabolism with higher plasma levels in women throughout their life. Statin treatment affects PCSK9 levels also showing evidence of sex-differential effects. It remains unclear whether these differences can be explained by genetics. METHODS: We performed genome-wide association meta-analyses (GWAS) of PCSK9 levels stratified for sex and statin treatment in six independent studies of Europeans (8936 women/11,080 men respectively 14,825 statin-free/5191 statin-treated individuals)...
March 26, 2024: Biology of Sex Differences
https://read.qxmd.com/read/38525555/lactiplantibacillus-plantarum-strains-kabp011-kabp012-and-kabp013-modulate-bile-acids-and-cholesterol-metabolism-in-humans
#4
JOURNAL ARTICLE
T Padro, V de Santisteban, P Huedo, M Puntes, M Aguiló, J Espadaler-Mazo, L Badimon
AIMS: Probiotics with high bile salt hydrolase (BSH) activity have shown to promote cardiovascular health. However, their mechanism(s) of action remain poorly understood. Here, we performed a pilot exploratory study to investigate effects of a 4-week intervention with escalating doses of a BSH-active formula containing Lactiplantibacillus plantarum strains KABP011, KABP012 and KABP013 on bile acid (BA), lipid profile and lipoprotein function. METHODS AND RESULTS: Healthy overweight individuals were included in this study...
March 25, 2024: Cardiovascular Research
https://read.qxmd.com/read/38525353/%C3%AF-a-new-species-of-the-genus-soriculus-soricidae-eulipotyphla-mammalia-from-medog-in-the-eastern-himalaya
#5
JOURNAL ARTICLE
Xiaoxin Pei, Zhongzheng Chen, Quan Li, Xueyou Li, Changzhe Pu, Kang Luo, Jing Luo, Mingjin Pu, Hongjiao Wang, Laxman Khanal, Xuelong Jiang
Himalayan shrews of the genus Soriculus (Soricidae, Eulipotyphla), currently represented by four nominal species, are endemic to the Himalayas and the Gaoligong Mountains. In April 2022 and April 2023, a total of 10 specimens of Soriculus were collected from Beibeng and Damu, Medog County, Tibet, China. The morphology of the specimens was compared with the four recognised species of the genus Soriculus . Additionally, two mitochondrial ( Cyt b and 12S ) and three nuclear ( APOB , BRCAI and RAG2 ) genes were sequenced to test the phylogenetic relationships of these specimens with the other species...
2024: ZooKeys
https://read.qxmd.com/read/38522226/serum-lipids-and-cognitive-outcomes-in-multiple-sclerosis-a-systematic-review-and-meta-analysis
#6
REVIEW
Sarvin Sanaie, Narges Koohi, Reza Mosaddeghi-Heris, Shirin Rezai, Elahe Movagharnia, Hanie Karimi, Seyedehyasmin Moghaddamziabari, Sina Hamzehzadeh, Elnaz Gholipour-Khalili, Mahnaz Talebi, Amirreza Naseri
BACKGROUND: Cognitive impairment is highly prevalent in multiple sclerosis (MS) with poorly understood underlying mechanisms. Lipids are considered to be associated with MS progression through the inflammatory and oxidative stress pathways, brain atrophy, cellular signaling, and tissue physiology. In addition, serum lipids are proposed as a modifiable factor affecting the neuropsychiatric condition; therefore, this study aims to assess the association between serum lipid levels and cognitive outcomes in MS...
February 29, 2024: Multiple Sclerosis and related Disorders
https://read.qxmd.com/read/38518848/substitution-of-dietary-monounsaturated-fatty-acids-from-olive-oil-for-saturated-fatty-acids-from-lard-increases-ldl-apolipoprotein-b-100-fractional-catabolic-rate-in-subjects-with-dyslipidemia-associated-with-insulin-resistance-a-randomized-controlled-trial
#7
JOURNAL ARTICLE
Louis-Charles Desjardins, Francis Brière, André J Tremblay, Maryka Rancourt-Bouchard, Jean-Philippe Drouin-Chartier, Jacques Corbeil, Valéry Lemelin, Amélie Charest, Ernst J Schaefer, Benoît Lamarche, Patrick Couture
BACKGROUND: The substitution of monounsaturated acids (MUFAs) for saturated fatty acids (SFAs) is recommended for cardiovascular disease prevention but its impact on lipoprotein metabolism in subjects with dyslipidemia associated with insulin resistance (IR) remains largely unknown. OBJECTIVE: This study aimed to evaluate the impact of substituting MUFAs for SFAs on the in vivo kinetics of apolipoprotein (apo)B-containing lipoproteins and on the plasma lipidomic profile in adults with IR-induced dyslipidemia...
