keyword
https://read.qxmd.com/read/38536827/effects-of-aflibercept-and-bevacizumab-on-cell-viability-cell-metabolism-and-inflammation-in-hypoxic-human-m%C3%A3-ller-cells
#1
JOURNAL ARTICLE
Monique Matsuda, Rafael André da Silva, Vinicius Moraes de Paiva Roda, Mônica Valéria Marquezini, Mário Luiz Ribeiro Monteiro, Dânia Emi Hamassaki
Anti-VEGF (vascular endothelial growth factor) drugs such as aflibercept (AFL) and bevacizumab (BVZ) inhibit pathological neo-angiogenesis and vascular permeability in retinal vascular diseases. As cytokines and growth factors are produced by Müller glial cells under stressful and pathological conditions, we evaluated the in vitro effect of AFL (Eylea®, 0.5 mg/mL) and BVZ (Avastin®, 0.5 mg/mL) on cell viability/metabolism, and cytokine/growth factor production by Müller cells (MIO-M1) under cobalt chloride (CoCl2)-induced hypoxia after 24h, 48h and 72h...
2024: PloS One
https://read.qxmd.com/read/38536776/electroacupuncture-stimulation-enhances-the-permeability-of-the-blood-brain-barrier-a-systematic-review-and-meta-analysis-of-preclinical-evidence-and-possible-mechanisms
#2
JOURNAL ARTICLE
Nuo Xu, Peng Gong, Shiting Xu, Yangyun Chen, Mengyuan Dai, Zhaoxing Jia, Xianming Lin
An important cellular barrier to maintain the stability of the brain's internal and external environment is the blood-brain barrier (BBB). It also prevents harmful substances from entering brain tissue through blood circulation while providing protection for the central nervous system. It should be noted, however, that the intact BBB can be a barrier to the transport of most drugs into the brain via the conventional route of administration, which can prevent them from reaching effective concentrations for the treatment of disorders affecting the central nervous system...
2024: PloS One
https://read.qxmd.com/read/38536455/matching-proposed-clinical-and-mri-criteria-of-aggressive-multiple-sclerosis-to-serum-and-cerebrospinal-fluid-markers-of-neuroaxonal-and-glial-injury
#3
JOURNAL ARTICLE
Martin A Schaller-Paule, Michelle Maiworm, Jan Hendrik Schäfer, Lucie Friedauer, Elke Hattingen, Katharina Johanna Wenger, Frank Weber, Jasmin Jakob, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
BACKGROUND: Definitions of aggressive MS employ clinical and MR imaging criteria to identify highly active, rapidly progressing disease courses. However, the degree of overlap between clinical and radiological parameters and biochemical markers of CNS injury is not fully understood. Aim of this cross-sectional study was to match clinical and MR imaging hallmarks of aggressive MS to serum/CSF markers of neuroaxonal and astroglial injury (neurofilament light chain (sNfL, cNfL), and glial fibrillary acidic protein (sGFAP, cGFAP))...
March 27, 2024: Journal of Neurology
https://read.qxmd.com/read/38535583/viral-infections-are-they-a-trigger-and-risk-factor-of-alzheimer-s-disease
#4
REVIEW
Meagan D Rippee-Brooks, Wenzhe Wu, Jianli Dong, Miguel Pappolla, Xiang Fang, Xiaoyong Bao
Alzheimer's Disease (AD), a progressive and debilitating condition, is reported to be the most common type of dementia, with at least 55 million people believed to be currently affected. Many causation hypotheses of AD exist, yet the intriguing link between viral infection and its possible contribution to the known etiology of AD has become an attractive focal point of research for the field and a challenging study task. In this review, we will explore the historical perspective and milestones that led the field to investigate the viral connection to AD...
