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visceral leishmaniasis

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https://www.readbyqxmd.com/read/28811600/exploring-leishmania-secretory-proteins-to-design-b-and-t-cell-multi-epitope-subunit-vaccine-using-immunoinformatics-approach
#1
Nazia Khatoon, Rajan Kumar Pandey, Vijay Kumar Prajapati
Visceral leishmaniasis (VL) is a fatal form of leishmaniasis which affects 70 countries, worldwide. Increasing drug resistance, HIV co-infection, and poor health system require operative vaccination strategy to control the VL transmission dynamics. Therefore, a holistic approach is needed to generate T and B memory cells to mediate long-term immunity against VL infection. Consequently, immunoinformatics approach was applied to design Leishmania secretory protein based multi-epitope subunit vaccine construct consisting of B and T cell epitopes...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811000/a-case-of-cutaneous-leishmaniasis-guyanensis-mimicking-otitis-externa
#2
Eric S Goodrich, Stephen C Sears, Timothy Sorrells, James K Radike, Anis Miladi, Jonathan S Glass
Cutaneous leishmaniasis typically presents as a painless papule progressing to an ulcer or plaque. In this case study of the ear, the disease manifested as a small painful bump progressing into redness and swelling about the ear with purulent drainage. After multiple oral/intravenous antipseudomonal, antistaphylococcal, and antifungal treatments, there was no improvement. The skin progressed to an erythematous plaque and hemorrhagic ulcer; punch biopsy and speciation revealed Leishmaniasis guyanensis. The patient was switched to a seven-dose course of intravenous L-amphotericin B (visceral leishmaniasis protocol)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28807304/association-between-mast-cells-tissue-remodelation-and-parasite-burden-in-the-skin-of-dogs-with-visceral-leishmaniasis
#3
Jamille Mirelle de Oliveira Cardoso, Henrique Gama Ker, Rodrigo Dian de Oliveira Aguiar-Soares, Nádia das Dores Moreira, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Bruno Mendes Roatt, Paula Melo de Abreu Vieira, Wendel Coura-Vital, Cláudia Martins Carneiro, Alexandre Barbosa Reis
Canine visceral leishmaniosis (CVL) is a zoonosis of major public health impact caused by organisms of the genus Leishmania which is transmitted to human and animals by phlebotomine sand flies. The skin is the first point of contact with Leishmania parasites for sandy fly vectors and it is considered an important reservoir compartment in infected dogs. The aim of this study was to determine the main histophatologic alterations in ear skin of dogs naturally infected by Leishmania infantum with different clinical status and different degrees of parasitism...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28799248/molecular-detection-of-wolbachia-pipientis-in-natural-populations-of-sandfly-vectors-of-leishmania-infantum-in-endemic-areas-first-detection-in-lutzomyia-longipalpis
#4
N O DA Rocha, S M Lambert, A G Dias-Lima, F S Julião, B M P S Souza
A polymerase chain reaction-based method was used to screen sandflies for infection with Wolbachia (Rickettsiales: Rickettsiaceae), an intracellular bacterial endosymbiont found in many arthropods and filarial hosts. Positive results were obtained in five of 200 field-collected sandflies and were confirmed by sequencing. All sandflies were Lutzomyia longipalpis (Diptera: Psychodidae) captured in a region endemic for visceral leishmaniasis in Brazil. This is the first study to identify Wolbachia infection in this Lutzomyia species, which is the main vector of leishmaniasis in the study area...