March 20, 2024: American Journal of Clinical Nutrition
https://read.qxmd.com/read/38514665/identification-of-a-novel-ldlr-p-glu179met-variant-in-thai-families-with-familial-hypercholesterolemia-and-response-to-treatment-with-pcsk9-inhibitor
#8
JOURNAL ARTICLE
Burabha Pussadhamma, Chaiyasith Wongvipaporn, Atthakorn Wutthimanop, Manit Nuinoon, Sureerut Porntadavity, Nutjaree Jeenduang
Familial hypercholesterolemia (FH) is a genetic disease characterized by elevated LDL-C levels. In this study, two FH probands and 9 family members from two families from northeastern Thailand were tested for LDLR, APOB, and PCSK9 variants by whole-exome sequencing, PCR-HRM, and Sanger sequencing. In silico analysis of LDLR was performed to analyse its structure‒function relationship. A novel variant of LDLR (c.535_536delinsAT, p.Glu179Met) was detected in proband 1 and proband 2 in homozygous and heterozygous forms, respectively...
March 21, 2024: Scientific Reports
https://read.qxmd.com/read/38514330/-the-diagnostic-value-of-genetic-testing-in-familial-hypercholesterolemia-in-patients-with-premature-myocardial-infarction
#9
JOURNAL ARTICLE
Y X Cui, J X Song, Z Y Li, S F Li, C F Liu, H Chen
Objective: To evaluate the diagnostic value of gene testing in familial hypercholesterolemia (FH) in patients with premature myocardial infarction(PMI). Methods: This study was a single center cross-sectional study. A retrospective analysis was made on PMI patients who visited the People's Hospital of Peking University from May 1, 2015 to March 31, 2017. Clinical data of patients was collected and gene testing of FH related genes low density lipoprotein receptor (LDLR), proprotein convertase subtilisin/kexin type 9 (PCSK9), apolipoprotein B(APOB) and low density lipoprotein receptor adaptor protein 1(LDLRAP1) was carried out...
March 24, 2024: Zhonghua Xin Xue Guan Bing za Zhi
https://read.qxmd.com/read/38513732/role-of-interleukin-6-signaling-pathway-in-the-anti-inflammatory-effects-of-statins-on-coronary-artery-disease-evidence-from-mendelian-randomization-analysis
#10
JOURNAL ARTICLE
Mojgan Yazdanpanah, Nahid Yazdanpanah, Mojtaba Chardoli, Abbas Dehghan
BACKGROUND: Statins are currently widely used in the prevention of coronary artery disease (CAD) primarily for lipid-lowering with a potential anti-inflammatory effect. However, it is not clear if their potential anti-inflammatory effects are mediated through the interleukin 6 (IL-6) signaling pathway. METHODS: Using the Mendelian randomization (MR) approach followed by multivariable MR analyses, we examined the extent to which the effects of statins on CAD might be mediated through the IL-6 signaling pathway...
March 19, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38513336/high-prevalence-of-familial-hypercholesterolemia-due-to-the-founder-effect-of-the-ldlr-c-2271del-variant-in-communities-of-oaxaca-mexico
#11
JOURNAL ARTICLE
Perla Graciela Rodríguez-Gutiérrez, Teresita de Jesús Hernández-Flores, Paola Montserrat Zepeda-Olmos, Christian Daniel Reyes-Rodríguez, Kiabeth Robles-Espinoza, Ulises Solís-Gómez, Juan Ramón González-García, María Teresa Magaña-Torres
INTRODUCTION: In Mexico, familial hypercholesterolemia (FH) is underdiagnosed, but population screening in small communities where at least one homozygous patient has already been detected results in a useful and inexpensive approach to reduce this problem. Considering that we previously reported nine homozygous cases from the state of Oaxaca, we decided to perform a population screening to identify patients with FH and to describe both their biochemical and genetic characteristics. METHODS: LDL cholesterol (LDLc) was quantified in 2,093 individuals from 11 communities in Oaxaca; either adults with LDLc levels ≥170 mg/dL or children with LDLc ≥130 mg/dL were classified as suggestive of FH and therefore included in the genetic study...