March 8, 2024: Pathogens
https://read.qxmd.com/read/38535038/tumor-like-lesions-in-primary-angiitis-of-the-central-nervous-system-the-role-of-magnetic-resonance-imaging-in-differential-diagnosis
#5
REVIEW
Marialuisa Zedde, Manuela Napoli, Claudio Moratti, Claudio Pavone, Lara Bonacini, Giovanna Di Cecco, Serena D'Aniello, Ilaria Grisendi, Federica Assenza, Grégoire Boulouis, Thanh N Nguyen, Franco Valzania, Rosario Pascarella
Primary Angiitis of the Central Nervous System (PACNS) is a rare disease and its diagnosis is a challenge for several reasons, including the lack of specificity of the main findings highlighted in the current diagnostic criteria. Among the neuroimaging pattern of PACNS, a tumefactive form (t-PACNS) is a rare subtype and its differential diagnosis mainly relies on neuroimaging. Tumor-like mass lesions in the brain are a heterogeneous category including tumors (in particular, primary brain tumors such as glial tumors and lymphoma), inflammatory (e...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534921/spatially-resolved-microglia-macrophages-in-recurrent-glioblastomas-overexpress-fatty-acid-metabolism-and-phagocytic-genes
#6
JOURNAL ARTICLE
Akshitkumar M Mistry, Jonah Daneshmand, SeonYeong Jamie Seo, Norman L Lehman, Donald M Miller, Dylan A Goodin, Hermann B Frieboes, Joseph Chen, Adrianna Masters, Brian J Williams, Kavitha Yaddanapudi
BACKGROUND: Glioblastoma (GBM) tumors are rich in tumor-associated microglia/macrophages. Changes associated with treatment in this specific cell population are poorly understood. Therefore, we studied changes in gene expression of tumor-associated microglia/macrophages (Iba1+) cells in de novo versus recurrent GBMs. METHODS: NanoString GeoMx® Digital Spatial Transcriptomic Profiling of microglia/macrophages (Iba1+) and glial cells (Gfap+) cells identified on tumor sections was performed on paired de novo and recurrent samples obtained from three IDH-wildtype GBM patients...
February 23, 2024: Current Oncology
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#7
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38534343/the-exon-junction-complex-factor-rbm8a-in-glial-fibrillary-acid-protein-expressing-astrocytes-modulates-locomotion-behaviors
#8
JOURNAL ARTICLE
Shravan Asthana, Jennifer Mott, Mabel Tong, Zifei Pei, Yingwei Mao
The role of RNA Binding Motif Protein 8a (RBM8A), an exon junction complex (EJC) component, in neurodevelopmental disorders has been increasingly studied for its crucial role in regulating multiple levels of gene expression. It regulates mRNA splicing, translation, and mRNA degradation and influences embryonic development. RBM8A protein is expressed in both neurons and astrocytes, but little is known about RBM8A's specific role in glial fibrillary acid protein (GFAP)-positive astrocytes. To address the role of RBM8A in astrocytes, we generated a conditional heterozygous knockout (KO) mouse line of Rbm8a in astrocytes using a GFAP-cre line...
March 13, 2024: Cells
https://read.qxmd.com/read/38534318/nicotinic-acetylcholine-receptors-in-glial-cells-as-molecular-target-for-parkinson-s-disease
#9
REVIEW
Érica Novaes Soares, Ana Carla Dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizabi
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease...
March 7, 2024: Cells
https://read.qxmd.com/read/38534205/meningeal-damage-and-interface-astroglial-scarring-in-the-rat-brain-exposed-to-a-laser-induced-shock-wave-s
#10
JOURNAL ARTICLE
Satoko Kawauchi, Akemi Kono, Yuriko Muramatsu, Grant Hennes, Shuta Seki, Susumu Tominaga, Yasue Haruyama, Yukari Komuta, Izumi Nishidate, Susumu Matsukuma, Yushan Wang, Shunichi Sato
In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), grey-white matter junctions (GM-WM), ventricular wall (VW) and regions surrounding cortical blood vessels, accurately reproducing clinical IAS...
