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https://www.readbyqxmd.com/read/28750217/association-of-hsd11b1-gene-polymorphisms-with-type-2-diabetes-and-metabolic-syndrome-in-south-indian-population
#1
Nayana Devang, Kapaettu Satyamoorthy, Padmalatha S Rai, M Nandini, Satish Rao, Nagaraja M Phani, Prabha Adhikari
BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type 1 (11β-HSD1) is an NADP or NADPH-dependent enzyme that generates cortisol from cortisone for a local glucocorticoid action. Functional polymorphisms within 11beta-hydroxysteroid dehydrogenase Type 1 (HSD11B1) gene have shown an association with various factors, including insulin resistance (IR) and hypertension. In our study, we have assessed the association of HSD11B1 (rs12086634 and rs846910) gene polymorphisms with type 2 diabetes (T2D) and metabolic syndrome (metS)...
July 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28749965/major-bioactive-phenolics-in-bergenia-species-from-the-indian-himalayan-region-method-development-validation-and-quantitative-estimation-using-uhplc-qqqlit-ms-ms
#2
Renu Pandey, Brijesh Kumar, Baleshwar Meena, Mukesh Srivastava, Tripti Mishra, Vandana Tiwari, Mahesh Pal, Narayanan K Nair, Dalip K Upreti, Tikam Singh Rana
Bergenia species are important medicinal plants used in indigenous systems of medicine for their antilithiatic and diuretic properties. An ultra-high performance liquid chromatography coupled to hybrid linear ion trap triple quadrupole mass spectrometry (UHPLC-QqQLIT-MS/MS) method has been developed and validated for the estimation of quantitative variation of eight major bioactive phenolics in the rhizomes (150 samples) of four species of this herb, Bergenia (B. ciliata, B. ligulata, B. purpurascens and B...
2017: PloS One
https://www.readbyqxmd.com/read/28749964/transmission-risk-of-two-chikungunya-lineages-by-invasive-mosquito-vectors-from-florida-and-the-dominican-republic
#3
Barry W Alto, Keenan Wiggins, Bradley Eastmond, Daniel Velez, L Philip Lounibos, Cynthia C Lord
Between 2014 and 2016 more than 3,800 imported human cases of chikungunya fever in Florida highlight the high risk for local transmission. To examine the potential for sustained local transmission of chikungunya virus (CHIKV) in Florida we tested whether local populations of Aedes aegypti and Aedes albopictus show differences in susceptibility to infection and transmission to two emergent lineages of CHIKV, Indian Ocean (IOC) and Asian genotypes (AC) in laboratory experiments. All examined populations of Ae...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28749780/the-prevalence-of-extended-spectrum-beta-lactamase-producing-multidrug-resistant-escherichia-coli-in-poultry-chickens-and-variation-according-to-farming-practices-in-punjab-india
#4
Charles H Brower, Siddhartha Mandal, Shivdeep Hayer, Mandeep Sran, Asima Zehra, Sunny J Patel, Ravneet Kaur, Leena Chatterjee, Savita Mishra, B R Das, Parminder Singh, Randhir Singh, J P S Gill, Ramanan Laxminarayan
BACKGROUND: Agricultural use of antimicrobials in subtherapeutic concentrations is increasing in response to the rising demand for food animal products worldwide. In India, the use of antimicrobials in food animal production is unregulated. Research suggests that many clinically important antimicrobials are used indiscriminately. This is the largest study to date in India that surveys poultry production to test for antimicrobial resistance and the occurrence of extended-spectrum (ESBLs) modulated by farming and managerial practices...
July 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28749643/non-communicable-disease-risk-factors-and-their-trends-in-india
#5
Suzanne Nethan, Dhirendra Sinha, Ravi Mehrotra
Background: India is a populous country of about 1.3 billion. Non communicable diseases (NCDs) contribute to around 5.87 million (60%) of all deaths in India. Hence, the objectives of this paper are to find baseline information on different NCD risk factors coverage and to determine their trends in India. Methods: For this systematic review, PubMed, Google and different surveillance systems were searched. Of the search results, 41 papers/survey reports were eventually assessed for eligibility. National and state representative data on NCD risk factors (for the major NCDs like cardiovascular diseases, chronic respiratory disease, cancer and diabetes) having World Health Organization(WHO) indicator definitions, covering rural and urban population, were included in the study...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749399/re-establishment-of-normal-radioactive-iodine-uptake-reference-range-in-the-era-of-universal-salt-iodization-in-the-indian-population
#6
Sanjana Ballal, Ramya Soundararajan, Chandrasekhar Bal
BACKGROUND & OBJECTIVES: The reference radioactive iodine uptake (RAIU) values established in the 1970s in the era of widespread iodine deficiency were relatively high. Now, after four decades of successful Universal Salt Iodization (USI) programme in India, there is a need to re-establish these reference ranges. The present study was aimed to quantify the two-hour and 24-h RAIU values in iodine sufficient euthyroid individuals and validate the results in Graves' and Hashimoto's thyroiditis patients...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28749396/validity-of-broselow-tape-for-estimating-weight-of-indian-children
#7
Vivek Shah, Sandeep B Bavdekar