March 20, 2024: Archives of Medical Research
https://read.qxmd.com/read/38511326/remnant-cholesterol-not-ldl-cholesterol-explains-peripheral-artery-disease-risk-conferred-by-apob-a-cohort-study
#12
JOURNAL ARTICLE
Benjamin N Wadström, Kasper M Pedersen, Anders B Wulff, Børge G Nordestgaard
BACKGROUND: Elevated apoB-containing lipoproteins (=remnants+LDLs [low-density lipoproteins]) are a major risk factor for atherosclerotic cardiovascular disease, including peripheral artery disease (PAD) and myocardial infarction. We tested the hypothesis that remnants and LDL both explain part of the increased risk of PAD conferred by elevated apoB-containing lipoproteins. For comparison, we also studied the risk of chronic limb-threatening ischemia and myocardial infarction. METHODS: apoB, remnant cholesterol, and LDL cholesterol were measured in 93 461 individuals without statin use at baseline from the Copenhagen General Population Study (2003-2015)...
March 21, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38491971/the-association-of-circulating-lipoprotein-lipids-and-apolipoproteins-with-risk-of-endometriosis-a-mendelian-randomization-study
#13
JOURNAL ARTICLE
Xiwen He, Shengyu Xie, Yi Liu
BACKGROUND: Endometriosis is a poorly understood disease that affects up to 196 million women worldwide and imposes high costs in terms of economic burden and quality of life of women. Traits of circulating lipids have been related to the onset and progression of endometriosis in previous observational studies but the results have remained contradictory. METHODS: We performed univariable and multivariable Mendelian randomization (MR) analyses using instrument variables to genetically predict the associations of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglycerides, and apolipoprotein (apo) A-I and B from the UK Biobank with endometriosis (consisting of 8288 cases and 68 969 controls from the FinnGen consortium)...
March 16, 2024: Postgraduate Medical Journal
https://read.qxmd.com/read/38490635/a-targeted-proteomics-method-for-quantifying-plasma-apolipoprotein-kinetics-in-individual-mice-using-stable-isotope-labeling
#14
JOURNAL ARTICLE
Baohai Shao, Masami Shimizu-Albergine, Farah Kramer, Jenny E Kanter, Jay W Heinecke, Tomas Vaisar, Bettina Mittendorfer, Bruce W Patterson, Karin E Bornfeldt
Altered apolipoprotein kinetics play a critical role in promoting dyslipidemia and atherogenesis. Human apolipoprotein kinetics have been extensively evaluated, but similar studies in mice are hampered by the lack of robust methods suitable for the small amounts of blood that can be collected at sequential time points from individual mice. We describe a targeted liquid chromatography tandem mass spectrometry method for simultaneously quantifying the stable isotope enrichment of several apolipoproteins represented by multiple peptides in serial blood samples (15 μL each) obtained after retro-orbital injection of 13 C6 ,15 N2 -lysine (Lys8) in mice...
March 13, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38482694/zebrafish-apob-containing-lipoprotein-metabolism-a-closer-look
#15
REVIEW
Tabea Moll, Steven A Farber
Zebrafish have become a powerful model of mammalian lipoprotein metabolism and lipid cell biology. Most key proteins involved in lipid metabolism, including cholesteryl ester transfer protein, are conserved in zebrafish. Consequently, zebrafish exhibit a human-like lipoprotein profile. Zebrafish with mutations in genes linked to human metabolic diseases often mimic the human phenotype. Zebrafish larvae develop rapidly and externally around the maternally deposited yolk. Recent work revealed that any disturbance of lipoprotein formation leads to the accumulation of cytoplasmic lipid droplets and an opaque yolk, providing a visible phenotype to investigate disturbances of the lipoprotein pathway, already leading to discoveries in microsomal triglyceride transfer protein and ApoB (apolipoprotein B)...
