Christina Manniche, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Peter Høgh, Marianne Juhler, Anne-Mette Hejl
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) remains a challenge to differentiate from subcortical ischemic vascular disease (SIVD). Despite major research efforts, the cerebrospinal fluid (CSF) biomarker profiles of the two diseases are still not known in detail. OBJECTIVE: To determine if novel CSF biomarkers, neurofilament light (NFL) reflecting axonal damage, the synaptic protein neurogranin (NG), and the astroglial marker chitinase-3-like protein 1 (YKL-40), and the core Alzheimer's disease (AD) biomarkers, amyloid-β 42 (Aβ42), total tau (t-tau), phosphorylated tau (p-tau), can differentiate iNPH from SIVD...
May 4, 2020: Journal of Alzheimer's Disease: JAD