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visceral leishmaniasis

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https://www.readbyqxmd.com/read/29160649/-performance-of-the-katex-test-in-screening-and-diagnosis-for-visceral-leishmaniasis-in-a-reference-hospital
#1
C Fernández-Roldán, J Rodríguez-Grangér, R Javier Martínez, M A López-Ruz, J M Navarro-Marí, J Gutiérrez-Fernández
OBJECTIVE: Performing of diagnostic test simple using samples not invasive in the diagnosis of visceral leishmaniasis (VL) may be very beneficial, being necessary comparing to traditional methods. The objective of this study was to know the reliability of test KAtex in the urine of patients with suspicion of VL. METHODS: Retrospectively were reviewed the medical histories of patients with suspected of VL to which are performed the test between 2009 and 2015. For its analysis were selected the patients to which is them had made study of the parasite in bone marrow...
November 21, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/29160515/visceral-leishmaniasis-and-leishmaniasis-hiv-coinfection-comparative-study
#2
João Victor Soares Coriolano Coutinho, Fabiana Silva Dos Santos, Rosângela do Socorro Pereira Ribeiro, Iara Brito Bucar Oliveira, Victória Bezerra Dantas, Ana Barbara Feliciano Souza Santos, Jéssyca Rodrigues Tauhata
INTRODUCTION: This study aimed to draw clinical and epidemiological comparisons between visceral leishmaniasis (VL) and VL associated with human immunodeficiency virus (HIV) infection. METHOD: Retrospective study. RESULTS: Of 473 cases of VL, 5.5% were coinfected with HIV. The highest proportion of cases of both VL and VL/HIV were found among men. A higher proportion of VL cases was seen in children aged 0-10 years, whereas coinfection was more common in those aged 18-50 years...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160510/changes-in-the-epidemiology-of-visceral-leishmaniasis-in-brazil-from-2001-to-2014
#3
Lisiane Lappe Dos Reis, Antônio Alcirley da Silva Balieiro, Fernanda Rodrigues Fonseca, Maria Jacirema Ferreira Gonçalves
INTRODUCTION: Visceral leishmaniasis (VL) is a neglected disease, with territorial expansion and regional differences in Brazil that require explanation. This study aimed to describe changes in the epidemiology of VL in Brazil from 2001 to 2014. METHODS: The incidence rates, sociodemographic and clinical data, and case evolution were subgrouped from 2001 to 2006 and from 2007 to 2014 and presented descriptively. Spatial distribution of disease incidence rates and changes in the spatial and temporal pattern were examined...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160507/epidemiological-profile-of-patients-co-infected-with-visceral-leishmaniasis-and-hiv-aids-in-northeast-brazil
#4
Graça Maria de Castro Viana, Marcos Antonio Custódio Neto da Silva, João Victor de Sousa Garcia, Helaine Dias Guimarães, Gelson Farias Arcos, Augusto Viana Arouche Santos, Pedro Viana da Paixão, Maria do Desterro Soares Brandão Nascimento, Carolina de Souza Galvão
INTRODUCTION: Visceral leishmaniasis (VL) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) co-infection has been a research topic of interest worldwide. In Brazil, it has been observed that there is a relative underreporting and failure in the understanding and management of this important association. The aim of this study was to analyze epidemiological and clinical aspects of patients with VL with and without HIV/AIDS. METHODS: We conducted an observational and analytical study of patients with VL followed in a Reference Service in the State of Maranhão, Brazil from 2007-2013...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29155831/prevalence-and-risk-factors-associated-with-leishmania-infection-in-trang-province-southern-thailand
#5
Jipada Manomat, Saovanee Leelayoova, Lertwut Bualert, Peerapan Tan-Ariya, Suradej Siripattanapipong, Mathirut Mungthin, Tawee Naaglor, Phunlerd Piyaraj
BACKGROUND: Autochthonous cutaneous and visceral leishmaniasis (VL) caused by Leishmania martiniquensis and Leishmania siamensis have been considered emerging infectious diseases in Thailand. The disease burden is significantly underestimated, especially the prevalence of Leishmania infection among HIV-positive patients. METHODS: A cross-sectional study was conducted to determine the prevalence and risk factors associated with Leishmania infection among patients with HIV/AIDS living in Trang province, southern Thailand, between 2015 and 2016...
