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https://www.readbyqxmd.com/read/27920546/chronotherapy-with-low-dose-modified-release-prednisone-for-the-management-of-rheumatoid-arthritis-a-review
#1
REVIEW
Stefano Paolo Beltrametti, Aurora Ianniello, Clara Ricci
To date, rheumatoid arthritis (RA) remains a debilitating, life-threatening disease. One major concern is morning symptoms (MS), as they considerably impair the patients' quality of life and ability to work. MS change in a circadian fashion, resembling the fluctuations of inflammatory cytokines such as interleukin-6, whose levels are higher in RA patients compared to healthy donors. Conversely, serum levels of the potent anti-inflammatory glucocorticoid cortisol are similar to that of healthy subjects, suggesting an imbalance that sustains a pro-inflammatory state...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27881095/a-regional-consensus-recommendation-on-brain-atrophy-as-an-outcome-measure-in-multiple-sclerosis
#2
Raed Alroughani, Dirk Deleu, Khalid El Salem, Jasem Al-Hashel, K John Alexander, Mohamed Assem Abdelrazek, Adel Aljishi, Jaber Alkhaboori, Faisal Al Azri, Nahida Al Zadjali, Majed Hbahbih, Tag Eldin Sokrab, Mohamed Said, Àlex Rovira
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory and neurodegenerative processes leading to irreversible neurological impairment. Brain atrophy occurs early in the course of the disease at a rate greater than the general population. Brain volume loss (BVL) is associated with disability progression and cognitive impairment in patients with MS; hence its value as a potential target in monitoring and treating MS is discussed. METHODS: A group of MS neurologists and neuro-radiologists reviewed the current literature on brain atrophy and discussed the challenges in assessing and implementing brain atrophy measurements in clinical practice...
November 24, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27879053/n-arylsulfonyl-indolines-as-retinoic-acid-receptor-related-orphan-receptor%C3%A2-%C3%AE-ror%C3%AE-agonists
#3
Christelle Doebelin, Rémi Patouret, Ruben D Garcia-Ordonez, Mi Ra Chang, Venkatasubramanian Dharmarajan, Dana S Kuruvilla, Scott J Novick, Li Lin, Michael D Cameron, Patrick R Griffin, Theodore M Kamenecka
The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH 17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH 17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy...
December 6, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27875788/simultaneous-determination-and-pharmacokinetic-study-of-four-phenolic-acids-in-rat-plasma-using-uflc-ms-ms-after-intravenous-administration-of-salvianolic-acid-for-injection
#4
Xiuman Xie, Jingzhuo Miao, Wanyang Sun, Jingyi Huang, Dongxiang Li, Shuming Li, Ling Tong, Guoxiang Sun
A simple, sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method was established for simultaneous determination and pharmacokinetic study of rosmarinic acid (RA), salvianolic acid D (Sal D), lithospermic acid (LA) and salvianolic acid B (Sal B) in rat plasma after intravenous administration of salvianolic acid for injection (SAFI). Three doses of administration, containing 14, 28 and 56mg/kg, were investigated in this study. Plasma samples were pretreated using protein precipitation (PP) with pre-cooled acetonitrile...
November 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27833448/a-possible-link-between-the-epstein-barr-virus-infection-and-autoimmune-thyroid-disorders
#5
REVIEW
Anna Dittfeld, Katarzyna Gwizdek, Marek Michalski, Romuald Wojnicz
The Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a member of the Herpesviridae virus family. EBV infection can cause infectious mononucleosis (IM) in the lytic phase of EBV's life cycle. Past EBV infection is associated with lymphomas, and may also result in certain allergic and autoimmune diseases. Although potential mechanisms of autoimmune diseases have not been clearly elucidated, both genetic and environmental factors, such as infectious agents, are considered to be responsible for their development...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27831763/thyroid-patient-salivary-radioiodine-transit-and-dysfunction-assessment-using-chewing-gums
#6
Demetrios Okkalides
Radiation-induced salivary gland dysfunction is the most frequent side-effect of I-131 thyroid therapy. Here, a novel saliva sampling method with ordinary chewing gums administered to the patients at appropriate time intervals post-treatment (TIPT) was used to relate this effect to chewing gum saliva activity (CGSA) content. Saliva samples were acquired after the oral administration of prescribed I-131 activity (radioactivity administered [RA]) to 19 differentiated thyroid cancer (DTC) and 16 hyperthyroidism patients of the radioisotope unit (RIU) during 2014 and 2015...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27830970/assessment-of-both-articular-synovitis-and-tenosynovitis-by-ultrasound-is-useful-for-evaluations-of-hand-dysfunction-in-early-rheumatoid-arthritis-patients
#7
Ayako Nishino, Shin-Ya Kawashiri, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yasuhiro Nagata, Takahiro Maeda, Kiyoshi Aoyagi, Atsushi Kawakami
OBJECTIVES: We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS: Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joints and 12 tendons. Each joint and tendon was scored by gray-scale (GS) and power Doppler (PD) on a scale from 0 to 3. The sums of the GS or PD scores were used as the articular synovitis score and the tenosynovitis score...