March 27, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38533577/plasma-neurofilament-light-chain-is-increased-in-niemann-pick-type-c-but-glial-fibrillary-acidic-protein-remains-normal
#11
JOURNAL ARTICLE
Dhamidhu Eratne, Courtney Lewis, Wendy Kelso, Samantha Loi, Wei-Hsuan Michelle Chiu, Kaj Blennow, Henrik Zetterberg, Alexander F Santillo, Dennis Velakoulis, Mark Walterfang
OBJECTIVE: Niemann-Pick Type C (NPC) is a genetic neurodegenerative lysosomal storage disorder commonly associated with psychiatric symptoms and delays to accurate diagnosis and treatment. This study investigated biomarker levels and diagnostic utility of plasma neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in NPC compared to healthy controls. METHODS: Patients with NPC were recruited from a specialist assessment and management service...
March 27, 2024: Acta Neuropsychiatrica
https://read.qxmd.com/read/38533497/the-interaction-of-lipocalin-2-and-astrocytes-in-neuroinflammation-mechanisms-and-therapeutic-application
#12
REVIEW
Qianqian Tan, Chenxi Zhang, Xiuqin Rao, Wei Wan, Wei Lin, Shupeng Huang, Jun Ying, Yue Lin, Fuzhou Hua
Neuroinflammation is a common pathological process in various neurological disorders, including stroke, Alzheimer's disease, Parkinson's disease, and others. It involves the activation of glial cells, particularly astrocytes, and the release of inflammatory mediators. Lipocalin-2 (Lcn-2) is a secretory protein mainly secreted by activated astrocytes, which can affect neuroinflammation through various pathways. It can also act as a pro-inflammatory factor by modulating astrocyte activation and polarization through different signaling pathways, such as NF-κB, and JAK-STAT, amplifying the inflammatory response and aggravating neural injury...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532785/nebulization-of-low-dose-aspirin-ameliorates-huntington-s-pathology-in-n171-82q-transgenic-mice
#13
JOURNAL ARTICLE
Susanta Mondal, Shelby Prieto, Suresh B Rangasamy, Debashis Dutta, Kalipada Pahan
Huntington Disease (HD), a devastating hereditary neurodegenerative disorder, is caused by expanded CAG trinucleotide repeats in the huntingtin gene ( Htt ) on chromosome 4. Currently, there is no effective therapy for HD. Although aspirin, acetylsalicylic acid, is one of the most widely-used analgesics throughout the world, it has some side effects. Even at low doses, oral aspirin can cause gastrointestinal symptoms, such as heartburn, upset stomach, or pain. Therefore, to bypass the direct exposure of aspirin to stomach, here, we described a new mode of use of aspirin and demonstrated that nebulization of low-dose of aspirin (10 μg/mouse/d=0...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532783/cinnamic-acid-a-natural-plant-compound-exhibits-neuroprotection-in-a-mouse-model-of-sandhoff-disease-via-ppar%C3%AE
#14
JOURNAL ARTICLE
Sumita Raha, Ramesh K Paidi, Debashis Dutta, Kalipada Pahan
Tay-Sachs disease (TSD) and its severe form Sandhoff disease (SD) are autosomal recessive lysosomal storage metabolic disorders, which often result into excessive GM2 ganglioside accumulation predominantly in lysosomes of nerve cells. Although patients with these diseases appear normal at birth, the progressive accumulation of undegraded GM2 gangliosides in neurons leads to early death accompanied by manifestation of motor difficulties and gradual loss of behavioral skills. Unfortunately, there is still no effective treatment available for TSD/SD...
March 2024: NeuroImmune Pharm Ther
https://read.qxmd.com/read/38532011/active-forgetting-and-neuropsychiatric-diseases
#15
REVIEW
Jacob A Berry, Dana C Guhle, Ronald L Davis
Recent and pioneering animal research has revealed the brain utilizes a variety of molecular, cellular, and network-level mechanisms used to forget memories in a process referred to as "active forgetting". Active forgetting increases behavioral flexibility and removes irrelevant information. Individuals with impaired active forgetting mechanisms can experience intrusive memories, distressing thoughts, and unwanted impulses that occur in neuropsychiatric diseases. The current evidence indicates that active forgetting mechanisms degrade, or mask, molecular and cellular memory traces created in synaptic connections of "engram cells" that are specific for a given memory...
