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https://www.readbyqxmd.com/read/28110289/associations-of-apolipoprotein-b-apolipoprotein-a-i-ratio-with-pre-diabetes-and-diabetes-risks-a-cross-sectional-study-in-chinese-adults
#1
Shuang Zheng, Tingting Han, Hua Xu, Huan Zhou, Xingxing Ren, Peihong Wu, Jun Zheng, Lihua Wang, Ming Zhang, Yihong Jiang, Yawen Chen, Huiying Qiu, Wei Liu, Yaomin Hu
BACKGROUND: Apolipoprotein B/apolipoprotein A-I (ApoB/ApoA-I) ratio is a useful predictor of cardiovascular risk. However, the association between the ApoB/ApoA-I ratio and the risk of type 2 diabetes mellitus (T2DM) is still obscure. AIMS: To investigate the associations between the ApoB/ApoA-I ratio and the risk of T2DM and pre-diabetes in a Chinese population, and to assess the role of gender in these associations. METHODS: A stratified random sampling design was used in this cross-sectional study which included 264 men and 465 women with normal glucose tolerance (NGT), pre-diabetes or T2DM...
January 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28106941/serum-apob-levels-independently-predict-the-development-of-non-alcoholic-fatty-liver-disease-a-7-year-prospective-study
#2
Jinghua Wang, Wanlin Zhu, Shujun Huang, Lei Xu, Min Miao, Chenjiao Wu, Chaohui Yu, Youming Li, Chengfu Xu
BACKGROUND & AIMS: Cross-sectional studies have shown that apolipoprotein B (apoB) is positively associated with the prevalence of non-alcoholic fatty liver disease (NAFLD). This study aimed to investigate the prospective relationship between the serum apoB levels and the development of NAFLD in a Chinese population. METHODS: A cohort of 7077 initially NAFLD-free participants was enrolled in this prospectively study. The incidence of NAFLD was calculated among participants with different baseline serum apoB quintiles...
January 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28104544/molecular-genetics-of-familial-hypercholesterolemia-in-israel-revisited
#3
Ronen Durst, Uche Ken Ibe, Shoshi Shpitzen, Daniel Schurr, Osnat Eliav, Marta Futema, Ros Whittall, Auryan Szalat, Vardiella Meiner, Hilla Knobler, Dov Gavish, Yaakov Henkin, Avishay Ellis, Ardon Rubinstein, Dror Harats, Rafael Bitzur, Bruno Hershkovitz, Steve E Humphries, Eran Leitersdorf
BACKGROUND AND AIMS: Familial hypercholesterolemia (FH) is an autosomal dominant disease caused by mutations in the genes for LDL receptor (LDLR), apolipoprotein B (APOB) and proprotein convertase subtilisin/kexin type9 (PCSK9). The purpose of the current investigation was to define the current spectrum of mutations causing FH in Israel. METHODS: New families were collected through the MEDPED (Make Early Diagnosis Prevent Early Death) FH program. Molecular analysis of the LDLR, PCSK9 and APOB genes was done using High Resolution Melt and direct sequencing in 67 index cases...
December 18, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28101967/host-related-factors-explaining-interindividual-variability-of-carotenoid-bioavailability-and-tissue-concentrations-in-humans
#4
Torsten Bohn, Charles Desmarchelier, Lars O Dragsted, Charlotte S Nielsen, Wilhelm Stahl, Ralph Rühl, Jaap Keijer, Patrick Borel
Carotenoid dietary intake and their endogenous levels have been associated with a decreased risk of several chronic diseases. There are indications that carotenoid bioavailability depends, in addition to the food matrix, on host factors. These include diseases (e.g. colitis), life-style habits (e.g. smoking), gender and age, as well as genetic variations including single nucleotide polymorphisms that govern carotenoid metabolism. These are expected to explain interindividual differences that contribute to carotenoid uptake, distribution, metabolism and excretion, and therefore possibly also their association with disease risk...
January 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28095410/cardiomyocyte-regulation-of-systemic-lipid-metabolism-by-the-apolipoprotein-b-containing-lipoproteins-in-drosophila
#5
Sunji Lee, Hong Bao, Zachary Ishikawa, Weidong Wang, Hui-Ying Lim
The heart has emerged as an important organ in the regulation of systemic lipid homeostasis; however, the underlying mechanism remains poorly understood. Here, we show that Drosophila cardiomyocytes regulate systemic lipid metabolism by producing apolipoprotein B-containing lipoproteins (apoB-lipoproteins), essential lipid carriers that are so far known to be generated only in the fat body. In a Drosophila genetic screen, we discovered that when haplo-insufficient, microsomal triglyceride transfer protein (mtp), required for the biosynthesis of apoB-lipoproteins, suppressed the development of diet-induced obesity...