November 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27812365/shared-genetic-etiology-of-autoimmune-diseases-in-patients-from-a-biorepository-linked-to-de-identified-electronic-health-records
#8
Nicole A Restrepo, Mariusz Butkiewicz, Josephine A McGrath, Dana C Crawford
: Autoimmune diseases represent a significant medical burden affecting up to 5-8% of the U.S. POPULATION: While genetics is known to play a role, studies of common autoimmune diseases are complicated by phenotype heterogeneity, limited sample sizes, and a single disease approach. Here we performed a targeted genetic association study for cases of multiple sclerosis (MS), rheumatoid arthritis (RA), and Crohn's disease (CD) to assess which common genetic variants contribute individually and pleiotropically to disease risk...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27810919/higher-latitude-is-significantly-associated-with-an-earlier-age-of-disease-onset-in-multiple-sclerosis
#9
Chunrong Tao, Steve Simpson, Ingrid van der Mei, Leigh Blizzard, Eva Havrdova, Dana Horakova, Vahid Shaygannejad, Alessandra Lugaresi, Guillermo Izquierdo, Maria Trojano, Pierre Duquette, Marc Girard, Franois Grand'Maison, Pierre Grammond, Raed Alroughani, Murat Terzi, Celia Oreja-Guevara, Seyed Aidin Sajedi, Gerardo Iuliano, Patrizia Sola, Jeannette Lechner-Scott, Vincent Van Pesch, Eugenio Pucci, Roberto Bergamaschi, Michael Barnett, Cristina Ramo, Bhim Singhal, Daniele LA Spitaleri, Mark Slee, Freek Verheul, Ricardo Fernández Bolaños, Maria Pia Amato, Edgardo Cristiano, Franco Granella, Suzanne Hodgkinson, Marcela Fiol, Orla Gray, Pamela McCombe, Maria Laura Saladino, José Luis Sánchez Menoyo, Neil Shuey, Steve Vucic, Cameron Shaw, Norma Deri, Walter Oleschko Arruda, Helmut Butzkueven, Tim Spelman, Bruce V Taylor
BACKGROUND: Age at onset (AAO) in multiple sclerosis (MS) is an important marker of disease severity and may have prognostic significance. Understanding what factors can influence AAO may shed light on the aetiology of this complex disease, and have applications in the diagnostic process. METHODS: The study cohort of 22 162 eligible patients from 21 countries was extracted from the MSBase registry. Only patients with MS aged ≥16 years were included. To reduce heterogeneity, only centres of largely European descent were included for analysis...
November 3, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/27802328/is-time-to-reach-edss-6-0-faster-in-patients-with-late-onset-versus-young-onset-multiple-sclerosis
#10
Raed Alroughani, Saeed Akhtar, Samar Ahmed, Raed Behbehani, Jasem Al-Hashel
BACKGROUND & OBJECTIVES: Published natural history data on late-onset of multiple sclerosis are limited. We aimed to assess the risk of attaining EDSS 6.0 among patients with late-onset (> 40 years) MS (LOMS) and young-onset (18-40 years) MS (YOMS). METHODS: This cross-sectional cohort study was conducted to identify LOMS and YOMS patients' with relapsing remitting course at MS diagnosis. Time (years) to reach sustained EDSS 6.0 was compared between LOMS and AOMS patients...
2016: PloS One
https://www.readbyqxmd.com/read/27797930/effects-of-liraglutide-on-heart-rate-and-heart-rate-variability-a-randomized-double-blind-placebo-controlled-crossover-study
#11
Preman Kumarathurai, Christian Anholm, Bjørn S Larsen, Rasmus Huan Olsen, Sten Madsbad, Ole Kristiansen, Olav W Nielsen, Steen B Haugaard, Ahmad Sajadieh
OBJECTIVE: Reduced heart rate variability (HRV) and increased heart rate (HR) have been associated with cardiovascular mortality. Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) increase HR, and studies have suggested that they may reduce HRV. We examined the effect of the GLP-1 RA liraglutide on HRV and diurnal variation of HR in overweight patients with newly diagnosed type 2 diabetes (T2D) and stable coronary artery disease (CAD). RESEARCH DESIGN AND METHODS: Liraglutide or placebo was administrated to a backbone therapy of metformin in this double-blind, placebo-controlled 12 + 12-week crossover study...