November 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29153064/-comparison-of-polymerase-chain-reaction-using-kinetoplast-dna-specific-primers-and-other-parasitological-methods-in-the-diagnosis-of-clinical-samples-of-suspected-patients-with-cutaneous-leishmaniasis-in-%C3%A5-anl%C3%A4-urfa
#6
Fadile Yıldız Zeyrek, Seray Töz, Fehmi Yüksel, Nevin Turgay, Yusuf Özbel
Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are seen endemically in Turkey and CL caused by Leishmania tropica is an important public health problem in southeastern as well as other regions of Turkey. The diagnosis has been usually made by clinical view of lesion and/or parasitologically using lesion aspiration smears. Histological examination does not, always reveal the parasite in the skin biopsy, particularly in chronic lesions. Besides this, due to CL infections caused by different species in endemic areas, diagnostic methods enabling species identification are in great need...
October 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29150609/atomic-resolution-snapshot-of-leishmania-ribosome-inhibition-by-the-aminoglycoside-paromomycin
#7
Moran Shalev-Benami, Yan Zhang, Haim Rozenberg, Yuko Nobe, Masato Taoka, Donna Matzov, Ella Zimmerman, Anat Bashan, Toshiaki Isobe, Charles L Jaffe, Ada Yonath, Georgios Skiniotis
Leishmania is a single-celled eukaryotic parasite afflicting millions of humans worldwide, with current therapies limited to a poor selection of drugs that mostly target elements in the parasite's cell envelope. Here we determined the atomic resolution electron cryo-microscopy (cryo-EM) structure of the Leishmania ribosome in complex with paromomycin (PAR), a highly potent compound recently approved for treatment of the fatal visceral leishmaniasis (VL). The structure reveals the mechanism by which the drug induces its deleterious effects on the parasite...
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29145397/post-kala-azar-dermal-leishmaniasis-in-the-indian-subcontinent-a-threat-to-the-south-east-asia-region-kala-azar-elimination-programme
#8
REVIEW
Eduard E Zijlstra, Fabiana Alves, Suman Rijal, Byron Arana, Jorge Alvar
BACKGROUND: The South-East Asia Region Kala-azar Elimination Programme (KAEP) is expected to enter the consolidation phase in 2017, which focuses on case detection, vector control, and identifying potential sources of infection. Post-kala-azar dermal leishmaniasis (PKDL) is thought to play a role in the recurrence of visceral leishmaniasis (VL)/kala-azar outbreaks, and control of PKDL is among the priorities of the KAEP. METHODOLOGY AND PRINCIPAL FINDING: We reviewed the literature with regard to PKDL in Asia and interpreted the findings in relation to current intervention methods in the KAEP in order to make recommendations...
