keyword
MENU ▼
Read by QxMD icon Read
search

visceral leishmaniasis

keyword
https://www.readbyqxmd.com/read/28324803/leishmania-donovani-resistant-to-ambisome-or-miltefosine-exacerbates-cd58-expression-on-nk-cells-and-promotes-trans-membrane-migration-in-association-with-cd2
#1
Pushkar Shivam, Sarita Kumari, Fauzia Jamal, Vikash Kumar, Manish Kumar, Sanjiva Bimal, Shyam Narayan, Vidya Nand Ravi Das, Krishna Pandey, Anil Kumar Gupta, Pradeep Das, Shubhankar Kumar Singh
Visceral leishmaniasis (VL) is a disease that is associated with compromised immunity and drug un-responsiveness as well as with the emergence of drug resistance in Leishmania donovani (Ld). Ld down-modulates cellular immunity by manipulating signaling agents, including a higher expression of the adhesion molecule CD58. The expression of CD58 and CD2 on natural killer (NK) cells facilitates intercellular adhesion and signaling. The influence of drug-resistant Ld on the expression of CD58 and CD2 was addressed in this study...
March 16, 2017: Cytokine
https://www.readbyqxmd.com/read/28319012/the-expanding-world-of-human-leishmaniasis
#2
James A Cotton
New Leishmania isolates form a novel group of human parasites related to Leishmania enrietti, with cases in Ghana, Thailand, and Martinique; other relatives infect Australian and South American wildlife. These parasites apparently cause both cutaneous and visceral disease, and may have evolved a novel transmission mechanism exploiting blood-feeding midges.
March 16, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28316391/antileishmanial-and-immunomodulatory-potential-of-ocimumsanctum-linn-and-cocosnucifera-linn-in-murine-visceral-leishmaniasis
#3
Gaurav Bhalla, Sukhbir Kaur, Jaspreet Kaur, Rupinder Kaur, Puneet Raina
The role of immunomodulation in the therapeutic treatment of visceral leishmaniasis has gained eminence in view of moderate to severe drawbacks of the currently available drugs like toxicity, drug resistance and prohibitive costs. The potential for modulation of the immune system of many herbal plants can be tapped to address these problems. We conducted the present research study to investigate the antileishmanial and immunomodulatory effects of Ocimum sanctum Linn. and Cocos nucifera Linn. during the progression of visceral leishmaniasis in BALB/c mouse model...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28301305/molecular-characterization-of-leishmania-parasites-in-giemsa-stained-slides-from-cases-of-human-cutaneous-and-visceral-leishmaniasis-eastern-algeria
#4
Nadia Beldi, Roukaya Mansouri, Jihene Bettaieb, Alia Yaacoub, Hejer Souguir Omrani, Yusr Saadi Ben Aoun, Farida Saadni, Ikram Guizani, Souheila Guerbouj
BACKGROUND: In Algeria, visceral leishmaniasis (VL) is due to Leishmania (L.) infantum, while three cutaneous forms (CL) are caused by Leishmania major, Leishmania tropica and Leishmania infantum. In this study, the use of Giemsa-stained slides was evaluated with two PCR techniques, in Eastern Algeria. MATERIALS AND METHODS: A total of 136 samples corresponding to 100 CL smears (skin scrapings) and 36 VL slides (bone marrow aspirates) collected from 2008 to 2014 were tested...
March 16, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28301296/distinct-leishmania-infantum-strains-circulate-in-humans-and-dogs-in-the-emilia-romagna-region-northeastern-italy
#5
Gianluca Rugna, Elena Carra, Francesco Corpus, Mattia Calzolari, Daniela Salvatore, Romeo Bellini, Antonietta Di Francesco, Erica Franceschini, Antonella Bruno, Giovanni Poglayen, Stefania Varani, Fabrizio Vitale, Giuseppe Merialdi
Human leishmaniasis is an emerging problem in Italy and is on the increase in the Emilia-Romagna region, northeastern part of the country. Nevertheless, studies dealing with the molecular characterization of Leishmania spp. circulating in these areas are limited. In the present work, we explored the genetic polymorphism of Leishmania isolates from 28 cases of canine leishmaniasis and three cases of human visceral leishmaniasis (VL), which occurred in 2013-2014 in the Emilia-Romagna region. The characterization was carried out in comparison with nine human isolates of Leishmania from other VL endemic Italian regions and two reference strains...
