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Linqiong Sang, Lin Chen, Li Wang, Jingna Zhang, Ye Zhang, Pengyue Li, Chuanming Li, Mingguo Qiu
Cognitive impairment caused by subcortical ischemic vascular disease (SIVD) has been elucidated by many neuroimaging studies. However, little is known regarding the changes in brain functional connectivity networks in relation to the severity of cognitive impairment in SIVD. In the present study, 20 subcortical ischemic vascular cognitive impairment no dementia patients (SIVCIND) and 20 dementia patients (SIVaD) were enrolled; additionally, 19 normal controls were recruited. Each participant underwent a resting-state functional MRI scan...
2018: Frontiers in Neurology
X X Zhao, C Z Shen, X X Xie, Q Q Xu, X Zhou, Z W Sun
Objective: To explore the change and value of platelet aggregability(PA)in patients with subcortical ischemic vascular disease (SIVD). Methods: A total of 108 patients with SIVD hospitalized in the Department of Neurology of the First Affiliated Hospital of Anhui Medical University from October 2015 to July 2017 were enrolled as SIVD group and 30 healthy cases were also in cluded as normal controlgroup (NC). According to magnetic resonance imaging(MRI), the SIVD group was further divided into two subtypes: lacunar infarction(LI) ( n =31)and leukoaraiosis(LA) ( n =77)...
March 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Erik Barry Erhardt, John C Pesko, Jillian Prestopnik, Jeffrey Thompson, Arvind Caprihan, Gary A Rosenberg
Binswanger's disease is a form of subcortical ischemic vascular disease (SIVD-BD) with extensive white matter changes. To test the hypothesis that biomarkers could improve classification of SIVD-BD, we recruited 62 vascular cognitive impairment and dementia (VCID) patients. Multimodal biomarkers were collected at entry into the study based on clinical and neuropsychological testing, multimodal magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) analysis. The patients' diagnoses were confirmed by long-term follow-up, and they formed a "training set" to test classification methods, including (1) subcortical ischemic vascular disease score (SIVDS), (2) exploratory factor analysis (EFA), (3) logistic regression (LR), and (4) random forest (RF)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
Perla do Nascimento Martins, Kelly Cristina Alves Silverio, Alcione Ghedini Brasolotto
PURPOSE: Investigate the vocal and laryngopharyngeal symptoms, vocal quality, Voice Activity and Participation Profile (VAPP), and vocal acoustic and auditory-perceptual characteristics from evangelical pastors comparing with the same aspects of nonprofessional voice men. METHOD: Sixty professionally active male subjects were divided into two groups: 30 pastors and 30 nonprofessional voice men, with ages between 24 and 59 years old. Participants answered the Screening Index for Voice Disorder (SIVD) questionnaire and the VAPP, as well as an auditory-perceptual and acoustic evaluation of the voice...
September 18, 2017: Journal of Voice: Official Journal of the Voice Foundation
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) is a major public health concern because of the increased incidence of vascular disease in the aging population and the impact of vascular disease on Alzheimer's disease. VCID is a heterogeneous group of diseases for which there are no proven treatments. Biomarkers can be used to select more homogeneous populations. Small vessel disease is the most prevalent form of VCID and is the optimal form for treatment trials because there is a progressive course with characteristic pathological changes...
September 13, 2017: Journal of Neurochemistry
Min-Chien Tu, Wen-Hui Huang, Yen-Hsuan Hsu, Chung-Ping Lo, Jie Fu Deng, Ching-Feng Huang
BACKGROUND: The causes of behavioral and psychological symptoms of dementia (BPSD) vary according to the dementia subtype and associated neuropathology. The present study aimed to (i) compare BPSD between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) across stages, and (ii) explore the associations with diffusion tensor imaging (DTI) in the corpus callosum (CC) and other major fibers. METHODS: Twenty-four patients with SIVD and 32 with AD were recruited...
July 28, 2017: BMC Neurology
Ariane Damasceno Pellicani, Alice Ramos Fontes, Francisco Flavio Santos, Aline Damasceno Pellicani, Lilian Neto Aguiar-Ricz
OBJECTIVES: This study aimed to describe and correlate the fundamental frequency behavior and the first four formants before and after exposure to usual and routinely prolonged voice use from teachers with over 4 years of experience in teaching. STUDY DESIGN: The study design is observational and transversal with quantitative and descriptive evaluations. METHODS: A total of 28 female teachers were subjected to the Screening Index for Voice Disorder (SIVD) and to recordings of the sustained vowel /a/ before and after exposure to prolonged voice use...