March 14, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38478535/impact-of-genetic-background-as-a-risk-factor-for-atherosclerotic-cardiovascular-disease-a-protocol-for-a-nationwide-genetic-case-control-cv-genes-study-in-brazil
#16
JOURNAL ARTICLE
Haliton Alves de Oliveira, Precil Diego Miranda de Menezes Neves, Gustavo Bernardes de Figueiredo Oliveira, Frederico Rafael Moreira, Maria Carolina Tostes Pintão, Viviane Zorzanelli Rocha, Cristiane de Souza Rocha, Viviane Nakano Katz, Elisa Napolitano Ferreira, Diana Rojas-Málaga, Celso Ferraz Viana, Fabiula Fagundes da Silva, Juliete Jorge Vidotti, Natalia Mariana Felicio, Leticia de Araújo Vitor, Karina Gimenez Cesar, Camila Araújo da Silva, Lucas Bassolli de Oliveira Alves, Álvaro Avezum
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based studies. Due to the polygenic nature of ASCVD, we aimed to assess the association of genomics with ASCVD risk and its impact on the occurrence of acute myocardial infarction, stroke, or peripheral artery thrombotic-ischemic events at population level. CardioVascular Genes (CV-GENES) is a nationwide, multicenter, 1:1 case-control study of 3,734 patients in Brazil...
2024: PloS One
https://read.qxmd.com/read/38469394/betaine-alleviates-high-fat-diet-induced-excessive-lipid-deposition-in-gibel-carp-hepatopancreas-and-l8824-cells-by-enhancing-vldl-secretion-through-hnf4-%C3%AE-mttp-pathway
#17
JOURNAL ARTICLE
Xiaojing Dong, Jianqiao Wang, Mengjie Zhao, Xuedi Du, Hongying Fan, Yuanyuan Fu, Zhiyuan Gong, Shuyan Miao
Betaine, a methyl donor, plays a crucial role in lipid metabolism. Previous studies have shown that appropriate betaine supplementation in a high-fat diet reduces triglycerides (TG) of serum and hepatopancreas in fish. However, the underlying mechanism remains unclear. This study examined whether betaine can enhance the secretion of very low-density lipoprotein (VLDL) and sought to identify the specific mechanisms through which this enhancement occurs. A lipid accumulation model was established in gibel carp and L8824 cells using a high-fat diet and oleic acid, respectively...
2024: Aquaculture Nutrition
https://read.qxmd.com/read/38465912/basic-and-translational-evidence-supporting-the-role-of-tm6sf2-in-vldl-metabolism
#18
JOURNAL ARTICLE
Jing Liu, Henry N Ginsberg, Gissette Reyes-Soffer
PURPOSE OF REVIEW: Transmembrane 6 superfamily member 2 (TM6SF2) gene was identified through exome-wide studies in 2014. A genetic variant from glutamic acid to lysine substitution at amino acid position 167 (NM_001001524.3:c.499G> A) (p.Gln167Lys/p.E167K, rs58542926) was discovered (p.E167K) to be highly associated with increased hepatic fat content and reduced levels of plasma triglycerides and LDL cholesterol. In this review, we focus on the discovery of TM6SF2 and its role in VLDL secretion pathways...
March 11, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38458338/causal-association-of-blood-lipids-with-all-cause-and-cause-specific-mortality-risk-a-mendelian-randomization-study
#19
JOURNAL ARTICLE
Jiawen Lu, Zhenqian Wang, Jiaying Zhang, Feng Jiao, Chenfeng Zou, Liyuan Han, Guozhi Jiang
Dyslipidemia has long been implicated in elevating mortality risk; yet the precise associations between lipid traits and mortality remained undisclosed. Our study aimed to explore the causal effects of lipid traits on both all-cause and cause-specific mortality. One-sample Mendelian randomization (MR) with linear and nonlinear assumptions was conducted in a cohort of 407,951 European participants from the UK Biobank. Six lipid traits, consisting of low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and lipoprotein(a), were included to investigate the causal associations with mortality...
March 6, 2024: Journal of Lipid Research
https://read.qxmd.com/read/38456474/effects-of-bempedoic-acid-on-markers-of-inflammation-and-lp-a
#20
JOURNAL ARTICLE
Sukhila Reddy, Abhizith Deoker
PURPOSE OF REVIEW: To study the effect of bempedoic acid on markers of inflammation and lipoprotein (a) to help determine if the drug would be useful to treat patients with elevated cardiovascular risks and residual cardiovascular risk despite optimal low-density lipoprotein cholesterol (LDL-C) levels. RECENT FINDINGS: Bempedoic acid is found to cause significant reduction in LDL-C and high-sensitivity C-reactive protein (hs-CRP) in various randomized clinical trials...
March 5, 2024: Current Opinion in Cardiology
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