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visceral leishmaniasis

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https://www.readbyqxmd.com/read/28441357/investigation-of-the-anti-leishmania-leishmania-infantum-activity-of-some-natural-sesquiterpene-lactones
#1
Imke F Wulsten, Thais A Costa-Silva, Juliana T Mesquita, Marta L Lima, Mariana K Galuppo, Noemi N Taniwaki, Samanta E T Borborema, Fernando B Da Costa, Thomas J Schmidt, Andre G Tempone
Leishmaniases are neglected infectious diseases caused by parasites of the 'protozoan' genus Leishmania. Depending on the parasite species, different clinical forms are known as cutaneous, muco-cutaneous, and the visceral leishmaniasis (VL). VL is particularly fatal and the therapy presents limitations. In the search for new anti-leishmanial hit compounds, seven natural sesquiterpene lactones were evaluated against promastigotes and intracellular amastigotes of Leishmania (Leishmania) infantum, a pathogen causing VL...
April 25, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28438522/detection-of-leishmania-infantum-dna-in-conjunctival-swabs-of-cats-by-quantitative-real-time-pcr
#2
Julia Cristina Benassi, Graziella U Benvenga, Helena Lage Ferreira, Vanessa F Pereira, Lara B Keid, Rodrigo Soares, Tricia Maria Ferreira de Sousa Oliveira
Although some studies have investigated the potential role of cats as a reservoir for Leishmania, their role in the epidemiology of visceral leishmaniasis (VL) is still poorly understood. Molecular diagnostic techniques are an important tool in VL diagnosis, and PCR shows high sensitivity and specificity for Leishmania spp. detection. Quantitative real-time PCR (qPCR) is a method that permits quantitative analysis of a large number of samples, resulting in more sensitive, accurate, and reproducible measurements of specific DNA present in the sample...
April 21, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28433520/corrigendum-to-therapeutic-effect-of-ursolic-acid-in-experimental-visceral-leishmaniasis-int-j-parasitol-drugs-drug-resist-7-2017-1-11
#3
Jessica A Jesus, Thais N Fragoso, Eduardo S Yamamoto, Marcia D Laurenti, Marcelo S Silva, Aurea F Ferreira, João Henrique G Lago, Gabriela Santos-Gomes, Luiz Felipe D Passero
No abstract text is available yet for this article.
April 4, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/28429896/production-of-a-conjugate-between-the-rk346-antigen-from-leishmania-infantum-and-the-horseradish-peroxidase-c-for-the-detection-of-rk346-antibodies
#4
Juan Rengifo-González, Yollyseth Medina-Mora, Sasha Silva-Barrios, María Elizabeth Márquez-Contreras, María Tibisay Ruiz, Ana J Cáceres, Juan Luis Concepción, Wilfredo Quiñones
It was designed and characterized a reporter system to be captured by an- tibodies bound to ELISA plates. The system was designed with the rK346 from Leishmania infantum, a highly antigenic and specific protein. The rK346 was coupled to the horseradish peroxidase C (HRPc) from Armoracia rusticana using glutaraldehyde or sulfo-SMCC. Gluta- raldehyde conjugation was performed in two steps. Separation of conjugates was carried out using a Sepharose S-200 in size exclusion chromatography (SEC); fractions were analyzed via HRPc activity and through ELISA plates sensitized with polyclonal anti-rK346 IgG puri- fied from rabbit serum...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28427904/leishmania-donovani-tyrosyl-trna-synthetase-structure-in-complex-with-a-tyrosyl-adenylate-analog-and-comparisons-with-human-and-protozoan-counterparts
#5
Ximena Barros-Álvarez, Keshia M Kerchner, Cho Yeow Koh, Stewart Turley, Els Pardon, Jan Steyaert, Ranae M Ranade, J Robert Gillespie, Zhongsheng Zhang, Christophe L M J Verlinde, Erkang Fan, Frederick S Buckner, Wim G J Hol
The crystal structure of Leishmania donovani tyrosyl-tRNA synthetase (LdTyrRS) in complex with a nanobody and the tyrosyl adenylate analog TyrSA was determined at 2.75 Å resolution. Nanobodies are the variable domains of camelid heavy chain-only antibodies. The nanobody makes numerous crystal contacts and in addition reduces the flexibility of a loop of LdTyrRS. TyrSA is engaged in many interactions with active site residues occupying the tyrosine and adenine binding pockets. The LdTyrRS polypeptide chain consists of two pseudo-monomers, each consisting of two domains...