November 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29141704/human-competence-to-transmit-leishmania-infantum-to-lutzomyia-longipalpis-and-the-influence-of-human-immunodeficiency-virus-infection
#9
Gabriel Reis Ferreira, José Carlos Castelo Branco Ribeiro, Antônio Meneses Filho, Teresinha de Jesus Cardoso Farias Pereira, Daniela Moura Parente, Humberto Feitosa Pereira, Jailthon Carlos da Silva, Danielle Alves Zacarias, Letiano Vieira da Silva, Symonara Karina Medeiros Faustino, Walfrido Salmito Almeida Neto, Dorcas Lamounier Costa, Ivete Lopes de Mendonça, Carlos Henrique Nery Costa
Visceral leishmaniasis (VL) caused by Leishmania infantum is a lethal disease transmitted by sand flies. Although, considered a zoonosis with dogs held as the main reservoirs, humans are also sources of infection. Therefore, control policies currently focused on dog culling may need to consider that VL and human immunodeficiency virus (HIV)/VL patients may also be infectious, contributing to transmission. Reservoir competence of patients with VL without and with HIV infection and of persons asymptomatically infected with Leishmania was assessed by xenodiagnosis with the vector Lutzomyia longipalpis...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140228/co-factor-independent-phosphoglycerate-mutase-of-leishmania-donovani-modulates-macrophage-signalling-and-promotes-t-cell-repertoires-bearing-epitopes-for-both-mhc-i-and-mhc-ii
#10
Manish K Singh, Fauzia Jamal, Amit K Dubey, Pushkar Shivam, Sarita Kumari, Pushpanjali, Ghufran Ahmed, Manas R Dikhit, S Narayan, V N R DAS, Krishna Pandey, K K Sinha, P DAS, Shubhankar K Singh
Immunoactivation depends upon the antigen potential to modulate T-cell repertoires. The present study has enumerated the effect of 61 kDa recombinant Leishmania donovani co-factor-independent phosphoglycerate mutase (rLd-iPGAM) on mononuclear cells of healthy and treated visceral leishmaniasis subjects as well as on THP-1 cell line. rLd-iPGAM stimulation induced higher expression of interleukin-1β (IL-1β) in the phagocytic cell, its receptor and CD69 on T-cell subsets. These cellular activations resulted in upregulation of host-protective cytokines IL-2, IL-12, IL-17, tumour necrosis factor-α and interferon-γ, and downregulation of IL-4, IL-10 and tumour growth factor-β...
November 15, 2017: Parasitology
https://www.readbyqxmd.com/read/29138100/amphotericin-b-for-treatment-of-visceral-leishmaniasis-a-systematic-review-and-meta-analysis-of-prospective-comparative-clinical-studies-including-dose-ranging-studies
#11
REVIEW
Chaturaka Rodrigo, Praveen Weeratunga, Sumadhya Deepika Fernando, Senaka Rajapakse
OBJECTIVES: The aim of this review is to evaluate the evidence for use of different formulations of amphotericin B, minimum effective dose for each formulation and its comparative efficacy against other drugs in achieving definitive cure of visceral leishmaniasis. METHODS: This systematic review and meta-analysis included following data sources; PubMed, EMBASE, Scopus, Web of Science and CINAHL. Controlled prospective clinical trials (randomized or non-randomized, including dose ranging studies) conducted between 1996 and 2017, with at least one treatment group receiving amphotericin B were included (published data only)...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29133249/immunomodulation-of-dual-specificity-phosphatase-4-during-visceral-leishmaniasis
#12
Shabina Parveen, Atish Roy Chowdhury, Junaid Jibran Jawed, Suchandra Bhattacharyya Majumdar, Bhaskar Saha, Subrata Majumdar
DUSP4, an inducible protein has a substrate specificity toward ERK1/2, a component of MAP kinase which is enhanced during Leishmania infection. The DUSP4(-/-) mice show increased susceptibility towards the infection caused by Toxoplasma gondii and Leishmania mexicana. These observations emphatically established the fact that unlike DUSP1, DUSP4 has host protective role. In our study, it has been Leishmania donovani, the causative agent of visceral leishmaniasis (VL) significantly reduced the expression of DUSP4 during infection...