BACKGROUND & OBJECTIVES: The Broselow tape has been validated in both ambulatory and simulated emergency situations in the United States and is believed to reduce complications arising from inaccurate drug dosing and equipment sizing in paediatric population. This study was conducted to determine the relationship between the actual weight and weight determined by Broselow tape in the Indian children and to derive an equation for determination of weight based on height in the Indian children...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28749120/effects-of-tobacco-habits-on-the-polymorphism-of-nfkb1-and-nfkb1a-gene-of-head-and-neck-squamous-cell-carcinoma-in-indian-population
#8
Abhishek Gupta, Vertica Agnihotri, Rahul Kumar, Ashish Datt Upadhyay, Suman Bhaskar, Sadanand Dwivedi, Sharmistha Dey
Background: Polymorphism of NFKB1 and NFKB1A are highly associated with cancer. We have assessed polymorphism in the promoter region of NFKB1 -94 del/ins ATTG (rs28362491) and NFKB1A -826 C/T (rs2233406) with the risk of HNSCC in Indian population. Methods: Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was used for the genotyping NFKB1 -94 del/ins ATTG and NFKB1A -826 C/T. Sequencing was done to validate the results of PCR-RFLP. Statistical analysis of data was done by Stata/SE-14...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749102/an-exploration-of-phytochemicals-from-simaroubaceae
#9
Biba Vikas, B S Akhil, P S R Suja, K Sujathan
Natural products such as plants, animals and minerals have been the basis of treatment of human diseases. Herbal remedies have been used for the treatment of many ailments. Many compounds have been derived from the plant species mentioned in the ancient texts of Indian system of medicine for the treatment of a number of ailments. The R and D thrust in the pharmaceutical sector is focused on development of new drugs, innovative/indigenous processes for known drugs and development of plant based drugs through investigation of leads from the traditional systems of medicine...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28748897/milk-alkali-syndrome-induced-by-h1n1-influenza-vaccine
#10
Abdullah K Al-Hwiesh, Ibrahiem Saeed Abdul-Rahman, Nadia Al-Oudah, Sana Al-Solami, Fahd A Al-Muhanna
Milk-Alkali syndrome (MAS) consists of a triad of hypercalcemia, metabolic alkalosis, and acute renal failure. We hereby report a 75-year-old Indian gentleman who presented to our emergency department with a history of generalized weakness and easy fatigability. Investigations were consistent with MAS secondary to calcium carbonate and calcitriol treatment to prevent osteoporosis, aggravated by H1N1 influenza vaccine. The patient was treated with hemodialysis and zoledronate. To our knowledge, this is the first reported case of such association in the literature...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748892/clinical-profile-of-geriatric-acute-kidney-injury-in-a-tertiary-care-center-from-south-india
#11
Eshwarappa Mahesh, Praveen Nallamuthu, Mahesh Kumar, Parampalli Rakesh Madhyastha, Gurudev Konanna
The incidence of acute kidney injury (AKI) is high in the elderly, who comprise an ever-growing segment of the population. Elderly patients pose a different set of diagnostic and therapeutic challenge owing to their associated comorbidities. AKI in the elderly is associated with an increased risk of mortality, morbidity, prolonged length of stay, and progression to chronic kidney disease. Data regarding the clinical profile of AKI in the elderly from the South Indian population are limited. Hence, we present this analysis of the etiological and prognostic factors associated with AKI in elderly population from South India...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748891/study-of-chronic-kidney-disease-mineral-bone-disorders-in-newly-detected-advanced-renal-failure-patients-a-hospital-based-cross-sectional-study
#12
Praveen Kumar Etta, R K Sharma, Amit Gupta
We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India. This is cross-sectional observational study. A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)]...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748832/temporo-spatial-distribution-of-insecticide-resistance-in-indian-malaria-vectors-in-the-last-quarter-century-need-for-regular-resistance-monitoring-and-management
#13
REVIEW
Kamaraju Raghavendra, Poonam Sharma Velamuri, Vaishali Verma, Natarajan Elamathi, Tapan Kumar Barik, Rajendra Mohan Bhatt, Aditya Prasad Dash
The Indian vector control programme similar to other programmes in the world is still reliant on chemical insecticides. Anopheles culicifacies is the major vector out of six primary malaria vectors in India and alone contributes about 2/3 malaria cases annually; and per se its control is actually control of malaria in India. For effective management of vectors, current information on their susceptibility status to different insecticides is essential. In this review, an attempt was made to compile and present the available data on the susceptibility status of different malaria vector species in India from the last 2...
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28748743/community-based-game-intervention-to-improve-south-asian-indian-americans-engagement-with-advanced-care-planning
#14
Kavita Radhakrishnan, Lauren Jodi Van Scoy, Regina Jillapalli, Shubhada Saxena, Miyong T Kim
OBJECTIVE: Advance care planning (ACP) allows individuals to express their preferences for medical treatment in the event that they become incapable of making their own decisions. This study assessed the efficacy of a conversation game intervention for increasing South Asian Indian Americans' (SAIAs') engagement in ACP behaviors as well as the game's acceptability and cultural appropriateness among SAIAs. DESIGN: Eligible community-dwelling SAIAs were recruited at SAIA cultural events held in central Texas during the summer of 2016...