August 11, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28798743/l-arginine-uptake-by-cationic-amino-acid-transporter-promotes-intra-macrophage-survival-of-leishmania-donovani-by-enhancing-arginase-mediated-polyamine-synthesis
#5
Abhishek Mandal, Sushmita Das, Ajay Kumar, Saptarshi Roy, Sudha Verma, Ayan Kumar Ghosh, Ruby Singh, Kumar Abhishek, Savita Saini, Abul Hasan Sardar, Bidyut Purkait, Ashish Kumar, Chitra Mandal, Pradeep Das
The survival of intracellular protozoan parasite, Leishmania donovani, the causative agent of Indian visceral leishmaniasis (VL), depends on the activation status of macrophages. l-Arginine, a semi-essential amino acid plays a crucial regulatory role for activation of macrophages. However, the role of l-arginine transport in VL still remains elusive. In this study, we demonstrated that intra-macrophage survival of L. donovani depends on the availability of extracellular l-arginine. Infection of THP-1-derived macrophage/human monocyte-derived macrophage (hMDM) with Leishmania, resulted in upregulation of l-arginine transport...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28797195/identification-of-two-natural-compound-inhibitors-of-leishmania-donovani-spermidine-synthase-spds-through-molecular-docking-and-dynamic-studies
#6
V M Vidhya, Vikash Kumar Dubey, Karthe Ponnuraj
Visceral leishmaniasis caused by the protozoan Leishmania donovani is the most severe form of leishmaniasis and it is potentially lethal if untreated. Despite the availability of drugs for treating the disease, the current drug regime suffers from drawbacks like antibiotic resistance and toxicity. New drugs have to be discovered in order to overcome these limitations. Our aim is to identify natural compounds from plant sources as putative inhibitors considering the occurrence of structural diversity in plant sources...
August 10, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28796786/phlebotomine-sand-fly-borne-pathogens-in-the-mediterranean-basin-human-leishmaniasis-and-phlebovirus-infections
#7
REVIEW
Martina Moriconi, Gianluca Rugna, Mattia Calzolari, Romeo Bellini, Alessandro Albieri, Paola Angelini, Roberto Cagarelli, Maria P Landini, Remi N Charrel, Stefania Varani
Pathogens transmitted to humans by phlebotomine sand flies are neglected, as they cause infectious diseases that are not on the priority list of national and international public health systems. However, the infections caused by protozoa of the Leishmania genus and viruses belonging to the Phlebovirus genus (family Phenuiviridae)-the most significant group of viruses transmitted by sand flies-have a relevant role for human pathology. These infections are emerging in the Mediterranean region and will likely spread in forthcoming decades, posing a complex threat to human health...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28794624/nanostructured-delivery-systems-with-improved-leishmanicidal-activity-a-critical-review
#8
REVIEW
Natascia Bruni, Barbara Stella, Leonardo Giraudo, Carlo Della Pepa, Daniela Gastaldi, Franco Dosio
Leishmaniasis is a vector-borne zoonotic disease caused by protozoan parasites of the genus Leishmania, which are responsible for numerous clinical manifestations, such as cutaneous, visceral, and mucocutaneous leishmaniasis, depending on the site of infection for particular species. These complexities threaten 350 million people in 98 countries worldwide. Amastigotes living within macrophage phagolysosomes are the principal target of antileishmanial treatment, but these are not an easy target as drugs must overcome major structural barriers...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28782325/gastrointestinal-leishmaniasis-in-non-endemic-region
#9
Sujeet Raina, Rashmi Kaul Raina, Anita Bodh, Baldev Singh Rana, Rajesh Sharma
We report a case of visceral leishmaniasis (VL) in an immunocompetent native from non-endemic region of India that presented with chronic diarrhoea. VL was not a differential diagnosis and was unexpectedly diagnosed as intestinal leishmaniasis through the identification of the Leishman-Donovan (LD) bodies in duodenal and colonic mucosa. The patient expired before receiving antileishmanial therapy.
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28780414/chitosan-coated-pluronicf127-micelles-for-effective-delivery-of-amphotericin-b-in-experimental-visceral-leishmaniasis
#10
Pankaj K Singh, Vivek K Pawar, Anil K Jaiswal, Yuvraj Singh, Cheruvu Hanumanth Srikanth, Mohini Chaurasia, Himangsu K Bora, Kavit Raval, Jaya Gopal Meher, Jiaur R Gayen, Anuradha Dube, Manish K Chourasia
The goal of study was to develop micellar formulation of Amphotericin B (AmB) to improve its antileishmanial efficacy. AmB loaded pluronic F127 (PF 127) micelles were developed and coated with chitosan (Cs-PF-AmB-M) to accord immunoadjuvant and macrophage targeting properties. Hemolysis and cytotoxicity studies demonstrated that Cs-PF-AmB-M was 7.93 fold (at 20μg/ml AmB concentration) and 9.35 fold less hemolytic and cytotoxic, respectively in comparison to AmB suspension. Flow cytometry studies indicated that Cs-PF-FITC-M was 21...