November 10, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29128045/recombinant-prohibitin-protein-of-leishmania-infantum-acts-as-a-vaccine-candidate-and-diagnostic-marker-against-visceral-leishmaniasis
#13
Daniel S Dias, Patrícia A F Ribeiro, Vívian T Martins, Daniela P Lage, Fernanda F Ramos, Anna L T Dias, Marcella R Rodrigues, Áquila S B Portela, Lourena E Costa, Rachel B Caligiorne, Bethina T Steiner, Miguel A Chávez-Fumagalli, Beatriz C S Salles, Thaís T O Santos, Julia A G Silveira, Danielle F Magalhães-Soares, Bruno M Roatt, Ricardo A Machado-de-Ávila, Mariana C Duarte, Daniel Menezes-Souza, Eduardo S Silva, Alexsandro S Galdino, Eduardo A F Coelho
Visceral leishmaniasis (VL) represents a serious public health problem, as Leishmania infantum is one of main disease causative agents in the Americas. In a previous immunoproteomic study, the prohibitin (PHB) protein was identified in L. infantum promastigote and amastigote extracts by antibodies in asymptomatic and symptomatic VL dog sera. This protein was found to be highly conserved between different Leishmania spp., but it presented a low identity with amino acid sequences of other organisms. The aim of the present study was to evaluate the cellular response induced by the recombinant PHB (rPHB) protein in BALB/c mice, as well as in PBMCs purified from untreated and treated VL patients, as well as to evaluate its protective efficacy against an infection by L...
November 9, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29116318/land-use-land-cover-and-prevalence-of-canine-visceral-leishmaniasis-in-teresina-piau%C3%A3-state-brazil-an-approach-using-orbital-remote-sensing
#14
Anna Barreto Fernandes Figueiredo, Guilherme Loureiro Werneck, Maria do Socorro Pires E Cruz, João Pereira da Silva, Andréa Sobral de Almeida
This study examines the association between land use and land cover and the occurrence of canine visceral leishmaniasis (VL). This is a case-control study in which cases were households with seropositive dogs for canine VL and controls were households with seronegative dogs. We used remote sensing images (CBERS: 2/CCD and 2B/HRC) to describe land use and cover in squares of 625m2 in the study area. Odds of canine VL were twice as high in households located in squares with an area ≤ 25m2 covered by residential structures with little vegetation in comparison to those where the cover reached ≥ 600m2...
November 6, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29116252/leptin-regulates-granzyme-a-pd-1-and-ctla-4-expression-in-t-cell-to-control-visceral-leishmaniasis-in-balb-c-mice
#15
Alti Dayakar, Sambamurthy Chandrasekaran, Jalaja Veronica, Vadloori Bharadwaja, Radheshyam Maurya
Visceral leishmaniasis (VL) is responsible for several deaths in malnourished children accompanied by diminished circulating leptin and impaired cell-mediated immunity. Typically, leptin deficiency is associated with the Th2 polarization that markedly coincides with the pathogenesis of VL. The aim of the present study was to unravel the prophylactic role of leptin in malnutrition-coupled VL mice. Interestingly, we observed that L. donovani infection itself reduces the serum leptin levels in malnutrition. Exogenous leptin restored severe body weight loss and parasite load in the spleen and liver of malnourished infected mice compared to controls...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113609/dermotropic-leishmania-donovani-in-sri-lanka-visceralizing-potential-in-clinical-and-preclinical-studies
#16
K K G D U L Kariyawasam, A Selvapandiyan, H V Y D Siriwardana, A Dube, P Karunanayake, S A S C Senanayake, R Dey, S Gannavaram, H L Nakhasi, N D Karunaweera
The visceralizing potential of apparently dermotropic Leishmania donovani in Sri Lanka (L. donovani-SL) was investigated through long-term follow-up of cutaneous leishmaniasis (CL) patients and in vivo and in vitro experimental infection models. CL patients (n = 250) treated effectively with intra-lesional antimony therapy were followed-up six monthly for 4 years. There was no clinical evidence of visceralization of infection (VL) during this period. Infection of BALB/c mice with L. donovani-SL (test) through intra-dermal route led to the development of cutaneous lesions at the site of inoculation with no signs of systemic dissemination, in contrast to the observations made in animals similarly infected with a visceralizing strain of L...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29113597/antigenicity-immunogenicity-and-protective-efficacy-of-a-conserved-leishmania-hypothetical-protein-against-visceral-leishmaniasis
#17
Daniel S Dias, Vívian T Martins, Patrícia A F Ribeiro, Fernanda F Ramos, Daniela P Lage, Grasiele S V Tavares, Débora V C Mendonça, Miguel A Chávez-Fumagalli, Jamil S Oliveira, Eduardo S Silva, Dawidson A Gomes, Michele A Rodrigues, Mariana C Duarte, Alexsandro S Galdino, Daniel Menezes-Souza, Eduardo A F Coelho
In this study, a Leishmania hypothetical protein, LiHyS, was evaluated regarding its antigenicity, immunogenicity and protective efficacy against visceral leishmaniasis (VL). Regarding antigenicity, immunoblottings and an enzyme-linked immunosorbent assay using human and canine sera showed high sensitivity and specificity values for the recombinant protein (rLiHyS) in the diagnosis of VL. When evaluating the immunogenicity of LiHyS, which is possibly located in the parasite's flagellar pocket, proliferative assays using peripheral blood mononuclear cells from healthy subjects or VL patients showed a high proliferative index in both individuals, when compared to the results obtained using rA2 or unstimulated cultures...