July 27, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28748667/a-model-of-genital-herpes-simplex-virus-type-1-infection-in-rhesus-macaques
#15
Meropi Aravantinou, Ines Frank, Geraldine Arrode-Bruses, Moriah Szpara, Brooke Grasperge, James Blanchard, Agegnehu Gettie, Nina Derby, Elena Martinelli
BACKGROUND: Although HSV-2 is the major cause of genital lesions, HSV-1 accounts for half of new cases in developed countries. METHODS: Three healthy SHIV-SF162P3-infected Indian rhesus macaques were inoculated with 4×10(8) pfu of HSV-1 twice, with the second inoculation performed after the vaginal mucosa was gently abraded with a cytobrush. RESULTS: HSV-1 DNA was detected in vaginal swabs 5 days after the second but not the first inoculation in all three macaques...
August 2017: Journal of Medical Primatology
https://www.readbyqxmd.com/read/28748528/parenting-practices-and-children-s-dental-caries-experience-a-structural-equation-modelling-approach
#16
S Kumar, J Tadakamadla, M J Zimmer-Gembeck, J Kroon, R Lalloo, N W Johnson
AIM: To evaluate the direct and mediated associations between parenting practices and dental caries experience in Indian school children. METHODS: The target population consisted of school children and their parents (N=1539) of Medak district in the state of Telangana, India. Parents completed a questionnaire that consisted of questions related to socioeconomic status (SES), family structure, the number of children, their own oral hygiene behaviour and parenting practices...
July 27, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28748515/tumor-necrosis-factor-%C3%AE-308-polymorphism-in-north-indian-rheumatoid-arthritis-patients-and-association-with-mrna-and-serum-tnf-%C3%AE
#17
Mohd Jahid, Rehan-Ul-Haq, Puja Kumari Jha, Diwesh Chawla, Rajnish Avasthi, Rafat Sultana Ahmed
Rheumatoid arthritis (RA) is a severely disabling chronic autoimmune disorder that leads to progressive inflammation of the joints and surrounding tissues. TNF-α, a potent proinflammatory cytokine, plays a pivotal role in the pathogenesis of RA. The endogenous formation of TNF-α may be influenced by TNF-α promoter polymorphisms. Hence, the present study was designed to explore any possible association between genetic polymorphism of TNF-α -308 G/A, messenger RNA (mRNA) expression, serum levels of TNF-α, and inflammatory markers in North Indian RA patients...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748222/an-improved-plasmodium-cynomolgi-genome-assembly-reveals-an-unexpected-methyltransferase-gene-expansion
#18
Erica M Pasini, Ulrike Böhme, Gavin G Rutledge, Annemarie Voorberg-Van der Wel, Mandy Sanders, Matt Berriman, Clemens Hm Kocken, Thomas Dan Otto
BACKGROUND: Plasmodium cynomolgi, a non-human primate malaria parasite species, has been an important model parasite since its discovery in 1907. Similarities in the biology of P. cynomolgi to the closely related, but less tractable, human malaria parasite P. vivax make it the model parasite of choice for liver biology and vaccine studies pertinent to P. vivax malaria. Molecular and genome-scale studies of P. cynomolgi have relied on the current reference genome sequence, which remains highly fragmented with 1,649 unassigned scaffolds and little representation of the subtelomeres...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28747138/perspectives-on-rehabilitation-of-children-with-cerebral-palsy-exploring-a-cross-cultural-view-of-parents-from-india-and-canada-using-the-international-classification-of-functioning-disability-and-health
#19
Pranay Jindal, Joy C MacDermid, Peter Rosenbaum, Briano DiRezze, Amitesh Narayan
PURPOSE: To explore parents' perspectives on rehabilitation of their child with cerebral palsy and their information needs. METHODS: Semistructured interviews were conducted with parents of children with CP from India (n = 11) and Canada (n = 7). Data were analyzed through an interpretive description approach using the International Classification of Functioning, Disability and Health framework. RESULTS: Body Structure and Function: Indian parents were more focused on fixing body structure and function challenges, and independent walking, than Canadian parents...
July 26, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28746322/approximation-of-height-of-an-individual-using-somatometry-of-human-male-skull
#20
J Acharya, B S K Shetty, R Shrestha, T Kanchan
INTRODUCTION: Numerous population specific studies conducted on skeletal remains have aimed to standardize the identification process. Known for ethnic and sexual variations, skull bone can also assist the identification process by estimating stature of the individual. The present study focuses on estimation of stature from skull bone using uni-variate and multi-variate regression models in south Indian population. METHODS: Stature and maximum cranial length, maximum cranial breadth, bi-pterion breadth, parietal cord and upper facial breadth were measured in wet skulls of 113 males, autopsied at Government Hospital of Kudla, Karnataka...
April 2017: JNMA; Journal of the Nepal Medical Association
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