October 19, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27789276/tear-fluid-protein-changes-in-dry-eye-syndrome-associated-with-rheumatoid-arthritis-a-proteomic-approach
#12
Saijyothi Venkata Aluru, Agarwal Shweta, Srinivasan Bhaskar, Krishnan Geetha, Rajappa M Sivakumar, Tatu Utpal, Prema Padmanabhan, Narayanasamy Angayarkanni
PURPOSE: Sjögren syndrome (SS) secondary to rheumatoid arthritis (RA) affects lacrimal and salivary glands, and therefore dry eye syndrome (DES) is more prevalent in patients with RA. This study used a proteomic approach to identify potential biomarkers in tear of DES secondary to RA (DES-RA). METHODS: Tear specimens were collected with Schirmer strips from patients with DES with RA, patients with other types of dry eye (namely, primary Sjögrens and non-Sjögrens [NSS]), and age-matched controls...
October 24, 2016: Ocular Surface
https://www.readbyqxmd.com/read/27775663/differential-amino-acid-carbohydrate-and-lipid-metabolism-perpetuations-involved-in-a-subtype-of-rheumatoid-arthritis-with-chinese-medicine-cold-pattern
#13
Hongtao Guo, Xuyan Niu, Yan Gu, Cheng Lu, Cheng Xiao, Kevin Yue, Ge Zhang, Xiaohua Pan, Miao Jiang, Yong Tan, Hongwei Kong, Zhenli Liu, Guowang Xu, Aiping Lu
Pattern classification is a key approach in Traditional Chinese Medicine (TCM), and it is used to classify the patients for intervention selection accordingly. TCM cold and heat patterns, two main patterns of rheumatoid arthritis (RA) had been explored with systems biology approaches. Different regulations of apoptosis were found to be involved in cold and heat classification in our previous works. For this study, the metabolic profiling of plasma was explored in RA patients with typical TCM cold or heat patterns by integrating liquid chromatography/mass spectrometry (LC/MS) and gas chromatography/mass spectrometry (GC/MS) platforms in conjunction with the Ingenuity Pathway Analysis (IPA) software...
October 21, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27752829/determination-of-piroxicam-from-rat-articular-tissue-and-plasma-based-on-lc-ms-ms
#14
Han Sol Kim, Ha Ra Cho, Myoung Jin Ho, Myung Joo Kang, Yong Seok Choi
Osteoarthritis (OA) is the most common type of arthritis. To manage OA, in general, oral administration of non-steroidal anti-inflammatory drugs (NSAIDs) is used. Recently, the analgesic and anti-inflammatory efficacy of piroxicam (PX), a long-acting NSAID, by intra-articular (IA) administration in OA was reported, and the possibility that PX is distributed in articular tissues at a certain concentration was raised. Thus, herein, novel LC-MS/MS methods to detect PX in rat articular tissue and plasma are presented...
October 17, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27726376/immunogenic-hla-dr-presented-self-peptides-identified-directly-from-clinical-samples-of-synovial-tissue-synovial-fluid-or-peripheral-blood-in-patients-with-rheumatoid-arthritis-or-lyme-arthritis
#15
Qi Wang, Elise E Drouin, Chunxiang Yao, Jiyang Zhang, Yu Huang, Deborah R Leon, Allen C Steere, Catherine E Costello
HLA-DR-molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory forms of arthritis. Here, we used LC-MS/MS to identify HLA-DR-presented self-peptides in cells taken directly from clinical samples: ST, synovial fluid mononuclear cells (SFMC), or peripheral blood mononuclear cells (PBMC) from five patients with rheumatoid arthritis (RA) and eight with Lyme arthritis (LA). We identified 1,593 non-redundant HLA-DR-presented peptides, derived from 870 source proteins...