March 16, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28288798/probing-the-efficacy-of-a-heterologous-leishmania-l-viannia-braziliensis-recombinant-enolase-as-a-candidate-vaccine-to-restrict-the-development-of-l-infantum-in-balb-c-mice
#6
Thaís T O Santos, Vívian T Martins, Daniela P Lage, Lourena E Costa, Beatriz C S Salles, Ana M R S Carvalho, Daniel S Dias, Patrícia A F Ribeiro, Miguel A Chávez-Fumagalli, Ricardo A Machado-de-Ávila, Bruno M Roatt, Danielle F de Magalhães-Soares, Daniel Menezes-Souza, Eduardo A F Coelho, Mariana C Duarte
In the present study, the Leishmania braziliensis enolase protein was evaluated as a vaccine candidate against visceral leishmaniasis (VL). The DNA sequence was cloned and the recombinant protein (rEnolase) was evaluated as a vaccine, associated with saponin, as an immune adjuvant. The protective efficacy of the rEnolase plus saponin combination was investigated in BALB/c mice against Leishmania infantum infection. The results revealed that the vaccine induced higher levels of IFN-γ, IL-12, and GM-CSF when a capture ELISA and flow cytometry were performed, as well as an antileishmanial nitrite production after using in vitro stimulation with rEnolase and an antigenic Leishmania preparation...
March 10, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28288415/deciphering-the-interplay-between-cysteine-synthase-and-thiol-cascade-proteins-in-modulating-amphotericin-b-resistance-and-survival-of-leishmania-donovani-under-oxidative-stress
#7
Kuljit Singh, Vahab Ali, Krishn Pratap Singh, Parool Gupta, Shashi S Suman, Ayan K Ghosh, Sanjiva Bimal, Krishna Pandey, Pradeep Das
Leishmania donovani is the causative organism of the neglected human disease known as visceral leishmaniasis which is often fatal, if left untreated. The cysteine biosynthesis pathway of Leishmania may serve as a potential drug target because it is different from human host and regulates downstream components of redox metabolism of the parasites; essential for their survival, pathogenicity and drug resistance. However, despite the apparent dependency of redox metabolism of cysteine biosynthesis pathway, the role of L...
March 7, 2017: Redox Biology
https://www.readbyqxmd.com/read/28282232/an-atypical-case-of-leishmaniasis-associated-with-chronic-duodenitis-in-a-dog
#8
Ignacio Ayala, Luis Jesus Bernal, Juan Diego Garcia-Martinez, Miguel Angel Gomez, Jose Antonio Navarro, Antonio Bernabe
We describe an atypical case of duodenal leishmaniasis in a boxer dog presenting with chronic diarrhea and poor general condition. Antidiarrheic therapy was previously administered without success and inflammatory bowel disease localized to the small intestine was suspected, given the chronic clinical signs and by ruling out other known causes of gastrointestinal inflammation. Endoscopic biopsy of duodenum showed a moderate increase in lamina propria lymphocytes, plasma cells, and macrophages. Basophilic bodies were seen in the cytoplasm of numerous macrophages, suggestive of Leishmania spp, confirmed by immunostaining, and a diagnosis of granulomatous duodenitis associated to Leishmania infection was made...
March 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28280494/a-chimera-containing-cd4-and-cd8-t-cell-epitopes-of-the-leishmania-donovani-nucleoside-hydrolase-nh36-optimizes-cross-protection-against-leishmania-amazonesis-infection
#9
Marcus Vinícius Alves-Silva, Dirlei Nico, Alexandre Morrot, Marcos Palatnik, Clarisa B Palatnik-de-Sousa
The Leishmania donovani nucleoside hydrolase (NH36) and NH A34480 of Leishmania amazonensis share 93% of sequence identity. In mice, the NH36 induced protection against visceral leishmaniasis is mediated by a CD4+ T cell response against its C-terminal domain (F3). Besides this CD4+ Th1 response, prevention and cure of L. amazonensis infection require also additional CD8+ and regulatory T-cell responses to the NH36 N-terminal (F1 domain). We investigated if mice vaccination with F1 and F3 domains cloned in tandem, in a recombinant chimera, with saponin, optimizes the vaccine efficacy against L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28280488/toll-like-receptor-2-is-required-for-inflammatory-process-development-during-leishmania-infantum-infection
#10
Laís A Sacramento, Jéssica L da Costa, Mikhael H F de Lima, Pedro A Sampaio, Roque P Almeida, Fernando Q Cunha, João S Silva, Vanessa Carregaro
Visceral leishmaniasis (VL) is a chronic and fatal disease caused by Leishmania infantum in Brazil. Leukocyte recruitment to infected tissue is a crucial event for the control of infections such as VL. Among inflammatory cells, neutrophils are recruited to the site of Leishmania infection, and these cells may control parasite replication through oxidative or non-oxidative mechanisms. The recruitment, activation and functions of the neutrophils are coordinated by pro-inflammatory cytokines and chemokines during recognition of the parasite by pattern recognition receptors (PRRs)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28279761/evaluation-of-caax-prenyl-protease-ii-of-leishmania-donovani-as-potential-drug-target-infectivity-and-growth-of-the-parasite-is-significantly-lowered-after-the-gene-knockout
#11
Ruchika Bhardwaj, Mousumi Das, Shalini Singh, Adarsh Kumar Chiranjivi, Sitraraau Vijaya Prabhu, Sanjeev Kumar Singh, Vikash Kumar Dubey
Prenylation pathway is responsible for post translational modification of various signal proteins, including proteins of Ras superfamily. CAAX prenyl proteases are known to be key players in prenylation pathway. In the current study, we have evaluated CAAX prenyl protease II as a possible drug target against Leishmania donovani parasite, the causative agent of visceral leishmaniasis. Gene knockout strategy was employed to target CAAX prenyl protease II and subsequent effects were studied. CAAX prenyl protease II knockout resulted in significant decrease in growth and infectivity...