August 2, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28775162/peripheral-blood-and-bone-marrow-involvement-by-visceral-leishmaniasis
#11
Parker W Clement, K David Li
No abstract text is available yet for this article.
August 3, 2017: Blood
https://www.readbyqxmd.com/read/28767981/protection-mediated-by-chemokine-cxcl10-in-balb-c-mice-infected-by-leishmania-infantum
#12
Webertty Mayk Eufrásio Figueiredo, Sayonara de Melo Viana, Dorotheia Teixeira Alves, Priscila Valera Guerra, Zirlane Castelo Branco Coêlho, Helene Santos Barbosa, Maria Jania Teixeira
BACKGROUND: Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response. Chemokines have a direct involvement in the pathogenesis of leishmaniasis, causing a rapid change in the expression of these molecules during infection by Leishmania. OBJECTIVES: Herein, it was investigated the role of CXCL10 in controlling infection by L. infantum. METHODS: RAW 264...
August 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28765172/leishmania-donovani-inhibits-inflammasome-dependent-macrophage-activation-by-exploiting-the-negative-regulatory-proteins-a20-and-ucp2
#13
Anand Kumar Gupta, Kuntal Ghosh, Shreyasi Palit, Jayita Barua, Pijush K Das, Anindita Ukil
In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1β over the infected control. Moreover, administering anti-IL-1β antibody to infected Amp B-treated mice showed significantly less parasite clearance. Investigation revealed that Leishmania inhibits stimuli-induced expression of a multiprotein signaling platform, NLRP3 inflammasome, which in turn inhibits caspase-1 activation mediated maturation of IL-1β from its pro form. Attenuation of NLRP3 and pro-IL-1β in infection was found to result from decreased NF-κB activity...
August 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28764187/visceral-leishmaniasis-in-an-immunocompromised-patient-diagnostic-bone-marrow-cytomorphology
#14
Manjari Kishore, Garima Baweja Madaan
No abstract text is available yet for this article.
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761480/detection-of-potentially-diagnostic-leishmania-antigens-with-western-blot-analysis-of-sera-from-patients-with-cutaneous-and-visceral-leishmaniases
#15
Seyyed Javad Seyyedtabaei, Ali Rostami, Ali Haghighi, Mehdi Mohebali, Bahram Kazemi, Shirzad Fallahi, Adel Spotin
BACKGROUND: Visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL) are important public health problems in Iran. We aimed to evaluate the diagnostic potential of Western blot (WB) compared with indirect immunofluorescence test (IFAT) to serodiagnosis of leishmaniasis. METHODS: This study was performed from 2010-2014 and participants were different parts of Iran. Serum samples were obtained from 43 patients with proven CL, 33 patients with proven VL, 39 patients with other parasitic diseases and 23 healthy individuals...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761456/visceral-leishmaniasis-in-southeastern-iran-a-narrative-review
#16
REVIEW
Iraj Sharifi, Mohammad Reza Aflatoonian, Mohammad Hossein Daei Parizi, Ali Hosseininasab, Mahshid Mostafavi, Mehdi Bamorovat, Abass Aghaei Afshar, Mehdi Mohebali, Hossein Keshavarz, Hamid Daneshvar, Zahra Babaei, Hossein Mahmoudvand, Mohammad Ali Mohammadi, Fatemeh Sharifi, Mohammad Barati, Hossein Kamiabi, Tabandeh Khaleghi
BACKGROUND: Visceral leishmaniasis (VL) has strong links with poverty, substantial medical and veterinary impacts. This review aimed to focus in studies published during 1994-2016 on VL in southeastern Iran. METHODS: The present review is based on expert knowledge and historical studies published during the past 23 yr (1994-2016) on VL in southeastern Iran. In addition, related literature found in PubMed by using the keywords such as visceral leishmaniasis, kala-azar, and Leishmania infantum are included...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28760482/evaluation-of-chemical-spraying-and-environmental-management-efficacy-in-areas-with-minor-previous-application-of-integrated-control-actions-for-visceral-leishmaniasis-in-brazil
#17
Fabiana de Oliveira Lara-Silva, Érika Monteiro Michalsky, Consuelo Latorre Fortes-Dias, Vanessa de Oliveira Pires Fiuza, Edelberto Santos Dias
Leishmaniases are vector-borne diseases that are transmitted to humans through the bite of Leishmania-infected phlebotomine sand flies (Diptera:Psychodidae). The main proved vector of visceral leishmaniais (VL) in the New World - Lutzomyia longipalpis - is well-adapted to urban areas and has extensive distribution within the five geographical regions of Brazil. Integrated public health actions directed for the vector, domestic reservoir and humans for the control of VL are preferentially applied in municipalities with higher epidemiological risk of transmission...