April 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28426153/a-non-pathogenic-recombinant-leishmania-expressing-lipophosphoglycan-3-against-experimental-infection-with-leishmania-infantum
#6
Leila Pirdel, Safar Farajnia
Visceral leishmaniasis (VL) is caused by Leishmania infantum in the Mediterranean basin and affects primarily children and immunosuppressed individuals. Various strategies of vaccination have so far been examined by either protein or DNA without achievable complete protection against the disease. The live non-pathogenic lizard parasite, Leishmania tarentolae, expressing elected Leishmania antigens has recently provided a promising new approach as a safe and effective live vaccine candidate to prevent leishmaniasis...
April 20, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28423167/what-pre-columbian-mummies-could-teach-us-about-south-american-leishmaniases
#7
Denis Sereno, Mohammad Akhoundi, Franck Dorkeld, Bruno Oury, Hooman Momen, Pascale Perrin
A recent report on the taxonomic profile of the human gut microbiome in pre-Columbian mummies (Santiago-Rodriguez et al. 2016) gives for the first time evidence of the presence of Leishmania DNA (sequences similar to Leishmania donovani according to the authors) that can be reminiscent of visceral leishmaniasis during the pre-Columbian era. It is commonly assumed that Leishmania infantum, the etiological agent of American visceral leishmaniasis (AVL) was introduced into the New World by the Iberian conquest...
April 1, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28419136/occurrence-of-leishmania-infantum-in-the-central-nervous-system-of-naturally-infected-dogs-parasite-load-viability-co-infections-and-histological-alterations
#8
Valéria da Costa Oliveira, Viviane Cardoso Boechat, Artur Augusto Velho Mendes Junior, Maria de Fátima Madeira, Luiz Claudio Ferreira, Fabiano Borges Figueiredo, Monique Paiva Campos, Francisco das Chagas de Carvalho Rodrigues, Raquel de Vasconcellos Carvalhaes de Oliveira, Maria Regina Reis Amendoeira, Rodrigo Caldas Menezes
Zoonotic visceral leishmaniasis is caused by the protozoan Leishmania infantum and little is known about the occurrence and pathogenesis of this parasite in the CNS. The aims of this study were to evaluate the occurrence, viability and load of L. infantum in the CNS, and to identify the neurological histological alterations associated with this protozoan and its co-infections in naturally infected dogs. Forty-eight Leishmania-seropositive dogs from which L. infantum was isolated after necropsy were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28416006/leishmania-major-large-rab-gtpase-is-highly-immunogenic-in-individuals-immune-to-cutaneous-and-visceral-leishmaniasis
#9
Rym Chamakh-Ayari, Mehdi Chenik, Ahmed Sahbi Chakroun, Narges Bahi-Jaber, Karim Aoun, Amel Meddeb-Garnaoui
BACKGROUND: We previously identified a Leishmania (L.) major large RAB GTPase (LmlRAB), a new atypical RAB GTPase protein. It is highly conserved in Leishmania species while displaying low level of homology with mammalian homologues. Leishmania small RAB GTPases proteins have been involved in regulation of exocytic and endocytic pathways whereas the role of large RAB GTPases proteins has not been characterized yet. We report here the immunogenicity of both recombinant rLmlRAB and rLmlRABC, in individuals with immunity against L...
April 17, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28415438/development-of-high-efficacy-peptide-coated-iron-oxide-nanoparticles-encapsulated-amphotericin-b-drug-delivery-system-against-visceral-leishmaniasis
#10
Rishikesh Kumar, Krishna Pandey, Ganesh C Sahoo, Susmita Das, Vnr Das, R K Topno, Pradeep Das
Visceral leishmaniasis, a protozoan disease transmitted by phlebotomine sandflies which affect mostly in Indian sub-continent. The treatment for visceral leishmaniasis (VL) caused by Leishmania donovani are limited and unsatisfactory. Currently available drug against such as miltefosine and polymer based drugs amBisome has high efficacy against VL but found serious side effects and poor absorbance. To overcome this, we developed peptide (glycine) coated iron oxide (Fe3O4) nanoparticles (GINPs) encapsulated amphoterecin B (AmB) drug against visceral leishmaniasis...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414744/knockdown-resistance-mutations-predict-ddt-resistance-and-pyrethroid-tolerance-in-the-visceral-leishmaniasis-vector-phlebotomus-argentipes
#11
Bruno Gomes, Bidyut Purkait, Rinki Michelle Deb, Aarti Rama, Rudra Pratap Singh, Geraldine Marie Foster, Michael Coleman, Vijay Kumar, Mark Paine, Pradeep Das, David Weetman
BACKGROUND: Indoor residual spraying (IRS) with DDT has been the primary strategy for control of the visceral leishmaniasis (VL) vector Phlebotomus argentipes in India but efficacy may be compromised by resistance. Synthetic pyrethroids are now being introduced for IRS, but with a shared target site, the para voltage-gated sodium channel (VGSC), mutations affecting both insecticide classes could provide cross-resistance and represent a threat to sustainable IRS-based disease control. METHODOLOGY/PRINCIPAL FINDINGS: A region of the Vgsc gene was sequenced in P...
