Haliton Alves de Oliveira, Precil Diego Miranda de Menezes Neves, Gustavo Bernardes de Figueiredo Oliveira, Frederico Rafael Moreira, Maria Carolina Tostes Pintão, Viviane Zorzanelli Rocha, Cristiane de Souza Rocha, Viviane Nakano Katz, Elisa Napolitano Ferreira, Diana Rojas-Málaga, Celso Ferraz Viana, Fabiula Fagundes da Silva, Juliete Jorge Vidotti, Natalia Mariana Felicio, Leticia de Araújo Vitor, Karina Gimenez Cesar, Camila Araújo da Silva, Lucas Bassolli de Oliveira Alves, Álvaro Avezum
Atherosclerotic Cardiovascular Disease (ASCVD) represents the leading cause of death worldwide, and individual screening should be based on behavioral, metabolic, and genetic profile derived from data collected in large population-based studies. Due to the polygenic nature of ASCVD, we aimed to assess the association of genomics with ASCVD risk and its impact on the occurrence of acute myocardial infarction, stroke, or peripheral artery thrombotic-ischemic events at population level. CardioVascular Genes (CV-GENES) is a nationwide, multicenter, 1:1 case-control study of 3,734 patients in Brazil...
2024: PloS One