July 29, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28758666/maldi-ms-imaging-investigation-of-the-host-response-to-visceral-leishmaniasis
#18
C F Jaegger, F Negrão, D M Assis, K R A Belaz, C F F Angolini, A M A P Fernandes, V G Santos, A Pimentel, D R Abánades, S Giorgio, M N Eberlin, D F O Rocha
Mass spectrometry imaging (MSI) of animal tissues has become an important tool for in situ molecular analyses and biomarker studies in several clinical areas, but there are few applications in parasitological studies. Leishmaniasis is a neglected tropical disease, and experimental mouse models have been essential to evaluate pathological and immunological processes and to develop diagnostic methods. Herein we have employed MALDI MSI to examine peptides and low molecular weight proteins (2 to 20 kDa) differentially expressed in the liver during visceral leishmaniasis in mice models...
July 31, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28754315/insights-into-the-phosphatidylcholine-and-phosphatidylethanolamine-biosynthetic-pathways-in-leishmania-parasites-and-characterization-of-a-choline-kinase-from-leishmania-infantum
#19
Sergio A Pulido, Victoria H Nguyen, Juan F Alzate, David L Cedeño, Monika A Makurath, Amalia Ríos-Vásquez, Sandra M Duque-Benítez, Marjorie A Jones, Sara M Robledo, Jon A Friesen
The protozoan parasite Leishmania infantum is a causative agent of the disease visceral leishmaniasis, which can be fatal if not properly treated. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis pathways are attractive targets for new antileishmanial compounds since these Leishmania cell membrane phospholipids are important for parasite morphology and physiology. In this work we observed Leishmania synthesize PC and PE from extracellular choline and ethanolamine, respectively, suggesting the presence of CDP-choline and CDP-ethanolamine pathways...
July 25, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28747911/f1-domain-of-the-leishmania-leishmania-donovani-nucleoside-hydrolase-promotes-a-th1-response-in-leishmania-leishmania-infantum-cured-patients-and-in-asymptomatic-individuals-living-in-an-endemic-area-of-leishmaniasis
#20
Eugenia Carrillo, Laura Fernandez, Ana Victoria Ibarra-Meneses, Micheli L B Santos, Dirlei Nico, Paula M de Luca, Cristiane Bani Correa, Roque Pacheco de Almeida, Javier Moreno, Clarisa B Palatnik-de-Sousa
The Leishmania (Leishmania) donovani nucleoside hydrolase NH36 is the main antigen of the Leishmune(®) vaccine and one of the promising candidates for vaccination against visceral leishmaniasis. The antigenicity of the N-terminal (F1), the central (F2), or the C-terminal recombinant domain (F3) of NH36 was evaluated using peripheral blood mononuclear cells (PBMC) from individuals infected with L. (L.) infantum from an endemic area of visceral leishmaniasis of Spain. Both NH36 and F1 domains significantly increased the PBMC proliferation stimulation index of cured patients and infected asymptomatic individuals compared to healthy controls...
2017: Frontiers in Immunology
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