April 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28407812/diagnostic-antigens-for-visceral-leishmaniasis-clarification-of-nomenclatures
#12
REVIEW
Tapan Bhattacharyya, Tegwen Marlais, Michael A Miles
BACKGROUND: Stimulated by the increasing recent use of 'K' or 'rK' nomenclature for antigens reported for visceral leishmaniasis (VL) diagnostic serology, we wished to give a chronological synopsis of their reporting and the potentially confusing terminology. METHODS: The literature was examined for 'K' or 'rK' terminology for VL diagnostic antigens, with emphasis on the original publications in which terms were first used. RESULTS: A chronological account of the first use of these 'K' and 'rK' nomenclatures was compiled...
April 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28403568/preparative-chiral-separation-and-absolute-configuration-of-the-synthetic-pterocarpanquinone-lqb-118
#13
Gabriel S Scatena, Neila M Cassiano, Chaquip D Netto, Paulo R R Costa, Quezia B Cass, João M Batista
The racemic pterocarpanquinone LQB-118 is active, in mice and hamsters, against tegumentary and visceral leishmaniasis. This compound also presents antiinflammatory and antineoplastic activity in mice. The low level of toxicity observed in these studies makes LQB-118 a promising drug candidate. In order to conduct further biological testing to investigate enantioselectivity in the above-mentioned activities, a multimilligram amount of each enantiomer of LQB-118 was produced. Furthermore, vibrational circular dichroism (VCD) and Density Functional Theory (DFT) calculations were used to determine unambiguously their absolute configurations...
May 2017: Chirality
https://www.readbyqxmd.com/read/28399053/short-course-regimens-of-liposomal-amphotericin-b-for-the-treatment-of-mediterranean-visceral-leishmaniasis-in-children-an-11-year-retrospective-study-at-a-tertiary-care-center
#14
Panagiotis Krepis, Ioanna Argyri, Adamantia Krepi, Areti Syrmou, Nikos Spyridis, Maria Tsolia
BACKGROUND: Visceral leishmaniasis (VL) remains an important public health problem in endemic regions. Current anti-leishmanial agents share several limitations including potentially serious side effects and the risk of clinical failure. OBJECTIVES: Aim of the present study was to examine the effectiveness and safety of short-course liposomal amphotericin B (L-AmB) regimens in the treatment of childhood VL in our area. METHODS: The cases of 43 VL patients (20 males, 23 females, mean age 4...
April 10, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28397794/protein-malnutrition-promotes-dysregulation-of-molecules-involved-in-t-cell-migration-in-the-thymus-of-mice-infected-with-leishmania-infantum
#15
Monica Losada-Barragán, Adriana Umaña-Pérez, Sergio Cuervo-Escobar, Luiz Ricardo Berbert, Renato Porrozzi, Fernanda N Morgado, Daniella Areas Mendes-da-Cruz, Wilson Savino, Myriam Sánchez-Gómez, Patricia Cuervo
Protein malnutrition, the most deleterious cause of malnutrition in developing countries, has been considered a primary risk factor for the development of clinical visceral leishmaniasis (VL). Protein malnutrition and infection with Leishmania infantum leads to lymphoid tissue disorganization, including changes in cellularity and lymphocyte subpopulations in the thymus and spleen. Here we report that protein malnutrition modifies thymic chemotactic factors by diminishing the CCL5, CXCL12, IGF1, CXCL9 and CXCL10 protein levels in infected animals...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28384307/studies-on-sand-fly-fauna-and-ecological-analysis-of-phlebotomus-orientalis-in-the-highland-and-lowland-foci-of-kala-azar-in-northwestern-ethiopia
#16
Esayas Aklilu, Araya Gebresilassie, Solomon Yared, Mizan Kindu, Habte Tekie, Meshesha Balkew, Alon Warburg, Asrat Hailu, Teshome Gebre-Michael
BACKGROUND: Visceral leishmaniasis (VL) also known as kala-azar is a growing health problem in Ethiopia with an estimated annual VL incidence between 3700 and 7400. The disease is mainly endemic in northwestern parts of the country. The aim of the current study was to determine the sand fly fauna and ecology of Phlebotomus orientalis in two endemic and ecologically distinct areas of northwestern Ethiopia. METHODS: Sand flies were collected using CDC light traps, sticky traps and pyrethrum spray catches from peri-domestic, mixed forest, farm field and indoor habitats from both Libo-Kemkem (May 2011-April 2012) and Metema (October 2012-September 2013) districts...