November 8, 2017: Parasitology
https://www.readbyqxmd.com/read/29109466/haplotype-selection-as-an-adaptive-mechanism-in-the-protozoan-pathogen-leishmania-donovani
#18
Pablo Prieto Barja, Pascale Pescher, Giovanni Bussotti, Franck Dumetz, Hideo Imamura, Darek Kedra, Malgorzata Domagalska, Victor Chaumeau, Heinz Himmelbauer, Michel Pages, Yvon Sterkers, Jean-Claude Dujardin, Cedric Notredame, Gerald Frank Späth
The parasite Leishmania  donovani causes a fatal disease termed visceral leishmaniasis. The process through which the parasite adapts to environmental change remains largely unknown. Here we show that aneuploidy is integral for parasite adaptation and that karyotypic fluctuations allow for selection of beneficial haplotypes, which impact transcriptomic output and correlate with phenotypic variations in proliferation and infectivity. To avoid loss of diversity following karyotype and haplotype selection, L...
November 6, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/29097645/susceptibility-status-of-wild-population-of-phlebotomus-sergenti-diptera-psychodidae-to-different-imagicides-in-a-endemic-focus-of-cutaneous-leishmaniasis-in-northeast-of-iran
#19
Kourosh Arzamani, Hassan Vatandoost, Yavar Rassi, Mohammad Reza Abai, Amir Ahmad Akhavan, Mohammad Alavinia, Kamran Akbarzadeh, Mehdi Mohebali, Sayena Rafizadeh
BACKGROUND & OBJECTIVES: Phlebotomine sandflies (Diptera: Psychodidae) transmit several important zoonotic diseases to humans and leishmaniasis is one of them. Two types of leishmaniasis, viz. visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are endemic in Iran. The main vector of anthroponotic cutaneous leishmaniasis (ACL) is Phlebotomus sergenti. The aim of the present study was to determine the susceptibility status of wild strain of P. sergenti to different imagicides of DDT, bendiocarb and permethrin at the median lethal time, LT50 level...
July 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29096720/neglected-tropical-diseases-in-brazilian-children-and-adolescents-data-analysis-from-2009-to-2013
#20
Eduardo Brandão, Sebastián Romero, Maria Almerice Lopes da Silva, Fred Luciano Neves Santos
BACKGROUND: Neglected tropical diseases (NTDs) prevail in conditions of poverty and contribute to the maintenance of social inequality. Out of the NTDs prioritized by the Brazilian Ministry of Health, four parasitic infections require mandatory notification: acute Chagas disease, leishmaniasis, malaria, and schistosomiasis. Data on the behaviour of these NTDs in the young population are currently limited. This study seeks to analyse the epidemiological aspects of these parasitic infections in children and adolescents in Brazil...
November 3, 2017: Infectious Diseases of Poverty
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