January 17, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28087520/atheroprotective-vaccination-with-mhc-ii-restricted-apob-peptides-induces-peritoneal-il-10-producing-cd4-t-cells
#6
Takayuki Kimura, Kevin Tse, Sara McArdle, Teresa Gerhardt, Jacqueline Miller, Zbigniew Mikulski, John Sidney, Alessandro Sette, Dennis Wolf, Klaus Ley
Although immunization with MHC class II-restricted ApoB peptides has been shown to be atheroprotective, the mechanism is unclear. Here, we investigated CD4(+) T cell populations in immunized atherosclerotic mice. Peptides (16-mers) from mouse ApoB, the core protein of low-density lipoprotein (LDL), were screened for binding to I-A(b) by computer prediction and confirmed by radiolabeled peptide competition. Three new peptides, P101 (FGKQGFFPDSVNKALY, 5.5 nM IC50), P102 (TLYALSHAVNSYFDVD, 6.8 nM), and P103 (LYYKEDKTSLSASAAS, 95 nM) were tested in an atherosclerosis model (Apoe(-/-) mice on western diet)...
January 13, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28086886/biochemical-mechanism-underlying-hypertriglyceridemia-and-hepatic-steatosis-hepatomegaly-induced-by-acute-schisandrin-b-treatment-in-mice
#7
Yi Zhang, Jing Zhao, Shu-Feng Zhou, Zhi-Ling Yu, Xiao-Yan Wang, Pei-Li Zhu, Zhu-Sheng Chu, Si-Yuan Pan, Ming Xie, Kam-Ming Ko
BACKGROUND: It has been demonstrated that acute oral administration of schisandrin B (Sch B), an active dibenzocyclooctadiene isolated from Schisandrae Fructus (a commonly used traditional Chinese herb), increased serum and hepatic triglyceride (TG) levels and hepatic mass in mice. The present study aimed to investigate the biochemical mechanism underlying the Sch B-induced hypertriglyceridemia, hepatic steatosis and hepatomegaly. METHODS: Male ICR mice were given a single oral dose of Sch B (0...
January 13, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28077518/th17-cytokine-responses-in-lyme-disease-correlate-with-borreliaburgdorferi-antibodies-during-early-infection-in-patients-with-erythema-migrans-and-with-autoantibodies-late-in-the-illness-in-patients-with-antibiotic-refractory-lyme-arthritis
#8
Klemen Strle, Katherine B Sulka, Annalisa Pianta, Jameson T Crowley, Sheila L Arvikar, Anthony Anselmo, Ruslan Sadreyev, Allen C Steere
BACKGROUND: Control of Lyme disease is attributed predominantly to innate and adaptive TH1 immune responses, whereas the role of TH17 responses is less clear. Here we characterized these inflammatory responses in patients with erythema migrans (EM) or Lyme arthritis (LA) to elucidate their role early and late in the infection. METHODS: Levels of 21 cytokines and chemokines, representative of innate, TH1, and TH17 immune responses, were assessed by Luminex in acute and convalescent sera from 91 EM patients, in serum and synovial fluid from 141 LA patients, and in serum from 57 healthy subjects...
January 11, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28072742/the-nonlinear-association-between-apolipoprotein-b-to-apolipoprotein-a1-ratio-and-type-2-diabetes
#9
Yong Mao, Yang Xu, Leihong Lu
The ratio of ApoB/apolipoprotein A1 (ApoA1) has been found to be associated with type 2 diabetes, and it was proposed as a new biomarker for type 2 diabetes predictions. Previous studies have assumed that the association between apoB/apoA1 and type 2 diabetes was linear. However, the linearity assumption has rarely been examined. In the present study, we aimed to examine whether this association showed a linear trend in a nationally representative population.Participants aged 18 years and over (n = 8220) were selected from the China Health Nutrition Survey (CHNS)...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28069890/apobec1-complementation-factor-a1cf-is-not-required-for-c-to-u-rna-editing-in-vivo
#10
Elizabeth M Snyder, Christopher McCarty, Adrienne Mehalow, Karen Svenson, Stephen Murray, Ron Korstanje, Robert E Braun
Editing of the human and murine ApoB mRNA by APOBEC1, the catalytic enzyme of the protein complex that catalyzes C-to-U RNA editing, creates an internal stop codon within the APOB coding sequence, generating two protein isoforms. It has been long held that APOBEC1-mediated editing activity is dependent on the RNA binding protein A1CF. The importance of A1CF in adult tissues has been unclear as a previously reported null allele displays embryonic lethality. This work aimed to address the function of A1CF in adult mouse tissues using a conditional A1cf allele...