June 20, 2017: Journal of Voice: Official Journal of the Voice Foundation
Liliana Ramirez-Gomez, Ling Zheng, Bruce Reed, Joel Kramer, Dan Mungas, Chris Zarow, Harry Vinters, John M Ringman, Helena Chui
BACKGROUND/AIMS: The aim of this study was to assess the ability of neuropsychological tests to differentiate autopsy-defined Alzheimer disease (AD) from subcortical ischemic vascular dementia (SIVD). METHODS: From a sample of 175 cases followed longitudinally that underwent autopsy, we selected 23 normal controls (NC), 20 SIVD, 69 AD, and 10 mixed cases of dementia. Baseline neuropsychological tests, including Memory Assessment Scale word list learning test, control oral word association test, and animal fluency, were compared between the three autopsy-defined groups...
2017: Dementia and Geriatric Cognitive Disorders
Maria Lúcia Vaz Masson, Tânia Maria de Araújo
OBJECTIVE: This study aimed to compare the effects of two protective strategies, voice amplification (VA) and 0.9% NaCl nebulization (NEB), on teachers' voice in the work setting. METHODS: An interventional evaluator-blind study was conducted, assigning 53 teachers from two public high schools to one of the two protective strategy groups (VA or NEB). Vocal function was assessed in a sound-treated booth before and after a 4-week period. Assessment included the severity of voice impairment (Consensus Auditory-Perceptual Evaluation of Voice [CAPE-V]), acoustic analysis of fundamental frequency (f0), sound pressure level (SPL), jitter, shimmer, glottal-to-noise excitation ratio (GNE), noise (VoxMetria), and the self-rated Screening Index for Voice Disorder (SIVD)...
May 31, 2017: Journal of Voice: Official Journal of the Voice Foundation
Sang Jun Park, Shin Hyung Kim, Seon Ju Kim, Duck Mi Yoon, Kyung Bong Yoon
Purpose. Intravascular injection rates are higher during traditional S1 transforaminal epidural steroid injection (TFESI) compared with lumbar transforaminal injection. We compared the incidences of intravascular injection between the medial and lateral approaches to the S1 foramen during S1 TFESI. Materials and Methods. A total of 139 patients underwent one or more TFESIs (170 total injections). The patients received S1 TFESI by either medial or lateral side of S1 foramen under fluoroscopic anteroposterior view using digital subtraction method...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
Yawen Sun, Xin Ge, Xu Han, Wenwei Cao, Yao Wang, Weina Ding, Mengqiu Cao, Yong Zhang, Qun Xu, Yan Zhou, Jianrong Xu
The presence and pattern of iron accumulation in subcortical vascular mild cognitive impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed to examine brain iron deposition in svMCI subjects using quantitative susceptibility mapping (QSM). Moreover, we aimed to investigate the correlation between brain iron deposition and the severity of cognitive impairment as indicated by z-scores. We recruited 20 subcortical ischemic vascular disease (SIVD) patients who fulfilled the criteria for svMCI...
2017: Frontiers in Aging Neuroscience
Yun Jeong Hong, Chan-Mi Kim, Ji Eun Kim, Jee Hoon Roh, Jae Seung Kim, Sang Won Seo, Duk L Na, Jae-Hong Lee
We investigated the amyloid and vascular burden in Pittsburgh compound B (PiB)-negative subcortical vascular mild cognitive impairment (svMCI) and PiB-negative subcortical ischemic vascular dementia (SIVD) to elucidate the potential roles of amyloid deposition and small vessel disease (SVD). Thirty-eight svMCI patients and 42 SIVD patients were enrolled. The regional PiB uptake values and SVD markers were obtained and compared between groups. Additionally, correlations among amyloid burden, SVD, and cognition were made...
July 2017: Neurobiology of Aging
Min-Chien Tu, Chung-Ping Lo, Ching-Feng Huang, Yen-Hsuan Hsu, Wen-Hui Huang, Jie Fu Deng, Yung-Chuan Lee
OBJECTIVE: To describe and compare diffusion tensor imaging (DTI) parameters between patients with subcortical ischemic vascular disease (SIVD) and Alzheimer's disease (AD) diagnosed using structuralized neuropsychiatric assessments, and investigate potential neuronal substrates related to cognitive performance. METHODS: Thirty-five patients with SIVD, 40 patients with AD, and 33 cognitively normal control (NC) subjects matched by age and education level were consecutively recruited and underwent cognitive function assessments and DTI examinations...