October 11, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27720952/retinoylation-covalent-modification-by-retinoic-acid-of-rho-gdi%C3%AE-in-the-human-myeloid-leukemia-cell-line-hl60-and-its-functional-significance
#16
Noriko Takahashi, Toshihiro Ohba, Masahiko Imai, Shinya Hasegawa, Katsuhiko Takahashi, Masahiro Yamasaki, Yuri Kameoka
Retinoic acid (RA) has a variety of biological effects in mammalian cells and tissues. It is well known that RA induces differentiation of human acute promyelocytic leukemia (APL) HL60 cells, fresh human APL cells, and clinical remission in patients with APL. Retinoylation (acylation of proteins by RA) is a possible pathway for RA action. However, an understanding of the role that retinoylation plays in the actions of RA is lacking. In the current study, several retinoylated proteins were detected in RA-treated HL60 fractions following Mono Q anion exchange chromatography and analysis using two-dimensional polyacrylamide gel electrophoresis...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27720807/mechanical-sensitivity-and-electrophysiological-properties-of-acutely-dissociated-dorsal-root-ganglion-neurons-of-rats
#17
Viacheslav Viatchenko-Karpinski, Jianguo G Gu
Primary afferent fibers use mechanically activated (MA) currents to transduce innocuous and noxious mechanical stimuli. However, it is largely unknown about the differences in MA currents between the afferents for sensing innocuous and noxious stimuli. In the present study, we used dorsal root ganglion (DRG) neurons acutely dissociated from rats and studied their MA currents and also their intrinsic membrane properties. Recorded from small-sized DRG neurons, we found that most of these neurons were mechanically sensitive (MS) showing MA currents...
October 5, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27714146/a-hybrid-mos2-nanosheet-cdse-nanocrystal-phototransistor-with-a-fast-photoresponse
#18
Hyun-Soo Ra, Do-Hyun Kwak, Jong-Soo Lee
2-Dimensional (2D) and 0-dimensional (0D) hybrid nanostructures have been reported as promising new systems for highly-sensitive and wavelength-tunable photodetectors. Although the performance of hybrid photodetectors was enhanced by charge injection from 0D nanocrystals (NCs) to 2D nanosheets (NSs), the response time of hybrid photodetectors is still very slow due to the trapping and leakage of residual carriers at the interfaces of the hybrid materials. Here, we demonstrate a MoS2/CdSe hybrid phototransistor with enhanced responsivity of 2...
October 6, 2016: Nanoscale
https://www.readbyqxmd.com/read/27696449/the-disappearance-rate-and-risk-assessment-of-thiacloprid-residues-in-asian-pear-using-liquid-chromatography-confirmed-with-tandem-mass-spectrometry
#19
Md Humayun Kabir, A M Abd El-Aty, Md Musfiqur Rahman, Sung-Woo Kim, Jeong-Heui Choi, Young-Jun Lee, Lieu T B Truong, Kang-Bong Lee, Mi-Ra Kim, Ho-Chul Shin, Jae-Han Shim
This study was undertaken to quantify the residue levels and propose the dissipation kinetics of thiacloprid formulated as suspension concentrate (SC) in field-incurred Asian pears grown under two different open-field conditions. Samples were extracted with 20% distilled water in acetonitrile; partitioned with brine water and dichloromethane; and purified with a Florisil solid-phase extraction (SPE) cartridge. The analyte was identified with liquid chromatography (LC)-ultraviolet detector (UVD), and field-incurred samples were confirmed using LC-tandem mass spectrometry (MS/MS)...
October 3, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27683916/highly-active-immunomodulatory-therapy-ameliorates-accumulation-of-disability-in-moderately-advanced-and-advanced-multiple-sclerosis
#20
Nathaniel Lizak, Alessandra Lugaresi, Raed Alroughani, Jeannette Lechner-Scott, Mark Slee, Eva Havrdova, Dana Horakova, Maria Trojano, Guillermo Izquierdo, Pierre Duquette, Marc Girard, Alexandre Prat, Pierre Grammond, Raymond Hupperts, Francois Grand'Maison, Patrizia Sola, Eugenio Pucci, Roberto Bergamaschi, Celia Oreja-Guevara, Vincent Van Pesch, Cristina Ramo, Daniele Spitaleri, Gerardo Iuliano, Cavit Boz, Franco Granella, Javier Olascoaga, Freek Verheul, Csilla Rozsa, Edgardo Cristiano, Shlomo Flechter, Suzanne Hodgkinson, Maria Pia Amato, Norma Deri, Vilija Jokubaitis, Tim Spelman, Helmut Butzkueven, Tomas Kalincik
OBJECTIVE: To evaluate variability and predictability of disability trajectories in moderately advanced and advanced multiple sclerosis (MS), and their modifiability with immunomodulatory therapy. METHODS: The epochs between Expanded Disability Status Scale (EDSS) steps 3-6, 4-6 and 6-6.5 were analysed. Patients with relapse-onset MS and having reached 6-month confirmed baseline EDSS step (3/4/6) were identified in MSBase, a global observational MS cohort study...
September 28, 2016: Journal of Neurology, Neurosurgery, and Psychiatry
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