January 9, 2017: RNA
https://www.readbyqxmd.com/read/28062946/upregulated-absorption-of-dietary-palmitic-acids-with-changes-in-intestinal-transporters-in-non-alcoholic-steatohepatitis-nash
#11
Hiroki Utsunomiya, Yasunori Yamamoto, Eiji Takeshita, Yoshio Tokumoto, Fujimasa Tada, Teruki Miyake, Masashi Hirooka, Masanori Abe, Teru Kumagi, Bunzo Matsuura, Yoshio Ikeda, Yoichi Hiasa
BACKGROUND: Palmitic acid is an important risk factor for the pathogenesis of non-alcoholic steatohepatitis (NASH), but changes in palmitic acid intestinal absorption in NASH are unclear. The aim of this study was to clarify changes in palmitic acid intestinal absorption and their association with the pathogenesis of NASH. METHODS: A total of 106 participants were recruited to the study, of whom 33 were control subjects (control group), 32 were patients with NASH Brunt stage 1-2 [early NASH (e-NASH)], and 41 were patients with NASH Brunt stage 3-4 [advanced NASH (a-NASH)]...
January 6, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28062492/poliovirus-receptor-related-2-a-cholesterol-responsive-gene-affecting-atherosclerosis-development-by-modulating-leukocyte-migration
#12
Aránzazu Rossignoli, Ming-Mei Shang, Hanna Gladh, Christine Moessinger, Hassan Foroughi Asl, Husain Ahammad Talukdar, Oscar Franzén, Steffen Mueller, Johan L M Björkegren, Erika Folestad, Josefin Skogsberg
OBJECTIVE: Recently, poliovirus receptor-related 2 (Pvrl2) emerged as a top gene in a global gene expression study aiming to detect plasma cholesterol-responsive genes causally related to atherosclerosis regression in hypercholesterolemic mice. PVRL2 is an adherens junction protein implied to play a role in transendothelial migration of leukocytes, a key feature in atherosclerosis development. In this study, we investigated the effect of Pvrl2 deficiency on atherosclerosis development and transendothelial migration of leukocytes activity...
January 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28062489/lipoprotein-a-mass-levels-increase-significantly-according-to-apoe-genotype-an-analysis-of-431%C3%A2-239-patients
#13
Patrick M Moriarty, Stephen A Varvel, Philip L S M Gordts, Joseph P McConnell, Sotirios Tsimikas
OBJECTIVE: Lipoprotein(a) [Lp(a)] levels are genetically determined by hepatocyte apolipoprotein(a) synthesis, but catabolic pathways also influence circulating levels. APOE genotypes have different affinities for the low-density lipoprotein (LDL) receptor and LDL-related protein-1, with ε2 having the weakest binding to LDL receptor at <2% relative to ε3 and ε4. APPROACH AND RESULTS: APOE genotypes (ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε3, ε3/ε4, and ε4/ε4), Lp(a) mass, directly measured Lp(a)-cholesterol levels, and a variety of apoB-related lipoproteins were measured in 431 239 patients...
January 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28056980/association-of-the-sptlc3-rs364585-polymorphism-and-serum-lipid-profiles-in-two-chinese-ethnic-groups
#14
Qing-Hui Zhang, Rui-Xing Yin, Hui Gao, Feng Huang, Jin-Zhen Wu, Shang-Ling Pan, Wei-Xiong Lin, De-Zhai Yang
BACKGROUND: Little is known about the association of the single nucleotide polymorphism (SNP) of rs364585 near serine palmitoyl-transferase long-chain base subunit 3 gene (SPTLC3) and serum lipid profiles. The present study was detected the association of the SPTLC3 rs364585 SNP and several environmental factors with serum lipid profiles in the Han and Jing populations. METHODS: Genotyping of the SPTLC3 rs364585 SNP was performed in 824 unrelated individuals of Han and 783 participants of Jing by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis, and then confirmed by direct sequencing...