2017: PloS One
Gary A Rosenberg
Vascular cognitive impairment and dementia (VCID) include a wide spectrum of chronic manifestations of vascular disease related to large vessel strokes and small vessel disease (SVD). Lacunar strokes and white matter (WM) injury are consequences of SVD. The main vascular risk factor for SVD is brain hypoperfusion from cerebral blood vessel narrowing due to chronic hypertension. The hypoperfusion leads to activation and degeneration of astrocytes with the resulting fibrosis of the extracellular matrix (ECM)...
March 1, 2017: Clinical Science (1979-)
Mandy Busse, Ralf Kunschmann, Henrik Dobrowolny, Jessica Hoffmann, Bernhard Bogerts, Johann Steiner, Thomas Frodl, Stefan Busse
N-Methyl-D-aspartate glutamate receptor (NMDA-R) antibodies (Abs) could play a role in neurodegenerative disorders. Since, in these diseases, NMDA-R Abs were detected in serum, but only sporadic in cerebrospinal fluid (CSF), the origin and impact of the Abs are still unresolved. We examined the presence of NMDA-R Abs in serum and CSF using a cell-based immunofluorescence assay as well as the function of the blood-CSF-barrier (B-CSF-B) by determination of Q albumin (ratio of albumin in CSF and serum) in patients with mild cognitive impairment (MCI; N = 59) and different types of dementia, Alzheimer's disease (AD; N = 156), subcortical ischemic vascular dementia (SIVD; N = 61), and frontotemporal dementia (FTD; N = 34)...
February 8, 2017: European Archives of Psychiatry and Clinical Neuroscience
Yen-Hsuan Hsu, Ching-Feng Huang, Chung-Ping Lo, Tzu-Lan Wang, Chi-Cheng Yang, Min-Chien Tu
BACKGROUND: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. METHODS: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging...
2016: Dementia and Geriatric Cognitive Disorders
Yiting Zhou, Jing Zhang, Lu Wang, Ying Chen, Yushan Wan, Yang He, Lei Jiang, Jing Ma, Rujia Liao, Xiangnan Zhang, Liyun Shi, Zhenghong Qin, Yudong Zhou, Zhong Chen, Weiwei Hu
Subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion exhibits progressive white matter and cognitive impairments. However, its pathogenetic mechanisms are poorly understood. We investigated the role of interleukin-1β (IL-1β) and its receptor IL-1 receptor type 1 (IL-1R1) in an experimental SIVD model generated via right unilateral common carotid arteries occlusion (rUCCAO) in mice. We found that IL-1β expression was elevated in the corpus callosum at the early stages after rUCCAO...
February 2017: Brain, Behavior, and Immunity
Yawen Sun, Wenwei Cao, Weina Ding, Yao Wang, Xu Han, Yan Zhou, Qun Xu, Yong Zhang, Jianrong Xu
Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score...
2016: Frontiers in Aging Neuroscience
Caroline Greenan, Lynn Murphy, Ly-Mee Yu, Patrick G Kehoe, Elizabeth Coulthard, Philip Bath, Robert Stewart, Rob Jones, Anne Corbett, Alan Thomas, Peter Connelly, Frank Arrojo, Rachel Canning, Sylvia Wallach, Catherine Henderson, Bernadette McGuinness, Mike O'Sullivan, Clive Holmes, Martin Knapp, Clive Ballard, Peter Passmore
BACKGROUND: Vascular dementia is the second most common cause of dementia affecting over seven million people worldwide, yet there are no licensed treatments. There is an urgent need for a clinical trial in this patient group. Subcortical ischaemic vascular dementia is the most common variant of vascular dementia. This randomised trial will investigate whether use of calcium channel blockade with amlodipine, a commonly used agent, can provide the first evidence-based pharmacological treatment for subcortical ischaemic vascular dementia...
July 18, 2016: Trials
A Melo, M A Faria, E Pinto, C Mansilha, I M P L V O Ferreira
Water disinfection plays a crucial role in water safety but it is also a matter of concern as the use of disinfectants promotes the formation of disinfection by-products (DBPs). Haloacetic acids (HAAs) are one of the major classes of DBPs since they are frequently found in treated water, are ubiquitous, pervasive and have high water solubility, so a great concern emerged about their formation, occurrence and toxicity. Exposure to HAAs is influenced by consumption patterns and diet of individuals thus their bioavailability is an important parameter to the overall toxicity...
October 2016: Chemosphere
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