2017: PloS One
https://www.readbyqxmd.com/read/28380110/leptomonas-seymouri-and-crithidia-fasciculata-exoantigens-can-discriminate-human-cases-of-visceral-leishmaniasis-from-american-tegumentary-leishmaniasis-ones
#17
Norival Kesper, Marta Maria G Teixeira, José Angelo L Lindoso, Clara Lúcia Barbieri, Eufrosina Setsu Umezawa
Exoantigens (exo) from Leptomonas seymouri and Crithidia fasciculata were used in an enzyme linked immunosorbent assay (ELISA), showing 100% reactivity with sera from visceral leishmaniasis (VL) cases, and no reactivity with American tegumentary leishmaniasis (ATL) ones. Our results have indicated that these exoantigens can be applied in the discrimination of VL and ATL cases.
April 3, 2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28373107/immuno-informatics-based-approaches-to-identify-cd8-t-cell-epitopes-within-the-leishmania-donovani-3-ectonucleotidase-in-cured-visceral-leishmaniasis-subjects
#18
Vijaya Mahantesh, Ajay Amit, Manas R Dikhit, Ashish K Singh, T Venkateshwaran, V N R Das, Pradeep Das, Sanjiva Bimal
Leishmaniases are vector-borne diseases for which no vaccine exists. These diseases are caused by the Leishmania species complex. Activation of the CD8(+) T cell is crucial for protection against intracellular pathogens, and peptide antigens are attractive strategies for the precise activation of CD8(+) T in vaccine development against intracellular infections. The traditional approach to mine the epitopes is an arduous task. However, with the advent of immunoinformatics, in silico epitope prediction tools are available to expedite epitope identification...
April 1, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/28370779/comparison-of-recombinant-proteins-of-kinesin-39-heat-shock-protein-70-heat-shock-protein-83-and-glycoprotein-63-for-antibody-detection-of-leishmania-martiniquensis-infection
#19
Suradej Siripattanapipong, Hirotomo Kato, Peerapan Tan-Ariya, Mathirut Mungthin, Saovanee Leelayoova
Leishmania martiniquensis, a zoonotic hemoflagellate, is a causative agent of cutaneous (CL) and visceral leishmaniasis (VL) among humans and animals. This organism, firstly reported in Martinique Island, now has become an emerging infectious agent in Thailand. Symptomatic cases of L. martiniquensis infection among humans have continuously increased. In the meantime, asymptomatic infection of this novel species has seriously created national public health awareness and concern to prevent and control disease transmission...
March 28, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28370072/expression-profiling-of-sudanese-visceral-leishmaniasis-patients-pre-and-post-treatment-with-sodium-stibogluconate
#20
Mohamed A M Salih, Michaela Fakiola, Paul A Lyons, Brima M Younis, Ahmed M Musa, Ahmed M Elhassan, Denise Anderson, Genevieve Syn, Muntaser E Ibrahim, Jenefer M Blackwell, Hiba S Mohamed
Visceral leishmaniasis (VL) in Sudan caused by Leishmania donovani is fatal in susceptible individuals if untreated. Treatment with Sodium Stibogluconate (SSG) leads to post kala azar dermal leishmaniasis (PKDL) in 58% of patients. Here Affymetrix microarrays were used to identify genes differentially expressed in lymph nodes (N=9 paired samples) pre- and post-treatment with SSG. Using the Bioconductor package limma, 438 genes from 28,869 post quality-control probe-sets were differentially expressed (Pnominal ≤0...
March 31, 2017: Parasite Immunology
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