January 5, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28054633/serum-apob-levels-in-depressive-patients-associated-with-cognitive-deficits
#15
Li Hui, Mei Han, Xiang Dong Du, Bao Hua Zhang, Shu Chang He, Tian Nan Shao, Guang Zhong Yin
Cognitive deficits have been regarded as one of the most significant clinical symptoms of depressive disorder. Accumulating evidence has shown that apolipoprotein B (ApoB) levels, which are responsible for inducing neurodegeneration, may be involved in cognitive deficits. This study examines cognitive deficits, and the correlation of serum ApoB levels with cognitive deficits of depressive disorder. 90 depressive patients and 90 healthy controls with matched age and gender were recruited. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053201/evidence-that-supports-the-prescription-of-low-carbohydrate-high-fat-diets-a-narrative-review
#16
Timothy David Noakes, Johann Windt
Low-carbohydrate high-fat (LCHF) diets are a highly contentious current topic in nutrition. This narrative review aims to provide clinicians with a broad overview of the effects of LCHF diets on body weight, glycaemic control and cardiovascular risk factors while addressing some common concerns and misconceptions. Blood total cholesterol and LDL-cholesterol concentrations show a variable, highly individual response to LCHF diets, and should be monitored in patients adhering to this diet. In contrast, available evidence from clinical and preclinical studies indicates that LCHF diets consistently improve all other markers of cardiovascular risk-lowering elevated blood glucose, insulin, triglyceride, ApoB and saturated fat (especially palmitoleic acid) concentrations, reducing small dense LDL particle numbers, glycated haemoglobin (HbA1c) levels, blood pressure and body weight while increasing low HDL-cholesterol concentrations and reversing non-alcoholic fatty liver disease (NAFLD)...
January 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28051891/the-relationship-between-thyroid-function-and-metabolic-changes-in-chinese-women-with-polycystic-ovary-syndrome
#17
Dongmei Yin, Xiangyan Ruan, Xuanxuan Tian, Juan Du, Yue Zhao, Yamei Cui, Yanglu Li, Alfred O Mueck
OBJECTIVES: Aim was to evaluate endocrine, metabolic and thyroid parameters which could help to explore the relationship between thyroid function and metabolic changes in Chinese polycystic ovary syndrome (PCOS) patients. METHODS: Within a prospective study in PCOS patients compared with healthy women, thyroid parameters were assessed, as well as changes of endocrine, metabolic and clinical characteristics. RESULTS: 144 PCOS patients and 48 normo-ovulatory women matched by age as controls were included...
January 4, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28045435/maternal-circulating-lipid-profile-during-early-pregnancy-racial-ethnic-differences-and-association-with-spontaneous-preterm-delivery
#18
Xinhua Chen, Theresa O Scholl, Thomas P Stein, Robert A Steer, Keith P Williams
Prior reports on the association between altered maternal serum lipid levels with preterm delivery are inconsistent. Ethnic differences in serum lipids during pregnancy and their relation to preterm delivery have not been studied. We examined the relationships of six maternal lipids during early pregnancy with the risk of spontaneous preterm delivery (SPTD). The design represents a case-control study nested within a large prospective, multiethnic cohort of young, generally healthy pregnant women. SPTD cases (n = 183) and controls who delivered at term (n = 376) were included...
January 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28040472/proatherogenic-effects-of-4-hydroxynonenal
#19
Anne Nègre-Salvayre, Sandra Garoby-Salom, Audrey Swiader, Myriam Rouahi, Mélanie Pucelle, Robert Salvayre
4-hydroxy-2-nonenal (HNE) is a α,β-unsaturated hydroxyalkenal generated by peroxidation of n-6 polyunsaturated fatty acid. This reactive carbonyl compound exhibits a huge number of biological properties that result mainly from the formation of HNE-adducts on free amino groups and thiol groups in proteins. In the vascular system, HNE adduct accumulation progressively leads to cellular dysfunction and tissue damages that are involved in the progression of atherosclerosis and related diseases. HNE contributes to the atherogenicity of oxidized LDL, by forming HNE-apoB adducts that deviate the LDL metabolism to the scavenger receptor pathway of macrophagic cells, and lead to the formation of foam cells...
December 28, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28035522/analysis-of-gene-candidate-snp-and-ancestral-origin-associated-to-obesity-and-postoperative-weight-loss-in-a-cohort-of-obese-patients-undergoing-rygb
#20
David Velázquez-Fernández, Gabriela Mercado-Celis, Jeny Flores-Morales, Diana Clavellina-Gaytán, Ramón Vidrio, Eduardo Vidrio, Maureen Mosti, Hugo Sánchez-Aguilar, Donaji Rodriguez, Pablo León, Miguel F Herrera
INTRODUCTION: Obesity is the result of a complex interaction between multiple genetic traits and psychological, behavioral, nutritional and environmental factors. OBJECTIVES: The aims of the study were (a) to comparatively evaluate the presence of 20 candidate gene single nucleotide polymorphisms (SNPs) in morbidly obese patients, (2) their association to comorbid conditions and (3) their impact on weight loss after a Roux-en-Y gastric bypass (RYGB). PATIENTS AND METHODS: Two hundred forty-nine patients were eligible for this study...
December 29, 2016: Obesity Surgery
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