March 7, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28279458/elimination-of-visceral-leishmaniasis-in-the-indian-subcontinent-a-comparison-of-predictions-from-three-transmission-models
#12
Epke A Le Rutte, Lloyd A C Chapman, Luc E Coffeng, Sarah Jervis, Epco C Hasker, Shweta Dwivedi, Morchan Karthick, Aritra Das, Tanmay Mahapatra, Indrajit Chaudhuri, Marleen C Boelaert, Graham F Medley, Sridhar Srikantiah, T Deirdre Hollingsworth, Sake J de Vlas
We present three transmission models of visceral leishmaniasis (VL) in the Indian subcontinent (ISC) with structural differences regarding the disease stage that provides the main contribution to transmission, including models with a prominent role of asymptomatic infection, and fit them to recent case data from 8 endemic districts in Bihar, India. Following a geographical cross-validation of the models, we compare their predictions for achieving the WHO VL elimination targets with ongoing treatment and vector control strategies...
March 2017: Epidemics
https://www.readbyqxmd.com/read/28278151/visceral-leishmaniasis-in-somalia-a-review-of-epidemiology-and-access-to-care
#13
REVIEW
Temmy Sunyoto, Julien Potet, Marleen Boelaert
Somalia, ravaged by conflict since 1991, has areas endemic for visceral leishmaniasis (VL), a deadly parasitic disease affecting the rural poor, internally displaced, and pastoralists. Very little is known about VL burden in Somalia, where the protracted crisis hampers access to health care. We reviewed evidence about VL epidemiology in Somalia and appraised control options within the context of this fragile state's health system. VL has been reported in Somalia since 1934 and has persisted ever since in foci in the southern parts of the country...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28267441/natural-infection-of-nesokia-indica-with-leishmania-major-and-leishmania-infantum-parasites-in-damghan-city-northern-iran
#14
Behrad Pourmohammadi, Sadegh Mohammadi-Azni, Mohsen Kalantari
Various species of rodents are proven reservoir hosts of zoonotic cutaneous leishmaniasis in different provinces of Iran and potential reservoir hosts of zoonotic visceral leishmaniasis. Therefore, this study was conducted to determine the leishmanial infection of rodents in Damghan city from April to September, 2015. Sum of 100 rodents of three species; Nesokia indica (95), Mus musculus (3), and Microtus socialis (2), were trapped alive and their tissue samples were examined using parasitological and molecular (nested-PCR) methods...
March 4, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28263760/integrating-genomics-and-proteomics-permits-identification-of-immunodominant-antigens-associated-with-drug-resistance-in-human-visceral-leishmaniasis-in-india
#15
Neeloo Singh, Shyam Sundar
Resistance of human pathogens like Leishmania to drugs is a growing concern where the multidrug-resistant phenotype renders chemotherapy ineffective. The acquired resistance of Leishmania to antimony has promoted intense research on the mechanisms involved but the question has not been resolved yet. In this study we have explored host-pathogen- drug interactions leading to identification of pharmacological determinants of host macrophages that resist the sodium antimony gluconate (SAG) mediated intracellular parasite killing...