March 26, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38530364/satellite-glial-gpr37l1-and-its-ligand-maresin-1-regulate-potassium-channel-signaling-and-pain-homeostasis
#16
JOURNAL ARTICLE
Sangsu Bang, Changyu Jiang, Jing Xu, Sharat Chandra, Aidan McGinnis, Xin Luo, Qianru He, Yize Li, Zilong Wang, Xiang Ao, Marc Parisien, Lorenna Oliveira Fernandes de Araujo, Sahel Jahangiri Esfahani, Qin Zhang, Raquel Tonello, Temugin Berta, Luda Diatchenko, Ru-Rong Ji
G protein-coupled receptor 37-like 1 (GPR37L1) is an orphan GPCR with largely unknown functions. Here we report that Gpr37l1/GRP37L1 ranks among the most highly expressed GPCR transcripts in mouse and human dorsal root ganglia (DRGs), selectively expressed in satellite glial cells (SGCs). Peripheral neuropathy induced by streptozotoxin (STZ) and paclitaxel (PTX) led to reduced GPR37L1 expression on the plasma membrane expression in mouse and human DRGs. Transgenic mice with Gpr37l1 deficiency exhibited impaired resolution of neuropathic pain symptoms following PTX and STZ-induced pain, whereas overexpression of Gpr37l1 in mouse DRGs reversed pain...
March 26, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38530227/methylene-blue-and-its-potential-in-the-treatment-of-traumatic-brain-injury-brain-ischemia-and-alzheimer-s-disease
#17
REVIEW
Nickolay K Isaev, Elizaveta E Genrikhs, Elena V Stelmashook
Traumatic brain injury (TBI) and brain ischemia/reperfusion cause neurodegenerative processes that can continue after the acute stage with the development of severe brain atrophy with dementia. In this case, the long-term neurodegeneration of the brain is similar to the neurodegeneration characteristic of Alzheimer's disease (AD) and is associated with the accumulation of beta amyloid and tau protein. In the pathogenesis of AD as well as in the pathogenesis of cerebral ischemia and TBI oxidative stress, progressive inflammation, glial activation, blood-brain barrier dysfunction, and excessive activation of autophagy are involved, which implies the presence of many targets that can be affected by neuroprotectors...
March 27, 2024: Reviews in the Neurosciences
https://read.qxmd.com/read/38530221/synergism-between-hypothalamic-astrocytes-and-neurons-in-metabolic-control
#18
REVIEW
Laura M Frago, Alfonso Gomez-Romero, Roberto Collado-Pérez, Jesús Argente, Julie A Chowen
Astrocytes are no longer considered as passive support cells. In the hypothalamus, these glial cells actively participate in the control of appetite, energy expenditure and the processes leading to obesity and its secondary complications. Here we briefly review studies supporting this conclusion and the advances made in understanding the underlying mechanisms.
March 26, 2024: Physiology
https://read.qxmd.com/read/38529953/correction-for-querbes-et-al-a-jc-virus-induced-signal-is-required-for-infection-of-glial-cells-by-a-clathrin-and-eps15-dependent-pathway
#19
JOURNAL ARTICLE
W Querbes, A Benmerah, D Tosoni, P P Di Fiore, Walter J Atwood
No abstract text is available yet for this article.
March 26, 2024: Journal of Virology
https://read.qxmd.com/read/38529606/comparative-outcomes-of-intravenous-intranasal-and-intracerebroventricular-transplantation-of-human-neural-stem-cells-in-mice-model-of-ischemic-stroke
#20
JOURNAL ARTICLE
Mengze Zhang, Yaying Song, Chong Xie, Yangtai Guan
BACKGROUND: Transplantation of neural stem cells improves ischemic stroke outcomes in rodent models and is currently in the clinical test stage. However, the optimal delivery route to achieve improved efficacy remains undetermined. OBJECTIVE: This study aims to evaluate three more clinically feasible delivery routes: intravenous (IV), intranasal (IN), and intracerebroventricular (ICV). We compared the therapeutic efficacies of the three routes of transplanting human neural stem cells (hNSCs) into mice with permanent middle cerebral artery obstruction (pMCAO)...
March 25, 2024: Current Stem Cell Research & Therapy
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