March 3, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28250251/studying-ddt-susceptibility-at-discriminating-time-interval-focusing-maximum-limit-of-exposure-time-survived-by-ddt-resistant-phlebotomus-argentipes-diptera-psychodidae-an-investigatory-report
#16
Aarti Rama, Shreekant Kesari, Pradeep Das, Vijay Kumar
Extensive application of routine insecticide i.e., Dichlorodiphenyltrichloroethane (DDT) to control Phlebotomus argentipes (Diptera: Psychodidae), the proven vector of Visceral leishmaniasis (VL) in India, had evoked the problem of resistance/ tolerance against DDT, eventually nullifying the DDT dependent strategies to handle the nuisance caused by them. Because tolerating an hour exposure of DDT is not so challenging for resistant P. argentipes, estimating susceptibility by exposing sand flies to insecticide for just an hour becomes trivial and futile task...
February 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28249021/single-locus-genotyping-to-track-leishmania-donovani-in-the-indian-subcontinent-application-in-nepal
#17
Keshav Rai, Narayan Raj Bhattarai, Manu Vanaerschot, Hideo Imamura, Gebreyohans Gebru, Basudha Khanal, Suman Rijal, Marleen Boelaert, Chiranjib Pal, Prahlad Karki, Jean-Claude Dujardin, Gert Van der Auwera
BACKGROUND: We designed a straightforward method for discriminating circulating Leishmania populations in the Indian subcontinent (ISC). Research on transmission dynamics of visceral leishmaniasis (VL, or Kala-azar) was recently identified as one of the key research priorities for elimination of the disease in the ISC. VL in Bangladesh, India, and Nepal is caused by genetically homogeneous populations of Leishmania donovani parasites, transmitted by female sandflies. Classical methods to study diversity of these protozoa in other regions of the world, such as microsatellite typing, have proven of little use in the area, as they are not able to discriminate most genotypes...
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28249007/safety-evaluation-of-a-vaccine-effect-in-maternal-reproductive-outcome-and-fetal-anomaly-frequency-in-rats-using-a-leishmanial-vaccine-as-a-model
#18
Rafaianne Q Moraes-Souza, Ana Paula Reinaque, Thaigra S Soares, Ana Luiza T Silva, Rodolfo C Giunchetti, Maria A S Takano, Milena A Akamatsu, Flávia S Kubrusly, Fernanda Lúcio-Macarini, Isaias Raw, Dmitri Iourtov, Paulo Lee Ho, Lilian L Bueno, Ricardo T Fujiwara, Gustavo T Volpato
While the immunogenic potential of the vaccination against infectious diseases was extensively shown, data on the safety assessment of recombinant proteins in vaccine formulations administered during pregnancy are still scarce. In the current study, the antigenicity of a vaccine against leishmaniasis (based on Leishmania braziliensis recombinant protein peroxidoxin) during pregnancy and possible maternal reproductive outcomes and fetal anomalies after immunization with a leishmanial vaccine or adjuvant alone (Bordetella pertussis derived MPLA adjuvant) were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28247922/evolution-of-cutaneous-leishmaniasis-in-the-last-30-years-in-a-tertiary-hospital-of-the-european-mediterranean-coast
#19
Joaquim Marcoval, Rosa M Penín
BACKGROUND: Although with a lower incidence than in other geographic areas, leishmaniasis is also endemic on the European Mediterranean coast. However, there are few studies on the clinical features of cutaneous lesions of leishmaniasis in Europe. Our objective was to review the clinical features of cutaneous leishmanial lesions in our European Mediterranean population in the last 30 years and compare the clinical features of immunosuppressed and nonimmunosuppressed patients. METHODS: The clinical features of cutaneous lesions of leishmaniasis diagnosed between 1987 and 2016 at Bellvitge Hospital in Barcelona, Spain, were retrospectively analyzed...
March 1, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28225906/the-current-status-of-the-lutzomyia-longipalpis-diptera-psychodidae-phlebotominae-species-complex
#20
Nataly A Souza, Reginaldo P Brazil, Alejandra S Araki
Lutzomyia longipalpis s.l. is a complex of sibling species and is the principal vector of American visceral leishmaniasis. The present review summarises the diversity of efforts that have been undertaken to elucidate the number of unnamed species in this species complex and the phylogenetic relationships among them. A wide variety of evidence, including chemical, behavioral and molecular traits, suggests very recent speciation events and complex population structure in this group. Although significant advances have been achieved to date, differential vector capacity and the correlation between structure of parasite and vector populations have yet to be elucidated...
March 2017: Memórias do Instituto Oswaldo Cruz
keyword
keyword
96524
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"